67 completed, 12 recruiting, 11 terminated, 11 unknown. 113 Phase 2, 18 Phase 1, 9 Phase 3.
Follow Obsessive-Compulsive Disorder: new trials by email Literature Review of Obsessive-Compulsive Disorder trials Research Report on Obsessive-Compulsive Disorder
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Psilocybin for Treatment of OCD-2 Low Dose Psilocybin, High Dose Psilocybin - Obsessive - Compulsive Disorder | Phase 1 / Phase 2 | Not yet recruiting | Francisco A Moreno | 20 | 2026-09-08 | 2026-05-12 |
| Sonication-based OCD Neurosurgical Intervention Via Capsulotomy ExAblate MR-guided Focused Ultrasound Bilateral Anterior Capsulotomy - Obsessive-Compulsive Disorder | Phase 1 / Phase 2 | Not yet recruiting | Brigham and Women's Hospital | 66 | 2026-08-01 | 2026-02-25 |
| SONATA LIFU for OCD Low Intensity Focused Ultrasound, Sham (No Treatment) - Obsessive Compulsive Disorder | Phase 2 | Recruiting | University of Pennsylvania | 40 | 2026-07-01 | 2026-07-27 |
| Semaglutide (Wegovy) Treatment for Trichotillomania Semaglutide - Trichotillomania (Hair-Pulling Disorder), Trichotillomania | Phase 2 | Not yet recruiting | University of Chicago | 10 | 2026-06-01 | 2026-06-10 |
| Valbenazine in Obsessive Compulsive Disorder Valbenazine, Placebo - Obsessive-Compulsive Disorder | Phase 2 | Not yet recruiting | University of Chicago | 30 | 2026-06-01 | 2026-06-10 |
| Aripiprazole in Body Focused Repetitive Behaviors Placebo, Aripiprazole - Trichotillomania (Hair-Pulling Disorder), Dermatillomania | Phase 2 | Not yet recruiting | University of Chicago | 100 | 2026-06-01 | 2025-10-02 |
| Pilot Study of RR-HNK in OCD RR-HNK/Hydroxynorketamine, Placebo - Obsessive-Compulsive Disorder | Phase 1 / Phase 2 | Recruiting | Carolyn Rodriguez | 45 | 2026-01-23 | 2026-08-12 |
| MDMA-Assisted CBT for OCD (MDMA-CBT4OCD Study) 3,4-Methyl enedioxy methamphetamine, Methamphetamine, Cognitive Behavioral Therapy (CBT) - Obsessive-Compulsive Disorder | Phase 2 | Recruiting | Carolyn Rodriguez | 40 | 2025-09-10 | 2026-03-05 |
| Search for Novel Transcranial Magnetic Stimulation (TMS) Targets for Mental Illness Transcranial magnetic stimulation - Major Depressive Disorder, Obsessive-Compulsive Disorder | Phase 2 | Recruiting | Brigham and Women's Hospital | 180 | 2025-01-30 | 2026-07-16 |
| Evaluating the Feasibility, Safety and Efficacy of Psychotherapy Assisted Psilocybin for Treatment of Severe OCD psychotherapy assisted psilocybin - Obsessive-compulsive Disorder | Phase 2 | Recruiting | Beersheva Mental Health Center | 15 | 2024-11-25 | 2025-11-19 |
| Safety and Efficacy of Pramipexole Treatment in Resistant Obsessive-Compulsive Disorder (OCD) Pramipexole 0.088mg/tid, Pramipexole 0.18 mg/tid, Pramipexole 0.35 mg/tid - Obsessive-Compulsive Disorder | Phase 2 | Recruiting | Clinical Academic Center (2CA-Braga) | 48 | 2024-08-20 | 2025-01-06 |
| Examining Mu Opioid Mechanisms of Ketamine's Rapid Effects in OCD (MKET2) Ketamine, Naltrexone Pill, Placebo pill - Obsessive-Compulsive Disorder | Phase 2 | Recruiting | Stanford University | 150 | 2024-02-24 | 2026-04-24 |
| Efficacy of Valbenazine for the Treatment of Trichotillomania in Adults Valbenazine Oral Capsule, Placebo Oral capsule - Trichotillomania (Hair-Pulling Disorder) | Phase 2 | Recruiting | Yale University | 20 | 2024-02-02 | 2026-02-03 |
| Behavioral Treatment and Memantine in Body Focused Repetitive Behaviors Memantine, ComB Behavioral Therapy - Skin-Picking, Trichotillomania (Hair-Pulling Disorder) | Phase 2 / Phase 3 | Active not recruiting | University of Chicago | 26 | 2023-08-02 | 2026-07-07 |
| A Clinical Trial of Tolcapone in Obsessive Compulsive Disorder Tolcapone, Placebo - Obsessive-Compulsive Disorder, OCD | Phase 2 | Completed | University of Chicago | 49 | 2023-06-22 | 2026-09-23 |
| A Clinical Trial of Fecal Microbiota Transplantation in a Population With Obsessive-compulsive Disorder FMT Capsule + SIMBA Capsule - Obsessive-Compulsive Disorder | Phase 2 | Unknown | Valerie Taylor | 20 | 2023-06-01 | 2023-11-30 |
| Efficacy of Treatment With Pramipexole or Risperidone in Patients With Refractory Obsessive-compulsive Disorder (OCD) Pramipexole, Risperidone - Obsessive-Compulsive Disorder | Phase 2 | Withdrawn | Clinical Academic Center (2CA-Braga) | 2022-06-01 | 2024-09-19 | |
