612 completed, 389 unknown, 193 recruiting, 97 not yet recruiting. 380 Not applicable, 231 Phase 2, 144 Phase 3, 119 Phase 1, 104 Phase 4.
Follow Liver Cirrhosis: new trials by email Literature Review of Liver Cirrhosis trials Research Report on Liver Cirrhosis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Fiber-Optic Navigation During TIPS Creation: A Prospective Pilot Study Fiber-Optic Navigation System - Liver Cirrhosis, Refractory Ascites | Not applicable | Not yet recruiting | Medical University Innsbruck | 30 | 2027-01-01 | 2026-03-13 |
| Pomegranate Dietary Supplements in AUD and ALD Pomegranate Dietary Ssupplement - Alcohol Use Disorder, Alcohol-associated Liver Disease | Not yet recruiting | University of Louisville | 144 | 2027-01-01 | 2026-07-24 | |
| Inflammatory and Neuroimmune Guided Investigation of Underlying Fatigue in Patients With Cirrhosis Cirrhosis Alcoholic, Fatigue Symptom | Not yet recruiting | King's College London | 50 | 2027-01-01 | 2026-10-27 | |
| Within-Session Repeatability of EUS-Guided Portal Pressure Gradient Measurement Repeated EUS-Guided Portal Pressure Gradient Measurement - Portal Hypertension, Chronic Liver Disease | Not yet recruiting | University Hospital Muenster | 150 | 2027-01-01 | 2026-10-26 | |
| Erlotinib for Hepatocellular Carcinoma Chemoprevention erlotinib hydrochloride, Placebo - Cirrhosis, Liver, Advanced Liver Fibrosis | Phase 2 | Not yet recruiting | University of Texas Southwestern Medical Center | 60 | 2026-12-01 | 2026-06-24 |
| Trial to Evaluate ALN-CIDEB in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) ALN-CIDEB, Placebo - Metabolic Dysfunction-Associated Steatotic Liver Disease, MASLD | Phase 3 | Not yet recruiting | Regeneron Pharmaceuticals | 1500 | 2026-11-06 | 2026-10-02 |
| Different Treatment Frequencies for Hepatic Fibrosis Due to Schistosomiasis Praziquantel 40 mg/kg per dose given once annually, Praziquantel 40 mg/kg given three times per year - Schistosomiasis, Schistosoma Mansoni | Phase 2 / Phase 3 | Not yet recruiting | Rhode Island Hospital | 600 | 2026-11-01 | 2026-08-12 |
| Nemolizumab for the Treatment of Moderate to Severe Chronic Hepatic Pruritus Nemolizumab-ilto - Chronic Hepatic Pruritus, Cholestatic Liver Disease | Phase 2 | Not yet recruiting | Mayo Clinic | 15 | 2026-11-01 | 2026-09-28 |
| Predicting Response and Exposure Changes in Cirrhosis for Effectiveness Five-Drug CYP Probe Cocktail - Liver Cirrhosis | Not applicable | Not yet recruiting | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 45 | 2026-11-01 | 2026-08-11 |
| Lifestyle, Dietary Patterns, and Cardiometabolic Risk in Metabolic Dysfunction-Associated Steatotic Liver Disease Among People Living With HIV Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), HIV Infections | Not yet recruiting | Assiut University | 250 | 2026-11-01 | 2026-10-06 | |
| J-LINX: Japan LINerixibat eXtension Study Linerixibat - Pruritus | Phase 3 | Not yet recruiting | GlaxoSmithKline | 40 | 2026-10-09 | 2026-10-06 |
| Endohepatology-Based Reclassification of Treatment Indication in High-Risk MASLD Non-invasive MASLD and portal hypertension assessment, Single-session endohepatology assessment - Metabolic Dysfunction-Associated Steatotic Liver Disease, Metabolic Dysfunction-Associated Steatohepatitis | Recruiting | University Hospital Muenster | 500 | 2026-10-05 | 2026-10-20 | |
| The Correlation Between hs CRP TG Triglycerides Glucose Index in NAFLD and Liver Fibrosis • Fasting triglycerides (TG) • Fasting plasma glucose • High-sensitivity C-reactive protein (hs-CRP) • Liver enzymes (ALT, AST, GGT) • Platelet count • HbA1c • Lipid profile (total cholesterol, HDL-C, - Liver Fibrosis | Not yet recruiting | Assiut University | 96 | 2026-10-02 | 2026-04-07 | |
| Wearable Patch Ultrasound Probe for Diagnosis of Liver Stiffness Wearable Patch-Type Ultrasound Probe, Transient Elastography (FibroScan) - Liver Fibrosis, Liver Cirrhosis | Not yet recruiting | Second Affiliated Hospital of Xi'an Jiaotong University | 150 | 2026-10-01 | 2026-07-21 | |
| A Novel Extracorporeal Liver Support Therapy In ALCF and to Evaluate the Efficacy of DIALIVE 2.0, a Liver Dialysis Device. Standard of Care (Investigator Choice), DIALIVE 2.0 liver dialysis Device plus available Standard of Care - Acute-on-Chronic Liver Failure (ACLF), Liver Cirrhosis | Not applicable | Recruiting | Yaqrit Ltd | 72 | 2026-10-01 | 2026-09-22 |
| Impact of Overt and Subclinical Hypothyroidism on Liver Fibrosis in Patients With MASLD Metabolic Dysfunction-Associated Steatotic Liver Disease, Non-Alcoholic Fatty Liver Disease | Not yet recruiting | Assiut University | 120 | 2026-10-01 | 2026-09-18 | |
