41 completed, 3 terminated, 1 active not recruiting, 1 suspended. 17 Phase 4, 10 Phase 1, 10 Phase 3, 9 Not applicable, 5 Phase 2.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| CHAO Tos: Codeina, HederA Helix, LevOdropropizina Para la TOS Codeine, Levodropropizine, Ivy Leaves Cough Liquid - Upper Resp Tract Infection | Phase 4 | Completed | Pontificia Universidad Catolica de Chile | 196 | 2025-05-13 | 2025-12-03 |
| Fixed Combination of Dipyrone and Codeine for Controlling Pain After Pelvic-abdominal Surgery Fixed dose combination Dipyrone and Codeine, Dipyrone, Codeine - Pain, Postoperative | Phase 3 | Completed | Brazilian Clinical Research Institute | 491 | 2023-03-16 | 2026-05-11 |
| An Randomized Control Trial Comparing Two Drug Combinations for Pain Management After Third Molars Surgery diclofenac / acetaminophen /codeine, ibuprofen/acetaminophen/codeine - Impacted Third Molar Tooth, PAIN | Not applicable | Suspended | University of Zimbabwe | 78 | 2023-03-01 | 2023-01-05 |
| Evaluation of the Analgesic Efficacy of the Combination of Dexketoprofen + Paracetamol and the Combination of Naproxen Sodium + Codeine in Patients With Acute Dental Pain Dexketoprofen Trometamol + Paracetamol, Naproxen Sodium + Codeine Phosphate - Acute Dental Pain | Phase 4 | Completed | ibrahim doğru | 100 | 2023-01-10 | 2025-04-08 |
| COMPARISON OF EFFICACY OF DIFFERENT DRUG COMBINATIONS IN ACUTE SCIATICA Lacosamide 50 MG Oral Tablet [Vimpat], Codeine Phosphate, Diclofenac Sodium - Sciatica Acute, Sciatica | Phase 3 | Completed | Pakistan Institute of Medical Sciences | 120 | 2021-09-28 | 2022-11-23 |
| Preoperative Acetaminophen- Caffeine- Codeine Combination and Anaesthetic Success in Patients With Acute Pulpitis Acetaminophen and codeine and caffeine, Acetaminophen, Placebo - Symptomatic Irreversible Pulpitis | Not applicable | Completed | Cairo University | 69 | 2021-01-09 | 2021-07-21 |
| Project 1 Aim 2, Adaptations of the Brain in Chronic Pain With Opioid Exposure Carbidopa-Levodopa 25 Mg-100 Mg Oral Tablet, Naproxen 500 Mg, Opioids - Opioid Use, Opioid Dependence | Phase 2 | Active not recruiting | Northwestern University | 60 | 2021-01-01 | 2024-11-27 |
| Limitations of Aerobic Capacity in Chronic Heart Failure Exercise with and without Codeine - Chronic Heart Failure | Not applicable | Completed | University of Leeds | 91 | 2019-12-01 | 2024-10-26 |
| Colonic Motor Patterns in Healthy Volunteers Naloxegol, codeine phosphate, Placebo - Opioid-Induced Constipation | Phase 4 | Completed | Universitaire Ziekenhuizen KU Leuven | 15 | 2018-06-27 | 2023-03-16 |
| Inter- and Intra-individual Variations in Metformin Pharmacokinetics - The Importance of Genes and Drug Interactions Oral metformin, Intravenous metformin, Oral codeine and oral metformin - Metformin, Organic Cation Transporter 1 | Phase 1 | Completed | University of Southern Denmark | 228 | 2018-03-01 | 2020-06-25 |
| Efficacy of Naproxen-codeine, Naproxen+Dexamethasone, and Naproxen on Myofascial Pain naproxen sodium+codeine phosphate, naproxen sodium+dexamethasone, naproxen sodium, paracetamol - Temporomandibular Disorder | Phase 4 | Completed | Yuzuncu Yil University | 200 | 2018-03-01 | 2021-02-15 |
| Opioid Analgesics for Acute Fracture Pain in Adults Discharged From the ED Codeine, Oxycodone, Hydromorphone - Acute Pain | Not applicable | Terminated | Mount Sinai Hospital, Canada | 5 | 2018-02-05 | 2019-10-02 |
| Comparative Analgesic Effects of Paracetamol/Codeine and Ibuprofen on Pain After Third Molar Surgery paracetamol 500 mg plus codeine 30 mg preoperative administration, ibuprofen 400 mg preoperative administration, Placebo oral tablet preoperative administration - To Control Pain After Third Molar Surgery | Phase 4 | Completed | University of Roma La Sapienza | 120 | 2018-01-01 | 2021-01-29 |
