15 completed, 3 recruiting, 1 not yet recruiting. 14 Not applicable, 3 Phase 1, 1 Early Phase 1, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 14 | Completed 10, Recruiting 3, Not yet recruiting 1 |
| Phase 1 | 3 | Completed 3 |
| Early Phase 1 | 1 | Completed 1 |
| Phase 2 | 1 | Completed 1 |
Follow Flavoring Agents: new trials by email Literature Review of Flavoring Agents trials Research Report on Flavoring Agents
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effects of Milk Probiotics Intervention on Blood Glucose Control Middle-aged and Elderly People With Pre-diabetes a special probiotics from Mengniu Group, supplemented with milk powder, regular milk powder does not contain any additional supplementation, and the color, flavor, shape, taste, and weight are same with the probiotic milk powder - Pre-biabetes | Not applicable | Not yet recruiting | Huilian Zhu | 110 | 2025-12-01 | 2025-11-25 |
| Using Bitter Taste Receptor Blockers to Improve the Palatability of Pediatric Medicines Flavor additives - Healthy Adults | Not applicable | Recruiting | Monell Chemical Senses Center | 100 | 2025-03-18 | 2025-04-16 |
| Abuse Liability and Appeal of Oral Nicotine Products Flavor, Nicotine concentration - Nicotine Dependence | Not applicable | Recruiting | University of Southern California | 320 | 2024-02-09 | 2026-07-09 |
| HONEY for the Treatment of POst-Tonsillectomy Pain Manuka honey MGO 1000, Sugar-based syrup, thickened with sodium alginate and flavoured with honey flavouring - Post Surgical Pain, Analgesia | Not applicable | Recruiting | East and North Hertfordshire NHS Trust | 100 | 2023-09-04 | 2026-07-07 |
| Testing the Effect of ENDS Flavors on Neurotransmission Flavor - Tobacco Dependence | Not applicable | Completed | Milton S. Hershey Medical Center | 36 | 2023-06-01 | 2026-08-07 |
| Effects of E-cigarette Flavors on Youth TCORS 2.0 Flavoring Agents, Nicotine - Nicotine Use Disorder | Phase 1 | Completed | Yale University | 42 | 2022-11-07 | 2024-08-09 |
| Examining the Effect of Exogenous Ketone Supplementation on Glucose Control in Type 2 Diabetes Exogenous Ketone Monoester, Placebo - Diabetes Mellitus, Type 2 | Not applicable | Completed | University of British Columbia | 15 | 2022-02-15 | 2023-04-13 |
| The Effect of Sweet Flavoring on the Rewarding and Reinforcing Value of Cigarillo Use Among Young Adults Flavor - Tobacco Use, Cigar Smoking | Early Phase 1 | Completed | University of Pennsylvania | 95 | 2021-09-14 | 2024-05-17 |
| Sensory Analysis and Taste Modulation of Ketone Esters Flavor additive - Flavor Perception in Normal, Healthy Adults | Not applicable | Completed | Monell Chemical Senses Center | 19 | 2020-08-30 | 2022-03-21 |
| Clinical Study of the Effect of Two Experimental Lozenges on Oral Malodor After Single Use Experimental lozenge with the enzyme Polyphenol oxidase and green coffee extract, Experimental lozenge with the enzyme Polyphenol oxidase, green coffee extract and flavor, Placebo lozenge control (sorbitol only) - Oral Malodor | Not applicable | Completed | Novozymes A/S | 156 | 2020-02-06 | 2023-07-18 |
| Acceptance of Different Thickeners in Dysphagia Modified starch without flavoring, Mofidied starch with Bi1 aromas, Xanthan gum without flavoring - Dysphagia, Dysphagia, Oropharyngeal | Not applicable | Completed | Complexo Hospitalario Universitario de A Coruña | 42 | 2020-02-03 | 2020-03-12 |
