19 completed, 1 active not recruiting, 1 not yet recruiting, 1 recruiting. 22 Phase 1, 6 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 22 | Completed 19, Active not recruiting 1, Not yet recruiting 1, Recruiting 1 |
| Phase 2 | 6 | Completed 6 |
Follow Opioid Dependence: new trials by email Literature Review of Opioid Dependence trials Research Report on Opioid Dependence
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| VK4-116 Phase I Study With Food-Effect VK4-116, Placebo - Opioid Dependence, Opioid Use Disorder (OUD) | Phase 1 | Not yet recruiting | National Institute on Drug Abuse (NIDA) | 48 | 2026-08-01 | 2026-04-09 |
| A Clinical Trial to Assess Pharmacokinetic Profiles, Safety and Tolerability of IVL3004 and IVL4002 in Healthy Male Subjects. Vivitrol Injectable Product, IVL3004, IVL4002 - Opioid Dependence, Alcohol Dependence | Phase 1 | Recruiting | Inventage Lab., Inc. | 40 | 2024-09-11 | 2025-09-15 |
| STTEPP: Safety, Tolerability and Dose Limiting Toxicity of Lacosamide in Patients With Painful Chronic Pancreatitis Lacosamide - Chronic Pain, Chronic Pain Syndrome | Phase 1 | Active not recruiting | Indiana University | 21 | 2023-03-17 | 2026-06-03 |
| INDV-2000 First in Human INDV-2000, Placebo - Opioid Dependence | Phase 1 | Completed | Indivior Inc. | 73 | 2020-07-06 | 2024-05-16 |
| Remote Observed Dosing of Suboxone to Improve Clinical Practice Suboxone Remote Observed Dosing, Suboxone Attention Control - Opioid-use Disorder, Opioid Dependence | Phase 1 / Phase 2 | Completed | University of Pennsylvania | 16 | 2019-04-01 | 2023-07-27 |
| Drug Interaction and Subjective Effects of Compounds for Opioid Use Disorder Lorcaserin, Placebo - Opioid Abuse, Opioid Dependence | Phase 1 | Completed | Virginia Commonwealth University | 32 | 2017-01-30 | 2020-11-12 |
| Oxytocin Treatment of Opioid Dependence Intranasal Oxytocin Spray, Placebo - Opioid Dependence, Opioid Withdrawal | Phase 1 / Phase 2 | Completed | University of North Carolina, Chapel Hill | 12 | 2016-02-01 | 2019-08-07 |
| Medication-Assisted Treatment for Youth With Substance Use Disorders Naltrexone - Opioid Use Disorder, Opioid Dependence | Phase 1 | Completed | New York State Psychiatric Institute | 11 | 2015-09-01 | 2018-10-31 |
| Improving Buprenorphine Detoxification Outcomes With Isradipine Isradipine, Placebo - Opioid Dependence | Phase 1 / Phase 2 | Completed | University of Arkansas | 28 | 2013-10-01 | 2017-06-05 |
| Study of the Treatment of Experimental Pain in Opioid Dependent Persons on Methadone or Buprenorphine Maintenance Placebo, Hydromorphone, Buprenorphine - Opioid Dependence, Pain | Phase 1 | Completed | Johns Hopkins University | 132 | 2013-08-01 | 2017-09-11 |
| Pharmacokinetic & Pharmacodynamic Interaction of Lofexidine and Buprenorphine in Buprenorphine Maintained Patients Lofexidine HCl, Lofexidine-matching sugar pill - Opioid Dependence, Buprenorphine Withdrawal Syndrome | Phase 1 | Completed | USWM, LLC (dba US WorldMeds) | 30 | 2013-03-01 | 2018-02-23 |
| Main Study of Lofexidine and Methadone Pharmacodynamic Interaction in Methadone Maintained Patients Lofexidine HCl, Lofexidine-matching sugar pill - Opioid Dependence, Methadone Withdrawal Syndrome | Phase 1 | Completed | USWM, LLC (dba US WorldMeds) | 27 | 2012-07-01 | 2017-10-26 |
| Pilot Study of Lofexidine and Methadone Pharmacodynamic Interaction in Methadone Maintained Patients Lofexidine HCl - Opioid Dependence, Methadone Withdrawal Syndrome | Phase 1 | Completed | USWM, LLC (dba US WorldMeds) | 6 | 2012-02-01 | 2018-02-23 |
| Aprepitant Effects in Intravenous Heroin Dependence Aprepitant, Placebo pill - Opioid Dependence | Phase 1 | Completed | NYU Langone Health | 64 | 2012-01-01 | 2021-08-23 |
