50 completed, 20 unknown, 12 recruiting, 9 terminated. 44 Not applicable, 21 Phase 4, 12 Phase 3, 8 Phase 2, 1 Early Phase 1.
Follow Tonsillitis: new trials by email Literature Review of Tonsillitis trials Research Report on Tonsillitis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Single Dose of Intravenous Penicillin as an Adjunct to Oral Penicillin in the Treatment of Acute Tonsillitis, Peritonsillar Phlegmon, and Peritonsillar Abscess Benzylpenicillin, Isotonic NaCl (Placebo) - Acute Tonsillitis, Peritonsillar Abscess | Phase 4 | Not yet recruiting | Tejs Ehlers Klug | 154 | 2026-10-01 | 2026-10-26 |
| Heart Rate Variability and Early Cytokine Profile in Pediatric Adenotonsillectomy Heart Rate Monitoring, Vagal Bradycardia | Active not recruiting | Duzce University | 76 | 2026-07-01 | 2026-07-22 | |
| Recovery From Tonsil Surgery. extracapsular tonsillectomy, intracapsular tonsillectomy - Recurrent Tonsillitis, Chronic Tonsillitis | Not applicable | Not yet recruiting | Turku University Hospital | 90 | 2026-06-01 | 2026-05-20 |
| Suprazygomatic Maxillary Nerve Block in Pediatric Tonsillectomy Suprazygomatic maxillary nerve block (SZMN) with bupivacaine, Suprazygomatic maxillary nerve block (SZMN) with placebo - Tonsillitis | Not applicable | Recruiting | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 60 | 2026-01-01 | 2026-09-22 |
| Evaluation of the Efficacy of Streptococcus Salivarius Evol12® in the Reduction of Recurrent Adenotonsillitis in Children Bactoblis® Evol (Streptococcus salivarius Evol12®), Placebo - Recurrent Tonsillitis | Not applicable | Completed | Liaquat University of Medical & Health Sciences | 216 | 2025-11-26 | 2026-07-24 |
| Coblation Tonsillectomy Versus Cold Dissection Tonsillectomy coblation tonsillectomy, cold dissection tonsillectomy - Tonsillitis | Not applicable | Completed | Shahida Islam Medical Complex | 60 | 2025-11-20 | 2026-03-09 |
| Perspectives on Antibiotics and Tracking Symptoms in Children Garmin Smartwatch - Urinary Tract Infection, Cellulitis | Not applicable | Recruiting | Murdoch Childrens Research Institute | 300 | 2025-09-16 | 2026-10-07 |
| Transoral Ultrasound Versus no Transoral Ultrasound in Diagnostic Workup of Peritonsillar Abscess Transoral Ultrasound - Peritonsillar Abscess, Peritonsillar Cellulitis | Not applicable | Recruiting | Copenhagen University Hospital, Rigshospitalet | 368 | 2025-06-09 | 2026-09-08 |
| Trimethoprim-sulfamethoxazole vs. Clindamycin for the Treatment of Children With Invasive MRSA Infections Trimethoprim Sulfamethoxazole - Methicillin Resistant Staphylococcus Aureus, Osteomyelitis Acute | Phase 4 | Recruiting | Indiana University | 100 | 2025-05-20 | 2026-07-29 |
| SUPRATHEL 250 as a Treatment for Oropharyngeal Wounds Suprathel 250, Comparator - Tonsillitis, Tonsillectomy | Not applicable | Recruiting | Alaa Emara | 80 | 2025-04-30 | 2026-07-27 |
| The Effect of Systemic Nonsteroidal Anti-inflammatory Drugs (NSAIDs) Vs Intraoperative Infiltration of Steroids in Tonsillar Bed Following Tonsillectomy on Post Tonsillectomy Pain. Dexamethasone, NSAIDs, Control (Standard treatment) - Tonsillitis Chronic, Tonsillitis Recurrent | Not applicable | Recruiting | Ain Shams University | 75 | 2025-03-08 | 2025-06-25 |
| Study on the Efficacy and Safety of a Device for Post-op Recovery in Pediatric Adenectomy/Adenotonsillectomy. Munatoril Aerosol Combo, Iperclenny - Adenoidal Disorder, Tonsillitis | Not applicable | Unknown | Pharmaluce srl | 90 | 2024-12-01 | 2024-07-03 |
| Optimization of Pediatric Tonsillectomy to IMprove AnaLgesia Methadone, Fentanyl/Hydromorphone - Pain, Postoperative, Tonsillar Hypertrophy | Phase 4 | Recruiting | Duke University | 440 | 2024-11-21 | 2025-12-05 |
| Complicated Infections in Otorhinolaryngology Treatment with surgery and/or conservative measures - Sinusitis, Otitis | Recruiting | University Medical Centre Ljubljana | 2550 | 2024-09-01 | 2026-04-29 | |
| Opioid Sparing Anesthesia Care for Pediatric Patients Having Tonsil Surgery Dexmedetomidine, Acetaminophen, Ketorolac - Tonsillitis, Post-operative Nausea and Vomiting (PONV) | Not applicable | Completed | Boston Children's Hospital | 62 | 2024-05-09 | 2026-05-18 |
