28 completed, 2 terminated, 1 active not recruiting, 1 recruiting. 34 Phase 3, 2 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 34 | Completed 28, Terminated 2, Active not recruiting 1, Recruiting 1, Unknown 1, Withdrawn 1 |
| Phase 2 | 2 | Completed 1, Unknown 1 |
Follow Osteoarthritis of the Knee: new trials by email Literature Review of Osteoarthritis of the Knee trials Research Report on Osteoarthritis of the Knee
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Phase III Study of CLS2901C in Patients With Osteoarthritis of the Knee CLS2901C (human [allogeneic] chondrocyte sheets) - Osteoarthritis of the Knee | Phase 3 | Recruiting | CellSeed Inc. | 96 | 2023-10-20 | 2026-07-09 |
| A Pragmatic Trial to Determine the Benefit of Behaviorally Enhanced Exercise Incentives and Corticosteroid Injections in Osteoarthritis of the Knee Marching On for Veterans With Osteoarthritis of the Knee Social Incentives and Gamification to Promote Exercise, Corticosteroid Injection given in A-B order, No Social Incentive applied - Osteoarthritis of the Knee | Phase 3 | Active not recruiting | VA Office of Research and Development | 221 | 2022-03-14 | 2025-03-20 |
| 3-year, Open-Label Study Evaluating Safety, Tolerability, and Efficacy of Lorecivivint in Knee Osteoarthritis Lorecivivint - Osteoarthritis of the Knee | Phase 3 | Terminated | Biosplice Therapeutics, Inc. | 72 | 2021-07-15 | 2026-03-31 |
| Extended and Controlled Release Liposomal Formulated Dexamethasone for Chronic Knee OA Pain TLC599, DSP, Normal Saline - Osteoarthritis of the Knee | Phase 3 | Completed | Taiwan Liposome Company | 504 | 2019-11-26 | 2024-10-08 |
| Study to Assess the Safety of Repeat Administration of FX006 Administered to Patients With Osteoarthritis of the Knee FX006 32 mg - Osteoarthritis of the Knee | Phase 3 | Completed | Pacira Pharmaceuticals, Inc | 208 | 2017-02-20 | 2024-01-24 |
| A Study to Evaluate the Efficacy & Safety of an Intra-Articular Ampion Injection for Pain of Osteoarthritis of the Knee 4 mL injection of AMPION™, 4 mL injection of Placebo - Osteoarthritis of the Knee | Phase 3 | Completed | Ampio Pharmaceuticals. Inc. | 480 | 2015-09-01 | 2022-08-09 |
| Repeat Injection of Cingal® for Osteoarthritis of the Knee Cingal - Osteoarthritis of the Knee | Phase 3 | Completed | Anika Therapeutics, Inc. | 242 | 2015-02-01 | 2022-03-22 |
| An Extension Study of Duloxetine in Osteoarthritis and Knee Pain (Extension of F1J-JE-HMGX, NCT02248480) Duloxetine - Osteoarthritis of the Knee | Phase 3 | Completed | Eli Lilly and Company | 93 | 2015-01-01 | 2019-09-18 |
| Study of FX006 for the Treatment of Pain in Patients With Osteoarthritis of the Knee FX006, Placebo, TCA IR 40 - Osteoarthritis of the Knee | Phase 3 | Completed | Pacira Pharmaceuticals, Inc | 486 | 2015-01-01 | 2024-01-24 |
| A Study of Duloxetine (LY248686) in Participants With Chronic Osteoarthritis and Knee Pain in Japan Duloxetine, Placebo - Osteoarthritis of the Knee | Phase 3 | Completed | Eli Lilly and Company | 354 | 2014-10-01 | 2019-09-26 |
| A Multiple Injection Study Evaluating Safety and Efficacy of Ampion in Osteoarthritis 4 mL injection of Ampion, 4 mL Injection of Placebo - Osteoarthritis of the Knee | Phase 3 | Completed | Ampio Pharmaceuticals. Inc. | 342 | 2014-09-01 | 2022-09-15 |
| A Randomized, Controlled Study to Evaluate Efficacy and Safety of Intra-articular Ampion for Osteoarthritis Pain in Knee 4 mL injection of Ampion, 4 mL Injection of Placebo - Osteoarthritis of the Knee | Phase 3 | Completed | Ampio Pharmaceuticals. Inc. | 538 | 2014-01-01 | 2022-08-09 |
| Hydros and Hydros-TA Joint Therapy for Pain Associated With Knee Osteoarthritis Hydros, Hydros-TA, Triamcinolone Acetonide - Osteoarthritis of the Knee | Phase 3 | Completed | Carbylan Therapeutics, Inc. | 510 | 2014-01-01 | 2016-08-25 |
| Apitox, Honeybee Toxin for Pain and Inflammation of Osteoarthritis Apitox, purified honeybee toxin, lyophilized in saline, histamine - Osteoarthritis of the Knee | Phase 3 | Completed | Apimeds, Inc. | 363 | 2013-12-01 | 2016-12-13 |
