108 completed, 17 unknown, 12 terminated, 9 recruiting. 45 Not applicable, 38 Phase 2, 27 Phase 3, 22 Phase 1, 18 Phase 4.
Follow Opioid Dependence: new trials by email Literature Review of Opioid Dependence trials Research Report on Opioid Dependence
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| VK4-116 Phase I Study With Food-Effect VK4-116, Placebo - Opioid Dependence, Opioid Use Disorder (OUD) | Phase 1 | Not yet recruiting | National Institute on Drug Abuse (NIDA) | 48 | 2026-08-01 | 2026-04-09 |
| Transcranial Direct Current Stimulation (tDCS) for Treatment of Substance Use Disorder Transcranial Direct Current Stimulator (tDCS), Cognitive Reappraisal Training - Cocaine Use Disorder, Cocaine Dependence | Not applicable | Recruiting | Icahn School of Medicine at Mount Sinai | 240 | 2026-02-25 | 2026-10-13 |
| Assessing the Acceptability, Feasibility, Effectiveness and Cost-effectiveness of LADB long-acting depot buprenorphine (LADB) - Opioid Dependence | Not yet recruiting | PATH | 760 | 2025-11-01 | 2025-10-07 | |
| Standardized Natural Psilocybin-assisted Psychotherapy for Tapering of Opioid Medication Psilocybin-assisted Psychotherapy - Opioid Dependence, Chronic Pain | Phase 2 | Recruiting | University of British Columbia | 10 | 2025-10-27 | 2025-12-04 |
| Better Options for Chronic Cancer Pain Multimodal pain care, Medication optimization, Buprenorphine rotation - Chronic Pain, Cancer Survivor | Phase 4 | Recruiting | VA Office of Research and Development | 294 | 2025-10-07 | 2026-05-11 |
| Buprenorphine as a Post-operative Analgesic in Opioid-Naive Patients After Ankle Fracture Surgery Buprenorphine Transdermal System, Placebo Patch - Pain, Postoperative, Ankle Fracture Surgery | Phase 4 | Recruiting | Jenna-Leigh Wilson | 100 | 2025-04-21 | 2026-04-06 |
| The MOUD Plus Pilot: Counseling and Peer Support to Support Retention for Medically Complex Patients With Opioid Use Disorder Seen In Primary Care MOUD "Plus" Intervention (treatment as usual + coordinated counseling and referral to community based peer), Treatment As Usual (primary care with low threshold MOUD prescribing) - Opioid Dependence, Substance Abuse Disorders | Not applicable | Active not recruiting | Oregon Health and Science University | 70 | 2025-03-24 | 2026-10-21 |
| fMRI and Opioid Abstinence fMRI - Drug Use Disorder, Opioid Dependence | Recruiting | Yale University | 240 | 2024-12-12 | 2026-08-07 | |
| A Clinical Trial to Assess Pharmacokinetic Profiles, Safety and Tolerability of IVL3004 and IVL4002 in Healthy Male Subjects. Vivitrol Injectable Product, IVL3004, IVL4002 - Opioid Dependence, Alcohol Dependence | Phase 1 | Recruiting | Inventage Lab., Inc. | 40 | 2024-09-11 | 2025-09-15 |
| Gut Microbiota Dysbiosis in Opioid Use Disorders: Implications for Clinical Symptoms and Relapse Rate. stool analysis - Opioid Use, Opioid Use Disorder | Unknown | Assiut University | 52 | 2024-02-01 | 2024-01-30 | |
| DE-eSCALation of Opioids Post-surgical dischargE Rapid Opioid de-escalation, Gradual Opioid de-escalation, Continuation of opioids - Opioid Dependence | Not applicable | Unknown | University of Kent | 100 | 2024-01-11 | 2024-05-02 |
| OLP to Manage Pain in TJA: A Feasibility Study Open Label Placebo, Patient medication as standardly prescribed - Opioid Dependence, Opioid Abuse | Early Phase 1 | Withdrawn | University of Alabama at Birmingham | 2023-12-01 | 2025-05-13 | |
| Exploratory Dose Ranging Study Assessing APH-1501 for the Treatment of Opioid Addiction APH-1501, Placebo - Addiction, Opioid Dependence | Phase 2 | Unknown | Aphios | 32 | 2023-10-01 | 2021-07-27 |
| Measuring Acute Drug Demand in Humans Drug A (Blinded Drug), Drug B (Blinded Drug), Drug C (Blinded Drug) - Opioid Use Disorder, Opioid Dependence | Early Phase 1 | Recruiting | University of Maryland, Baltimore | 75 | 2023-08-08 | 2026-06-23 |
