33 completed, 4 terminated, 2 unknown, 2 withdrawn. 21 Phase 1, 10 Early Phase 1, 7 Phase 2, 3 Not applicable, 2 Phase 3.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Cocaine and Pentoxifylline (BED IN 47) Placebo, Cocaine (IV), Pentoxifylline - Cocaine Use Disorder | Early Phase 1 | Recruiting | William Stoops | 30 | 2025-11-10 | 2026-06-08 |
| Phase1, STP7 Cocaine Drug-Drug Interaction Study STP7 (mavoglurant), Placebo, Cocaine Hydrochloride - Cocaine Use Disorder | Phase 1 | Completed | Stalicla SA | 21 | 2024-04-15 | 2026-04-23 |
| Intranasal Cocaine and Temperature Regulation During Exercise Cocaine, Lidocaine - Hyperthermia, Cocaine Use | Phase 1 / Phase 2 | Completed | University of Texas Southwestern Medical Center | 27 | 2023-09-01 | 2025-07-14 |
| Cocaine and Zolmitriptan Cocaine, Placebo oral capsule, Zolmitriptan - Cocaine Use Disorder | Early Phase 1 | Completed | William Stoops | 12 | 2021-10-15 | 2025-08-05 |
| Neurobehavioral Mechanisms of Cocaine Choice Money, Cocaine HCl - Cocaine Use Disorder | Early Phase 1 | Completed | Joshua A. Lile, Ph.D. | 15 | 2021-01-15 | 2025-04-03 |
| Suvorexant and Cocaine Suvorexant, Cocaine, Placebo oral capsule - Cocaine Use Disorder | Early Phase 1 | Completed | William Stoops | 8 | 2019-07-11 | 2023-02-09 |
| Behavioral Effects of Drugs (Inpatient): 38 Craving Manipulation, Cocaine, Placebo - Cocaine Use, Unspecified | Early Phase 1 | Terminated | William Stoops | 5 | 2019-05-15 | 2024-05-23 |
| Behavioral Effects of Drugs: Inpatient (35) Cocaine, Placebo oral capsule, Methylphenidate - Cocaine Use Disorder | Early Phase 1 | Completed | Craig Rush | 9 | 2018-06-01 | 2019-06-25 |
| Investigation of Cocaine Addiction Using mGluR5 PET and fMRI Psychiatric and Cognitive Testing, Cocaine Self-adminstration, Positron Emission Tomography - Cocaine Dependence | Phase 1 | Completed | Yale University | 32 | 2018-02-26 | 2024-02-29 |
| A Study of Metyrapone and Oxazepam Combination Product (EMB-001) and Cocaine EMB-001, Placebo, Cocaine IV - Cocaine Use Disorder | Phase 1 | Completed | Embera NeuroTherapeutics, Inc. | 18 | 2016-07-01 | 2017-08-01 |
| Topical Application of Cocaine HCl 4%, or 10%, or Placebo Solution in Local (Topical) Anesthesia Cocaine HCl 4% Topical Solution, Cocaine HCl 10% Topical Solution, Placebo Topical Solution - Any Ear Nose or Throat Conditions, With Identified Need for a Diagnostic Procedure or Surgery on or Through the Mucous Membranes of the Nasal Cavities | Phase 3 | Completed | Lannett Company, Inc. | 646 | 2015-09-01 | 2017-05-16 |
| Complementary Combination Therapy for Cocaine Dependence Doxazosin, Modafinil, cocaine - Cocaine Dependence | Phase 1 | Completed | Baylor College of Medicine | 45 | 2015-08-01 | 2022-04-26 |
| Reinforcing Effects of Cocaine During Phendimetrazine Maintenance Phendimetrazine, Cocaine, Placebo - Cocaine Use Disorder | Phase 1 | Completed | William Stoops | 30 | 2015-08-01 | 2019-07-02 |
