Oropharyngeal Neoplasms: Clinical Trials

140 completed, 79 recruiting, 47 active not recruiting, 43 unknown. 138 Phase 2, 92 Not applicable, 56 Phase 1, 35 Phase 3, 5 Phase 4.

By phase and status

Phase	Trials	Status
Phase 2	138	Completed 47, Recruiting 34, Active not recruiting 21, Terminated 14, Unknown 11, Withdrawn 6, Not yet recruiting 5
Not applicable	92	Completed 36, Recruiting 16, Unknown 15, Withdrawn 9, Active not recruiting 8, Terminated 6, Not yet recruiting 2
Phase 1	56	Completed 23, Recruiting 10, Active not recruiting 6, Terminated 5, Unknown 5, Not yet recruiting 4, Withdrawn 3
Phase 3	35	Completed 14, Active not recruiting 8, Recruiting 6, Terminated 4, Unknown 2, Not yet recruiting 1
Phase 4	5	Completed 2, Active not recruiting 1, Recruiting 1, Unknown 1
Early Phase 1	3	Completed 1, Recruiting 1, Terminated 1

Follow Oropharyngeal Neoplasms: new trials by email Literature Review of Oropharyngeal Neoplasms trials Research Report on Oropharyngeal Neoplasms

Trials newest first · largest first

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Proactively Intervening On Early Cranial Nerve Injury As A Delayed Sequela Of Oropharyngeal Cancer: A Randomized Feasibility Clinical Trial For Pro-Habilitation (proNERVE RCT) Prednisone, Ajovy, Manual Therapy - Cranial Nerve Injury, Oropharyngeal Cancer	Phase 1	Not yet recruiting	M.D. Anderson Cancer Center	48	2027-03-01	2026-09-21
Testing the Addition of an Anti-Cancer Drug, Camonsertib, to Radiation Therapy for Recurrent Head and Neck Squamous Cell Carcinoma Biospecimen Collection, Camonsertib, Computed Tomography - Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Recurrent Head and Neck Squamous Cell Carcinoma	Phase 1	Recruiting	National Cancer Institute (NCI)	39	2027-02-13	2026-09-03
Off-line Adaptive Proton Therapy Off-line Adaptive Proton Therapy (o-APT) Workflow Evaluation - Oropharyngeal Carcinoma		Not yet recruiting	University Medical Center Groningen	100	2026-10-01	2026-10-08
Ficerafusp Alfa, Pembrolizumab, and Stereotactic Body Radiotherapy (SBRT) for Head and Neck Squamous Cell Carcinoma (HNSCC) Hypofractionated Stereotactic Body Radiotherapy (SBRT), Pembrolizumab, Ficerafusp alfa - Head and Neck Squamous Cell Carcinoma, HPV-Negative Squamous Cell Carcinoma	Phase 1 / Phase 2	Not yet recruiting	Washington University School of Medicine	45	2026-09-30	2026-08-13
A Study to Evaluate CRB-701 Compared to Investigator's Choice Therapy in Previously Treated Oropharyngeal Squamous Cell Carcinoma CRB-701, capcitabine, Cetuximab (EGFR inhibitor) - Oropharyngeal Carcinoma (OPC)	Phase 3	Recruiting	Corbus Pharmaceuticals Inc.	260	2026-09-29	2026-10-08
Intraoperative Methadone for the Management of Postoperative Pain in Patients With Head and Neck Cancers Electronic Health Record Review, Fentanyl, Laryngoscopy - Head and Neck Carcinoma, Hypopharyngeal Carcinoma	Phase 4	Recruiting	OHSU Knight Cancer Institute	58	2026-09-22	2026-10-05
SPECT-CT Guided ELEctive Contralateral Neck Treatment in Lateralized Oropharyngeal Cancer Lymphatic mapping with SPECT-CT, Bilateral neck radiotherapy, Ipsilateral neck radiotherapy & SPECT-CT guided contralateral neck radiotherapy - Oropharyngeal Squamous Cell Carcinoma, Oropharyngeal Cancers	Not applicable	Not yet recruiting	UNICANCER	128	2026-09-01	2026-07-21
Thermotherapy for Head and Neck Cancer Patients Thermotherapy, Radiotherapy, Concurrent chemoradiation - Head and Neck Cancer, Oropharyngeal Carcinoma	Phase 1	Recruiting	Erasmus Medical Center	30	2026-09-01	2026-09-02
A Single Arm Phase II Trial in p16-positive Oropharynx Cancer of Selective Dose De-escalation of nodAl VolumEs at Minimal Risk and Primary Site Disease (SAVED) Dose de-escalation to contralateral neck., Dose de-escalation to gross disease to contralateral neck, Dose de-escalation to gross disease - Head and Neck Cancer, Head and Neck Squamous Cell Cancer	Phase 2	Not yet recruiting	University of Maryland, Baltimore	132	2026-09-01	2026-08-14
