165 completed, 28 unknown, 11 recruiting, 8 terminated. 85 Not applicable, 48 Phase 3, 44 Phase 2, 32 Phase 4, 19 Phase 1.
Follow Calcium: new trials by email Literature Review of Calcium trials Research Report on Calcium
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Sequential Treatment With Romosozumab Followed by Denosumab vs. Zoledronic Acid for Gains in HIP BMD Romosozumab, Zoledronic Acid 5 MG in 5 ML Injection, Calcium 500 mg and Vitamin D3 800 IU - Osteoporosis in Post-menopausal Women | Phase 4 | Not yet recruiting | Sahlgrenska University Hospital | 216 | 2027-01-11 | 2026-08-19 |
| The Effectiveness of a Weight-dependent Algorithm for Dosing Vitamin D. Vitamin D3, Calcium, and Vitamin C - Hypovitaminosis D | Not applicable | Not yet recruiting | Atlantic Health System | 200 | 2027-01-01 | 2026-10-20 |
| EFFICACY OF BIOMIN FLUORIDE VERSUS SODIUM FLUORIDE VARNISHES, WITH AND WITHOUT DIODE LASER ON WHITE SPOT LESIONS REMINERALIZATION IN PRIMARY TEETH. BioMin® fluoride varnish: 5% NaF varnish incorporating bioactive glass (calcium/phosphate releasing)., (BioMin® + Diode Laser), (Duraphat varnish + Diode laser) - White Spot Lesions [Initial Caries] on Smooth Surface of Tooth | Not applicable | Recruiting | Yassmin Mohamed | 80 | 2026-10-01 | 2026-09-30 |
| Bone Management in Pregnancy Outcomes in Epilepsy Supplementation with calcium + vitamin D daily. - Epilepsy, Pregnant Woman | Not applicable | Recruiting | The Fourth Affiliated Hospital of Zhejiang University School of Medicine | 80 | 2026-06-01 | 2026-06-16 |
| Pediatric Safety Follow-up Study of Prior Treatment With Romosozumab for Osteogenesis Imperfecta Vitamin D, Calcium - Osteogenesis Imperfecta | Phase 3 | Recruiting | Amgen | 71 | 2026-03-18 | 2026-06-22 |
| Improved Treatment and Monitoring of Alzheimer's Disease Semaglutide (Rybelsus®) combined with other interventions, Placebo, Semaglutide (Rybelsus®) - Alzheimer Disease (AD) | Phase 2 | Not yet recruiting | Rune Skovgaard Rasmussen | 180 | 2026-01-01 | 2025-08-22 |
| Effects of Total Thyroid Removal on Parathyroid Function and Quality of Life high-dose calcium (400 mg x 4), vitamin D (19 mikg x 4), and active vitamin D supplementation (2 mikg x 2), Ommit routine blood test post operative day 1 - Hypoparathyroidism Post-surgical, Quality of Life | Not applicable | Enrolling by invitation | Aarhus University Hospital | 150 | 2026-01-01 | 2026-02-02 |
| Impact of Pilates Exercises on Bone Mineral Density in Breast Cancer Survivors Receiving Hormonal Therapy Pilates Exercises, Calcium and Vitamin D Supplementation - Breast Cancer, Breast Cancer Survivors | Not applicable | Completed | Benha University | 60 | 2026-01-01 | 2026-07-24 |
| Calcium Replacement Therapy in Postoperative Hypoparathyroidism Calcium carbonate 1250 mg (500 mg elemental calcium) twice a day, Calcium carbonate 1250 mg (500 mg elemental calcium) 4 times a day - Post-Thyroidectomy Hypoparathyroidism Treatment | Not applicable | Recruiting | Tartu University Hospital | 50 | 2025-11-18 | 2026-05-11 |
| Effect of Tirzepatide and Bimagrumab on Body Composition, Insulin Sensitivity, and Bone in Adults With Obesity Bimagrumab, Tirzepatide, Calcium/Vitamin D - Obesity | Phase 2 | Recruiting | Massachusetts General Hospital | 63 | 2025-11-05 | 2026-03-27 |
| Effect of Enzymatic-Containing Mouth Spray (Oral7®) on Xerostomia Symptoms, Salivary Flow Rate, and Oral Health-Related Quality of Life in Older Patients Oral7® mouth spray contains Natural Enzymes (Lactoperoxidase, Glucose Oxidase, Lactoferrin, Lysozyme), Calcium, Xylitol, Aloe Vera, Natural peppermint. - Xerostomia, Geriatric | Not applicable | Recruiting | ZAINAB MAT YUDIN | 100 | 2025-09-18 | 2026-05-22 |
| Effect of Extracellular Calcium on Carbetocin Mediated Contractility in Human Myometrium Oxytocin, Carbetocin, Calcium - Postpartum Hemorrhage (Primary) | Not applicable | Recruiting | Samuel Lunenfeld Research Institute, Mount Sinai Hospital | 40 | 2025-09-15 | 2025-09-24 |
| Efficacy and Safety of Low-dose Calcium Supplementation in Pregnancy Calcium - Pregnancy | Phase 4 | Completed | First People's Hospital of Hangzhou | 117 | 2025-09-10 | 2026-08-25 |