| Impact of Sustained Release d-Amphetamine on Choice Between Cocaine and a Non-Drug Reinforcer Cocaine, Sustained Release d-Amphetamine - Active Cocaine Users | Early Phase 1 | Completed | Joshua A. Lile, Ph.D. | 18 | 2015-02-01 | 2019-04-11 |
| GLP-1 Agonism for Blocking Cocaine Euphoria and Self-Administration cocaine hydrochloride, exenatide, placebo - Cocaine Dependence | Phase 1 | Completed | Yale University | 13 | 2014-11-01 | 2023-02-16 |
| Topiramate-Phentermine Combinations for Cocaine Dependence Cocaine, Placebo, Phentermine - Cocaine Use Disorder | Phase 1 | Completed | University of Kentucky | 38 | 2014-09-01 | 2019-11-27 |
| Phendimetrazine and Cocaine Cocaine, Placebo - Cocaine Use Disorder | Early Phase 1 | Completed | William Stoops | 11 | 2014-09-01 | 2017-09-27 |
| n-Acetylcysteine and Cocaine Cocaine, n-Acetylcysteine, Placebo - Cocaine Abuse, Cocaine Dependence | Early Phase 1 | Completed | University of Kentucky | 15 | 2014-05-01 | 2017-01-04 |
| Topical Application of Cocaine HCl 4% and 10% on Safety and Efficacy in Local (Topical) Anesthesia Cocaine HCl 4% Topical Solution, Cocaine HCl 10% Topical Solution, Placebo Topical Solution - Diagnostic, Procedures and Surgeries on or Through Accessible Mucous Membranes | Phase 3 | Terminated | Lannett Company, Inc. | 159 | 2014-03-01 | 2017-05-12 |
| Impact of a Non-Drug Choice on Cocaine Reinforcement Cocaine, Placebo - Cocaine Dependence | Early Phase 1 | Completed | Joshua A. Lile, Ph.D. | 9 | 2014-01-01 | 2019-05-17 |
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Cocaine-Related Disorders (21) · Substance-Related Disorders (2) · Behavior, Addictive (1) · Disease (1) · Hemorrhage (1) · Hyperthermia (1) · Impulsive Behavior (1) · Insulin Resistance (1) · Iron Deficiencies (1) · Macular Degeneration (1) · Motor Activity (1) · Opioid-Related Disorders (1) · Substance Withdrawal Syndrome (1)
National Institute on Drug Abuse (NIDA) (8) · William Stoops (6) · Yale University (5) · New York State Psychiatric Institute (4) · Joshua A. Lile, Ph.D. (3) · Lannett Company, Inc. (2) · University of Kentucky (2) · University of Texas Southwestern Medical Center (2) · Baylor College of Medicine (1) · Biotie Therapies Inc. (1) · Craig Rush (1) · Embera NeuroTherapeutics, Inc. (1) · Indivior Inc. (1) · Johns Hopkins University (1) · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's (1)
United States (39) · Canada (2) · United Kingdom (1)
Margaret Haney, Ph.D. (3) · Dean Wong, M.D., Ph.D. (2) · Debra Kelsh, MD (2) · Dorothy Hatsukami, Ph.D. (2) · John Roache, Ph.D. (2) · William W Stoops, PhD (2) · Annie Umbricht, M.D. (1) · Bradley D Vince, DO (1) · Constanza J Valdes, MD (1) · Craig R Rush, Ph.D. (1) · Craig R Rush, PhD (1) · F. Gerald Moeller, MD (1) · Gustavo Angarita, M.D. (1) · Herbert Kleber, M.D. (1) · Igor Elman (1)
PMID 38551365, PMID 10430763, PMID 17692748, PMID 18346162, PMID 21389184, PMID 23283356, PMID 24678064, PMID 28881319, PMID 41249021
K01DA042998 (1), P50DA009236 (1), R01DA023650 (1), R01DA027065 (1), R01DA032254 (1), R01DA036553 (1), R01DA045023 (1), R01DA048617 (1), R01DA052203 (1), R01DA063069 (1), R21DA040914 (1), R25MH071584 (1), U01DA038879 (1)