36 completed, 12 terminated, 8 unknown, 3 withdrawn. 62 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 62 | Completed 36, Terminated 12, Unknown 8, Withdrawn 3, Recruiting 2, Active not recruiting 1 |
Follow Obstructive Sleep Apnea: new trials by email Literature Review of Obstructive Sleep Apnea trials Research Report on Obstructive Sleep Apnea
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Mini-dose Dexmedetomidine-Esketamine Supplemented Analgesia in Patients at High-risk of OSA Dexmedetomidine-esketamine combination, Placebo - Obstructive Sleep Apnea, Surgery | Phase 4 | Completed | Peking University First Hospital | 100 | 2024-09-11 | 2026-09-04 |
| Zolpidem on CPAP Acclimatization in OSA Zolpidem, Placebo - Obstructive Sleep Apnea | Phase 4 | Unknown | Siriraj Hospital | 30 | 2023-10-15 | 2023-10-16 |
| Effect of Eszopiclone on Adherence to CPAP and Severity of Insomnia in Patients With COMISA Eszopiclone 3 mg, Placebo - Obstructive Sleep Apnea, Insomnia | Phase 4 | Completed | University of Sao Paulo General Hospital | 60 | 2023-08-24 | 2026-05-29 |
| Evaluation of Trazodone in OSA-MCI Trazodone, Placebo - Mild Cognitive Impairment, Obstructive Sleep Apnea | Phase 4 | Active not recruiting | Chinese University of Hong Kong | 134 | 2022-05-10 | 2026-01-06 |
| Spironolactone to Improve Apnea and Cardiovascular Markers in Obstructive Sleep Apnea Patients Spironolactone, Placebo - Obstructive Sleep Apnea | Phase 4 | Withdrawn | University of Michigan | 2022-03-01 | 2022-04-19 | |
| Applying Best Clinical Practices to Patients at High Risk of Respiratory Complications Sugammadex 100 MG/ML [Bridion] - Respiratory Complication, Obstructive Sleep Apnea | Phase 4 | Completed | University of California, Los Angeles | 12248 | 2022-02-18 | 2025-07-29 |
| Ketorolac on Postoperative Pain Reduction in Pediatric Patients with Adenotonsillectomy Ketorolac - Adenotonsillar Hypertrophy, Obstructive Sleep Apnea | Phase 4 | Completed | St. Louis University | 142 | 2022-02-08 | 2025-02-03 |
| First Line Obstructive Sleep Apnea Treatment Study Mandibular advancement device (MAD), Continuous positive airway pressure (CPAP) - Obstructive Sleep Apnea | Phase 4 | Completed | University Hospital, Antwerp | 136 | 2021-11-09 | 2025-02-14 |
| Solriamfetol's Effect on Cognitive Health in Apnea Participants During a Randomized Placebo-controlled Study Solriamfetol, Placebo - Excessive Daytime Sleepiness, Obstructive Sleep Apnea | Phase 4 | Completed | Axsome Therapeutics, Inc. | 59 | 2021-05-17 | 2026-01-26 |
| Optimal Dosage of Acetazolamide for OSA Treatment Acetazolamide, Placebo - Obstructive Sleep Apnea | Phase 4 | Completed | University Hospital, Antwerp | 91 | 2021-04-20 | 2025-09-24 |
| Dexmedetomidine Supplemented Analgesia in Patients at High-risk of Obstructive Sleep Apnea Dexmedetomidine, Placebo - Obstructive Sleep Apnea, Analgesia | Phase 4 | Completed | Peking University First Hospital | 152 | 2021-01-29 | 2022-12-13 |
| Tolterodine Relieves Overactive Bladder Symptoms in Women With Moderate-to-severe Obstructive Sleep Apnea Syndrome Tolterodine Tartrate 4 MG, Continuous positive airway pressure therapy (CPAP) - Overactive Bladder, Obstructive Sleep Apnea | Phase 4 | Completed | Yuzuncu Yil University | 60 | 2020-06-01 | 2022-02-22 |
| Acetazolamide Add-On Therapy to OSA Surgery Acetazolamide, Placebo - Obstructive Sleep Apnea | Phase 4 | Unknown | University Hospital, Antwerp | 26 | 2020-01-22 | 2024-06-18 |
| The Effect of PAP on ISSHL Comorbided With OSA non-invasive positive airway pressure, Methylprednisolone Hemisuccinate, Ginaton - Sudden Hearing Loss, Obstructive Sleep Apnea | Phase 4 | Recruiting | Beijing Tsinghua Chang Gung Hospital | 102 | 2019-11-01 | 2019-12-10 |
| Improving Outcomes in Pediatric Obstructive Sleep Apnea With Computational Fluid Dynamics 129-Xe - Obstructive Sleep Apnea | Phase 4 | Recruiting | Children's Hospital Medical Center, Cincinnati | 120 | 2019-08-15 | 2026-01-07 |
| Obstructive Sleep Apnea Treatment on Cardiovascular Events in Patients With Acute Cardiogenic Pulmonary Edema: CPAP-CARE STUDY. CPAP, Nasal Strips - Obstructive Sleep Apnea, Pulmonary Edema Cardiac Cause | Phase 4 | Terminated | University of Sao Paulo | 150 | 2019-04-01 | 2024-06-07 |
