7 completed, 1 not yet recruiting, 1 recruiting, 1 terminated. 9 Not applicable, 1 Early Phase 1, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 9 | Completed 7, Not yet recruiting 1, Recruiting 1 |
| Early Phase 1 | 1 | Withdrawn 1 |
| Phase 2 | 1 | Terminated 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| NEUROCUPLE™ as an Opioid Alternative Following Total Knee Arthroplasty NEUROCUPLE™ Patch, Sham patch, Enhanced Recovery After Surgery (ERAS) Standard of Care - Total Knee Arthroplasty Postoperative Pain, Opioid Reduction After TKA | Not applicable | Not yet recruiting | Jacques E. Chelly | 274 | 2026-12-01 | 2026-07-06 |
| Transition From Acute to Chronic Opioid Use and Chronic Pain Opioid-free anesthesia, Opioid-based anesthesia - Opioid Use Disorder | Early Phase 1 | Withdrawn | Jacques E. Chelly | 2026-07-01 | 2026-06-30 | |
| Vagal Stimulator to Reduce Nasogastric Tube Use Vagal Nerve Stimulator, Placebo Vagal Nerve Stimulator - Nasogastric Tube Intubation | Not applicable | Recruiting | Jacques E. Chelly | 60 | 2024-12-04 | 2026-11-05 |
| Auriculo-Nerve Stimulation on Post-Operative Opioid Requirement NSS-2 BRIDGE, Sham NSS-2 BRIDGE - Opioid Use, Auriculotherapy | Not applicable | Completed | Jacques E. Chelly | 286 | 2022-10-24 | 2026-07-24 |
| A Pilot Study Investigating the nCAP Signal Relief Patch in Subjects Undergoing Primary Hip or Knee Replacement Surgery nCAP Signal Relief Patch, Standard of Care - Opioid Use, Pain, Post Operative | Not applicable | Completed | Jacques E. Chelly | 79 | 2022-03-21 | 2024-04-18 |
| Auriculotherapy in the Treatment of Pre-Operative Anxiety Auriculotherapy cryopuncture device without nitrogen gas, Auriculotherapy cryopuncture device with nitrogen gas - Anxiety Preoperative | Not applicable | Completed | Jacques E. Chelly | 60 | 2021-04-13 | 2026-10-29 |
| Auriculotherapy for Surgical Pain Auriculotherapy cryopuncture device without nitrogen gas, Auriculotherapy cryopuncture device with nitrogen gas - Acute Pain, Surgery | Not applicable | Completed | Jacques E. Chelly | 50 | 2020-01-24 | 2022-03-17 |
| Perioperative Ketamine in Opioid-Tolerant Patients Undergoing Lumbar Spine Surgery Ketamine, Placebo Comparator - Opioid Dependence, Chronic Pain | Phase 2 | Terminated | Jacques E. Chelly | 1 | 2019-12-17 | 2024-01-30 |
| NSS-2-BRIDGE Study for Total Knee and Hip Arthroplasties, Bariatric, and Kidney Transplant Surgeries NSS-2 Bridge - Acute Pain, Arthropathy of Knee | Not applicable | Completed | Jacques E. Chelly | 20 | 2019-03-08 | 2022-08-03 |
| NSS-2 BRIDGE Device in Post-Operative Pain Management NSS-2 Bridge, Sham NSS-2 BRIDGE - Acute Pain, Surgery | Not applicable | Completed | Jacques E. Chelly | 65 | 2018-10-23 | 2021-11-01 |
| A Pain Study Comparing Two Commonly Used Medications to Treat Pain After Bowel Surgery Ropivacaine, Lidocaine - Postoperative Pain | Not applicable | Completed | Jacques E. Chelly | 68 | 2008-01-01 | 2018-03-20 |
Pain, Postoperative (4) · Acute Pain (3) · Agnosia (3) · Opioid-Related Disorders (2) · Abdominal Pain (1) · Cancer Pain (1) · Chronic Pain (1) · Shoulder Pain (1)
Enhanced Recovery After Surgery (2) · Standard of Care (2) · Dexmedetomidine (1) · Ketamine (1) · Lidocaine (1) · Ropivacaine (1)
United States (11)
Jacques E Chelly, MD (5) · Jacques E Chelly, MD, PhD, MBA (2) · Amy Monroe, MPH, MBA (1) · Andrea Fanelli, MD (1) · Jacques Chelly, MD, PhD, MBA (1) · Jacques E. Chelly, MD (1) · Jacques E. Chelly, MD, PhD, MBA (1)
R01DA054513 (1)