543 completed, 140 unknown, 102 recruiting, 47 terminated. 249 Not applicable, 244 Phase 2, 140 Phase 1, 99 Phase 3, 49 Phase 4.
Follow Salivary Gland Diseases: new trials by email Literature Review of Salivary Gland Diseases trials Research Report on Salivary Gland Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| 9-ING-41 Plus Carboplatin in Patients With Advanced, Metastatic Salivary Gland Carcinoma 9-ING-41, Carboplatin - Salivary Gland Carcinoma, Adenoid Cystic Carcinoma | Phase 2 | Withdrawn | Actuate Therapeutics Inc. | 2030-12-18 | 2022-02-22 | |
| Penn SICCA Follow-up Study Dry Eye, Sjogren's Syndrome | Not yet recruiting | University of Pennsylvania | 220 | 2027-01-01 | 2026-03-02 | |
| Continued Access to Deucravacitinib for Adult SLE/SjD and Pediatric PsO/PsA Study Completers Deucravacitinib - Systemic Lupus Erythematosus, Sjögren's Disease | Phase 3 | Not yet recruiting | Bristol-Myers Squibb | 2300 | 2026-12-31 | 2026-09-03 |
| Safety and Efficacy of Topical Infliximab in Autoimmune Dry Eye Disease Infliximab 0.1%, Loteprednol - Sjogren Syndrome, Sjogren Syndrome With Keratoconjunctivitis | Phase 2 | Not yet recruiting | Instituto de Oftalmología Fundación Conde de Valenciana | 38 | 2026-12-01 | 2026-06-26 |
| Exosome and Mesenchymal Stem Cell Treatment for Salivary Gland Dysfunction in Primary Sjögren Syndrome exosomes derived from human umbilical cord mesenchymal stem cells, Mesenchymal Stem Cells (MSC), Placebo - Sjogren Syndrome, Xerostomia | Phase 2 | Not yet recruiting | Banu Erkal | 30 | 2026-12-01 | 2026-09-24 |
| Safety and Efficacy of Universal CAR-T Cells (UWD-CD19) Combined With Immunosuppressants in the Treatment of Refractory Autoimmune Diseases anti-CD19 CAR-T cells - Systemic Lupus Erthematosus, Systemic Sclerosis (SSc) | Phase 1 / Phase 2 | Not yet recruiting | Peking University Third Hospital | 9 | 2026-11-01 | 2026-09-23 |
| R-2487 in Patients With Sjogren's Syndrome (SS) R-2487 - Sjogren's Syndrome, Sjögren | Phase 1 | Not yet recruiting | Rise Therapeutics LLC | 36 | 2026-11-01 | 2026-09-28 |
| A Study of BMS-986553 in Participants With Refractory Autoimmune Diseases BMS-986553 - Systemic Lupus Erythematosus, Sjögren's Disease | Phase 1 | Not yet recruiting | Bristol-Myers Squibb | 60 | 2026-10-30 | 2026-10-14 |
| Docetaxel and SX-682 in Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma, Salivary Gland Carcinoma, and Advanced Prostate Cancer SX-682, DTX - Head and Neck Cancer, Head and Neck Squamous Cell Carcinoma | Phase 1 / Phase 2 | Recruiting | National Cancer Institute (NCI) | 120 | 2026-10-27 | 2026-10-22 |
| Pain Phenotyping of Rheumatic Diseases - An Observational Study Bedside quantitative sensory testing - Rheumatic Diseases, Lupus Erythematosus, Systemic | Not yet recruiting | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) | 225 | 2026-10-27 | 2026-10-22 | |
| Effectiveness of an Oral Exercise Program for Xerostomia in Patients With Sjögren Disease Oral exercise - Sjogren Syndrome | Not applicable | Not yet recruiting | Nazli Elif Nacar | 56 | 2026-10-26 | 2026-10-08 |
| Effects of GLP-1 Receptor Agonists on Saliva and Oral Health GLP-1 Receptor Agonists - Type 2 Diabetes, Obesity & Overweight | Not yet recruiting | Kırıkkale University | 50 | 2026-10-16 | 2026-09-14 | |
| A Study of IBI355 in Participants With Moderate-to-Severe Sjögren's Disease Part A - Placebo for IBI355, Part B -Telitacicept, PartB -Placebo for Telitacicept - Sjögren's Disease | Phase 2 | Not yet recruiting | Innovent Biologics (Suzhou) Co. Ltd. | 198 | 2026-10-15 | 2026-09-23 |
