40 completed, 5 unknown, 4 recruiting, 3 not yet recruiting. 26 Not applicable, 11 Phase 2, 11 Phase 3, 9 Phase 1, 2 Early Phase 1.
Follow Menthol: new trials by email Literature Review of Menthol trials Research Report on Menthol
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study to Assess Nicotine Uptake From a Menthol Electronic Nicotine Delivery System Product Menthol 5%, Combustible cigarette - Smoking Behaviors, Smoking ( Cigarette) | Not applicable | Not yet recruiting | RAI Services Company | 28 | 2026-11-15 | 2026-10-20 |
| Abuse Liability of Four Modern Oral Nicotine Products Usual Brand (UB) filtered, menthol or non-menthol combustible cigarette, Wintergreen (fleece A), 12 mg nicotine, Wintergreen (fleece A), 9 mg nicotine - Smoking, Smoking Behaviors | Not applicable | Not yet recruiting | RAI Services Company | 50 | 2026-07-15 | 2026-07-06 |
| Abuse Liability of Two Modern Oral Nicotine Pouched Products Usual Brand (UB) filtered, menthol or non-menthol combustible cigarette, Modern Oral Pouch Wintergreen-A 9 mg Nicotine, Modern Oral Pouch Wintergreen-B 9 mg Nicotine - Smoking, Smoking Behaviors | Not applicable | Not yet recruiting | RAI Services Company | 40 | 2026-06-15 | 2026-05-19 |
| Efficacy of L-menthol on Breathlessness in Asthma L-menthol, Placebo - Asthma | Phase 2 | Recruiting | Region Skane | 20 | 2026-05-07 | 2026-08-19 |
| Efficacy of L-menthol on Breathlessness in Interstitial Lung Disease L-menthol, Placebo - Interstitial Lung Disease (ILD) | Phase 2 | Recruiting | Region Skane | 20 | 2026-04-13 | 2026-04-24 |
| Effects of Novel E-cigarette Constituents on Adults TCORS 3.0 E-liquid coolant (No WS-3) for non-menthol (1), E-liquid coolant (No WS-3) for low (0.1%) menthol (1), E-liquid coolant (No WS-3) for high (2.0%) menthol (1) - Nicotine Use Disorder | Not applicable | Recruiting | Yale University | 66 | 2025-06-20 | 2026-06-16 |
| Study of Gum Tissue Proteins in Smokers vs. Non-smokers After Cleaning Non Surgical Periodontal Treatment includes post operative mouth wash with Listerine® (ethanol 21.6%, methyl salicylate 0.06%, menthol 0.042%, thymol 0.064% and eucalyptol 0.092%) - Smoking ( Cigarette), Periodontitis Stage II | Not applicable | Completed | Al-Azhar University | 36 | 2024-11-11 | 2026-01-14 |
| A Single Group Study to Evaluate the Effects of a Topical Product on Cramps Associated With the Menstrual Cycle Topical Analgesic with Camphor and Menthol - Dysmenorrhea, Menstrual Cramps | Not applicable | Completed | Rael | 40 | 2024-10-03 | 2025-04-23 |
| Effect of Different E-cigarette Cooling Flavors on Adults' Sensory Experience TCORS 3.0 E-liquid coolant (WS-3, 0.05%), E-liquid coolant (WS-3, 0.1%), E-liquid coolant (WS-3, 0.5%) - E-Cig Use | Not applicable | Completed | Yale University | 31 | 2024-09-03 | 2026-02-18 |
| Effects of E-cigs vs Pouches on Cigarette Smoking and Addiction E-cigarette with 2.4% Nicotine with Menthol and Tobacco Flavors, E-cigarette with 2.4% Nicotine with Tobacco Flavor Only, E-cigarette with 5% Nicotine with Menthol and Tobacco Flavors - Smoking, Smoking Behaviors | Not applicable | Recruiting | Yale University | 256 | 2024-08-20 | 2026-03-19 |
| Transient Receptor Potential Channels TRPM8 Agonist, TRPV1 Agonist, TRPV4 Agonist - Aging | Early Phase 1 | Enrolling by invitation | Penn State University | 45 | 2024-07-17 | 2026-07-27 |
| Pharmacokinetic and Subjective Effects of Heated Tobacco Products Product A, Product B, Product C - Tobacco Use | Not applicable | Completed | Altria Client Services LLC | 80 | 2024-02-06 | 2026-03-27 |