| Efficacy and Stability of Dexmedetomidine Sedation Compared to Propofol Sedation in the Drug Induced Sleep Endoscopy Propofol Fresenius, Dexmedetomidine - Obstructive Sleep Apnea | Phase 4 | Unknown | Ospedale Monsignor R. Dimiccoli, Barletta | 28 | 2019-03-22 | 2019-03-29 |
| Impact of Sugammadex vs. Neostigmine Reversal on Post-Operative Recovery and Complications Sugammadex Sodium, Neostigmine - Obstructive Sleep Apnea | Phase 4 | Completed | University Health Network, Toronto | 120 | 2019-01-14 | 2025-03-20 |
| Effect of Ketorolac on Post Adenotonsillectomy Pain Ketorolac, Standard of Care - Obstructive Sleep Apnea | Phase 4 | Completed | Emory University | 63 | 2018-07-19 | 2024-09-19 |
| Effect of Long-acting Levodopa on Obstructive Sleep Apnea in Parkinson's Disease Sinemet CR, Placebo oral capsule - Parkinson's Disease, Obstructive Sleep Apnea | Phase 4 | Completed | McGill University Health Centre/Research Institute of the McGill University Health Centre | 36 | 2017-05-24 | 2024-03-13 |
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Sleep Apnea, Obstructive (62) · Sleep Apnea Syndromes (11) · Hypertension (5) · Disorders of Excessive Somnolence (4) · Agnosia (2) · Cardiovascular Diseases (2) · Hypoxia (2) · Pain, Postoperative (2) · Sleep Initiation and Maintenance Disorders (2) · Sleep Wake Disorders (2) · Tonsillitis (2) · Acidosis (1) · Apnea (1) · Asthma (1) · Atherosclerosis (1)
Dyssomnias (62) · Nervous System Diseases (62) · Respiration Disorders (62) · Respiratory Tract Diseases (62) · Sleep Disorders, Intrinsic (62) · Apnea (61) · Sleep Wake Disorders (60) · Sleep Apnea Syndromes (51) · Pathological Conditions, Signs and Symptoms (18) · Signs and Symptoms (13) · Mental Disorders (11) · Cardiovascular Diseases (10) · Vascular Diseases (10) · Neurologic Manifestations (8) · Pathologic Processes (6)
Continuous Positive Airway Pressure (7) · Dexmedetomidine (4) · Eszopiclone (3) · Propofol (3) · Sugammadex (3) · Acetazolamide (2) · Donepezil (2) · Drug Delivery Systems (2) · Ketorolac (2) · Modafinil (2) · Mometasone Furoate (2) · Neostigmine (2) · Occlusal Splints (2) · Saline Solution (2) · Spironolactone (2)
University of California, San Diego (4) · University of Sao Paulo (4) · University Hospital, Antwerp (3) · Emory University (2) · Hospital de Clinicas de Porto Alegre (2) · Inspire Medical Systems, Inc. (2) · Peking University First Hospital (2) · Regional Hospital Holstebro (2) · University Hospital, Grenoble (2) · University of Chicago (2) · University of Cincinnati (2) · Walter Reed Army Medical Center (2) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (1) · Associacao Fundo de Incentivo a Psicofarmcologia (1) · Associação Fundo de Incentivo à Pesquisa (1)
United States (24) · Brazil (9) · Belgium (5) · Canada (4) · China (3) · Denmark (2) · France (2) · Germany (2) · Italy (2) · Netherlands (2) · Turkey (Türkiye) (2) · Hong Kong (1) · South Korea (1) · Spain (1) · Sweden (1)
Armin Steffen, PD Dr. med. (2) · Christopher J Lettieri, MD (2) · Clemens Heiser, Dr. med. (2) · David L Steward, MD (2) · Denis Martinez, MD, PhD (2) · Erling B Pedersen, Professor (2) · Olivier Vanderveken, MD, PhD (2) · Alister Bates, PhD (1) · Andrew Goldberg, MD (1) · Andrzej Tykarski, Prof (1) · Bertram Pitt, MD (1) · Catharina Belge, M.D., Ph.D. (1) · Dalva Poyares, MD, PhD (1) · Daniela K. Andaku, MSc (1) · David A Ehrmann, M.D. (1)
PMID 10450601, PMID 10678860, PMID 10908222, PMID 10940788, PMID 11208620, PMID 11422885, PMID 15187032, PMID 16376782, PMID 17494787, PMID 17556718, PMID 17921053, PMID 1798888, PMID 18172212, PMID 18404673, PMID 18458174, PMID 18595959, PMID 18647805, PMID 18663661, PMID 18788656, PMID 19357147, PMID 19567493, PMID 19920270, PMID 20016520, PMID 20051221, PMID 20411620, PMID 20522795, PMID 20642206, PMID 21123449, PMID 22281004, PMID 22783709, PMID 23019248, PMID 23952854, PMID 24107724, PMID 25325463, PMID 25547036, PMID 25906818, PMID 26208670, PMID 26914592, PMID 2698218, PMID 27442715, PMID 28105667, PMID 28296427, PMID 28408103, PMID 28567688, PMID 29029237, PMID 29217597, PMID 29243273, PMID 2936235, PMID 29669139, PMID 30130421
2019 (1), R01HL075079 (1)