| Exploratory Study of the Efficacy of HuMoSCs (Human Monocyte-derived Suppressor Cells) on Glandular Involvement in Sjögren's Syndrome Blood sample, Salivary gland biopsy - Sjogren's Syndrome, Autoimmune Diseases | Not applicable | Not yet recruiting | Centre Hospitalier Universitaire Dijon | 20 | 2026-10-10 | 2026-10-06 |
| Effect of the Dietary Supplement to Alleviate Dry Mouth. Dietary Supplement - Xerostomia | Not applicable | Not yet recruiting | Lacer S.A. | 35 | 2026-10-01 | 2026-09-29 |
| Ocular Surface Changes and Meibomian Gland Dysfunction in Rheumatologic Patients Meibomian Gland Dysfunction, Dry Eye Syndromes | Not yet recruiting | Assiut University | 150 | 2026-10-01 | 2026-09-09 | |
| Abiraterone With Dalpiciclib in Salivary Gland Carcinoma abiraterone combined with dalpiciclib - Salivary Gland Carcinoma | Phase 2 | Recruiting | Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University | 36 | 2026-10-01 | 2026-09-11 |
| ONO-4915 in Patients With Primary Sjogren's Disease ONO-4915, Placebo - Sjogren's Disease | Phase 2 | Not yet recruiting | Ono Pharmaceutical Co., Ltd. | 60 | 2026-10-01 | 2026-09-16 |
| Effects of a 50+ Toothpaste on Halitosis and Oral Comfort in Healthy Adults 50+ Toothpaste, Standard Fluoride Toothpaste - Oral Malodor (Halitosis), Oral Dryness | Not applicable | Not yet recruiting | University of Pavia | 30 | 2026-10-01 | 2026-08-21 |
| A Trial in Healthy Adult Participants and Adults With Autoimmune Disease to Test How HBM7020 is Tolerated and Absorbed in the Body HBM7020 - Rheumatoid Arthritis, Systemic Lupus Erythematosus | Phase 1 | Recruiting | Otsuka Pharmaceutical Development & Commercialization, Inc. | 63 | 2026-09-24 | 2026-10-13 |
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Sjogren's Syndrome (318) · Xerostomia (275) · Salivary Gland Neoplasms (239) · Head and Neck Neoplasms (170) · Squamous Cell Carcinoma of Head and Neck (135) · Mumps (81) · Measles (71) · Rubella (69) · Lupus Erythematosus, Systemic (67) · Dry Eye Syndromes (58) · Sialorrhea (57) · Breast Neoplasms (53) · Carcinoma, Non-Small-Cell Lung (51) · Esthesioneuroblastoma, Olfactory (47) · Arthritis, Rheumatoid (44)
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Cisplatin (24) · measles, mumps, rubella, varicella vaccine (22) · Radiotherapy (20) · Docetaxel (19) · Measles-Mumps-Rubella Vaccine (16) · Carboplatin (13) · Cetuximab (12) · Biopsy (11) · Magnetic Resonance Spectroscopy (11) · Pilocarpine (11) · Blood Specimen Collection (10) · Low-Level Light Therapy (10) · Paclitaxel (10) · pembrolizumab (10) · Acupuncture Therapy (9)
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Barbara Murphy, MD (6) · Ching-Mao Chang, M.D., Ph.D. (6) · Athanassios Argiris, MD (4) · Blake M Warner, D.D.S. (4) · Daniel V Freeland, DO (4) · Aroonwan Lam-ubol, DDS, PhD (3) · Chris Nutting (3)
PMID 28279391, PMID 29784145, PMID 31095438, PMID 32939030, PMID 34503735, PMID 20882668, PMID 21280008, PMID 26631691, PMID 30309472, PMID 31838007, PMID 37612654, PMID 39839752, PMID 40086048, PMID 40341199, PMID 10435146, PMID 10530742, PMID 10775736, PMID 10929962, PMID 11180122, PMID 11208206, PMID 11355268, PMID 11395238, PMID 11491236, PMID 11508435, PMID 12108756, PMID 12533152, PMID 12673463, PMID 12765470, PMID 14697016, PMID 14718694, PMID 15361396, PMID 15368347, PMID 15529389, PMID 15590764, PMID 15659505, PMID 15712851, PMID 15716838, PMID 15990024, PMID 16094218, PMID 16142864, PMID 16424527, PMID 16452343, PMID 16470745, PMID 16567978, PMID 16648432, PMID 16700739, PMID 16759558, PMID 16760642, PMID 16804432, PMID 16980725
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