694 completed, 193 unknown, 133 recruiting, 76 terminated. 663 Not applicable, 72 Phase 2, 62 Phase 4, 46 Phase 3, 32 Phase 1.
Follow Obstructive Sleep Apnea: new trials by email Literature Review of Obstructive Sleep Apnea trials Research Report on Obstructive Sleep Apnea
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| PAP Systems External Clinical Studies (ECS) PAP System A (with Amalfi) then PAP System B (with CLA11), PAP System B (with CLA11) then PAP System A (with Amalfi) - Obstructive Sleep Apnea | Not applicable | Not yet recruiting | ResMed | 30 | 2028-08-01 | 2026-04-24 |
| Testing Settings of NovaResp's cMAP® Software During Home PAP Therapy Dynamic cMAP, Direct cMAP - Obstructive Sleep Apnea | Not applicable | Not yet recruiting | NovaResp Technologies Inc | 50 | 2027-11-30 | 2026-10-27 |
| KPAP vs EPR for Efficacy APAP + KPAP, APAP + EPR - Obstructive Sleep Apnea | Not applicable | Not yet recruiting | SleepRes Inc. | 24 | 2027-03-01 | 2026-08-04 |
| Automated vs Manual Polysomnography Scoring in Adults With Obstructive Sleep Apnea Polysomnographic Scoring (Automated vs. Manual) - Obstructive Sleep Apnea | Not yet recruiting | Ain Shams University | 50 | 2027-02-01 | 2026-09-23 | |
| PAP-NAP Device Clinical Study APL Device - Obstructive Sleep Apnea | Not applicable | Not yet recruiting | ResMed | 10 | 2027-01-01 | 2026-08-27 |
| Pediatric/Adolescent WatchPAT 400 Reliability Pilot Study WatchPAT 400 - Pediatric Sleep Disordered Breathing, Obstructive Sleep Apnea | Not applicable | Not yet recruiting | Milton S. Hershey Medical Center | 35 | 2026-12-01 | 2026-10-05 |
| Hypoglossal Nerve Stimulation in Obstructive Sleep Apnea With Complete Concentric Collapse Inspire Hypoglossal Nerve Stimulation System - Obstructive Sleep Apnea | Not applicable | Not yet recruiting | Brigham and Women's Hospital | 20 | 2026-12-01 | 2026-10-27 |
| Does the Timing of Insomnia Therapy (CBT-i) Impact the Usage and Compliance of Upper Airway Stimulation (UAS) Treatment of Obstructive Sleep Apnea (OSA) Digital Cognitive Behavioral Therapy (CBT-i)-COAST - Obstructive Sleep Apnea, Comorbid Insomnia and Sleep Apnea | Not applicable | Not yet recruiting | Thomas Kaffenberger | 100 | 2026-11-05 | 2026-09-24 |
| Effects of a Pacifier on Obstructive Sleep Apnea and Its Repercussions in Infants With Down Syndrome CURAPROX pacifier use, Pacifier diary, Polysomnography (PSG) to explore OSA - Obstructive Sleep Apnea, Down Syndrome (Trisomy 21) | Not applicable | Not yet recruiting | Hospices Civils de Lyon | 50 | 2026-11-02 | 2026-10-07 |
| Hypercapnic Burden in Adults With Obesity Undergoing Diagnostic Polysomnography for Suspected Obstructive Sleep Apnea Sleep Inertia Questionnaire (SIQ) - Obstructive Sleep Apnea, Obesity (BMI>30) | Not applicable | Not yet recruiting | Hospices Civils de Lyon | 150 | 2026-11-01 | 2026-09-09 |
| A Study Of Synthetic THC And Sleep Dronabinol, Placebo - Obstructive Sleep Apnea | Phase 2 / Phase 3 | Not yet recruiting | Mayo Clinic | 72 | 2026-11-01 | 2026-09-18 |
| EEG Markers From Polysomnography and Cognitive Performance in Obstructive Sleep Apnea Full-night polysomnography with EEG marker analysis and cognitive testing - Obstructive Sleep Apnea, Cognitive Impairment | Not yet recruiting | University of Split, School of Medicine | 100 | 2026-11-01 | 2026-10-27 | |
| Myofunctional Therapy for Obstructive Sleep Apnea Myofunctional Therapy - Obstructive Sleep Apnea | Not applicable | Enrolling by invitation | University of Minnesota | 30 | 2026-10-27 | 2026-10-28 |
| Physical Activity, Sleep Quality, and Respiratory Function in Obstructive Sleep Apnea Physical Activity Education - Obstructive Sleep Apnea, Sleep Quality | Not applicable | Recruiting | Medipol University | 48 | 2026-10-23 | 2026-10-27 |
