41 completed, 5 terminated, 3 active not recruiting, 3 not yet recruiting. 33 Not applicable, 10 Phase 2, 6 Phase 3, 5 Phase 4, 3 Phase 1.
Follow Muscle Cramp: new trials by email Literature Review of Muscle Cramp trials Research Report on Muscle Cramp
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The Effect of a Daily Magnesium and Melatonin Supplement on Sleep Quality in People With Nighttime Leg Cramps Magnesium and melatonin based multi-ingredient dietary supplementation, Placebo - Poor Sleep Quality, Leg Cramps, Nocturnal | Not applicable | Recruiting | StudySetGo | 50 | 2026-10-10 | 2026-11-02 |
| Comparative Study Between Leg Massage and Vibration on Cramps and Comfort for Patients Undergoing Hemodialysis massage, vibration - Hemodialysis, Renal Failure , Chronic | Not applicable | Not yet recruiting | University of Baghdad | 160 | 2026-09-10 | 2026-08-20 |
| Weighted Blanket in Pregnancy Weighted Blanket - Leg Cramps, Nocturnal, Poor Sleep Quality | Not applicable | Not yet recruiting | Ataturk University | 50 | 2025-12-30 | 2025-12-30 |
| Compression Stockings for Prevention of Hemodialysis Muscle Cramps compression stockings - Muscle Cramp | Not applicable | Completed | Karbala University | 82 | 2025-12-21 | 2026-05-19 |
| The Effect of Home-Based Walking on Symptoms and Health Profile of Hemodialysis Patients Group A (Home-based walking), Group B (Usual hemodialysis care ) - Muscle Cramp, Hemodialysis | Not applicable | Active not recruiting | Figen Akay | 24 | 2025-12-15 | 2026-08-31 |
| The Relationship of the Joint Blockage and Muscle Spasm Mobilization technique for sacroiliac joint - NO DECOMPENSATED ILLNESS, Muscle Cramps | Not applicable | Completed | Charles University, Czech Republic | 40 | 2025-11-10 | 2025-12-04 |
| Effect of Modifying Magnesium Concentration in Citrate-enriched Dialysate on Serum Magnesium Levels A - Dialysate magnesium 0.75, B - Dialysate magnesium 1.00 mmol/L - Dialysis; Complications | Not applicable | Completed | Universitaire Ziekenhuizen KU Leuven | 54 | 2025-01-28 | 2026-05-04 |
| Prevalence and Severity of Cramps in Chronic Kidney Disease Patients Cramps, Chronic Kidney Disease(CKD) | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 250 | 2025-01-01 | 2024-12-17 | |
| Effects of Telerehabilitation-based Motor Imagery and Exercise Combination in Individuals With Postural Kyphosis: A Randomized Controlled Trial Home Exercise Group - Posture, Kyphosis | Not applicable | Completed | Istanbul University - Cerrahpasa | 35 | 2024-11-15 | 2026-03-13 |
| Stretching Exercises for Dialysis Patients to Reduce Muscle Cramps Nurse-Led Intradialytic Stretching Exercises - Muscle Cramp, Renal Dialysis | Not applicable | Completed | Beni-Suef University | 60 | 2024-09-01 | 2025-12-04 |
| The Application of Wide Pulse High Frequency Neuromuscular Electrical Stimulation in Disorders Associated With Motoneuron Hyperexcitability wide pulse high frequency neuromuscular electrical stimulation training - Stroke, Cramp | Not applicable | Recruiting | University of Lausanne | 110 | 2023-10-01 | 2023-11-28 |
| Effect of Branched-chain Amino Acids (BCAA) to Muscle Cramps in Patients With Cirrhosis Branched-chain Amino Acid, Placebo - Muscle Cramp, Cirrhosis | Phase 4 | Completed | Mahidol University | 48 | 2023-04-01 | 2024-02-09 |
| The Effect of Grounding During Pregnancy Grounding, Sham grounding - Cramp, Limb, Pregnancy Related | Not applicable | Unknown | Ege University | 86 | 2022-11-01 | 2023-05-01 |
| TJ-68 Clinical Trial in Patients With Amyotrophic Lateral Sclerosis (ALS) and Muscle Cramps TJ-68, Placebo - Amyotrophic Lateral Sclerosis, Muscle Cramp | Phase 1 / Phase 2 | Completed | Hiroshi Mitsumoto | 11 | 2022-09-30 | 2025-05-01 |
| The RELAX Trial: Nonpharmaceutical Intervention for Nocturnal Muscle Cramps Behavioral intervention one, Behavioral intervention two - Cramps, Muscle Cramp | Not applicable | Completed | University of Michigan | 99 | 2022-08-30 | 2023-09-11 |
| Effect of 'Cramp Bites' on Period Cramps in Women Aged 18-25 Cramp Bites by Aunt Flo's Kitchen - Dysmenorrhea Primary, Dysmenorrhea | Phase 2 / Phase 3 | Completed | Cornell University | 12 | 2022-07-21 | 2024-04-12 |
| Outcomes of a Higher vs. Lower Hemodialysate Magnesium Concentration (Dial-Mag) Dialysate magnesium formulation of 1.5 mEq/L (0.75 mmol/L)., Dialysate magnesium formulation of ≤1.0 mEq/L (≤0.5 mmol/L). - Kidney Diseases, End-Stage Kidney Disease | Not applicable | Active not recruiting | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 25000 | 2022-04-04 | 2026-04-17 |
| Effectiveness of Intradialytic Exercise on Reduction in Fatigue and Muscle Cramps Intradialytic exercise - Dialysis; Complications | Not applicable | Completed | Institute of Liver and Biliary Sciences, India | 62 | 2021-11-01 | 2022-05-19 |
| Prevention of Leg Cramps Using Compression Stockings or Magnesium Supplements in the Age Group of 50 to 84 Compression stocking, Magnesium tablet, Placebo tablet - Muscle Cramp, Stockings, Compression | Not applicable | Unknown | Tampere University Hospital | 225 | 2021-02-01 | 2021-01-05 |
| Non-Pharmaceutical Intervention for Cirrhotic Cramps Reduction: The NICCles Trial Household Remedy, Tap water - Cirrhosis, Muscle Cramp | Not applicable | Completed | University of Michigan | 82 | 2021-01-18 | 2021-12-03 |
Showing 20 of 59. Sign in to see all of them.