| Rituximab Treatment for Psychosis And/or Obsessive Compulsive Disorder with Probable Immune System Involvement Rituximab - Obsessive-Compulsive Disorder, Obsessive-Compulsive Behavior | Phase 2 | Enrolling by invitation | Uppsala University Hospital | 40 | 2022-05-01 | 2024-11-19 |
| Epidiolex in Obsessive Compulsive Disorder and Related Disorders Cannabidiol - Obsessive-Compulsive Disorder, Trichotillomania (Hair-Pulling Disorder) | Phase 2 | Completed | University of Chicago | 4 | 2022-04-14 | 2026-07-29 |
| Multimodal Assessment of Cannabinoid Target Engagement in Adults With Obsessive-Compulsive Disorder Nabilone, Placebo - Obsessive-Compulsive Disorder | Phase 1 / Phase 2 | Withdrawn | New York State Psychiatric Institute | 2022-03-01 | 2024-05-21 |
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Trichotillomania (19) · Excoriation Disorder (8) · Anxiety Disorders (7) · Generalized Anxiety Disorder (4) · Asperger Syndrome (3) · Autistic Disorder (3) · Body Dysmorphic Disorders (3) · Compulsive Behavior (3) · Compulsive Personality Disorder (3) · Disruptive, Impulse Control, and Conduct Disorders (3) · Hoarding (3) · Mental Disorders (3) · Phobia, Social (3) · Anxiety, Separation (2)
Mental Disorders (110) · Anxiety Disorders (106) · Disruptive, Impulse Control, and Conduct Disorders (18) · Behavior (15) · Behavioral Symptoms (10) · Nervous System Diseases (9) · Pathological Conditions, Signs and Symptoms (8) · Self-Injurious Behavior (8) · Neurodevelopmental Disorders (7) · Neurologic Manifestations (5) · Signs and Symptoms (5) · Pathologic Processes (4) · Central Nervous System Diseases (3) · Child Development Disorders, Pervasive (3)
Ketamine (9) · Cognitive Behavioral Therapy (8) · Acetylcysteine (6) · Memantine (5) · Transcranial Magnetic Stimulation (5) · Cycloserine (4) · Fluoxetine (3) · Naltrexone (3) · Sugars (3) · Aripiprazole (2) · Celecoxib (2) · Deep Brain Stimulation (2) · Dronabinol (2) · Implosive Therapy (2) · Lamotrigine (2)
University of Chicago (16) · New York State Psychiatric Institute (14) · University of South Florida (8) · Yale University (7) · Stanford University (5) · Ruijin Hospital (3) · University of Sao Paulo General Hospital (3) · Brigham and Women's Hospital (2) · Butler Hospital (2) · Carolyn Rodriguez (2) · Clinical Academic Center (2CA-Braga) (2) · Karolinska Institutet (2) · Massachusetts General Hospital (2) · Mclean Hospital (2) · National Institute of Mental Health (NIMH) (2)
United States (80) · Brazil (5) · Canada (4) · China (4) · Sweden (3) · France (2) · Germany (2) · Israel (2) · Italy (2) · Belgium (1) · Bulgaria (1) · Czechia (1) · Mexico (1) · Netherlands (1) · Portugal (1)
Jon E Grant, MD, JD, MPH (7) · Eric Storch, Ph.D. (4) · Carolyn I. Rodriguez, M.D., Ph.D. (3) · Jon E Grant, JD, MD, MPH (3) · Bomin Sun, MD, PhD (2) · Brian P Brennan, M.D. (2) · Carolyn I Rodriguez, M.D., Ph.D. (2) · Carolyn I Rodriguez, MD, PhD (2) · Carolyn Rodriguez, MD, PhD (2) · Christopher J Pittenger, MD, Ph.D. (2) · Eric A Storch, Ph.D. (2) · Jon E Grant, M.D. (2) · Al Rivera, MD (1) · Alexander McGirr, MD, PhD (1) · Ana M Abrantes, Ph.D. (1)
PMID 34582562, PMID 23251869, PMID 35267254, PMID 16619660, PMID 16855529, PMID 17915977, PMID 18315448, PMID 18490925, PMID 19005196, PMID 19142108, PMID 19581567, PMID 20621362, PMID 20817153, PMID 20923629, PMID 20951978, PMID 21456040, PMID 21527129, PMID 21557884, PMID 21590520, PMID 22348650, PMID 23357440, PMID 23452680, PMID 23452681, PMID 23676198, PMID 23783065, PMID 23842022, PMID 24356715, PMID 25054836, PMID 25271779, PMID 25526831, PMID 25645373, PMID 26104826, PMID 26139231, PMID 26214725, PMID 27007062, PMID 27046314, PMID 27249077, PMID 27367832, PMID 27724833, PMID 28044255, PMID 28617566, PMID 30082367, PMID 30149332, PMID 30877851, PMID 33972795, PMID 34134828, PMID 34693989, PMID 34825898, PMID 35105633, PMID 35651818
2009 (1), 2019 (1), K23MH092434 (1), K23MH125315 (1), K24MH121571 (1), R01MH080966 (1), R01MH086513 (1), R01MH116038 (1), R01MH133553 (1), R34HD065274 (1), R34MH083115 (1), R34MH095502 (1), R42MH077362 (1)