13 completed, 10 recruiting, 4 terminated, 3 unknown. 19 Not applicable, 4 Phase 1, 3 Phase 2, 3 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 19 | Completed 7, Recruiting 6, Terminated 3, Unknown 3 |
| Phase 1 | 4 | Completed 3, Recruiting 1 |
| Phase 2 | 3 | Completed 1, Recruiting 1, Terminated 1 |
| Phase 4 | 3 | Recruiting 2, Withdrawn 1 |
Follow Nicotine Use Disorder: new trials by email Literature Review of Nicotine Use Disorder trials Research Report on Nicotine Use Disorder
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Implementation of Tobacco Cessation Programming at Community Behavioral Health Sites Enhanced Courage to Quit - Nicotine Use Disorder, Smoking Cessation | Not applicable | Recruiting | University of Chicago | 24 | 2026-07-20 | 2026-07-07 |
| Temporal Interference Methods for Addiction Treatment TI-NDBS, Sham TI-NDBS - Nicotine Use Disorder, Substance Use Disorders | Not applicable | Recruiting | Indiana University | 120 | 2026-01-22 | 2026-09-11 |
| Effects of Novel E-cigarette Constituents on Adults TCORS 3.0 E-liquid coolant (No WS-3) for non-menthol (1), E-liquid coolant (No WS-3) for low (0.1%) menthol (1), E-liquid coolant (No WS-3) for high (2.0%) menthol (1) - Nicotine Use Disorder | Not applicable | Recruiting | Yale University | 66 | 2025-06-20 | 2026-06-16 |
| Testing the Feasibility and Acceptability of Social Media and Digital Therapeutics to Decrease Vaping Behaviors quitSTART Mobile Application, Chatbot Feature in quitSTART Mobile Application - Nicotine Vaping, Nicotine Use Disorder | Phase 1 | Recruiting | Washington University School of Medicine | 189 | 2025-06-04 | 2026-04-13 |
| tDCS Plus Varenicline for Smoking Cessation Active Transcranial Direct Current Stimulation (tDCS), Varenicline 1mg BID, Sham Transcranial Direct Current Stimulation (tDCS) - Nicotine Dependence, Tobacco Smoking | Phase 4 | Recruiting | Centre for Addiction and Mental Health | 160 | 2025-03-10 | 2025-08-12 |
| Identify the Optimal TMS Pulse Protocol to Modulate Reward Activity Transcranial Magnetic Stimulation - Nicotine Use Disorder | Not applicable | Recruiting | Rutgers, The State University of New Jersey | 42 | 2024-08-01 | 2025-11-18 |
| Real-time eCounselling for Nicotine Addiction CBT-MI - Nicotine Use Disorder | Not applicable | Recruiting | Overcome | 60 | 2024-07-08 | 2024-11-29 |
| A Smartphone Application (ACT on Vaping) for Vaping Cessation in Young Adults Smartphone app, Text Message, Survey Administration - Nicotine Dependence, Nicotine Addiction | Not applicable | Completed | Fred Hutchinson Cancer Center | 61 | 2024-01-04 | 2025-06-24 |
| Study to Assess PK, PD, Nicotine Extraction, Palatability, Subjective Effects of Nicotine Pouches - Daily Nicotine Users Test product 1 - Test product 2 - Comparator product - Nicotine Use Disorder | Not applicable | Unknown | Amplicon AB | 12 | 2023-11-24 | 2023-12-14 |
| Identify the Optimal TMS Target to Modulate Reward Activity Active 10-Hz TMS to the DLPFC, Sham TMS-DLPFC - Nicotine Use Disorder | Not applicable | Recruiting | Rutgers, The State University of New Jersey | 36 | 2023-03-24 | 2025-11-17 |
| Smoking Cessation and Menstrual Cycle Phase Timing of nicotine replacement therapy start date, Nicotine Replacement Therapy Agent - Nicotine Dependence, Tobacco Smoking | Phase 4 | Recruiting | Centre for Addiction and Mental Health | 1200 | 2022-11-30 | 2026-03-19 |
| Effects of E-cigarette Flavors on Youth TCORS 2.0 Flavoring Agents, Nicotine - Nicotine Use Disorder | Phase 1 | Completed | Yale University | 42 | 2022-11-07 | 2024-08-09 |
| Pharmaceutically-Enhanced Reinforcement for Reduced Alcohol and Smoking Contingency Management, Non-contingent control - Alcohol Use Disorder (AUD), Nicotine Use Disorder | Phase 2 | Recruiting | Washington State University | 205 | 2022-07-11 | 2026-07-06 |