| Safety and Efficacy of Etoricoxib 30 mg Versus Celecoxib 200 mg in Korean Participants With Osteoarthritis Etoricoxib 30 mg, Celecoxib 200 mg - Osteoarthritis of the Knee | Phase 3 | Completed | Organon and Co | 239 | 2012-03-01 | 2022-02-09 |
| Trial to See if Topical Pennsaid for Knee Pain Affects Coagulation Values in Patients Who Are Also Taking Anticoagulants Pennsaid - Osteoarthritis of the Knee, Coagulopathy | Phase 3 | Completed | Nathan Wei, MD, FACP, FACR: | 22 | 2012-02-01 | 2014-06-26 |
| Efficacy and Safety of LBSA0103 Versus Hyruan Plus Injection in Patients With Knee Osteoarthritis Placebo, Hyruan Plus, LBSA0103 - Osteoarthritis of the Knee | Phase 3 | Completed | LG Life Sciences | 287 | 2011-12-01 | 2013-01-17 |
| Platelet Rich Plasma (PRP) as a Treatment for Knee Osteoarthritis PRP as a Treatment for Knee Osteoarthritis Platelet Rich Plasma (Preparation Rich in Growth Factors), Hyaluronic acid - Osteoarthritis of the Knee | Phase 2 / Phase 3 | Unknown | Meir Medical Center | 100 | 2011-09-01 | 2011-07-19 |
| Axial Alignment in Patients Operated Using the Visionaire Patient Matched Cutting Blocks Visionaire, Standard surgical technique - Osteoarthritis of the Knee | Phase 3 | Terminated | Smith & Nephew Orthopaedics AG | 70 | 2011-03-01 | 2015-04-14 |
| Efficacy and Safety Study of Glucosamine/Chondroitin Sulfate to Patients Treatment With Osteoarthrosis of the Knee Glucosamine sulphate and chondroitin sulphate association, Cosamin DS® (Nutramax) - Osteoarthritis of the Knee | Phase 3 | Completed | Eurofarma Laboratorios S.A. | 100 | 2010-08-01 | 2023-02-08 |
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Osteoarthritis, Knee (34) · Osteoarthritis (14) · Pain (5) · Arthritis (2) · Joint Diseases (2) · Arthralgia (1) · Chronic Pain (1) · Hemostatic Disorders (1) · Infections (1) · Inflammation (1) · Motor Activity (1) · Musculoskeletal Diseases (1) · Rheumatic Diseases (1)
Musculoskeletal Diseases (33) · Rheumatic Diseases (33) · Arthritis (32) · Joint Diseases (32) · Osteoarthritis (20) · Neurologic Manifestations (7) · Pathological Conditions, Signs and Symptoms (7) · Signs and Symptoms (7) · Pain (2) · Behavior (1) · Cardiovascular Diseases (1) · Connective Tissue Diseases (1) · Hematologic Diseases (1) · Hemic and Lymphatic Diseases (1) · Hemorrhagic Disorders (1)
Sodium Chloride (5) · Celecoxib (3) · Hyaluronic Acid (3) · Duloxetine Hydrochloride (2) · FX006 (2) · Intercellular Signaling Peptides and Proteins (2) · Ketoprofen (2) · Saline Solution (2) · Triamcinolone Acetonide (2) · Acetaminophen (1) · Anti-Inflammatory Agents, Non-Steroidal (1) · Arthroscopy (1) · Bee Venoms (1) · Buprenorphine (1) · Chondroitin (1)
Ampio Pharmaceuticals. Inc. (3) · Eli Lilly and Company (2) · IDEA AG (2) · Meir Medical Center (2) · Pacira Pharmaceuticals, Inc (2) · Seikagaku Corporation (2) · University of Western Ontario, Canada (2) · Anika Therapeutics, Inc. (1) · Apimeds, Inc. (1) · Biosplice Therapeutics, Inc. (1) · Carbylan Therapeutics, Inc. (1) · CellSeed Inc. (1) · Eurofarma Laboratorios S.A. (1) · Ferring Pharmaceuticals (1) · Hisamitsu Pharmaceutical Co., Inc. (1)
United States (16) · Canada (4) · Australia (3) · Japan (3) · Czechia (2) · Israel (2) · Poland (2) · South Korea (2) · United Kingdom (2) · Brazil (1) · Denmark (1) · Estonia (1) · Germany (1) · Hong Kong (1) · Hungary (1)
Howard Levy, MD (2) · Bo Young Yoon, MD (1) · Brian G Feagan, MD (1) · Carl Brown, PhD (1) · Chang Hee Suh, MD (1) · Christopher M. H. Kim, M.D. (1) · Cristiano F. Zerbini, Phd/MD (1) · Dianne Bryant, PhD (1) · Edwin Kuffner, MD (1) · Han-joo Baek, MD (1) · Howard Levy, M.D. (1) · Hyun Ah Kim, MD (1)
PMID 27250845, PMID 29156068, PMID 29780263, PMID 21174485, PMID 22342928, PMID 23542612, PMID 23996292, PMID 25133963, PMID 28549436, PMID 29713194, PMID 30126675, PMID 30464579, PMID 30657100, PMID 30741382, PMID 30968336, PMID 31505082, PMID 32021407, PMID 32245696, PMID 34791634, PMID 36269595, PMID 39412672