538 completed. 538 Phase 2, 82 Phase 1, 73 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 538 | Completed 538 |
| Phase 1 | 82 | Completed 82 |
| Phase 3 | 73 | Completed 73 |
Follow Mouth Diseases: new trials by email Literature Review of Mouth Diseases trials Research Report on Mouth Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Antimicrobial Photodynamic Therapy With ICG-Loaded Nanoparticles for Periodontitis Management Non- surgical periodontal therapy followed by photodynamic therapy with ICG-loaded nanoparticles, Non- surgical periodontal therapy followed by photodynamic therapy with ICG-loaded macroparticles, Non- surgical periodontal therapy only - Stage III Periodontitis | Phase 2 | Completed | Nada Mahmoud Soliman | 27 | 2026-06-01 | 2026-10-21 |
| Injectable Platelet-Rich Fibrin (i-PRF) and Oxygen-Releasing Gel in the Treatment of Stage II Periodontitis. Injectable Platelet-Rich Fibrin (i-PRF, Peroxoborate Oxygen-Releasing Oral Gel, Sterile 0.9% Saline Solution - Stage III Periodontitis | Phase 1 / Phase 2 | Completed | Assiut University | 24 | 2026-01-20 | 2026-10-05 |
| Fibrosis-Modulating Effects of Metformin and Pirfenidone in Oral Submucous Fibrosis Metformin Hydrochloride 500Mg Tablet, Pirfenidone (PFD), Beclomaethasone and Vitamin E - Oral Submucous Fibrosis | Phase 1 / Phase 2 | Completed | Ziauddin University | 45 | 2025-04-07 | 2026-02-03 |
| Effect of Arginine- and Glutamine-based Oral Formulations on Salivary Biomarkers and Clinical Severity of Radiation-induced Oral Mucositis in Head and Neck Cancer: A Randomized Controlled Trial L-arginine Oral Suspension, L-glutamine Oral Suspension, Maltodextrin Oral Suspension (Control) - Radiation Induced Oral Mucositis, Oral Mucositis | Phase 2 | Completed | Ain Shams University | 84 | 2025-04-01 | 2026-01-30 |
| Assessing Gingivitis of 3 Different Dentifrices Compared to a Negative Control. Stannous Fluoride Dentifrice, Sodium Fluoride Dentifrice, Sodium monofluorophosphate dentifrice - Gingivitis | Phase 2 | Completed | Procter and Gamble | 120 | 2025-03-25 | 2026-05-04 |
| The Effect Of Using Sticky Bone With Coronally Advanced Flap In Management Of Type 1 Gingival Recession sticky bone with coronally advanced flap, coronally advanced flap - Gingival Recession, Localized | Phase 2 | Completed | Minia University | 30 | 2025-03-01 | 2026-06-30 |
| The Impact of Ginger Mouthwash on the Pregnant Women With Stress and Gingivitis ginger mouthwash, chlorohexidine mouthwash, Placebo - Mouth Diseases, Bleeding Gum | Phase 2 | Completed | Al-Mustansiriyah University | 45 | 2025-01-25 | 2025-07-14 |
| Dusquetide for the Treatment of Behcet's Disease Dusquetide - Behçet Disease | Phase 2 | Completed | Soligenix | 8 | 2024-11-18 | 2026-08-26 |
| Efficacy of Locally Delivered Rosemary Extract Gel in Management of Periodontitis Herbal therapy, Placebo Drug - Periodontitis (Stage 3), Periodontal Pocket | Phase 2 | Completed | Ain Shams University | 48 | 2024-10-20 | 2026-04-13 |
| Efficacy, Safety, and Tolerability of SR750 in Patients With Trigeminal Neuralgia SR750 tablet, Placebo - Trigeminal Neuralgia | Phase 2 | Completed | Shanghai SIMR Biotechnology Co., Ltd. | 138 | 2024-09-16 | 2026-04-24 |
| Effects of the Adjunctive Use of Hyaluronic Acid-based Gel With Coranally Advanced Flap in the Gingival Recession Hyaluronic acid, Steril saline solution - Gingival Recession | Phase 1 / Phase 2 | Completed | Ordu University | 20 | 2024-09-01 | 2026-02-27 |
| Efficacy and Safety of Acyclovir-penciclovir Cream Versus an Abreva in the Suppression of Herpes Simplex Virus Eruptions acyclovir-penciclovir cream, Abreva - Herpes Simplex Oral | Phase 2 | Completed | University of Utah | 58 | 2024-08-19 | 2026-10-27 |
| Metformin Repurposing in Oral Submucous Fibrosis: Unveiling In Vitro Signaling Pathways, Progressing to Clinical Trial Metformin Hydrochloride, betamethasone dipropionate, Pentoxifylline - Oral Submucous Fibrosis | Phase 1 / Phase 2 | Completed | Ziauddin University | 30 | 2024-08-12 | 2025-05-02 |
| Clinical Investigation to Assess the Efficacy of Manual Toothbrushes in the Reduction of Plaque and Gingivitis. Test regimen, Control regimen - Plaque, Dental, Gingivitis | Phase 2 | Completed | Colgate Palmolive | 84 | 2024-07-26 | 2026-03-18 |
| Comparing the Effect of Different Intracanal Dressing on Failed Root Canal Treated Cases on Periapical Healing nanocurcumin gel, Curcumin Gel, Ciprofloxacin 500 mg +ibuprofen 400mg - Periapical Disease | Phase 2 | Completed | Ain Shams University | 60 | 2024-06-20 | 2025-11-17 |
| Ustekinumab for Intestinal Behçet's Syndrome With Myelodysplastic Syndrome Ustekinumab 90 mg - Behcet's Syndrome, Intestinal Type, Myelodysplastic Syndrome | Phase 2 | Completed | Liu Tian | 8 | 2024-03-24 | 2026-05-13 |
| The Use of Botulinum Toxin in the Management of Myofascial Pain Syndrome intramuscular Botulinum Toxin - Myofacial Pain Syndrome | Phase 1 / Phase 2 | Completed | Yassir R. Al-khannaq | 14 | 2024-03-12 | 2025-02-13 |
| A Lithium-containing Mouthwash Prevention and Treatment of Oral Mucositis and Dysgeusia in Patients Undergoing Radiotherapy lithium-containing mouthwash （Phase I）, Plcacebo mouthwash （Phase II）, lithium-containing mouthwash（Phase II） - Head and Neck Squamous Cell Carcinoma, Malignant Head and Neck Tumors | Phase 1 / Phase 2 | Completed | West China Hospital | 175 | 2024-03-01 | 2026-08-13 |
| Upadacitinib for Refractory Behcet's Syndrome Upadacitinib 15 MG - Behcet Syndrome | Phase 2 | Completed | Liu Tian | 27 | 2024-01-25 | 2025-12-02 |
| Nucleo CMP and Neurorubine Versus Carbamazepine for Classical Trigeminal Neuralgia Conventional Carbamazepine Therapy, Nucleo CMP and Neurorubine Combination - Trigeminal Neuralgia, Neuropathic Pain | Phase 2 | Completed | Karbala University | 38 | 2024-01-07 | 2025-12-26 |
Showing 20 of 538. Sign in to see all of them.
