316 completed, 80 unknown, 29 recruiting, 22 not yet recruiting. 501 Phase 3, 119 Phase 2.
Follow Mouth Diseases: new trials by email Literature Review of Mouth Diseases trials Research Report on Mouth Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Methadone as an Alternative Treatment for Children Underdoing HSCT PCA plus methadone (Experimental), PCA Alone (SOC) - Leukemia, Aplastic Anemia | Phase 3 | Suspended | University of Texas Southwestern Medical Center | 60 | 2028-01-01 | 2025-10-23 |
| Continued Access to Deucravacitinib for Adult SLE/SjD and Pediatric PsO/PsA Study Completers Deucravacitinib - Systemic Lupus Erythematosus, Sjögren's Disease | Phase 3 | Not yet recruiting | Bristol-Myers Squibb | 2300 | 2026-12-31 | 2026-09-03 |
| Effectiveness of Toothpaste Tablets on Plaque, Gingival Health and Caries Experiences Toothpaste Tablet, Conventional Toothpaste - Gingival Inflammation, Dental Caries | Phase 3 | Not yet recruiting | Loma Linda University | 50 | 2026-12-01 | 2026-07-10 |
| Periodontal Disease and Small Vulnerable Newborns in Rural Nepal: A Community-based Trial A package of oral health interventions, including a daily antiseptic oral rinse (alcohol-free cetylpyridinium chloride (0.075%)) - Preterm Birth, Low Birth Weight | Phase 3 | Not yet recruiting | Johns Hopkins Bloomberg School of Public Health | 2280 | 2026-10-01 | 2026-07-09 |
| Neoadjuvant Sintilimab Plus Chemotherapy for cT2N0M0 Oral Squamous Cell Carcinoma Sintilimab, Nab-Paclitaxel, Carboplatin - Oral Squamous Cell Carcinoma (OSCC), Head and Neck Squamous Cell Carcinoma | Phase 3 | Not yet recruiting | caohaotian | 300 | 2026-10-01 | 2026-09-18 |
| Clinical Study Examining the Control of Plaque and Gingivitis Silica Free Meridol, Meridol, Colgate Dental Product - Gingivitis | Phase 3 | Not yet recruiting | Colgate Palmolive | 135 | 2026-10-01 | 2026-09-25 |
| Surgical Treatment for Gingival Recessions After Orthodontic Treatment Coronally advanced flap and a de-epithelialized soft tissue graft, Coronally advanced flap and a subepithelial connective tissue graft, Coronally advanced flap and Mucoderm soft tissue collagen graft - Gingival Recessions, Generalized | Phase 2 / Phase 3 | Recruiting | Aziz Aliyev Azerbaijan State Advanced Training Institute for Doctors | 75 | 2026-09-01 | 2026-08-13 |
| Efficacy of Oral Hygiene Regimens in Patients Undergoing Non-Surgical Periodontal Treatment Active Oral Hygiene Regimen, Placebo Oral Hygiene Regimen - Periodontal Disease, Gingival Inflammation and Bleeding | Phase 3 | Not yet recruiting | Colgate Palmolive | 100 | 2026-09-01 | 2026-09-03 |
| A Study on the Immune Response and Safety of an Investigational Combined Measles, Mumps, Rubella and Varicella Vaccine, When Given to Healthy Children 4 to 6 Years of Age MMRVNS vaccine, MMRV vaccine, DTaP-IPV vaccine - Measles, Mumps | Phase 3 | Not yet recruiting | GlaxoSmithKline | 1860 | 2026-08-11 | 2026-08-03 |
| New In Situ Model Design for Caries and Erosion 0 ppm fluoride toothpaste, 250 ppm fluoride toothpaste (dose-response control), 1150 ppm fluoride toothpaste - Caries, Erosive Tooth Wear | Phase 3 | Active not recruiting | Indiana University | 12 | 2026-08-03 | 2026-09-30 |
| Protective Role of Alpha-Lipoic Acid in Chemotherapy-Induced Mucositis alpha lipoic acid 600 mg twice daily, Placebo Tablet - Colorectal Cancer | Phase 2 / Phase 3 | Recruiting | Ain Shams University | 50 | 2026-07-27 | 2026-07-30 |
| Impact of Minimally Invasive Endodontic Treatment on the Prognosis of Mandibular Permanent Molars With Necrotic Pulp and Apical Periodontitis Root canal treatment - Necrotic Mandibular Molars, Apical Periodontitis | Phase 2 / Phase 3 | Not yet recruiting | Mohamed Ashraf Abdeen | 60 | 2026-07-23 | 2026-08-13 |
| Clinical Evaluation of a Toothpaste for Dental Plaque Reduction and Prevention of Gum Problems 0.45% SnF HW with NaF (1450 F), 67% Bicarbonate with NaF (1400 F), Colgate Cavity Protection Toothpaste - Plaque, Dental Plaque | Phase 3 | Recruiting | Colgate Palmolive | 120 | 2026-07-20 | 2026-09-25 |
| Two Arm, Double-blind, Phase III Study Assessing Efficacy and Safety of Ianalumab Versus Placebo, in Participants With Sjögren's Disease With High Symptom Burden VAY736, Placebo - Sjögren´s Disease | Phase 3 | Recruiting | Novartis Pharmaceuticals | 570 | 2026-07-16 | 2026-10-13 |
| A Clinical Study to Compare BupiZenge With Lidocaine for Pain Due to Oral Mucositis in Patients With Head and Neck Cancer. BupiZenge 25 mg, Lidocaine viscous 2% - Head & Neck Cancer, Oral Mucositis | Phase 3 | Recruiting | OncoZenge AB | 150 | 2026-07-07 | 2026-10-27 |