| Comparing Two Agents Used to Stop Bleeding During Tonsil Removal Surgery: Adrenaline Versus Hydrogen Peroxide Adrenaline, Hydrogen Peroxide - Chronic Tonsillitis, Tonsillar Hypertrophy, Tonsillitis | Not applicable | Completed | Rawalpindi Medical College | 64 | 2024-02-01 | 2026-06-30 |
| Outcomes of Bipolar Electrocautery Tonsillectomy Versus Cold Steel Dissection Pediatric Tonsillectomy Bipolar electrocautery tonsillectomy technique, Cold steel dissection technique - Tonsillitis | Not applicable | Completed | RESnTEC, Institute of Research | 110 | 2023-11-01 | 2024-07-10 |
| Evaluating the Genetics and Immunology of Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis (PFAPA) Syndrome and Other Tonsil Disorders Periodic Fever, Aphthous Stomatitis, Pharyngitis, And Cervical Adenitis (Pfapa), Obstructive Sleep Apnea | Recruiting | National Institute of Allergy and Infectious Diseases (NIAID) | 1500 | 2023-05-23 | 2026-04-08 | |
| Lateral Pharyngoplasty Outcomes in Children Undergoing Tonsillectomy Lateral pharyngoplasty, Tonsillectomy - Sleep-Disordered Breathing, Sleep Apnea Syndromes in Children | Not applicable | Recruiting | Loma Linda University | 160 | 2023-05-17 | 2026-02-23 |
| Pediatric Pain Optimization After Tonsillectomy Fentanyl/Hydromorphone, Methadone - Obstructive Sleep Apnea, Tonsillitis | Phase 2 | Completed | Duke University | 66 | 2022-04-08 | 2024-10-17 |
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Pharyngitis (20) · Peritonsillar Abscess (13) · Sleep Apnea, Obstructive (13) · Pain (6) · Sleep Apnea Syndromes (5) · Common Cold (4) · Otitis Media (4) · Pain, Postoperative (4) · Respiratory Tract Infections (4) · Agnosia (3) · Bronchitis (2) · Hyperthermia (2) · Hypertrophy (2) · Infections (2)
Pharyngeal Diseases (100) · Respiratory Tract Diseases (100) · Stomatognathic Diseases (100) · Otorhinolaryngologic Diseases (99) · Infections (98) · Respiratory Tract Infections (96) · Pharyngitis (80) · Pathological Conditions, Signs and Symptoms (25) · Nervous System Diseases (19) · Signs and Symptoms (17) · Respiration Disorders (16) · Apnea (15) · Dyssomnias (15) · Neurologic Manifestations (15) · Sleep Disorders, Intrinsic (15)
Acetaminophen (7) · Tonsillectomy (7) · Dexmedetomidine (5) · Fentanyl (5) · Dexamethasone (4) · Amoxicillin (3) · Azithromycin (3) · Hydromorphone (3) · Morphine (3) · Penicillin V (3) · Penicillins (3) · Acupuncture, Ear (2) · Aspirin (2) · Ibuprofen (2) · Ketorolac (2)
Pfizer (4) · Bayer (3) · Oulu University Hospital (3) · Sanofi (3) · Advancis Pharmaceutical Corporation (2) · Duke University (2) · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's (2) · Nationwide Children's Hospital (2) · Selcuk University (2) · Tejs Ehlers Klug (2) · Turku University Hospital (2) · Washington University School of Medicine (2) · AB Biotics, SA (1) · Ain Shams University (1) · Ajou University School of Medicine (1)
United States (33) · Finland (7) · Canada (5) · Denmark (5) · France (5) · Germany (4) · Israel (4) · Norway (4) · Pakistan (4) · Sweden (4) · Turkey (Türkiye) (4) · Costa Rica (3) · Italy (3) · Argentina (2) · Chile (2)
Abhijit Biswas (1) · Ahmed Khan, MBBS, FCPS (1) · Aila Kristo, MD (1) · Alaa Emara (1) · Aleksi EJ Laajala, MD (1) · Anil Shah (1) · Anthony R Plunkett, MD (1) · Anthony Sheyn, MD, FACS (1) · Arlyne Thung, MD (1) · Beat Muller, MD (1) · Brian Weeks, MD (1)
PMID 12470586, PMID 15723913, PMID 15961165, PMID 16148700, PMID 16785404, PMID 17347187, PMID 17765762, PMID 20485304, PMID 21461792, PMID 21873895, PMID 22926176, PMID 23549975, PMID 24416649, PMID 25039393, PMID 25425696, PMID 25639490, PMID 26148331, PMID 26372517, PMID 26463725, PMID 26968881, PMID 27247344, PMID 27357971, PMID 27789145, PMID 28368530, PMID 28674113, PMID 28899626, PMID 31233129, PMID 31250024, PMID 31269273, PMID 31585944, PMID 31686648, PMID 32216750, PMID 34292473, PMID 34859602, PMID 36368940, PMID 36742935, PMID 38669011, PMID 38746736, PMID 38864363, PMID 41954901, PMID 42312422, PMID 42744363
2015 (1), 2016 (1), 2019 (1), R01HD114678 (1), UL1TR002345 (1)