| UBT251 Injection Phase Ⅲ Study (OSA-PAP) UBT251, Placebo - Obstructive Sleep Apnea, Obesity | Phase 3 | Not yet recruiting | The United Bio-Technology (Hengqin) Co., Ltd. | 150 | 2026-10-10 | 2026-09-08 |
| Transcutaneous Electrical Stimulation in Patients With Obstructive Sleep Apnoea ZeusOSA, CPAP - Obstructive Sleep Apnea | Not applicable | Not yet recruiting | Zeus Sleep Ltd | 186 | 2026-09-30 | 2026-09-22 |
| Effects of Mental Tasks on Breathing Patterns in Adults Using Chronic Opioids vs Non-opioid Users. Opiod Use Disorder, Obstructive Sleep Apnea | Enrolling by invitation | University of California, San Diego | 40 | 2026-09-16 | 2026-09-18 | |
| Combination Tonsillectomy and Hypoglossal Nerve Stimulation for OSA Patients With Lateral Pharyngeal Collapse Tonsillectomy, HGNS - Obstructive Sleep Apnea, Sleep Disordered Breathing | Not applicable | Recruiting | Brigham and Women's Hospital | 72 | 2026-09-15 | 2026-09-16 |
| Combination Upper-Airway Electrical and Pharmacological Stimulation for Obstructive Sleep Apnea Combination device and drug: Unilateral hypoglossal nerve stimulation & atomoxetine-plus-oxybutynin (HGNS+AtoOxy), Unilateral hypoglossal nerve stimulation (HGNS), active comparator condition, Atomoxetine-plus-oxybutynin (80/5 mg) (AtoOxy), active comparator condition - Obstructive Sleep Apnea, Sleep-disordered Breathing | Phase 1 / Phase 2 | Recruiting | Brigham and Women's Hospital | 24 | 2026-09-01 | 2026-09-21 |
| Real-World Performance and Safety of Apneal Dx for Sleep Apnea Screening Obstructive Sleep Apnea, Sleep Apnea Syndromes | Not yet recruiting | Mitral | 400 | 2026-09-01 | 2026-09-09 |
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Sleep Apnea, Obstructive (1238) · Sleep Apnea Syndromes (183) · Hypertension (49) · Obesity (48) · Apnea (32) · Snoring (32) · Sleep Wake Disorders (26) · Sleep Initiation and Maintenance Disorders (23) · Pulmonary Disease, Chronic Obstructive (21) · Down Syndrome (18) · Motor Activity (18) · Disorders of Excessive Somnolence (17) · Stroke (17) · Cognitive Dysfunction (16) · Diabetes Mellitus (16)
Dyssomnias (1235) · Nervous System Diseases (1235) · Sleep Disorders, Intrinsic (1235) · Respiratory Tract Diseases (1234) · Respiration Disorders (1229) · Sleep Wake Disorders (1212) · Apnea (1206) · Sleep Apnea Syndromes (1055) · Pathological Conditions, Signs and Symptoms (270) · Signs and Symptoms (204) · Cardiovascular Diseases (128) · Nutritional and Metabolic Diseases (115) · Mental Disorders (112) · Vascular Diseases (103) · Pathologic Processes (89)
Continuous Positive Airway Pressure (115) · Polysomnography (24) · Occlusal Splints (19) · Acetazolamide (12) · Eszopiclone (11) · Atomoxetine Hydrochloride (9) · Exercise (9) · Therapeutics (9) · Dexmedetomidine (8) · Standard of Care (7) · solriamfetol (7) · Bariatric Surgery (6) · Tonsillectomy (6) · Diet (5) · Drug Delivery Systems (5)
Fisher and Paykel Healthcare (48) · ResMed (31) · University of California, San Diego (27) · Brigham and Women's Hospital (22) · Chinese University of Hong Kong (19) · University Hospital, Grenoble (18) · VA Office of Research and Development (18) · University Hospital, Antwerp (16) · The University of Hong Kong (15) · University of Michigan (13) · Mayo Clinic (11) · Peking University First Hospital (11) · University Health Network, Toronto (11) · Inspire Medical Systems, Inc. (10) · University of British Columbia (10)
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Atul Malhotra, MD (8) · Olivier Vanderveken, MD, PhD (7) · Mary SM Ip, MD (5) · David T. Kent, MD (4) · Eric Deflandre, MD, PhD (4) · Erling B Pedersen, Professor (4) · Xiaowan Du (4) · Adam Ogna, MD (3) · Bhavi Ogra (3) · Bhavi Ogra, BSc (3) · Ching-Hsia Hung, PhD (3) · Indra Narang, MD (3) · Jeremy Orr, MD (3) · Joerg Steier, PhD (3) · Kate Ching Ching Chan, MD (3)
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