150 completed, 30 unknown, 12 terminated, 7 recruiting. 67 Not applicable, 57 Phase 2, 57 Phase 3, 24 Phase 1, 21 Phase 4.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Vitamin E Add-On Therapy, Thyroid Function & Oxidative Stress in Levothyroxine-Treated Hypothyroidism vitamin E, placebo - Hypothyroidism | Not applicable | Enrolling by invitation | Bangladesh Medical University | 74 | 2027-02-01 | 2026-08-25 |
| Vitamin E Versus Silymarin in Non Diabetic MASLD Patients Vitamin E 800 IU/d, Silymarin 420 mg, Placebo - Metabolic Dysfunction-Associated Steatoic Liver Disease | Phase 3 | Not yet recruiting | Kafrelsheikh University | 120 | 2026-10-16 | 2026-10-13 |
| A Study of Chiglitazar in Patients With Metabolic Dysfunction-associated Steatohepatitis and Type 2 Diabetes Mellitus Chiglitazar Placebo, Chiglitazar, vitamin E - MASH - Metabolic Dysfunction-Associated Steatohepatitis, T2DM (Type 2 Diabetes Mellitus) | Phase 2 | Recruiting | Shanghai Jiao Tong University School of Medicine | 300 | 2026-01-01 | 2026-06-03 |
| A Study to See Whether Taking a Mix of Vitamins Can Help Adults Recover Better After Surgery for Carpal Tunnel Syndrome Alpha-Lipoic Acid, Vitamin E, and Vitamin B Complex, Combination Vitamin B1,B6,B12 - Carpal Tunnel Syndrome | Not applicable | Recruiting | Hospital Universiti Sains Malaysia | 84 | 2025-12-08 | 2026-04-23 |
| RESOLving INflammation Through Diet for Health (RESOLVIN) Fish Oil, Camelina oil, Vitamin E - Cardiovascular (CV) Risk, Inflammation | Not applicable | Recruiting | Mario Negri Institute for Pharmacological Research | 324 | 2025-11-26 | 2026-10-09 |
| Comparative Study of Combination Treatment of Bionerv E+ Versus Vitamin B Complex in Treatment of Diabetic Polyneuropathy in Type 2 Diabetic Patients and Its Effect on Wound Healing Alpha-Lipoic Acid, Vitamin B1, Vitamin B6, Vitamin B12, Vitamin E, Vitamin B1, Vitamin B6, Vitamin B12 - Diabetic Foot Ulcer (DFU), Diabetic Symmetrical Polyneuropathy | Not applicable | Recruiting | BREGO Life Sciences | 100 | 2025-07-22 | 2026-10-16 |
| Vitamin E Plus Mefenamic Acid Versus Mefenamic Acid Alone for Treating Primary Dysmenorrhea in Women Mefenamic acid, Vitamin E capsule - Dysmenorrhea Primary, Vitamin E | Phase 4 | Completed | Nishtar Medical University | 60 | 2025-07-15 | 2026-03-12 |
| HMG Treatment Reduces Sperm DNA Fragmentation Human Menopausal Gonadotropin (hMG), Vitamin E - Sperm DNA Fragmentation | Phase 1 | Completed | Jinling Hospital, China | 114 | 2025-07-02 | 2026-10-14 |
| The Effect of Vitamin E Supplementation on Hospital Stay Duration in Non-cyanotic Heart Disease Children With Lower Respiratory Tract Infections Vitamin E - Respiratory Disease | Phase 4 | Not yet recruiting | Assiut University | 260 | 2025-06-01 | 2025-04-15 |
| Fibrosis-Modulating Effects of Metformin and Pirfenidone in Oral Submucous Fibrosis Metformin Hydrochloride 500Mg Tablet, Pirfenidone (PFD), Beclomaethasone and Vitamin E - Oral Submucous Fibrosis | Phase 1 / Phase 2 | Completed | Ziauddin University | 45 | 2025-04-07 | 2026-02-03 |
| Systemic Therapy of Open-label Prophylactic Pravastatin or Pentoxifylline/Tocopherol Prevention of Lymphedema Advancing to Eventual Fibrosis: an Interventional Registry-embedded Bayesian Randomized Trial for Radiation Sequelae (STOP4-LATE-FIBROSE) Pravastatin, Pentoxifylline, Tocopherol - Lymphedema, Fibrosis | Phase 2 | Recruiting | M.D. Anderson Cancer Center | 295 | 2025-02-13 | 2026-09-11 |
| Effect of Increasing Total Antioxidant Capacity in Autism Spectrum Disorder Placebo, Vitamin E and C - Autism Spectrum Disorder | Not applicable | Unknown | Rinvil Renaldi | 50 | 2024-09-28 | 2024-10-04 |
| Comparing the Effects of Aerobic & Resistance Exercises and Vitamins D & E on Oxidative Stress & Inflammatory Markers Among Patients with Depression Aerobic Exercises + Vitamin E, Resistance Exercises + Vitamin E, Aerobic Exercises + Vitamin D - Depression Disorders | Not applicable | Enrolling by invitation | Ziauddin University | 116 | 2024-09-02 | 2025-01-15 |
| The Effects of Topical Almond Oil and Tretinoin on Facial Wrinkles Topical Product: Almond Oil, Topical Product: Almond oil augmented with 0.5% Vitamin E, Topical Product: 0.025% Tretinoin oil augmented with castor oil - Collagen Degeneration, Wrinkle | Not applicable | Unknown | Integrative Skin Science and Research | 90 | 2024-07-22 | 2024-08-28 |
