30 completed, 3 terminated, 3 unknown, 1 active not recruiting. 38 Phase 2, 7 Phase 3, 6 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 38 | Completed 30, Terminated 3, Unknown 3, Active not recruiting 1, Recruiting 1 |
| Phase 3 | 7 | Completed 6, Unknown 1 |
| Phase 1 | 6 | Completed 6 |
Follow Opioid Dependence: new trials by email Literature Review of Opioid Dependence trials Research Report on Opioid Dependence
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Standardized Natural Psilocybin-assisted Psychotherapy for Tapering of Opioid Medication Psilocybin-assisted Psychotherapy - Opioid Dependence, Chronic Pain | Phase 2 | Recruiting | University of British Columbia | 10 | 2025-10-27 | 2025-12-04 |
| Exploratory Dose Ranging Study Assessing APH-1501 for the Treatment of Opioid Addiction APH-1501, Placebo - Addiction, Opioid Dependence | Phase 2 | Unknown | Aphios | 32 | 2023-10-01 | 2021-07-27 |
| Brain Mechanisms of Pharmacotherapy in Opioid Use Disorder Brixadi, Vivitrol - Opioid Dependence | Phase 2 | Terminated | University of Pennsylvania | 3 | 2022-08-01 | 2025-08-06 |
| HOPE Consortium Trial to Reduce Pain and Opioid Use in Hemodialysis Pain Coping Skills Training (PCST), Buprenorphine - End Stage Renal Disease, Chronic Pain | Phase 2 | Completed | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | 643 | 2021-01-03 | 2025-01-13 |
| Project 1 Aim 2, Adaptations of the Brain in Chronic Pain With Opioid Exposure Carbidopa-Levodopa 25 Mg-100 Mg Oral Tablet, Naproxen 500 Mg, Opioids - Opioid Use, Opioid Dependence | Phase 2 | Active not recruiting | Northwestern University | 60 | 2021-01-01 | 2024-11-27 |
| An Innovative Intervention for OUD Treatment Bridge Device, Lofexidine, Placebo - Opioid-Related Disorders, Opioid Dependence | Phase 2 / Phase 3 | Completed | Johns Hopkins University | 36 | 2020-11-15 | 2026-06-09 |
| Preliminary Efficacy and Safety of Ibogaine in the Treatment of Methadone Detoxification Ibogaine Hydrochloride - Drug Dependence, Drug Use Disorders | Phase 2 | Completed | International Center for Ethnobotanical Education, Research, and Service | 20 | 2020-10-28 | 2025-01-17 |
| Perioperative Ketamine in Opioid-Tolerant Patients Undergoing Lumbar Spine Surgery Ketamine, Placebo Comparator - Opioid Dependence, Chronic Pain | Phase 2 | Terminated | Jacques E. Chelly | 1 | 2019-12-17 | 2024-01-30 |
| Medical Management of Sleep Disturbance During Opioid Tapering Placebo oral capsule, Low Dose Suvorexant, High Dose Suvorexant - Opioid Dependence, Opioid Withdrawal | Phase 2 | Completed | Johns Hopkins University | 90 | 2019-07-01 | 2022-08-08 |
| Remote Observed Dosing of Suboxone to Improve Clinical Practice Suboxone Remote Observed Dosing, Suboxone Attention Control - Opioid-use Disorder, Opioid Dependence | Phase 1 / Phase 2 | Completed | University of Pennsylvania | 16 | 2019-04-01 | 2023-07-27 |
| A Study of Thienorphine Hydrochloride Tablets in Relapse Prevention Treatment of Opioid Dependence 0.2mg group, 0.5mg group, placebo control group - Opioid Dependence | Phase 2 | Unknown | Wei Hao | 180 | 2018-08-31 | 2018-09-04 |
| A Randomized, Double-Blind, Single-Center Clinical Study on the Efficacy of Naltrexone Implant in Antagonizing Opioid Agonist Hydromorphone 0.9g Naltrexone Implant + 0.6g Naltrexone Implant Placebo, 1.5g Naltrexone Implant - Opioid Dependence | Phase 2 | Completed | Shenzhen Sciencare Medical Industries Co., Ltd. | 31 | 2018-08-07 | 2025-06-11 |
| Liposomal Bupivacaine for Pain Control Following Thoracic Surgery. Liposomal bupivacaine, Bupivacaine, Epinephrine - Pain, Postoperative, Thoracic Diseases | Phase 2 / Phase 3 | Unknown | Massachusetts General Hospital | 200 | 2017-02-01 | 2017-01-30 |
| Effects of Glucocorticoids on Craving During Detoxification Treatment of Heroin and/or Stimulants Prednisolone, Placebo (for Prednisolone) - Opioid Dependence, Cocaine Dependence | Phase 2 | Terminated | Prof. Dominique de Quervain, MD | 4 | 2016-10-01 | 2019-05-23 |
| Oxytocin Treatment of Opioid Dependence Intranasal Oxytocin Spray, Placebo - Opioid Dependence, Opioid Withdrawal | Phase 1 / Phase 2 | Completed | University of North Carolina, Chapel Hill | 12 | 2016-02-01 | 2019-08-07 |