| Effects of E-Cigarette Flavors on Adults TCORS 2.0 Nicotine, Flavor - Nicotine Use Disorder | Phase 1 | Completed | Yale University | 130 | 2019-05-14 | 2025-12-19 |
| A 2 Part Study to Assess the Relative Bioavailability of Tablet Formulation Compared to Capsule Formulation and the Effect of Food and Taste Assessment on the Tablet Formulation in Healthy Participants RO7017773 Phase I Capsule, RO7017773 Phase II Tablet Unflavored, RO7017773 Phase II Tablet Sweetened/Flavored - Healthy Volunteers | Phase 1 | Completed | Hoffmann-La Roche | 24 | 2019-03-12 | 2020-05-28 |
| Addictive Potential of LCCs in Dual Users Flavored and unflavored little cigars/cigarillos (LCCs) - Tobacco Use Disorder, Dual Tobacco Use | Not applicable | Completed | UConn Health | 65 | 2018-08-28 | 2026-03-10 |
| Sensory Perception of Sweet Flavors in E-Cigarette E-cigarettes with varying concentrations of nicotine & flavor - Smoking | Not applicable | Completed | Oregon State University | 19 | 2018-01-21 | 2019-10-11 |
| Vascular EffectS of regUlar Cigarettes Versus electronIc Cigarette USe electronic cigarette + 16mg nicotine & flavor, electronic cigarette + 0mg nicotine & flavor, Tobacco cigarette - Vascular Diseases | Not applicable | Completed | University of Dundee | 145 | 2016-08-18 | 2019-02-06 |
| Rehydration Following Exercise-Induced Dehydration Water with flavoring and non-nutritive sweetener., High-Na low-CHO beverage, Low-Na high-CHO beverage - Dehydration Related to Exercise | Not applicable | Completed | University of Illinois at Chicago | 26 | 2013-07-01 | 2016-06-02 |
| Use of Probiotics in Oral Health of Patients With Dental Implants Probiotic tablets of Lactobacillus reuteri, Placebo tablets - Mucositis | Phase 2 | Completed | University of Valencia | 34 | 2008-01-01 | 2013-11-01 |
| Sensitive Periods in Early Flavor Learning Nutramigen (Flavor and Type of Infant Formula), Enfamil, milk-based formula - Healthy | Not applicable | Completed | Monell Chemical Senses Center | 79 | 2006-11-01 | 2012-10-03 |
Tobacco Use Disorder (5) · Smoking (3) · Cigar Smoking (2) · Agnosia (1) · Behavior, Addictive (1) · Cigarette Smoking (1) · Deglutition Disorders (1) · Dehydration (1) · Diabetes Mellitus, Type 2 (1) · Food Preferences (1) · Hyperglycemia (1) · Inflammation (1) · Ketosis (1) · Motor Activity (1) · Mucositis (1)
Monell Chemical Senses Center (3) · Yale University (2) · Complexo Hospitalario Universitario de A Coruña (1) · East and North Hertfordshire NHS Trust (1) · Hoffmann-La Roche (1) · Huilian Zhu (1) · Milton S. Hershey Medical Center (1) · Novozymes A/S (1) · Oregon State University (1) · UConn Health (1) · University of British Columbia (1) · University of Dundee (1) · University of Illinois at Chicago (1) · University of Pennsylvania (1) · University of Southern California (1)
United States (13) · Spain (2) · United Kingdom (2) · Canada (1)
Craig Horswill, PhD (1) · Erin L Mead, PhD,MHS (1) · George Mochloulis, MD (1) · Jacob George (1) · Jeffrey Milleman, DDS, MPA (1) · John R Monterosso, PhD (1) · Jonathan Little, PhD (1) · Julie A Mennella, PhD (1) · Juyun Lim (1) · Paul M Wise, Ph.D. (1) · Paul M Wise, PhD (1) · Phillip Smith, PhD (1) · Suchitra Krishnan-Sarin, PhD (1)
PMID 21187303, PMID 21310829, PMID 26497857, PMID 31740017, PMID 38050181, PMID 39496199, PMID 39804761, PMID 40489161, PMID 42303314
U54DA036151 (2), R61DA056764 (1), U54CA180905 (1)