| Improving Effective Contraceptive Use Among Opioid-maintained Women Contraceptive management program, Usual care - Contraceptive Usage, Opioid Dependence | Phase 1 | Completed | University of Vermont | 31 | 2011-10-01 | 2015-03-17 |
| Pilot Study of Varenicline to Treat Opioid Dependence Varenicline, Placebo - Chronic Pain, Opioid Dependence | Phase 1 | Completed | Mayo Clinic | 21 | 2011-06-01 | 2013-01-23 |
| Improved Strategies for Outpatient Opioid Detoxification oral naltrexone, Buprenorphine, Vivitrol - Opioid Dependence | Phase 1 | Completed | New York State Psychiatric Institute | 150 | 2011-06-01 | 2018-05-21 |
| Naltrexone for Opioid Dependent Released Human Immunodeficiency Virus Positive (HIV+) Criminal Justice Populations Extended-Release Naltrexone - HIV, AIDS | Phase 1 / Phase 2 | Completed | Yale University | 151 | 2011-03-01 | 2020-03-19 |
| Medications Development for Drug Abuse Disorders Buprenorphine/naloxone, Clonidine, Tramadol ER - Opioid Related Disorders, Opioid Dependence | Phase 1 / Phase 2 | Completed | Johns Hopkins University | 106 | 2010-10-01 | 2017-07-06 |
| A Within Subject Comparison of Opioid Withdrawal in Opioid Dependent Individuals buprenorphine, morphine - Opioid Abuse, Opioid Dependence | Phase 1 / Phase 2 | Completed | Johns Hopkins University | 12 | 2010-07-01 | 2017-03-03 |
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Opioid-Related Disorders (22) · Behavior, Addictive (2) · Chronic Pain (2) · Pain (2) · Acquired Immunodeficiency Syndrome (1) · Alcoholism (1) · Cocaine-Related Disorders (1) · Contraception Behavior (1) · Digestive System Diseases (1) · Hyperalgesia (1) · Multiple Sclerosis (1) · Pancreatic Diseases (1) · Pancreatitis (1) · Pancreatitis, Chronic (1) · Sexually Transmitted Diseases (1)
Chemically-Induced Disorders (22) · Mental Disorders (22) · Narcotic-Related Disorders (22) · Substance-Related Disorders (21) · Pathological Conditions, Signs and Symptoms (4) · Behavior (3) · Neurologic Manifestations (3) · Signs and Symptoms (3) · Communicable Diseases (2) · Compulsive Behavior (2) · Disease Attributes (2) · Genital Diseases (2) · Immune System Diseases (2) · Impulsive Behavior (2) · Infections (2)
Buprenorphine (3) · Naltrexone (3) · lofexidine (3) · vivitrol (3) · Buprenorphine, Naloxone Drug Combination (2) · Isradipine (2) · Aprepitant (1) · Clonidine (1) · Diltiazem (1) · Gabapentin (1) · Hydromorphone (1) · Lacosamide (1) · Methadone (1) · Morphine (1) · Nifedipine (1)
Johns Hopkins University (3) · USWM, LLC (dba US WorldMeds) (3) · National Institute on Drug Abuse (NIDA) (2) · New York State Psychiatric Institute (2) · University of Arkansas (2) · Indiana University (1) · Indivior Inc. (1) · Inventage Lab., Inc. (1) · Mayo Clinic (1) · NYU Langone Health (1) · University of North Carolina, Chapel Hill (1) · University of Pennsylvania (1) · University of Vermont (1) · Virginia Commonwealth University (1) · Yale University (1)
United States (20) · Australia (1)
James A Longstreth, PhD (3) · Charles W Gorodetzky, MD, PhD (2) · Adam Bisaga, M.D. (1) · Alison Oliveto, Ph.D. (1) · Alison Oliveto, PhD (1) · Aynur Unalp-Arida, MD, PhD (1) · Brenda Curtis, PhD (1) · Charles W. Gorodetzky, MD, PhD (1) · Cort A Pedersen, MD (1) · D. Andrew Tompkins, M.D., M.H.S. (1) · Elizabeth Evans, MD (1) · Eric C. Strain, M.D. (1) · Eric Strain, M.D. (1) · Frederick G Moeller, MD (1) · Frederick L Altice (1)
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U01DA030916 (3), K02DA032322 (1), K23DA029609 (1), R01DA008045 (1), R01DA010017 (1), R01DA010746 (1), R01DA018125 (1), R01DA027151 (1), R01DK132709 (1), R21DA035325 (1), U34DA045177 (1), U54DA037842 (1), U54DA038999 (1), UG3DA050308 (1)