609 completed, 239 recruiting, 180 unknown, 91 terminated. 341 Phase 2, 336 Not applicable, 220 Phase 1, 123 Phase 3, 24 Early Phase 1.
Follow Motor Neuron Disease: new trials by email Literature Review of Motor Neuron Disease trials Research Report on Motor Neuron Disease
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Multiple Dose Study to Investigate Safety, Tolerability and Pharmacokinetics of TBN Tetramethylpyrazine nitrone (TBN) tablet / Placebo - Healthy | Phase 1 | Not yet recruiting | Guangzhou Magpie Pharmaceuticals Co., Ltd. | 16 | 2028-09-01 | 2026-09-11 |
| Evaluation of Donor-Derived B Cell Infusions in Patients With Amyotrophic Lateral Sclerosis (ALS) B cell infusion - ALS - Amyotrophic Lateral Sclerosis | Phase 1 | Not yet recruiting | Mark Poznansky | 10 | 2027-09-01 | 2026-09-24 |
| Safety Study of XT-150 in Participants With ALS XT-150 - Amyotrophic Lateral Sclerosis (ALS) | Phase 1 | Not yet recruiting | Xalud Therapeutics, Inc. | 8 | 2027-03-01 | 2026-07-29 |
| A Study of Single Ascending Doses of NI112 in Adults With Amyotrophic Lateral Sclerosis (ALS) NI112, Placebo - Amyotrophic Lateral Sclerosis (ALS) | Phase 1 | Not yet recruiting | Sachi Bioworks Inc. | 40 | 2027-01-22 | 2026-10-30 |
| Interfacing With NeuroTechnology to Expand Neural Throughput (INTENT) INTENT Neural Interface System - Tetraplegia/Tetraparesis, Amyotrophic Lateral Sclerosis (ALS) | Not applicable | Recruiting | Johns Hopkins University | 5 | 2027-01-01 | 2026-10-09 |
| SPX-01 Gene Therapy in Pediatric Patients With Spinal Muscular Atrophy Type 1 (RISE) SPX-01 - Spinal Muscular Atrophy (SMA) | Early Phase 1 | Not yet recruiting | Exir Gene Pharmed | 1 | 2027-01-01 | 2026-10-29 |
| Dorsal Root Ganglion Stimulation After Lower Motor Neuron Damage Abbot Dorsal Root Ganglion Neurostimulator - Spinal Cord Injuries, Lower Motor Neuron Disease | Not applicable | Not yet recruiting | Peter J. Grahn, Ph.D. | 1 | 2026-12-01 | 2026-09-15 |
| Study to Investigate the Safety of the Transplantation (by Injection) of Human Glial Restricted Progenitor Cells (hGRPs; Q-Cells®) Into Subjects With Amyotrophic Lateral Sclerosis (ALS) Q-Cells - Amyotrophic Lateral Sclerosis | Phase 1 / Phase 2 | Not yet recruiting | Q Therapeutics, Inc. | 30 | 2026-12-01 | 2026-07-08 |
| Personalized Antisense Oligonucleotide Therapy for a Participant With TARDBP ALS nL-TARDB-002 - Amyotrophic Lateral Sclerosis (ALS) | Phase 1 / Phase 2 | Enrolling by invitation | n-Lorem Foundation | 1 | 2026-12-01 | 2026-07-14 |
| Brain-Computer Interface Communication Device for People With ALS Cognixion ONE AR-BCI configuration, Cognixion ONE screen-based BCI configuration, Existing eye-gaze speech generating device - Amyotrophic Lateral Sclerosis | Not applicable | Recruiting | Cognixion | 30 | 2026-11-15 | 2026-10-16 |
| A Real-World Medical Chart Review of Spinal Muscular Atrophy Patients Treated With Onasemnogene Abeparvovec in Saudi Arabia Spinal Muscular Atrophy | Not yet recruiting | Novartis Pharmaceuticals | 6 | 2026-11-01 | 2026-10-15 | |
| A Study of LY3873862 in Participants With Sporadic or Familial Amyotrophic Lateral Sclerosis (ALS). LY3873862, CYP450 Drug Cocktail, Placebo - Amyotrophic Lateral Sclerosis, Cytochrome P-450 Enzyme System | Phase 1 | Not yet recruiting | Eli Lilly and Company | 32 | 2026-11-01 | 2026-10-20 |
| A Registry of Cases of Spinal Muscular Atrophy Spinal Muscular Atrophy | Recruiting | St. Jude Children's Research Hospital | 30 | 2026-11-01 | 2026-10-22 | |
| Imaging Assessment of Swallowing and Speech Muscles in Inclusion Body Myositis IBM, Inclusion Body Myositis | Recruiting | Johns Hopkins University | 30 | 2026-11-01 | 2026-10-28 | |
