539 completed, 151 unknown, 77 recruiting, 73 terminated. 958 Phase 2, 166 Phase 1, 119 Phase 3.
Follow Mouth Diseases: new trials by email Literature Review of Mouth Diseases trials Research Report on Mouth Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| 9-ING-41 Plus Carboplatin in Patients With Advanced, Metastatic Salivary Gland Carcinoma 9-ING-41, Carboplatin - Salivary Gland Carcinoma, Adenoid Cystic Carcinoma | Phase 2 | Withdrawn | Actuate Therapeutics Inc. | 2030-12-18 | 2022-02-22 | |
| Safety and Efficacy of Topical Infliximab in Autoimmune Dry Eye Disease Infliximab 0.1%, Loteprednol - Sjogren Syndrome, Sjogren Syndrome With Keratoconjunctivitis | Phase 2 | Not yet recruiting | Instituto de Oftalmología Fundación Conde de Valenciana | 38 | 2026-12-01 | 2026-06-26 |
| Exosome and Mesenchymal Stem Cell Treatment for Salivary Gland Dysfunction in Primary Sjögren Syndrome exosomes derived from human umbilical cord mesenchymal stem cells, Mesenchymal Stem Cells (MSC), Placebo - Sjogren Syndrome, Xerostomia | Phase 2 | Not yet recruiting | Banu Erkal | 30 | 2026-12-01 | 2026-09-24 |
| Efficacy of Thymus Vulgaris Mouthwash in the Management of Biofilm-Induced Gingivitis Thymus vulgaris mouthwash, Chlorhexidine 0,12%, Placebo mouthwash - Plaque-Induced Gingivitis | Phase 2 | Not yet recruiting | University of Sulaimani | 60 | 2026-12-01 | 2026-10-29 |
| Docetaxel and SX-682 in Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma, Salivary Gland Carcinoma, and Advanced Prostate Cancer SX-682, DTX - Head and Neck Cancer, Head and Neck Squamous Cell Carcinoma | Phase 1 / Phase 2 | Recruiting | National Cancer Institute (NCI) | 120 | 2026-11-04 | 2026-10-30 |
| A Novel Proline-rich Peptide Hydrogel for Periodontal Regeneration in Adult Periodontitis Patients Hydrogel - Periodontal Disease, Intrabony Periodontal Defects | Phase 1 / Phase 2 | Not yet recruiting | Siddharth Shanbhag | 40 | 2026-11-01 | 2026-05-14 |
| Safety and Efficacy of Universal CAR-T Cells (UWD-CD19) Combined With Immunosuppressants in the Treatment of Refractory Autoimmune Diseases anti-CD19 CAR-T cells - Systemic Lupus Erthematosus, Systemic Sclerosis (SSc) | Phase 1 / Phase 2 | Not yet recruiting | Peking University Third Hospital | 9 | 2026-11-01 | 2026-09-23 |
| A Study of IBI355 in Participants With Moderate-to-Severe Sjögren's Disease Part A - Placebo for IBI355, Part B -Telitacicept, PartB -Placebo for Telitacicept - Sjögren's Disease | Phase 2 | Not yet recruiting | Innovent Biologics (Suzhou) Co. Ltd. | 198 | 2026-10-15 | 2026-09-23 |
| Effect of Gingival Mesenchymal Stem Cell-Derived Small Extracellular Vesicles in Management of Infra-bony Periodontal Defect Gingival mesenchymal stem cell derived small extracellular vesicles, β-calcium triphosphate (β-TCP) + collagen membrane - Infra-bony Periodontal Defect | Phase 2 | Not yet recruiting | Ain Shams University | 22 | 2026-10-01 | 2026-10-15 |
| Abiraterone With Dalpiciclib in Salivary Gland Carcinoma abiraterone combined with dalpiciclib - Salivary Gland Carcinoma | Phase 2 | Recruiting | Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University | 36 | 2026-10-01 | 2026-09-11 |