| Electronic PHES vs Paper-based PHES for Hepatic Encephalopathy Paper-based Psychometric Hepatic Encephalopathy Score (PHES), Electronic Psychometric Hepatic Encephalopathy Score (PHES) - Liver Cirrhosis, Hepatic Encephalopathy | Not applicable | Not yet recruiting | The First Affiliated Hospital with Nanjing Medical University | 80 | 2026-10-01 | 2026-10-01 |
| A Prospective Cohort Study on the Epidemiological Investigation, Diagnosis, and Treatment of Hepatic Encephalopathy wechat mini-program - Hepatic Encephalopathy, Minimal Hepatic Encephalopathy | Not yet recruiting | The First Affiliated Hospital with Nanjing Medical University | 700 | 2026-10-01 | 2026-10-01 | |
| Proximal Splenic Artery Embolization (PSAE) for the Treatment of Refractory Ascites in Decompensated Cirrhosis Proximal Splenic Artery Embolization - Ascites, Liver Cirrhosis | Not applicable | Not yet recruiting | Massachusetts General Hospital | 60 | 2026-10-01 | 2026-08-10 |
| Equivalence of Electronic vs Paper-based PHES in Diagnosing Hepatic Encephalopathy Paper-based PHES, Electronic PHES - Liver Cirrhosis, Hepatic Encephalopathy (HE) | Not applicable | Not yet recruiting | The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School | 80 | 2026-10-01 | 2026-10-14 |
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Liver Cirrhosis, Biliary (212) · Fibrosis (184) · Non-alcoholic Fatty Liver Disease (138) · Hypertension, Portal (122) · Carcinoma, Hepatocellular (101) · Liver Diseases (98) · Fatty Liver (75) · Hepatic Encephalopathy (59) · Hepatitis C (55) · Ascites (54) · Hepatitis B (46) · Liver Cirrhosis, Alcoholic (44) · Esophageal and Gastric Varices (36) · Liver Neoplasms (35)
Pathological Conditions, Signs and Symptoms (1506) · Pathologic Processes (1503) · Digestive System Diseases (1495) · Liver Diseases (1408) · Fibrosis (1322) · Biliary Tract Diseases (219) · Bile Duct Diseases (218) · Cholestasis, Intrahepatic (212) · Cholestasis (199) · Infections (167) · Nutritional and Metabolic Diseases (167) · Hepatitis (158) · Virus Diseases (144) · Blood-Borne Infections (136)
Ursodeoxycholic Acid (28) · Rifaximin (21) · Portasystemic Shunt, Transjugular Intrahepatic (19) · Albumins (17) · Standard of Care (16) · Blood Specimen Collection (14) · Carvedilol (14) · obeticholic acid (13) · Fenofibrate (12) · Propranolol (12) · Ribavirin (12) · Terlipressin (11) · entecavir (11) · Lactulose (10) · Probiotics (10)
Institute of Liver and Biliary Sciences, India (51) · Assiut University (32) · Assistance Publique - Hôpitaux de Paris (22) · Beijing Friendship Hospital (17) · Post Graduate Institute of Medical Education and Research, Chandigarh (17) · Air Force Military Medical University, China (16) · Gilead Sciences (15) · Seoul National University Hospital (15) · Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran (13) · University of Aarhus (13) · Xijing Hospital of Digestive Diseases (13) · West China Hospital (12) · AstraZeneca (11) · Intercept Pharmaceuticals (11) · Mayo Clinic (11)
United States (317) · China (258) · France (128) · Germany (113) · United Kingdom (111) · Spain (106) · Italy (102) · India (85) · Canada (83) · South Korea (74) · Belgium (60) · Egypt (52) · Denmark (50) · Mexico (41) · Netherlands (39)
Guo-Qing Jiang, MD (8) · Kiminori Kimura, MD (5) · Li Yang, MD (5) · Shiyao Chen, Professor (5) · Guohong Han, PhD & MD (4) · Hong You, Doctor (4) · Ming-Chih Hou, MD (4) · Xiaolong Qi, M.D. (4) · Aldo Torre Delgadillo, M.D. M.Sc (3)
PMID 37467180, PMID 25543678, PMID 33460002, PMID 21836029, PMID 16020491, PMID 16306522, PMID 16799972, PMID 19208350, PMID 25638527, PMID 26644276, PMID 27786365, PMID 28249726, PMID 28506905, PMID 29990488, PMID 30180806, PMID 31342529, PMID 31394282, PMID 32860184, PMID 33307033, PMID 33657443, PMID 34843068, PMID 35120736, PMID 36750244, PMID 37396307, PMID 37953500, PMID 37973887, PMID 38780109, PMID 39373164, PMID 40439725, PMID 40751304, PMID 41680079, PMID 42438428, PMID 10051462, PMID 10075602, PMID 10102814, PMID 10343210, PMID 10343514, PMID 10347106, PMID 10643630, PMID 10655252, PMID 10922085, PMID 10922086, PMID 10934332, PMID 11095334, PMID 1109749, PMID 11267312, PMID 11343232, PMID 11588440, PMID 11851836, PMID 11876689
2019 (7), 2016 (6), 2023 (6), 2014 (3), 2017 (3), 2018 (3), 2005 (2), 2009 (2), 2015 (2), R01AG006244 (2), U24DK130164 (2), 2008 (1), 5UL1TR002373-04 (1), I01CX002436 (1), I50HX002903 (1)