| Evaluation of the Addictive Potential of E-Cigarettes Nicotine Use Disorder, Tobacco Use Disorder | Completed | Central Institute of Mental Health, Mannheim | 81 | 2020-12-01 | 2024-03-29 | |
| Acute Effects of TCIG vs ECIG in PLWH TCIG, ECIG, sham control - E Cigarette Use, Vaping | Not applicable | Completed | University of California, Los Angeles | 37 | 2020-10-01 | 2023-10-04 |
| Families With Substance Use and Psychosis: A Pilot Study CRAFT-FT - Psychosis, Substance Use | Not applicable | Completed | Mclean Hospital | 29 | 2020-09-24 | 2022-10-12 |
| Temporal Interference Neurostimulation and Addiction Active TI-NDBS, Sham TI-NDBS, tDCS - Nicotine Use Disorder, Substance Use Disorders | Not applicable | Terminated | Indiana University | 10 | 2020-07-06 | 2025-06-24 |
| Cortical Excitability and Role of rTMS in Nicotine Use Disorder Repetitive transcranial magnetic stimulation - Nicotine Use Disorder | Not applicable | Unknown | Assiut University | 60 | 2020-05-04 | 2020-03-10 |
| Effects of E-Cigarette Flavors on Adults TCORS 2.0 Nicotine, Flavor - Nicotine Use Disorder | Phase 1 | Completed | Yale University | 130 | 2019-05-14 | 2025-12-19 |
| Behavioral Memory Modulation in Nicotine Addiction Retrieval Extinction Training (RET), Control Retrieval Extinction Training (RET) - Nicotine Use Disorder | Not applicable | Completed | Medical University of South Carolina | 191 | 2019-02-04 | 2025-04-30 |
Showing 20 of 31. Sign in to see all of them.
Tobacco Use Disorder (31) · Smoking (9) · Smoking Cessation (8) · Vaping (7) · Substance-Related Disorders (6) · Tobacco Smoking (5) · Alcoholism (3) · Behavior, Addictive (3) · Cigarette Smoking (3) · Tobacco Use (3) · Tobacco Use Cessation (2) · Bipolar Disorder (1) · Inflammation (1) · Marijuana Abuse (1) · Mental Disorders (1)
Chemically-Induced Disorders (31) · Mental Disorders (30) · Substance-Related Disorders (25) · Behavior (19) · Health Behavior (8) · Smoking (8) · Alcohol-Related Disorders (3) · Compulsive Behavior (3) · Impulsive Behavior (3) · Tobacco Use (3) · Bipolar and Related Disorders (1) · Mood Disorders (1) · Pathologic Processes (1) · Pathological Conditions, Signs and Symptoms (1) · Schizophrenia Spectrum and Other Psychotic Disorders (1)
Nicotine (5) · Flavoring Agents (2) · Transcranial Magnetic Stimulation (2) · BID protein, human (1) · Baclofen (1) · Magnetic Resonance Spectroscopy (1) · Menthol (1) · Nicotine Chewing Gum (1) · Nicotine Replacement Therapy (1) · Quetiapine Fumarate (1) · Tobacco Use Cessation Devices (1) · Transcranial Direct Current Stimulation (1) · Varenicline (1)
Medical University of South Carolina (3) · Yale University (3) · Centre for Addiction and Mental Health (2) · Indiana University (2) · Rutgers, The State University of New Jersey (2) · University of Chicago (2) · University of Pennsylvania (2) · VA Office of Research and Development (2) · Washington University School of Medicine (2) · Amplicon AB (1) · Assiut University (1) · Central Institute of Mental Health, Mannheim (1) · Fred Hutchinson Cancer Center (1) · Hadassah Medical Organization (1) · Mclean Hospital (1)
United States (23) · Canada (2) · Germany (1) · Israel (1) · Spain (1) · Sweden (1) · United Kingdom (1)
Laurie A Zawertailo, PhD (2) · Suchitra Krishnan-Sarin, PhD (2) · Avi Yakir, MD (1) · Damaris Rohsenow, PhD (1) · David Friedrich, MD (1) · Erik Rein-Hedin, MD (1) · Helen Hayward, BSc (1) · Himanshu P Upadhyaya, MS, MBBS (1) · Jaimee Heffner (1) · James Loughead (1) · Joshua Brown (1) · Julie McCarthy, PhD (1) · Magi Farre, MD, PhD (1) · Matthew Kreuter, PhD (1) · Michael Saladin, PhD (1)
PMID 17141485, PMID 20934835, PMID 33452340, PMID 34794514, PMID 34849423, PMID 36335079, PMID 37005655, PMID 37230961, PMID 37408953, PMID 40411791, PMID 40489161
U54DA036151 (3), K23DA050808 (1), P50MD017349 (1), R01CA201429 (1), R01DA017460 (1), R01DA043587 (1), R21DA062805 (1), R34DA054725 (1), UG3DA057032 (1)