| The Effect of Dexamethasone on Short Term Patient Response: IV vs Oral Administration Dexamethasone IV injection, Dexamethasone Capsule, Placebo IV administration - Post Operative Pain, Acute, Periodontitis | Phase 1 / Phase 2 | Not yet recruiting | The University of Texas Health Science Center at San Antonio | 40 | 2026-10-01 | 2026-09-21 |
| ONO-4915 in Patients With Primary Sjogren's Disease ONO-4915, Placebo - Sjogren's Disease | Phase 2 | Not yet recruiting | Ono Pharmaceutical Co., Ltd. | 60 | 2026-10-01 | 2026-09-16 |
| Ficerafusp Alfa, Pembrolizumab, and Stereotactic Body Radiotherapy (SBRT) for Head and Neck Squamous Cell Carcinoma (HNSCC) Hypofractionated Stereotactic Body Radiotherapy (SBRT), Pembrolizumab, Ficerafusp alfa - Head and Neck Squamous Cell Carcinoma, HPV-Negative Squamous Cell Carcinoma | Phase 1 / Phase 2 | Not yet recruiting | Washington University School of Medicine | 45 | 2026-09-30 | 2026-08-13 |
| Minimally Invasive Non-Surgical Periodontal Therapy Alone vs. Minimally Invasive Non-Surgical Periodontal Therapy With I-PRF With or Without Chlorhexidine on Stage III Periodontitis Patients Minimally Invasive Nonsurgical Therapy, Injectable Platelet-Rich Fibrin, Chlorhexidine 2% - Bony Defects, Periodontal Disease | Phase 1 / Phase 2 | Not yet recruiting | Cairo University | 63 | 2026-09-30 | 2026-08-27 |
| RP-008 in Combination With Daily Oral Varenicline for the Treatment of Trigeminal Neuralgia RP-008, Varenicline tartrate - Trigeminal Neuralgia | Phase 1 / Phase 2 | Recruiting | Kriya Therapeutics, Inc. | 24 | 2026-09-10 | 2026-10-23 |
| Low-cost Screening and Image-guided Photodynamic Therapy (PDT) of Premalignant and Malignant Oral Lesions 5-Amino Levulinic Acid - Oral Cancer, Oral Cavity Cancer | Phase 2 | Not yet recruiting | University of Massachusetts, Boston | 65 | 2026-09-01 | 2026-03-19 |
| Surgical Treatment for Gingival Recessions After Orthodontic Treatment Coronally advanced flap and a de-epithelialized soft tissue graft, Coronally advanced flap and a subepithelial connective tissue graft, Coronally advanced flap and Mucoderm soft tissue collagen graft - Gingival Recessions, Generalized | Phase 2 / Phase 3 | Recruiting | Aziz Aliyev Azerbaijan State Advanced Training Institute for Doctors | 75 | 2026-09-01 | 2026-08-13 |
| Corticotropin for Behçet's Disease: A Multicenter Randomized Controlled TrialAcronym. Repository Corticotropin Injection (ACTH), Study-matched inactive placebo injection, also called control injection - Behçet's Syndrome, Behçet's Syndrome (BS) | Phase 2 | Not yet recruiting | Peking University People's Hospital | 60 | 2026-09-01 | 2026-09-22 |
| A Phase 2a/b Study to Assess the Efficacy, Safety and Tolerability of DDY391 in Participants With Sjögren's Disease DDY391, Placebo - Sjögren's Disease | Phase 2 | Recruiting | Novartis Pharmaceuticals | 344 | 2026-08-24 | 2026-10-28 |
| Photobiomodulation Alone Versus Photobiomodulation Combined With Topical Oral Oxygen Therapy for Radiotherapy-Induced Oral Mucositis in Head and Neck Cancer Patients: A Randomized Clinical Trial sirolase xtent laser, blue m gel - Mucositis Oral, Head & Neck Cancer | Phase 1 / Phase 2 | Enrolling by invitation | Assiut University | 46 | 2026-08-15 | 2026-10-08 |
Showing 20 of 958. Sign in to see all of them.