| A Study to Learn About the Safety and Effects of Salanersen (BIIB115) When Given to Babies With Spinal Muscular Atrophy (SMA) Who Were Previously Treated With Onasemnogene Abeparvovec Salanersen, Sham Procedure - Muscular Atrophy, Spinal | Phase 3 | Recruiting | Biogen | 42 | 2026-10-31 | 2026-10-15 |
| Effects of Different Stiffness Settings During Robotic Isokinetic Training in Children With SMA Portable Isokinetic Knee Training Robot With an Individually Optimized Compliant Setting, Portable Isokinetic Knee Training Robot With a Rigid Setting - Spinal Muscular Atrophy (SMA) | Not applicable | Recruiting | Peking University Third Hospital | 13 | 2026-10-22 | 2026-10-23 |
| Evaluation of the Feasibility and Efficacy of a Chronic Brain-computer Interface for Speech Rehabilitation in Patients With Locked-in-syndrome (LIS) Chronic speech BCI - Locked in Syndrome, ALS (Amyotrophic Lateral Sclerosis) | Not applicable | Not yet recruiting | University Hospital, Grenoble | 3 | 2026-10-10 | 2026-07-13 |
| A Study to Learn About the Safety of BIIB147 and Its Effects in Adults With Amyotrophic Lateral Sclerosis (ALS) BIIB147, Placebo - Amyotrophic Lateral Sclerosis | Phase 1 / Phase 2 | Recruiting | Biogen | 69 | 2026-10-07 | 2026-10-26 |
| A Study of the Safety and Effectiveness of Onasemnogene Abeparvovec (Zolgensma) Intrathecal Injection in Spinal Muscular Atrophy Patients Spinal Muscular Atrophy | Recruiting | Novartis Pharmaceuticals | 80 | 2026-10-07 | 2026-10-22 | |
| iBCI Optimization for Veterans With Paralysis Mobile neural decoding platform (mobile iBCI) - Spinal Cord Injury, Amyotrophic Lateral Sclerosis | Not applicable | Not yet recruiting | VA Office of Research and Development | 2 | 2026-10-02 | 2026-07-27 |
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Amyotrophic Lateral Sclerosis (974) · Muscular Atrophy, Spinal (280) · Neuromuscular Diseases (72) · Spinal Muscular Atrophies of Childhood (61) · Bulbo-Spinal Atrophy, X-Linked (57) · Parkinson Disease (53) · Neurodegenerative Diseases (50) · Spinal Cord Injuries (45) · Alzheimer Disease (35) · Multiple Sclerosis (34) · Frontotemporal Dementia (31) · Nervous System Diseases (29) · Muscular Dystrophies (28) · Stroke (28)
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nusinersen (28) · Riluzole (24) · Blood Specimen Collection (19) · Risdiplam (18) · Zolgensma (13) · Spinal Puncture (10) · Surveys and Questionnaires (9) · Dexpramipexole (8) · Edaravone (8) · Exercise (8) · Sodium Chloride (7) · sodium phenylbutyrate and taurursodiol (7) · 4-phenylbutyric acid (6) · CK-2017357 (6) · Noninvasive Ventilation (6)
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Merit Cudkowicz, MD (10) · Jeremy Shefner, MD, PhD (8) · Bjorn Oskarsson, MD (6) · Dominic Rowe, MD (5) · Dongsheng Fan (5) · Mary Kay Floeter, M.D. (5) · Merit Cudkowicz, MD, MSc (5) · Terry Heiman-Patterson, MD (5) · Benjamin R Brooks, MD (4)
PMID 31420846, PMID 34383289, PMID 37148485, PMID 27939059, PMID 36008843, PMID 38705943, PMID 41224659, PMID 16434671, PMID 17980667, PMID 18506712, PMID 19251627, PMID 19440247, PMID 22415951, PMID 22529995, PMID 23300829, PMID 23463272, PMID 23952636, PMID 24067398, PMID 25982504, PMID 26247043, PMID 26751635, PMID 26823478, PMID 28284873, PMID 29091570, PMID 29287521, PMID 29443664, PMID 30048507, PMID 30124008, PMID 30814647, PMID 30879249, PMID 32896088, PMID 34433481, PMID 34536404, PMID 35532908, PMID 35577511, PMID 35790423, PMID 37254449, PMID 37396808, PMID 38010108, PMID 39287519, PMID 39457678, PMID 40067754, PMID 40067755, PMID 40067821, PMID 41366786, PMID 42016922, PMID 10540002, PMID 10826123, PMID 11015796, PMID 11050032
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