| Changes in Biomarker of Exposure in Adults Who Smoke Cigarettes Switching From Cigarettes to Heated Tobacco Products Ploom HTP Menthol HTS; MX3 (681), Ploom HTP Tobacco HTS; R8 (120), Smoking Abstinence (menthol) - Tobacco Use | Not applicable | Completed | Altria Client Services LLC | 921 | 2023-10-02 | 2026-05-27 |
| TRPM8 in Acute Ischemic Stroke by Topical Menthol Menthol, Placebo - Ischemic Stroke | Phase 2 | Completed | Taipei Medical University Hospital | 60 | 2023-05-26 | 2024-10-15 |
| Efficacy of L-menthol on Breathlessness in Chronic Obstructive Pulmonary Disease L-menthol, Placebo - Chronic Obstructive Pulmonary Disease (COPD) | Phase 2 | Completed | Region Skane | 20 | 2023-05-24 | 2025-12-09 |
| Impact of Flavors on Nicotine Perception and Self-Administration Via E-cigarettes Nicotine 0 mg/mL, Nicotine 6 mg/mL, Nicotine 12 mg/mL - Nicotine, E-liquid Flavors | Phase 2 | Completed | Yale University | 54 | 2022-10-27 | 2024-08-05 |
| Minimally Invasive Non-surgical Therapy for the Treatment of Splinted Stage IV Periodontitis Non Surgical Periodontal Treatment includes post operative mouth wash with Listerine® (ethanol 21.6%, methyl salicylate 0.06%, menthol 0.042%, thymol 0.064% and eucalyptol 0.092%), Minimally invasive non-surgical technique with mini five and after five minimally invasive instrument plus splint - Periodontitis, Stage IV Periodontitis | Not applicable | Completed | Minia University | 40 | 2022-08-11 | 2025-01-14 |
| Topical CBD for Musculoskeletal Pain GoodFOR Pain, Icy Hot, Tiger Balm - Pain | Phase 3 | Unknown | Apothyx, Co. | 100 | 2022-07-01 | 2022-06-09 |
| Clinical Adhesion Study Between ZTlido 1.8% and Three Over-the-counter External Analgesic Lidocaine-containing Patches ZTlido (Lidocaine Topical System) 1.8%, Salonpas (Lidocaine Patch 4%), Aspercreme (Lidocaine Patch 4%) - Healthy | Phase 1 | Completed | Scilex Pharmaceuticals, Inc. | 24 | 2021-07-01 | 2021-11-03 |
| Menthol and Mint Experimental Tobacco Marketplace (ETM) Study Tobacco e-liquids, Menthol and Tobacco e-liquids, Mint, Menthol and Tobacco e-liquids - Cigarette Smoking, Vaping | Not applicable | Completed | Wake Forest University Health Sciences | 66 | 2021-06-21 | 2024-06-26 |
Showing 20 of 58. Sign in to see all of them.
Smoking (12) · Vaping (8) · Pain (7) · Tobacco Use Disorder (6) · Tobacco Use (5) · Pruritus (4) · Cigarette Smoking (3) · Dyspnea (3) · Headache (3) · Periodontitis (3) · Colonic Neoplasms (2) · Cough (2) · Diabetes Mellitus (2) · Migraine Disorders (2) · Motor Activity (2)
Yale University (8) · Aalborg University (4) · GlaxoSmithKline (3) · RAI Services Company (3) · Region Skane (3) · Altria Client Services LLC (2) · Nihon Pharmaceutical Co., Ltd (2) · Penn State University (2) · R.J. Reynolds Vapor Company (2) · Sandoz (2) · Al-Azhar University (1) · Apothyx, Co. (1) · Azidus Brasil (1) · Baylor College of Medicine (1) · Columbia University (1)
United States (26) · Denmark (4) · Sweden (3) · Canada (2) · Egypt (2) · Japan (2) · Russia (2) · Taiwan (2) · United Kingdom (2) · Bangladesh (1) · Brazil (1) · China (1) · France (1) · Germany (1) · Kosovo (1)
Brian Keyser (2) · Suchitra Krishnan-Sarin, PhD (2) · Annelize Koch, MBChB (1) · Cheryl Oncken, M.D. (1) · Dana Cavallo, Ph.D. (1) · Dana Cavallo, PhD (1) · Dashnor Bukleta, Dr (1) · Dawn Hershman, MD (1) · Dmitri Lissin, MD (1) · Elise DeVito, PhD (1) · Guillaume Prieur (1) · Harry Alcorn, Jr., PharmD (1) · Ian M Paul, MD, MSc (1)
PMID 21059712, PMID 24637663, PMID 25762758, PMID 27260636, PMID 27344959, PMID 28345425, PMID 32297782, PMID 35729250, PMID 42249403, PMID 42406436
U54DA036151 (3), P50DA036151 (2), 2019 (1), P50DA036107 (1), R01DA046360 (1)