Comparing Radiation Plus Cetuximab to Radiation Plus Chemotherapy in People With Head and Neck Cancer Who Cannot Receive Cisplatin Biospecimen Collection, Carboplatin, Cetuximab - Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8	Phase 3	Recruiting	NRG Oncology	454	2026-07-31	2026-08-17
HPV-associated Oropharyngeal Carcinoma (HPV-OPC) HPV p16, HPV testing - positive results, HPV testing - negative results - Oropharyngeal Carcinoma (OPC)	Not applicable	Recruiting	Masaryk Memorial Cancer Institute	35	2026-05-25	2026-07-22
Testing the Addition of Chemotherapy or Chemo-Immunotherapy to the Usual Surgery for Advanced Head and Neck Cancer Biospecimen Collection, Carboplatin, Cemiplimab - Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8	Phase 2	Recruiting	National Cancer Institute (NCI)	180	2026-04-24	2026-10-26
A Study Evaluating the Contribution of Non-Coplanar Beam Arrangement in Reducing Toxicity in Radiotherapy for Upper Aerodigestive Tract Cancers Coplanar External Beam Radiotherapy, Non-Coplanar External Beam Radiotherapy - Squamous Cell Carcinoma of the Oral Cavity and Oropharynx	Not applicable	Not yet recruiting	Centre Georges Francois Leclerc	70	2026-04-01	2026-02-18
Impact of Postoperative Radiotherapy Versus PD-1 Inhibitor Maintenance on Survival in Resectable Locally Advanced Oral and Oropharyngeal Squamous Cell Carcinoma Observation, Postoperative Radiotherapy, PD-1 Inhibitor Maintenance Therapy - Locally Advanced Oral Squamous Cell Carcinoma, Locally Advanced Oropharyngeal Squamous Cell Carcinoma		Not yet recruiting	Zhujiang Hospital	85	2026-04-01	2026-03-09
Surgery With or Without Neoadjuvant Treatment of SBRT Plus Chemoimmunotherapy in Resectable Locally Advanced Oral and HPV-unrelated Oropharyngeal Squamous Cell Carcinoma Neoadjuvant treatment of SBRT plus chemoimmunotherapy followed by surgery and postoperative radiotherapy or chemoradiotherapy, Surgery and postoperative radiotherapy or chemoradiotherapy - Oral Cancer, Oropharyngeal Cancer	Phase 3	Not yet recruiting	Sun Yat-sen University	184	2026-02-24	2026-02-11
Neoadjuvant Chemotherapy and Programmed Cell Death Protein 1(PD-1) Inhibition for Head and Neck Cancer Treatment De-escalation (NeoScorch HN) Toripalimab + Chemotherapy, Toripalimab, Chemoradiotherapy or radiation - Head and Neck Cancer, Squamous Cell Carcinoma	Phase 2	Recruiting	Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins	75	2026-02-18	2026-04-23
Toripalimab in Combination With Standard Treatment for Human Papillomavirus (HPV) Positive Throat Cancer Toripalimab, Carboplatin, Paclitaxel - Oropharyngeal Cancer	Phase 2	Recruiting	University of Chicago	30	2026-02-01	2026-02-06
Oral Mucositis Management in Patients Receiving Radiation for Head and Neck Cancer: An Evaluation of a Barrier Based Treatment Gelclair Oral Mouth Rinse - Squamous Cell Carcinoma, Oropharyngeal Cancers	Phase 4	Active not recruiting	McMaster University	29	2025-12-15	2026-07-13
Dose Adjusted Chemoradiotherapy in HPV-Associated Oropharynx Cancer of the Elderly Modified dose and fields intensity modulated radiotherapy - Oropharynx Cancer, Frailty	Not applicable	Recruiting	Omar Mahmoud	20	2025-12-15	2026-09-29
Evaluating a Decreased Dose of Radiation Therapy to the Elective Neck for the Treatment of HPV-Related Oropharyngeal Cancer, ENLIGHT Trial Computed Tomography, Nasopharyngeal Laryngoscopy, Positron Emission Tomography - Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8	Phase 2	Recruiting	Northwestern University	100	2025-12-05	2026-07-14

Showing 20 of 372. Sign in to see all of them.