Head and Neck Neoplasms (77) · Salivary Gland Neoplasms (62) · Squamous Cell Carcinoma of Head and Neck (59) · Chronic Periodontitis (51) · Mouth Neoplasms (48) · Stomatitis (47) · Periodontitis (45) · Mucositis (40) · Sjogren's Syndrome (37) · Tongue Neoplasms (33) · Gingivitis (32) · Oropharyngeal Neoplasms (25) · Xerostomia (24) · Lichen Planus, Oral (21) · Periodontal Diseases (20)
Stomatognathic Diseases (538) · Periodontal Diseases (164) · Neoplasms (150) · Neoplasms by Site (150) · Salivary Gland Diseases (129) · Pathological Conditions, Signs and Symptoms (108) · Skin and Connective Tissue Diseases (95) · Pathologic Processes (82) · Neoplasms by Histologic Type (77) · Mouth Neoplasms (73) · Infections (71) · Head and Neck Neoplasms (69) · Neoplasms, Glandular and Epithelial (69) · Carcinoma (66)
Cisplatin (23) · Cetuximab (17) · Radiotherapy (13) · Tooth Exfoliation (13) · Metronidazole (11) · Root Planing (11) · Chlorhexidine (10) · Radiotherapy, Intensity-Modulated (9) · Metformin (8) · Amoxicillin (6) · Aspirin (6) · Celecoxib (6) · Doxycycline (6) · Drug Therapy (6) · Paclitaxel (6)
Government Dental College and Research Institute, Bangalore (29) · National Cancer Institute (NCI) (28) · GlaxoSmithKline (8) · National Institute of Dental and Craniofacial Research (NIDCR) (8) · Novartis Pharmaceuticals (8) · Ain Shams University (5) · Colgate Palmolive (5) · Dana-Farber Cancer Institute (5) · Islamic Azad University, Sanandaj (5) · M.D. Anderson Cancer Center (5) · Mashhad University of Medical Sciences (5) · Qazvin University Of Medical Sciences (5) · Alexandria University (4) · Fox Chase Cancer Center (4) · Isfahan University of Medical Sciences (4)
United States (206) · Canada (34) · Egypt (33) · India (33) · France (29) · Iran (23) · Brazil (19) · Germany (19) · China (17) · Italy (17) · United Kingdom (17) · Spain (14) · Israel (12) · Netherlands (12) · Turkey (Türkiye) (11)
Avani R Pradeep, MDS (3) · A R Pradeep, MDS (2) · Athanassios Argiris, MD (2) · Bahar Sadeghi, MD (2) · Bruno CV Gurgel, Doctor (2) · Chen-ping Zhang, MD, PhD (2) · Christopher Hull, MD (2) · Christopher M Hull, M.D. (2) · Corey J. Langer, MD (2) · Cristina Rodriguez (2) · Dilip Khambete, MDS (2)
PMID 33197289, PMID 12897619, PMID 18573992, PMID 25057165, PMID 35142535, PMID 12019707, PMID 12963779, PMID 14520092, PMID 15016256, PMID 15068108, PMID 15361396, PMID 15459950, PMID 15529389, PMID 15659505, PMID 15911160, PMID 16094218, PMID 16470745, PMID 16822220, PMID 16849759, PMID 16922026, PMID 17545536, PMID 18381950, PMID 18413833, PMID 18484593, PMID 18546285, PMID 18596969, PMID 18819792, PMID 18973181, PMID 19143902, PMID 19525472, PMID 19597921, PMID 19634157, PMID 19634161, PMID 19717547, PMID 19733615, PMID 19854713, PMID 19885903, PMID 19924794, PMID 20131246, PMID 20376235, PMID 20439512, PMID 20447554, PMID 20539208, PMID 20704622, PMID 20855800, PMID 20926833, PMID 21175873, PMID 21178655, PMID 21238793, PMID 21284052
P30CA006516 (5), 2015 (4), P30CA006927 (3), P30CA016672 (3), U10CA021115 (3), 2016 (2), 2019 (2), N01CM00071 (2), N01CM62201 (2), N01CM62202 (2), N01CM62203 (2), N01CM62206 (2), P30CA014599 (2), U10CA031946 (2), U10CA180868 (2)