| NIMA-Colon Cancer Study Standard hypercaloric-hyperproteic nutritional supplementation, HMB-enriched hypercaloric-hyperproteic nutritional supplementation with vitamin D and calcium, Supervised exercise program - Colon Cancer | Not applicable | Recruiting | Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud | 120 | 2025-07-01 | 2026-04-16 |
| Ionized Calcium Changes for Predicting Postoperative Hypocalcemia After Total Thyroidectomy Calcium - Postoperative Hypocalcemia, Postoperative Hypoparathyroidism | Completed | Emrecan Deniz | 327 | 2025-06-12 | 2026-07-14 | |
| Calcium Administration in Life-saving Management During Massive Hemorrhage calcium gluconate, Control: Placebo - Massive Hemorrhage, Trauma | Phase 2 / Phase 3 | Not yet recruiting | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 81 | 2025-05-01 | 2025-02-11 |
| Effects of Vitamin D and Calcium on Hyperglycemia and Dyslipidemia in Patients Gestational Diabetes vitamin D3 - Diabetes Mellitus, Gestational | Not applicable | Completed | Riphah International University | 60 | 2025-01-28 | 2026-03-17 |
| PRESS -PAR: Early Detection and PREvention of Symptomatic postSurgical hypoPARathyroidism After Thyroid Surgery" Active vitamin D, Calcium - Postoperative Hypoparathyroidism, Postsurgical Hypoparathyroidism | Not applicable | Recruiting | Nicolas Schlegel | 336 | 2025-01-08 | 2026-03-24 |
| Empiric Calcium in Massive Transfusion Calcium Gluconate - Hemorrhage, Trauma | Phase 3 | Withdrawn | University of California, Irvine | 2025-01-01 | 2026-03-30 | |
| Therapeutic Effects of Oat-based Cereal on Fetomaternal Outcomes Among Hypocalcemic Antenatal Women Oat-Based porridge, Calcium & Vitamin D3 supplementation - Hypocalcemia, Pregnancy Complications Affecting Fetus (Diagnosis) | Not applicable | Completed | University of Lahore Hospital (ULH) | 192 | 2024-08-01 | 2026-08-12 |
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Osteoporosis (53) · Bone Diseases, Metabolic (28) · Vitamin D Deficiency (20) · Breast Neoplasms (11) · Osteoporosis, Postmenopausal (11) · Hypocalcemia (7) · Obesity (6) · Fractures, Bone (5) · Pre-Eclampsia (5) · Colorectal Neoplasms (4) · Hypertension (4) · Osteoporotic Fractures (4) · Weight Loss (4) · Cardiovascular Diseases (3) · Fractures, Stress (3)
Novartis Pharmaceuticals (5) · Cairo University (4) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (4) · Amgen (3) · Creighton University (3) · Eli Lilly and Company (3) · Massachusetts General Hospital (3) · Mayo Clinic (3) · Northumbria University (3) · Seoul National University Hospital (3) · Susan L. Greenspan (3) · Benha University (2) · Chinese University of Hong Kong (2) · Copenhagen University Hospital, Rigshospitalet (2) · Donaghue Medical Research Foundation (2)
United States (82) · Germany (17) · Canada (15) · Denmark (14) · Egypt (12) · France (10) · United Kingdom (10) · China (9) · Spain (9) · Greece (7) · Italy (6) · Japan (6) · Mexico (6) · South Korea (6) · Belgium (5)
Susan L Greenspan, MD (4) · Erin Gaffney-Stomberg, Ph.D., R.D. (2) · John Aloia, MD (2) · Lee M Kaplan, MD, PhD (2) · Mageda Mikhail, MD (2) · Adem Az, M.D. (1) · Adetunji T Toriola, M.D., Ph.D. (1) · Adetunji T Toriola, M.D., Ph.D., MPH (1) · Ailsa L Hart, BA(Hons), BM BCh, MRCP, PhD (1) · Amie Hiller, MD BS (1)
PMID 10511362, PMID 11395985, PMID 14988471, PMID 15093843, PMID 1539892, PMID 16467232, PMID 16467233, PMID 16467234, PMID 16481635, PMID 16481636, PMID 16580279, PMID 16609086, PMID 16880313, PMID 16946216, PMID 17146025, PMID 17277040, PMID 17341712, PMID 17405972, PMID 17431740, PMID 17502530, PMID 17556697, PMID 17582069, PMID 17911175, PMID 17925539, PMID 18235052, PMID 18299491, PMID 18319414, PMID 18359949, PMID 18489937, PMID 18501061, PMID 18502208, PMID 18663162, PMID 18821668, PMID 18822620, PMID 19001202, PMID 19005970, PMID 19117033, PMID 19193613, PMID 19204221, PMID 19221190, PMID 19244376, PMID 19258546, PMID 19402886, PMID 19403636, PMID 19423530, PMID 19474140, PMID 19767090, PMID 19822825, PMID 19861511, PMID 19861516
2017 (2), 2008 (1), 2009 (1), 2015 (1), 2016 (1), 2023 (1), K23MH085005 (1), P30CA015083 (1), R01AG028086 (1), R01AG029364 (1), R01AG050302 (1), R01AG052123 (1), R01AG066825 (1), R01AR040736 (1), R01AR056651 (1)