Narrower conditions

Head and Neck Neoplasms (138)  ·  Mouth Neoplasms (137)  ·  Laryngeal Neoplasms (106)  ·  Hypopharyngeal Neoplasms (100)  ·  Squamous Cell Carcinoma of Head and Neck (96)  ·  Nasopharyngeal Neoplasms (50)  ·  Uterine Cervical Neoplasms (34)  ·  Carcinoma (33)  ·  Carcinoma, Squamous Cell (31)  ·  Salivary Gland Neoplasms (26)  ·  Carcinoma, Non-Small-Cell Lung (23)  ·  Esophageal Neoplasms (21)  ·  Lung Neoplasms (21)  ·  Carcinoma, Renal Cell (19)

Broader conditions

Stomatognathic Diseases (371)  ·  Otorhinolaryngologic Neoplasms (370)  ·  Pharyngeal Diseases (370)  ·  Neoplasms by Site (369)  ·  Otorhinolaryngologic Diseases (368)  ·  Pharyngeal Neoplasms (367)  ·  Neoplasms (359)  ·  Head and Neck Neoplasms (234)  ·  Mouth Diseases (149)  ·  Neoplasms by Histologic Type (139)  ·  Neoplasms, Glandular and Epithelial (137)  ·  Respiratory Tract Diseases (118)  ·  Respiratory Tract Neoplasms (111)  ·  Carcinoma (106)  ·  Laryngeal Diseases (105)

Interventions

Cisplatin (58)  ·  Radiotherapy (38)  ·  Radiotherapy, Intensity-Modulated (30)  ·  Magnetic Resonance Spectroscopy (23)  ·  Radiation (21)  ·  Carboplatin (19)  ·  pembrolizumab (18)  ·  Specimen Handling (16)  ·  Cetuximab (15)  ·  1,2-diaminocyclohexaneplatinum II citrate (14)  ·  Platinum (14)  ·  Surveys and Questionnaires (14)  ·  Paclitaxel (13)  ·  Biopsy (11)  ·  Surgical Procedures, Operative (11)

Sponsors

National Cancer Institute (NCI) (28)  ·  M.D. Anderson Cancer Center (27)  ·  Mayo Clinic (11)  ·  Memorial Sloan Kettering Cancer Center (10)  ·  Copenhagen University Hospital, Rigshospitalet (8)  ·  UNC Lineberger Comprehensive Cancer Center (8)  ·  Emory University (6)  ·  Abramson Cancer Center at Penn Medicine (5)  ·  Fudan University (4)  ·  Gustave Roussy, Cancer Campus, Grand Paris (4)  ·  Ohio State University Comprehensive Cancer Center (4)  ·  Roswell Park Cancer Institute (4)  ·  Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (4)  ·  University Health Network, Toronto (4)  ·  University Medical Center Groningen (4)

Countries

United States (234)  ·  France (30)  ·  Canada (25)  ·  China (15)  ·  Germany (13)  ·  United Kingdom (13)  ·  Denmark (12)  ·  Netherlands (8)  ·  Spain (8)  ·  Switzerland (8)  ·  Italy (7)  ·  Taiwan (6)  ·  Belgium (5)  ·  Australia (4)  ·  Czechia (4)

Top investigators

Nancy Lee, MD (3)  ·  Bhishamjit Chera, MD (2)  ·  Charalampos Floudas, M.D. (2)  ·  Chen-ping Zhang, MD, PhD (2)  ·  Christian S Hinrichs, M.D. (2)  ·  Christian S Hinrichs, MD (2)  ·  Colette Shen, MD (2)  ·  Eileen H. Shinn, PHD, MS, BA (2)  ·  Erich Sturgis, MD (2)  ·  Gregory D Zimet, PhD (2)  ·  Jean Bourhis, PhD (2)  ·  Loren K Mell (2)  ·  Martin Mahoney, MD (2)  ·  Michiel Kroesen, MD, Dr. (2)

Results publications

PMID 31536129, PMID 32017652, PMID 40692081, PMID 42032732, PMID 10623691, PMID 10924966, PMID 14511925, PMID 14520092, PMID 16849759, PMID 17293228, PMID 17709149, PMID 18809146, PMID 19380364, PMID 19525472, PMID 19643246, PMID 20403855, PMID 20439512, PMID 20447554, PMID 20632579, PMID 21266057, PMID 21654689, PMID 21775497, PMID 21831465, PMID 21985945, PMID 22241828, PMID 22252927, PMID 22253412, PMID 22319013, PMID 22344232, PMID 23083061, PMID 23199641, PMID 23541643, PMID 23639862, PMID 23733379, PMID 24778397, PMID 24821357, PMID 25057165, PMID 25229260, PMID 25498307, PMID 25823737, PMID 25965900, PMID 26062933, PMID 26186556, PMID 26429955, PMID 26516369, PMID 26581135, PMID 26611425, PMID 26923327, PMID 27609788, PMID 28498880

NIH funding

P30CA138292 (6), U10CA180868 (6), U10CA180820 (4), 2018 (2), P30CA006973 (2), P30CA014520 (2), UM1CA186690 (2), 2008 (1), 2009 (1), 2014 (1), 2019 (1), K01AT004415 (1), K24DC022077 (1), N01CM62201 (1), N01CN00033 (1)