Head and Neck Neoplasms (129) · Salivary Gland Neoplasms (113) · Squamous Cell Carcinoma of Head and Neck (112) · Mouth Neoplasms (111) · Stomatitis (94) · Sjogren's Syndrome (77) · Mucositis (74) · Periodontitis (71) · Chronic Periodontitis (61) · Oropharyngeal Neoplasms (53) · Xerostomia (47) · Gingivitis (46) · Tongue Neoplasms (46) · Laryngeal Neoplasms (45) · Hypopharyngeal Neoplasms (37)
Stomatognathic Diseases (955) · Neoplasms by Site (307) · Neoplasms (306) · Periodontal Diseases (239) · Salivary Gland Diseases (239) · Skin and Connective Tissue Diseases (192) · Pathological Conditions, Signs and Symptoms (181) · Head and Neck Neoplasms (168) · Neoplasms by Histologic Type (168) · Neoplasms, Glandular and Epithelial (156) · Carcinoma (141) · Mouth Neoplasms (134) · Pathologic Processes (129) · Skin Diseases (122)
Cisplatin (51) · Radiotherapy (26) · Cetuximab (22) · Carboplatin (19) · Tooth Exfoliation (18) · Docetaxel (17) · Radiotherapy, Intensity-Modulated (17) · pembrolizumab (17) · Magnetic Resonance Spectroscopy (15) · Root Planing (15) · Specimen Handling (15) · Paclitaxel (14) · Chlorhexidine (12) · Metronidazole (12) · Radiation (12)
National Cancer Institute (NCI) (42) · Government Dental College and Research Institute, Bangalore (29) · Cairo University (17) · National Institute of Dental and Craniofacial Research (NIDCR) (12) · Novartis Pharmaceuticals (12) · Ain Shams University (11) · Dana-Farber Cancer Institute (8) · GlaxoSmithKline (8) · M.D. Anderson Cancer Center (8) · Peking Union Medical College Hospital (8) · Mashhad University of Medical Sciences (7) · SVS Institute of Dental Sciences (7) · University of Washington (7) · Alexandria University (6) · Assistance Publique - Hôpitaux de Paris (6)
United States (351) · China (69) · Egypt (62) · Canada (55) · India (47) · France (46) · Germany (36) · Brazil (33) · Italy (32) · Spain (30) · United Kingdom (30) · Iran (29) · Taiwan (22) · Israel (20) · Poland (20)
Athanassios Argiris, MD (3) · Avani R Pradeep, MDS (3) · Bruno CV Gurgel, Doctor (3) · Emile Youssef, MD, PhD (3) · Michael McGuire, DDS (3) · Parthasarathy Madurantakam, DDS, PhD (3) · A R Pradeep, MDS (2) · Alan Ho, MD, PhD (2) · Alan L Ho (2) · Anurag Singh (2)
PMID 33197289, PMID 34503735, PMID 39532605, PMID 39584361, PMID 12897619, PMID 18573992, PMID 18973181, PMID 25057165, PMID 31838007, PMID 35142535, PMID 35435039, PMID 40086048, PMID 40341199, PMID 11013273, PMID 11240232, PMID 12019707, PMID 12692611, PMID 12963779, PMID 13411920, PMID 14520092, PMID 15016256, PMID 15057287, PMID 15064010, PMID 15068108, PMID 15108222, PMID 15110092, PMID 15159012, PMID 15287078, PMID 15361396, PMID 15459950, PMID 15529389, PMID 15602019, PMID 15659505, PMID 15911160, PMID 16004814, PMID 16094218, PMID 16332231, PMID 16415901, PMID 16470745, PMID 16616780, PMID 16760642, PMID 16822220, PMID 16849759, PMID 16884839, PMID 16922026, PMID 16950583, PMID 17507164, PMID 17545536, PMID 17986340, PMID 18155609
2015 (6), P30CA006516 (6), U10CA180868 (5), 2016 (4), P30CA016672 (4), 2019 (3), 2023 (3), P30CA006927 (3), P30CA023074 (3), U10CA021115 (3), U10CA032102 (3), U10CA180820 (3), U10CA180888 (3), 2018 (2), 2025 (2)