| Glutamatergic Modulation to Facilitate Naltrexone Initiation in Opioid Dependence CI-581aa, Naltrexone titration and XR-NTX initiation - Opioid Dependence | Phase 2 | Completed | New York State Psychiatric Institute | 16 | 2015-01-01 | 2019-04-08 |
| Buprenorphine/Naloxone Stabilization and Induction Onto Injection Naltrexone Buprenorphine/naloxone - Opioid Dependence | Phase 2 / Phase 3 | Completed | New York State Psychiatric Institute | 30 | 2014-09-01 | 2020-03-11 |
| Improving Buprenorphine Detoxification Outcomes With Isradipine Isradipine, Placebo - Opioid Dependence | Phase 1 / Phase 2 | Completed | University of Arkansas | 28 | 2013-10-01 | 2017-06-05 |
| A Randomized, 4-sequence, 2-period, Double-blind, Placebo Controlled Study With a DSM-IV-TR Diagnosis of Cocaine Abuse RBP-8000 100 mg, Placebo, Cocaine - Opioid Dependence, Opioid Related Disorders | Phase 2 | Completed | Indivior Inc. | 40 | 2013-04-01 | 2016-09-23 |
| Effects of Ibudilast on Oxycodone Self-administration in Opioid Abusers MN-166 (50 mg) First, Placebo First - Opioid Abuse, Opioid Dependence | Phase 2 | Completed | New York State Psychiatric Institute | 28 | 2012-11-01 | 2017-08-17 |
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Opioid-Related Disorders (38) · Substance-Related Disorders (6) · Chronic Pain (4) · Cocaine-Related Disorders (4) · Behavior, Addictive (3) · Pain (3) · Heroin Dependence (2) · Acquired Immunodeficiency Syndrome (1) · Agnosia (1) · Back Injuries (1) · Back Pain (1) · Kidney Failure, Chronic (1) · Marijuana Abuse (1) · Mental Disorders (1) · Pain, Postoperative (1)
Chemically-Induced Disorders (38) · Narcotic-Related Disorders (38) · Mental Disorders (37) · Substance-Related Disorders (32) · Neurologic Manifestations (6) · Pathological Conditions, Signs and Symptoms (6) · Signs and Symptoms (6) · Behavior (3) · Compulsive Behavior (3) · Impulsive Behavior (3) · Pain (3) · Nervous System Diseases (2) · Pathologic Processes (2) · Urogenital Diseases (2) · Blood-Borne Infections (1)
Buprenorphine (5) · Buprenorphine, Naloxone Drug Combination (5) · Naltrexone (5) · vivitrol (4) · Memantine (3) · Methadone (3) · Gabapentin (2) · Morphine (2) · Tramadol (2) · Analgesics, Opioid (1) · Bupivacaine (1) · Clonidine (1) · Cocaine (1) · Codeine (1) · Cognitive Behavioral Therapy (1)
New York State Psychiatric Institute (8) · Johns Hopkins University (6) · Prof. Dominique de Quervain, MD (2) · University of Arkansas (2) · University of Pennsylvania (2) · Yale University (2) · Aphios (1) · Baylor College of Medicine (1) · BioDelivery Sciences International (1) · Indivior Inc. (1) · International Center for Ethnobotanical Education, Research, and Service (1) · Jacques E. Chelly (1) · Massachusetts General Hospital (1) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (1) · National Institute on Drug Abuse (NIDA) (1)
United States (30) · Switzerland (2) · Canada (1) · China (1) · Spain (1)
Adam Bisaga, MD (2) · Alison Oliveto, Ph.D. (2) · Adam Bisaga, M.D. (1) · Alison Oliveto, PhD (1) · Andrew S Huhn, PhD (1) · Antje Kemter, MD (1) · Apkar V Apkarian, PhD (1) · Bradley D Vince, DO (1) · Brenda Curtis, PhD (1) · Cort A Pedersen, MD (1) · Elias Dakwar, MD (1) · Elizabeth Evans, M.D. (1) · Eric C. Strain, M.D. (1) · Eric Strain (1) · Eric Strain, M.D. (1)
PMID 40342086, PMID 11058673, PMID 12873949, PMID 1517644, PMID 15919269, PMID 16002025, PMID 17341537, PMID 21715107, PMID 22013534, PMID 22227789, PMID 23049275, PMID 23335901, PMID 23952897, PMID 24227768, PMID 24674234, PMID 25175864, PMID 25823919, PMID 25866297, PMID 25912739, PMID 26218852, PMID 26308513, PMID 26447431, PMID 26507422, PMID 26560326, PMID 26962719, PMID 27042786, PMID 27790554, PMID 28700791, PMID 29373393, PMID 33281447, PMID 33953123, PMID 38086444, PMID 39627496, PMID 39786400, PMID 42526778, PMID 9879238
2016 (1), K02DA032322 (1), K23DA000429 (1), K23DA021209 (1), P50DA009236 (1), P50DA018197 (1), R01DA008045 (1), R01DA010017 (1), R01DA015822 (1), R01DA018125 (1), R01DA019497 (1), R01DA027124 (1), R01DA027138 (1), R01DA048761 (1), R21DA035325 (1)