144 completed, 54 recruiting, 49 unknown, 25 not yet recruiting. 77 Phase 2, 62 Not applicable, 43 Phase 1, 26 Phase 3, 17 Phase 4.
Follow Sjogren's Syndrome: new trials by email Literature Review of Sjogren's Syndrome trials Research Report on Sjogren's Syndrome
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Penn SICCA Follow-up Study Dry Eye, Sjogren's Syndrome | Not yet recruiting | University of Pennsylvania | 220 | 2027-01-01 | 2026-03-02 | |
| Continued Access to Deucravacitinib for Adult SLE/SjD and Pediatric PsO/PsA Study Completers Deucravacitinib - Systemic Lupus Erythematosus, Sjögren's Disease | Phase 3 | Not yet recruiting | Bristol-Myers Squibb | 2300 | 2026-12-31 | 2026-09-03 |
| Safety and Efficacy of Topical Infliximab in Autoimmune Dry Eye Disease Infliximab 0.1%, Loteprednol - Sjogren Syndrome, Sjogren Syndrome With Keratoconjunctivitis | Phase 2 | Not yet recruiting | Instituto de Oftalmología Fundación Conde de Valenciana | 38 | 2026-12-01 | 2026-06-26 |
| Exosome and Mesenchymal Stem Cell Treatment for Salivary Gland Dysfunction in Primary Sjögren Syndrome exosomes derived from human umbilical cord mesenchymal stem cells, Mesenchymal Stem Cells (MSC), Placebo - Sjogren Syndrome, Xerostomia | Phase 2 | Not yet recruiting | Banu Erkal | 30 | 2026-12-01 | 2026-09-24 |
| Safety and Efficacy of Universal CAR-T Cells (UWD-CD19) Combined With Immunosuppressants in the Treatment of Refractory Autoimmune Diseases anti-CD19 CAR-T cells - Systemic Lupus Erthematosus, Systemic Sclerosis (SSc) | Phase 1 / Phase 2 | Not yet recruiting | Peking University Third Hospital | 9 | 2026-11-01 | 2026-09-23 |
| R-2487 in Patients With Sjogren's Syndrome (SS) R-2487 - Sjogren's Syndrome, Sjögren | Phase 1 | Not yet recruiting | Rise Therapeutics LLC | 36 | 2026-11-01 | 2026-09-28 |
| A Study of BMS-986553 in Participants With Refractory Autoimmune Diseases BMS-986553 - Systemic Lupus Erythematosus, Sjögren's Disease | Phase 1 | Not yet recruiting | Bristol-Myers Squibb | 60 | 2026-10-30 | 2026-10-14 |
| Pain Phenotyping of Rheumatic Diseases - An Observational Study Bedside quantitative sensory testing - Rheumatic Diseases, Lupus Erythematosus, Systemic | Not yet recruiting | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) | 225 | 2026-10-27 | 2026-10-22 | |
| Effectiveness of an Oral Exercise Program for Xerostomia in Patients With Sjögren Disease Oral exercise - Sjogren Syndrome | Not applicable | Not yet recruiting | Nazli Elif Nacar | 56 | 2026-10-26 | 2026-10-08 |
| A Study of IBI355 in Participants With Moderate-to-Severe Sjögren's Disease Part A - Placebo for IBI355, Part B -Telitacicept, PartB -Placebo for Telitacicept - Sjögren's Disease | Phase 2 | Not yet recruiting | Innovent Biologics (Suzhou) Co. Ltd. | 198 | 2026-10-15 | 2026-09-23 |
| Exploratory Study of the Efficacy of HuMoSCs (Human Monocyte-derived Suppressor Cells) on Glandular Involvement in Sjögren's Syndrome Blood sample, Salivary gland biopsy - Sjogren's Syndrome, Autoimmune Diseases | Not applicable | Not yet recruiting | Centre Hospitalier Universitaire Dijon | 20 | 2026-10-10 | 2026-10-06 |
| Ocular Surface Changes and Meibomian Gland Dysfunction in Rheumatologic Patients Meibomian Gland Dysfunction, Dry Eye Syndromes | Not yet recruiting | Assiut University | 150 | 2026-10-01 | 2026-09-09 | |
| ONO-4915 in Patients With Primary Sjogren's Disease ONO-4915, Placebo - Sjogren's Disease | Phase 2 | Not yet recruiting | Ono Pharmaceutical Co., Ltd. | 60 | 2026-10-01 | 2026-09-16 |
| A Trial in Healthy Adult Participants and Adults With Autoimmune Disease to Test How HBM7020 is Tolerated and Absorbed in the Body HBM7020 - Rheumatoid Arthritis, Systemic Lupus Erythematosus | Phase 1 | Recruiting | Otsuka Pharmaceutical Development & Commercialization, Inc. | 63 | 2026-09-24 | 2026-10-13 |
| A Study of ATG-201 in Adult Participants With Autoimmune Diseases ATG-201 - Systemic Lupus Erythematosus, Systemic Sclerosis (SSc) | Phase 1 | Not yet recruiting | Antengene Biologics Limited | 149 | 2026-09-01 | 2026-09-21 |