Amyotrophic Lateral Sclerosis (6) · Pain (6) · Fibrosis (5) · Muscle Weakness (5) · Spasm (5) · Liver Cirrhosis (4) · Myalgia (4) · Sleep-Wake Transition Disorders (4) · Fatigue (3) · Motor Neuron Disease (3) · Muscular Diseases (3) · Nervous System Diseases (3) · Neuromuscular Diseases (3) · Renal Insufficiency, Chronic (3)
Musculoskeletal Diseases (59) · Neurologic Manifestations (59) · Neuromuscular Manifestations (59) · Pathological Conditions, Signs and Symptoms (59) · Signs and Symptoms (59) · Muscular Diseases (56) · Nervous System Diseases (56) · Pathologic Processes (20) · Nutritional and Metabolic Diseases (14) · Metabolic Diseases (12) · Neuromuscular Diseases (10) · Central Nervous System Diseases (7) · Mental Disorders (7) · Digestive System Diseases (6) · Proteostasis Deficiencies (6)
Baclofen (2) · Magnesium (2) · Simvastatin (2) · Stockings, Compression (2) · Vitamin E (2) · Amino Acids, Branched-Chain (1) · Atorvastatin (1) · BID protein, human (1) · Botulinum Toxins, Type A (1) · Calcium (1) · Carnitine (1) · Creatine (1) · Dronabinol (1) · Hot Temperature (1) · Hydroxychloroquine (1)
Flex Pharma, Inc. (2) · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's (2) · Massachusetts General Hospital (2) · Mayo Clinic (2) · National Institute of Mental Health (NIMH) (2) · Purdue University (2) · University of Michigan (2) · University of Texas Southwestern Medical Center (2) · Assistance Publique - Hôpitaux de Paris (1) · Ataturk University (1) · Beni-Suef University (1) · Bjorn Oskarsson, MD (1) · Cantonal Hospital of St. Gallen (1) · Catherine Buettner (1) · Charles University, Czech Republic (1)
United States (27) · Turkey (Türkiye) (7) · Canada (3) · Egypt (3) · Switzerland (3) · Iraq (2) · South Korea (2) · Austria (1) · Belgium (1) · Botswana (1) · Czechia (1) · France (1) · India (1) · Thailand (1)
Berdine Martin, PhD (2) · Bjorn Oskarsson, MD (2) · Connie Weaver, PhD (2) · Elliot Tapper, MD (2) · Steven J Russell, MD PhD (2) · Amit X Garg, PhD, MD (1) · Andrew Scanga, MD (1) · Angelika Hammerer, MD (1) · Asem A Elfert, MD (1) · Asem A Elfert, Professor (1) · Azra Alizad, MD (1) · Bjorn Meijers, MD, PhD (1) · Catherine Buettner, MD, MPH (1) · Cebrail Cebrailov, M.D. (1)
PMID 10403745, PMID 11208726, PMID 12806613, PMID 12924658, PMID 12963433, PMID 15222044, PMID 16206505, PMID 17234504, PMID 17387740, PMID 19570764, PMID 19932545, PMID 20192911, PMID 21563202, PMID 22018642, PMID 22757749, PMID 22825550, PMID 22835465, PMID 22963024, PMID 23183941, PMID 23542334, PMID 23958263, PMID 24872223, PMID 24931572, PMID 24942957, PMID 26850709, PMID 27351006, PMID 27467714, PMID 27909047, PMID 28518283, PMID 28623895, PMID 29447778, PMID 29653741, PMID 30444744, PMID 31834056, PMID 32533302, PMID 32712600, PMID 34844641, PMID 35191232, PMID 35385471, PMID 35389756, PMID 37311173, PMID 37430314, PMID 38860445, PMID 39787573, PMID 39972246, PMID 41393273, PMID 41680812, PMID 41803821, PMID 42417484, PMID 62115
K23AR055664 (1), R01HD061908 (1), R01HL081893 (1), R01HL148664 (1)