| Non-surgical Treatment of Chronic Periodontitis With an Adjunctive Vitamin E and Coenzyme Q10 Supplementation Receive 30 mg of Coq10 - Periodontal Diseases | Not applicable | Enrolling by invitation | Islamic Azad University, Sanandaj | 120 | 2024-03-20 | 2024-11-20 |
| Clinical Effects of New Approach on Patients With Non-alcoholic Steatohepatitis Rosuvastatin 20mg - Non-alcoholic Steatohepatitis | Early Phase 1 | Completed | Beni-Suef University | 175 | 2023-12-17 | 2025-02-06 |
| Effect of Eurycoma Longifolia (DLBS5055) and Multivitamins (Vitamin C+Vitamin E+ β-carotene) for Infertile Males DLBS5055 200mg, Placebo DLBS5055, Multivitamin (Vitamin C 500mg + Vitamin E 100IU + Beta Carotene 10000IU) - Male Infertility | Phase 4 | Active not recruiting | Duta Wacana Christian University | 90 | 2023-11-11 | 2025-03-27 |
| The Effect of "KB-120" Small Molecular Nutrient in Women With Decreased Ovarian Reserve "KB-120" small molecular nutrient and vitamin E, Vitamin E - Diminished Ovarian Reserve | Not applicable | Unknown | Women's Hospital School Of Medicine Zhejiang University | 80 | 2023-10-15 | 2023-10-23 |
| Comparison of Effectiveness of Obeticholic Acid With Vitamin E in Patients of Non-alcoholic Fatty Liver Disease Obeticholic Acid 10 MG, Vitamin E 400mg - Non Alcoholic Fatty Liver Disease | Phase 2 | Completed | King Edward Medical University | 90 | 2023-08-24 | 2025-08-05 |
| Ketotifen in Non-Alcoholic Fatty Liver Disease Patients Ketotifen, Vitamin E - Hepatic Disease | Phase 4 | Completed | Tanta University | 60 | 2023-05-20 | 2026-02-06 |
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Non-alcoholic Fatty Liver Disease (23) · Fatty Liver (13) · Cardiovascular Diseases (11) · Diabetes Mellitus, Type 2 (11) · Diabetes Mellitus (10) · Prostatic Neoplasms (9) · Alzheimer Disease (6) · Heart Diseases (6) · Breast Neoplasms (5) · Colorectal Neoplasms (5) · Kidney Failure, Chronic (5) · Obesity (5) · Asthma (4) · Coronary Artery Disease (4) · Depression (4)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (7) · University of North Carolina, Chapel Hill (6) · Ain Shams University (5) · National Eye Institute (NEI) (5) · Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh (4) · Tanta University (4) · Augusta University (3) · Brigham and Women's Hospital (3) · M.D. Anderson Cancer Center (3) · National Heart, Lung, and Blood Institute (NHLBI) (3) · Physicians Committee for Responsible Medicine (3) · SWOG Cancer Research Network (3) · University Health Network, Toronto (3) · Vanderbilt University (3) · Alliance for Clinical Trials in Oncology (2)
United States (85) · Canada (14) · Egypt (14) · Pakistan (9) · China (8) · Iran (8) · Italy (8) · Spain (7) · Bangladesh (6) · India (4) · Malaysia (4) · United Kingdom (4) · Brazil (3) · France (3) · Indonesia (3)
Neil Fleshner (3) · Alp Ikizler, MD (2) · David B. Peden, MD, MS (2) · Jonathan Himmelfarb, MD (2) · Linda E Sousse, PhD, MBA (2) · Neal D Barnard (2) · Susan Goodin, PharmD, FCCP, BCOP (2) · Abbot R. Laptook, MD (1) · Abhik Das, PhD (1) · Abraham Morgentaler, MD (1) · Adolfo D. Rodriguez-Carrizalez, M.Sc. (1) · Aisha Wali, BDS, MPH (1)
PMID 27519183, PMID 37916745, PMID 39981557, PMID 19237716, PMID 22338037, PMID 34039021, PMID 40434633, PMID 10488881, PMID 10916520, PMID 10924859, PMID 14605526, PMID 14732621, PMID 15480814, PMID 15542159, PMID 15557412, PMID 15724034, PMID 16221223, PMID 16864722, PMID 16953900, PMID 17161253, PMID 17210817, PMID 17310025, PMID 17332146, PMID 17592099, PMID 17698683, PMID 17701157, PMID 17704543, PMID 17938390, PMID 17998490, PMID 18043905, PMID 18339679, PMID 18405673, PMID 18455517, PMID 18460663, PMID 18514203, PMID 18598891, PMID 18599520, PMID 18687132, PMID 18687721, PMID 18786751, PMID 18804555, PMID 18835953, PMID 18975365, PMID 18984888, PMID 18993042, PMID 18997197, PMID 19064521, PMID 19066368, PMID 19066370, PMID 19116389
U10CA037429 (3), P01AT002620 (2), P30CA072720 (2), R01AG016381 (2), R01ES023349 (2), 2009 (1), 2018 (1), K23HL080030 (1), M01RR000069 (1), N01HV68165 (1), N01HV68166 (1), N01HV68167 (1), N01HV68168 (1), N01HV68169 (1), N01HV68170 (1)