| CD19/BCMA-Targeted Universal CAR-T Cell Injection for the Treatment of Autoimmune Diseases RD06-05 CAR-T Cell Injection - SLE - Systemic Lupus Erythematosus, Systemic Sclerosis | Early Phase 1 | Not yet recruiting | Nanjing Bioheng Biotech Co., Ltd. | 30 | 2026-09-01 | 2026-07-16 |
| Sjogren's Mini-Pill Oral and Gut Microbiome Study Mini-Pill - Sjogren's Syndrome | Not applicable | Not yet recruiting | Tufts University | 90 | 2026-08-31 | 2026-07-29 |
| A Phase 2a/b Study to Assess the Efficacy, Safety and Tolerability of DDY391 in Participants With Sjögren's Disease DDY391, Placebo - Sjögren's Disease | Phase 2 | Recruiting | Novartis Pharmaceuticals | 344 | 2026-08-24 | 2026-10-13 |
| A Phase 1, First-in-Human Study of CND319 in Healthy Participants and Patients With Rheumatic Diseases CND319 - Healthy Participants Study, Rheumatoid Arthritis | Phase 1 | Recruiting | Candid Therapeutics | 105 | 2026-07-22 | 2026-10-21 |
| Two Arm, Double-blind, Phase III Study Assessing Efficacy and Safety of Ianalumab Versus Placebo, in Participants With Sjögren's Disease With High Symptom Burden VAY736, Placebo - Sjögren´s Disease | Phase 3 | Recruiting | Novartis Pharmaceuticals | 570 | 2026-07-16 | 2026-10-13 |
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Lupus Erythematosus, Systemic (67) · Dry Eye Syndromes (55) · Arthritis, Rheumatoid (44) · Scleroderma, Systemic (44) · Xerostomia (43) · Autoimmune Diseases (38) · Myositis (32) · Scleroderma, Diffuse (20) · Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (19) · Antiphospholipid Syndrome (15) · Arthritis, Psoriatic (14) · Dermatomyositis (13) · Spondylitis, Ankylosing (13) · Fatigue (11)
Skin and Connective Tissue Diseases (318) · Eye Diseases (317) · Immune System Diseases (317) · Mouth Diseases (317) · Musculoskeletal Diseases (317) · Stomatognathic Diseases (317) · Joint Diseases (316) · Lacrimal Apparatus Diseases (314) · Connective Tissue Diseases (313) · Salivary Gland Diseases (313) · Rheumatic Diseases (311) · Arthritis (309) · Autoimmune Diseases (280) · Xerostomia (275) · Arthritis, Rheumatoid (274)
Blood Specimen Collection (9) · ianalumab (7) · Hydroxychloroquine (6) · Rituximab (5) · Tacrolimus (4) · belimumab (4) · Abatacept (3) · Acupuncture Therapy (3) · Cyclosporine (3) · Dehydroepiandrosterone (3) · Sodium Chloride (3) · telitacicept (3) · Acetylcysteine (2) · Dextrans (2) · Exercise (2)
National Institute of Dental and Craniofacial Research (NIDCR) (17) · Novartis Pharmaceuticals (14) · Peking Union Medical College Hospital (8) · Taipei Veterans General Hospital, Taiwan (8) · University of Sao Paulo General Hospital (8) · Amgen (7) · University Hospital, Brest (6) · Assistance Publique - Hôpitaux de Paris (5) · Bristol-Myers Squibb (4) · Kahramanmaras Sutcu Imam University (4) · Pamukkale University (4) · Peking University People's Hospital (4) · University Hospital, Montpellier (4) · University Medical Center Groningen (4) · University of Pennsylvania (4)
United States (107) · France (55) · China (53) · Taiwan (30) · Brazil (25) · Italy (25) · Germany (24) · Turkey (Türkiye) (24) · United Kingdom (24) · Spain (21) · Poland (20) · Canada (18) · Australia (17) · Hungary (17) · Argentina (15)
Ching-Mao Chang, M.D., Ph.D. (6) · Ilias G Alevizos, D.M.D. (3) · Adeline Vanderver, MD (2) · Blake M Warner, D.D.S. (2) · Emilio C Campos, MD (2) · Hen-Hong Chang, M.D., Ph.D. (2) · Jill P. Buyon, MD (2) · Sarfaraz A Hasni, M.D. (2)
PMID 21280008, PMID 30309472, PMID 31095438, PMID 32939030, PMID 39839752, PMID 10929962, PMID 11180122, PMID 11508435, PMID 12765470, PMID 15361396, PMID 15368347, PMID 15529389, PMID 15590764, PMID 16142864, PMID 16648432, PMID 16980725, PMID 16987829, PMID 16996579, PMID 17471524, PMID 17665393, PMID 17986340, PMID 18195175, PMID 19854713, PMID 20131246, PMID 20191499, PMID 20309693, PMID 20360188, PMID 20391423, PMID 20538173, PMID 20610299, PMID 20696016, PMID 21109517, PMID 21540203, PMID 21602492, PMID 21859696, PMID 21969015, PMID 22089462, PMID 22298793, PMID 22626746, PMID 22825366, PMID 22832822, PMID 22908326, PMID 22927248, PMID 22931582, PMID 22949223, PMID 22955120, PMID 22992045, PMID 23123020, PMID 23334994, PMID 23525305
2015 (4), 2018 (4), 2025 (4), 2023 (3), 2016 (2), 2019 (2), R37AI049660 (1), U01NS106845 (1), U54NS115052 (1), UM1CA186688 (1)