| APG-157 in Locally Advanced Head and Neck Squamous Cell Carcinoma APG-157, Surgery, Radiation/Chemotherapy - Head and Neck Cancer, Head and Neck (HNSCC) | Phase 3 | Not yet recruiting | Aveta Biomics, Inc. | 826 | 2026-07-01 | 2026-07-01 |
| Topical Phenytoin for Management of Gingival Recession phenytoin cream, Placebo - Gingival Recession | Phase 2 / Phase 3 | Not yet recruiting | Cairo University | 30 | 2026-06-01 | 2026-05-15 |
| Study to Investigate Toothpaste on Antibacterial Effects in the Different Regions of the Mouth stannous fluoride toothpaste, 0.76% Sodium Monofluorophosphate (Na MFP) toothpaste - Plaque, Gingivitis | Phase 3 | Completed | Colgate Palmolive | 95 | 2026-05-18 | 2026-09-24 |
| A Study on the Immune Response and Safety of an Investigational Combined Measles, Mumps, Rubella and Varicella Vaccine, When Administered as Intramuscular Injection to Healthy Children 15 Months to 6 Years of Age MMRVNS, MMRV - Measles, Measles-Mumps-Rubella+Chickenpox Vaccine | Phase 3 | Recruiting | GlaxoSmithKline | 1209 | 2026-05-11 | 2026-07-08 |
| To Assess the Efficacy of Two Brushing Regimens: in the Reduction of Established Dental Plaque and Gingivitis. Colgate SNaP Total 10/10, 1.5 Taurate, Colgate Great Regular Flavor Toothpaste, Flat Trimmed Extra Clean TB - Plaque, Dental, Gingivitis | Phase 3 | Active not recruiting | Colgate Palmolive | 85 | 2026-05-11 | 2026-05-27 |
Showing 20 of 501. Sign in to see all of them.
Gingivitis (51) · Stomatitis (47) · Periodontitis (44) · Head and Neck Neoplasms (42) · Chronic Periodontitis (41) · Mumps (39) · Measles (36) · Periodontal Diseases (36) · Rubella (35) · Mucositis (33) · Mouth Neoplasms (31) · Squamous Cell Carcinoma of Head and Neck (29) · Chickenpox (28) · Sjogren's Syndrome (26) · Oropharyngeal Neoplasms (18)
Stomatognathic Diseases (501) · Periodontal Diseases (166) · Infections (118) · Pathological Conditions, Signs and Symptoms (108) · Salivary Gland Diseases (98) · Neoplasms by Site (83) · Neoplasms (77) · Skin and Connective Tissue Diseases (74) · Pathologic Processes (70) · Gingival Diseases (63) · Virus Diseases (58) · Musculoskeletal Diseases (53) · Skin Diseases (51) · Periodontitis (50)
measles, mumps, rubella, varicella vaccine (18) · Triclosan (13) · Fluorides (12) · Tooth Exfoliation (11) · Radiotherapy (9) · Measles-Mumps-Rubella Vaccine (8) · hydrated silica gel-based toothpaste (8) · Chlorhexidine (7) · Fibroblast Growth Factor 7 (7) · Metronidazole (7) · Root Planing (7) · Amoxicillin (6) · Botulinum Toxins, Type A (6) · Chickenpox Vaccine (6) · Cisplatin (6)
Colgate Palmolive (35) · Government Dental College and Research Institute, Bangalore (24) · Cairo University (16) · GlaxoSmithKline (15) · Merck Sharp & Dohme LLC (14) · Amgen (9) · Dr. D. Y. Patil Dental College & Hospital (7) · Novartis Pharmaceuticals (7) · Ain Shams University (6) · Assistance Publique - Hôpitaux de Paris (6) · National Cancer Institute (NCI) (6) · Al-Azhar University (5) · Islamic Azad University, Sanandaj (5) · University of Baghdad (5) · Dow University of Health Sciences (4)
United States (126) · France (47) · India (41) · Brazil (40) · Egypt (38) · China (37) · Germany (30) · Italy (30) · Spain (29) · Canada (28) · United Kingdom (21) · Taiwan (17) · South Korea (16) · Israel (14) · Mexico (14)
Magda Feres, Professor (3) · Cassiano K Rosing, PhD (2) · Chikara Ieda (2) · Chris Nutting (2) · Deyu Hu, DDS, MS (2) · Giampietro Farronato, Professor (2) · Gianguido Cossellu, Fellow (2) · Gregory Seymour, BDS (2)
PMID 12897619, PMID 18573992, PMID 23959319, PMID 10423050, PMID 10477976, PMID 11002408, PMID 12419687, PMID 12533152, PMID 12839405, PMID 14718694, PMID 15016256, PMID 15161841, PMID 15287367, PMID 15316186, PMID 15602019, PMID 15621359, PMID 16161031, PMID 16225582, PMID 16391299, PMID 16415901, PMID 16452343, PMID 16567978, PMID 16804432, PMID 16862549, PMID 17079762, PMID 17181736, PMID 17293228, PMID 17502347, PMID 17580258, PMID 17668979, PMID 17716312, PMID 17716313, PMID 18413833, PMID 18454655, PMID 18596969, PMID 18611924, PMID 18672990, PMID 18696746, PMID 18754720, PMID 19125084, PMID 19142042, PMID 19175713, PMID 19273678, PMID 19295226, PMID 19332518, PMID 19366435, PMID 19563331, PMID 19596158, PMID 19610028, PMID 19711612
2023 (4), 2025 (4), U10CA180820 (3), U10CA180868 (3), 2008 (2), 2016 (2), 2018 (2), 2009 (1), 2014 (1), 2017 (1), 4UH3DE031129-02 (1), K23NS050485 (1), P01CA106451 (1), P30CA008748 (1), P30CA016042 (1)