8 completed, 2 terminated. 10 Phase 2, 2 Phase 1, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 10 | Completed 8, Terminated 2 |
| Phase 1 | 2 | Completed 2 |
| Phase 3 | 2 | Completed 2 |
Follow Muscle Cramp: new trials by email Literature Review of Muscle Cramp trials Research Report on Muscle Cramp
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| TJ-68 Clinical Trial in Patients With Amyotrophic Lateral Sclerosis (ALS) and Muscle Cramps TJ-68, Placebo - Amyotrophic Lateral Sclerosis, Muscle Cramp | Phase 1 / Phase 2 | Completed | Hiroshi Mitsumoto | 11 | 2022-09-30 | 2025-05-01 |
| Effect of 'Cramp Bites' on Period Cramps in Women Aged 18-25 Cramp Bites by Aunt Flo's Kitchen - Dysmenorrhea Primary, Dysmenorrhea | Phase 2 / Phase 3 | Completed | Cornell University | 12 | 2022-07-21 | 2024-04-12 |
| Tolperisone in Acute Muscle Spasm of the Back Tolperisone, Placebo - Back Pain, Acute Pain | Phase 2 | Completed | Neurana Pharmaceuticals, Inc. | 415 | 2019-02-01 | 2022-02-01 |
| PET Imaging of Phosphodiesterase-4 (PDE4) in Brain and Peripheral Organs of McCune-Albright Syndrome Brain PET Imaging with 11C Rolipram, Whole Body PET Baseline with 11C Rolipram, Whole Body PET Blocked with Roflumilast - Nervous System Disease | Phase 1 / Phase 2 | Completed | National Institute of Mental Health (NIMH) | 16 | 2018-04-04 | 2020-10-19 |
| A Study to Assess the Safety and Effectiveness of FLX-787 in Subjects With Charcot-Marie-Tooth Disease Experiencing Muscle Cramps. FLX-787-ODT (orally disintegrating tablet), Placebo ODT - Charcot-Marie-Tooth Disease | Phase 2 | Terminated | Flex Pharma, Inc. | 27 | 2017-10-16 | 2018-08-29 |
| A Study to Assess FLX-787 in Subjects With Motor Neuron Disease Experiencing Muscle Cramps. FLX-787-ODT (orally disintegrating tablet), Placebo ODT - Motor Neuron Disease | Phase 2 | Terminated | Flex Pharma, Inc. | 54 | 2017-07-28 | 2018-08-29 |
| Botulinum Toxin for Cramps in Diabetic Neuropathy Botulinum toxin type A, Normal saline - Muscle Cramps Aggravated, Diabetes Mellitus | Phase 2 | Completed | Presidio Ospedaliero Garibaldi-Centro | 50 | 2014-09-27 | 2017-08-03 |
| Safety and Efficacy of Baclofen for Treatment of Muscle Spasms in Patients With Cirrhosis: A Pilot Study Baclofen - Muscle Cramps, Cirrhosis | Phase 2 | Completed | University of Virginia | 10 | 2012-10-01 | 2015-02-05 |
| Clinical Trial of CoQ10 for Mild-to-Moderate Statin-Associated Muscle Symptoms Coenzyme Q10, Placebo - Pain, Weakness | Phase 2 / Phase 3 | Completed | Catherine Buettner | 68 | 2009-12-01 | 2017-01-23 |
| Levetiracetam for Cramps, Spasticity and Neuroprotection in Motor Neuron Disease Levetiracetam - Motor Neuron Disease, Amyotrophic Lateral Sclerosis | Phase 2 | Completed | Duke University | 20 | 2006-05-01 | 2013-06-19 |
Amyotrophic Lateral Sclerosis (3) · Nervous System Diseases (3) · Spasm (3) · Motor Neuron Disease (2) · Muscular Atrophy, Spinal (2) · Neurodegenerative Diseases (2) · Neuromuscular Diseases (2) · Acute Pain (1) · Asthenia (1) · Back Pain (1) · Charcot-Marie-Tooth Disease (1) · Diabetes Mellitus (1) · Diabetic Neuropathies (1) · Dysmenorrhea (1)
Muscular Diseases (10) · Musculoskeletal Diseases (10) · Neurologic Manifestations (10) · Neuromuscular Manifestations (10) · Pathological Conditions, Signs and Symptoms (10) · Signs and Symptoms (10) · Nervous System Diseases (7) · Metabolic Diseases (4) · Neuromuscular Diseases (4) · Nutritional and Metabolic Diseases (4) · Pathologic Processes (4) · Central Nervous System Diseases (3) · Proteostasis Deficiencies (3) · Spinal Cord Diseases (3) · TDP-43 Proteinopathies (3)
BID protein, human (1) · Baclofen (1) · Botulinum Toxins, Type A (1) · Levetiracetam (1) · Roflumilast (1) · Saline Solution (1) · Tolperisone (1) · coenzyme Q10 (1) · shakuyaku-kanzoh-toh (1)
Flex Pharma, Inc. (2) · Catherine Buettner (1) · Cornell University (1) · Duke University (1) · Hiroshi Mitsumoto (1) · National Institute of Mental Health (NIMH) (1) · Neurana Pharmaceuticals, Inc. (1) · Presidio Ospedaliero Garibaldi-Centro (1) · University of Virginia (1)
United States (8)
Bjorn Oskarsson, MD (1) · Catherine Buettner, MD, MPH (1) · Hiroshi Mistumoto, MD, Dsc. (1) · Nicolas Johnson, MD (1) · Richard S Bedlack, MD, PhD (1) · Robert B Innis, M.D. (1) · Zachary Henry, M.D. (1)
K23AR055664 (1)