| The Effects of Daily Anti-inflammatory Supplementation on Foundation Pain Index Scores in Chronic Opiate Patients Root.Health Dietary Supplement - Pain, Chronic, Opioid Dependence | Not applicable | Terminated | Hudson Medical | 1 | 2023-07-10 | 2025-03-13 |
| STTEPP: Safety, Tolerability and Dose Limiting Toxicity of Lacosamide in Patients With Painful Chronic Pancreatitis Lacosamide - Chronic Pain, Chronic Pain Syndrome | Phase 1 | Active not recruiting | Indiana University | 21 | 2023-03-17 | 2026-06-03 |
| Novel Induction to Buprenorphine/Naloxone buprenorphine/naloxone - Opioid Use Disorder, Opioid Use | Phase 4 | Terminated | Bicycle Health | 33 | 2023-02-06 | 2024-08-20 |
| Effects on Mortality and Clinical Course of a Patient's Choice Model for Opioid Maintenance Treatment for Opioid Dependence - Evaluation of a System Enabling a Large Expansion of Treatment Providers and Treatment Access Opioid maintenance treatment - Opioid Dependence, Overdose | Unknown | Region Skane | 2500 | 2023-01-31 | 2023-01-10 | |
| Return to Work - Will Brief Intervention Reduce Opioid-induced Back Pain? Brief Intervention - Opioid Dependence, Low Back Pain | Not applicable | Unknown | University Hospital, Akershus | 10 | 2022-08-01 | 2022-06-29 |
| Brain Mechanisms of Pharmacotherapy in Opioid Use Disorder Brixadi, Vivitrol - Opioid Dependence | Phase 2 | Terminated | University of Pennsylvania | 3 | 2022-08-01 | 2025-08-06 |
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Opioid-Related Disorders (160) · Substance-Related Disorders (15) · Chronic Pain (14) · Behavior, Addictive (13) · Pain (10) · Cocaine-Related Disorders (9) · Heroin Dependence (6) · Pain, Postoperative (5) · Acquired Immunodeficiency Syndrome (4) · Agnosia (3) · Osteoarthritis, Knee (3) · Alcoholism (2) · Contraception Behavior (2) · Depression (2) · Drug Overdose (2)
Chemically-Induced Disorders (160) · Narcotic-Related Disorders (160) · Mental Disorders (159) · Substance-Related Disorders (145) · Pathological Conditions, Signs and Symptoms (33) · Neurologic Manifestations (27) · Signs and Symptoms (27) · Behavior (20) · Pain (15) · Compulsive Behavior (13) · Impulsive Behavior (13) · Pathologic Processes (13) · Infections (9) · Urogenital Diseases (9) · Communicable Diseases (8)
Buprenorphine (19) · Buprenorphine, Naloxone Drug Combination (18) · vivitrol (10) · Methadone (8) · Naltrexone (8) · lofexidine (5) · Gabapentin (4) · Therapeutics (4) · Memantine (3) · Opiate Substitution Treatment (3) · Oxycodone (3) · Heroin (2) · Hydromorphone (2) · Isradipine (2) · Methods (2)
New York State Psychiatric Institute (11) · Yale University (11) · Johns Hopkins University (10) · University of Pennsylvania (6) · NYU Langone Health (5) · Indivior Inc. (4) · National Institute on Drug Abuse (NIDA) (4) · Titan Pharmaceuticals (4) · USWM, LLC (dba US WorldMeds) (4) · BioDelivery Sciences International (3) · Brigham and Women's Hospital (3) · University of Arkansas (3) · University of British Columbia (3) · Alkermes, Inc. (2) · Baylor College of Medicine (2)
United States (122) · Canada (6) · Australia (3) · Malaysia (2) · Norway (2) · Sweden (2) · Switzerland (2) · Austria (1) · China (1) · Germany (1) · Iran (1) · Spain (1) · Ukraine (1) · United Kingdom (1) · Vietnam (1)
Alison Oliveto, Ph.D. (3) · Charles W Gorodetzky, MD, PhD (3) · James A Longstreth, PhD (3) · Adam Bisaga, M.D. (2) · Adam Bisaga, MD (2) · Elias Dakwar, MD (2) · Kenneth Silverman, Ph.D. (2) · Sarah H. Heil, Ph.D. (2) · Adam Hanina, MBA, MPhil (1) · Adeeba Kamarulzaman, MBBS (1) · Alaa El-Din Darwish Othman, professor (1) · Alain Litwin, MD (1) · Alexander Wong, MD (1) · Alexandra Hajduk, PhD (1) · Alison Oliveto, PhD (1)
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U01DA030916 (3), R01DA010017 (2), 1RM1DA055310-01 (1), 2016 (1), 3UG1DA040316-06S4 (1), I01CX002902 (1), K02DA032322 (1), K23DA000429 (1), K23DA021209 (1), K23DA029609 (1), K23DA053390 (1), KL2TR002530 (1), P30DK072488 (1), P50DA009236 (1), P50DA009241 (1)