| Clinical Evaluation of the VIPUN Balloon Catheter 0.1 VIPUN Balloon Catheter 0.1 deflated, Codeine Phosphate, Placebo - Healthy, Motility Disorder | Not applicable | Completed | Universitaire Ziekenhuizen KU Leuven | 22 | 2017-09-25 | 2018-05-04 |
| Codeine on Pharyngeal and Esophageal Motility Codeine Phosphate, Siripus simplex - Esophageal Motility Disorders | Phase 4 | Completed | Universitaire Ziekenhuizen KU Leuven | 22 | 2017-09-07 | 2018-12-24 |
| Gabapentin for Pain Control After Osmotic Dilator Insertion and Prior to D&E Procedure: a Randomized Controlled Trial Gabapentin 600mg, Placebo oral capsule, acetaminophen/codeine and ibuprofen - Abortion, Induced, Cervical Preparation | Phase 4 | Completed | University of California, Davis | 121 | 2017-03-20 | 2020-04-14 |
| E7 TCR T Cells for Human Papillomavirus-Associated Cancers E7 TCR cells, Aldesleukin, Fludarabine - Papillomavirus Infections, Cervical Intraepithelial Neoplasia | Phase 1 / Phase 2 | Completed | National Cancer Institute (NCI) | 224 | 2017-01-27 | 2026-03-09 |
| Comparative Effectiveness Study for Surgery vs. Non-Surgery in Patients With Low Back Pain open or endoscopic discectomy, epidural block, exercise - Low Back Pain | Not applicable | Completed | Seoul National University Hospital | 1102 | 2016-09-01 | 2023-04-12 |
| Proof-of-concept Study to Assess the Efficacy, Tolerability and Safety of a Single Intraarticular Dose of GZ389988 Versus Placebo in Patients With Painful Osteoarthritis of the Knee placebo, GZ389988, acetaminophen or paracetamol - Osteoarthritis | Phase 2 | Completed | Genzyme, a Sanofi Company | 104 | 2016-07-21 | 2022-04-13 |
| Effect of Naloxegol on Gastric, Small Bowel, and Colonic Transit in Healthy Subjects Naloxegol, Codeine, codeine placebo - Constipation Drug Induced | Phase 1 | Completed | Michael Camilleri | 72 | 2016-07-01 | 2017-08-30 |
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Pain (14) · Pain, Postoperative (5) · Agnosia (4) · Cough (3) · Anemia, Sickle Cell (2) · Headache (2) · Acute Pain (1) · Back Injuries (1) · Back Pain (1) · Breast Diseases (1) · Carcinoma in Situ (1) · Chronic Pain (1) · Depressive Disorder, Major (1) · Diabetic Neuropathies (1) · Diplopia (1)
Universitaire Ziekenhuizen KU Leuven (3) · Nexgen Pharma, Inc (2) · Ullevaal University Hospital (2) · Brazilian Clinical Research Institute (1) · Cairo University (1) · Children's Hospitals and Clinics of Minnesota (1) · Children's National Research Institute (1) · Diskapi Yildirim Beyazit Education and Research Hospital (1) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (1) · Federal University of the Valleys of Jequitinhonha and Mucuri (1) · Genzyme, a Sanofi Company (1) · Institut fuer anwendungsorientierte Forschung und klinische Studien GmbH (1) · Kirby Institute (1) · Matthias Schwab (1) · Mayo Clinic (1)
United States (15) · Canada (4) · Belgium (3) · Brazil (3) · Germany (3) · Jordan (2) · Norway (2) · Turkey (Türkiye) (2) · Argentina (1) · Australia (1) · Chile (1) · Denmark (1) · Egypt (1) · Israel (1) · Italy (1)
Gaute Lyngstad, DDS (2) · Michael Camilleri, MD (2) · Alaa M. Morsi (1) · Alex D Mitchell, MD (1) · Amy L Drendel, DO (1) · Andrew Chang, MD (1) · Apkar V Apkarian, PhD (1) · Catherine Varner, MD MSc (1) · Chun Kee Chung, Professor (1) · Dante Landucci, MD (1) · Dorothea Mostello, MD (1) · Geoff Hanks, MD (1) · Jacob V Aranda, MD, PhD (1)
PMID 20839388, PMID 23247002, PMID 24756302, PMID 24756514, PMID 24781936, PMID 25370510, PMID 25370513, PMID 26024112, PMID 26335066, PMID 26344676, PMID 26618282, PMID 26778344, PMID 26934136, PMID 27694262, PMID 27825374, PMID 28130349, PMID 28492874, PMID 28820793, PMID 31351965, PMID 32797734, PMID 32973880, PMID 33232555, PMID 33470341, PMID 33558725, PMID 34655316, PMID 34922726, PMID 37349498, PMID 41107344
2014 (1), U10EY017281 (1), U10EY017387 (1), UL1TR000135 (1)