Salivary Gland Neoplasms: Clinical Trials

154 completed, 29 recruiting, 26 unknown, 24 active not recruiting. 115 Phase 2, 72 Phase 1, 30 Not applicable, 14 Phase 3, 4 Early Phase 1.

By phase and status

Phase	Trials	Status
Phase 2	115	Completed 63, Active not recruiting 18, Recruiting 13, Unknown 10, Terminated 9, Withdrawn 2
Phase 1	72	Completed 47, Terminated 9, Active not recruiting 7, Recruiting 4, Unknown 3, Withdrawn 2
Not applicable	30	Completed 16, Unknown 6, Recruiting 3, Not yet recruiting 2, Active not recruiting 1, Terminated 1, Withdrawn 1
Phase 3	14	Completed 8, Unknown 3, Active not recruiting 1, Recruiting 1, Withdrawn 1
Early Phase 1	4	Recruiting 2, Completed 1, Terminated 1
Phase 4	1	Completed 1

Follow Salivary Gland Neoplasms: new trials by email Literature Review of Salivary Gland Neoplasms trials Research Report on Salivary Gland Neoplasms

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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
9-ING-41 Plus Carboplatin in Patients With Advanced, Metastatic Salivary Gland Carcinoma 9-ING-41, Carboplatin - Salivary Gland Carcinoma, Adenoid Cystic Carcinoma	Phase 2	Withdrawn	Actuate Therapeutics Inc.		2030-12-18	2022-02-22
Docetaxel and SX-682 in Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma, Salivary Gland Carcinoma, and Advanced Prostate Cancer SX-682, DTX - Head and Neck Cancer, Head and Neck Squamous Cell Carcinoma	Phase 1 / Phase 2	Recruiting	National Cancer Institute (NCI)	120	2026-10-28	2026-10-23
Abiraterone With Dalpiciclib in Salivary Gland Carcinoma abiraterone combined with dalpiciclib - Salivary Gland Carcinoma	Phase 2	Recruiting	Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University	36	2026-10-01	2026-09-11
Clinical Tolerance of an Intraparotid Injection of Bupivacaine, Combined With Dexamethasone, After Parotidectomy for Benign Tumor Intraparotid injection of bupivacaine/ dexamethasone - Parotid Neoplasm, Bupivacaine	Early Phase 1	Recruiting	Centre Hospitalier Universitaire de Nīmes	10	2026-05-18	2026-09-10
Swedish National Parotidectomy Study (SNaPs): Drainless Versus Standard Surgery Active wound drainage (Standard of Care), Omission of active wound drain - Parotid Neoplasms, Post-operative Complications	Not applicable	Recruiting	Uppsala University Hospital	600	2026-05-06	2026-06-04
Facial Nerve Monitoring During Parotid and Facial Surgery Using a Non-Invasive Patch Non-invasive facial nerve monitoring patch - Parotid Gland Tumor, Facial and Neck Rhytides	Not applicable	Not yet recruiting	Sheba Medical Center	20	2026-05-01	2026-04-13
DESTINY-PANTUMOUR04 Trastuzumab deruxtecan - Adenocarcinoma (NOS), Anal Cancer		Recruiting	AstraZeneca	100	2025-09-18	2026-09-25
Determining the Biodistribution of an Imaging Tracer (68Ga-FAPi-46) in Patients With Solid Tumors or Hematologic Cancers Computed Tomography, Fludeoxyglucose F-18, Gallium Ga 68 FAPi-46 - Anal Carcinoma, Bladder Carcinoma	Phase 1	Active not recruiting	Jonsson Comprehensive Cancer Center	30	2025-08-01	2026-10-20
Sacituzumab Govitecan in Metastatic Salivary Gland and Thyroid Cancers (SG-SGTC) Sacituzumab govitecan - Salivary Gland Cancer, Thyroid Cancer	Phase 2	Recruiting	National University Hospital, Singapore	32	2025-04-15	2025-07-25
PDO Based Drug Sensitive Test in R/M SGC No Intervention: Observational Cohort - Salivary Gland Cancers, Patient Derived Organoid		Recruiting	Huashan Hospital	40	2025-03-26	2025-09-03
A Phase 2 Trial of Ivonescimab for Patients With Advanced, Metastatic Salivary Gland Cancers Ivonescimab - Salivary Gland Cancer, Advanced Salivary Gland Carcinoma	Phase 2	Recruiting	Dana-Farber Cancer Institute	35	2025-02-26	2026-10-21
A Phase 2 Study of Zanidatamab in Patients With HER2-expressing Tumors Zanidatamab - Breast Cancer, Gastric Cancer	Phase 2	Recruiting	Jazz Pharmaceuticals	200	2025-01-14	2026-07-10
Investigating the Role of Adjuvant Proton Beam Therapy in Patients With Parotid Carcinoma Proton Beam Therapy - Parotid Cancer	Not applicable	Not yet recruiting	The Christie NHS Foundation Trust	97	2024-11-01	2024-08-21
Enhanced Assistance During Radiotherapy for Unmet Essential Needs Standard assistance, Enhanced assistance - Bone Cancer, Brain Cancer	Not applicable	Completed	Washington University School of Medicine	33	2024-10-04	2025-08-26
Gene Expression Profiling in a Validation Cohort of Locally Advanced and Recurrent/Metastatic Salivary Gland Cancers Observation - Salivary Gland Cancer		Unknown	Royal Marsden NHS Foundation Trust	250	2024-09-01	2024-08-09
Neratinib Tablets Monotherapy for Advanced Solid Tumors With HER2 Mutations Neratinib tablets - Advanced Solid Tumor	Phase 2	Unknown	Convalife (Shanghai) Co., Ltd.	60	2024-08-10	2024-07-25
Function-Preserving Surgery for Parotid Tumors: Intracapsular Versus Superficial Parotidectomy; A Randomized Clinical Trial. Superficial parotidectomy, Intracapsular parotidectomy (ICP) - Parotid Tumors, Parotidectomy	Not applicable	Completed	Al-Azhar University	120	2024-05-01	2025-09-22
Immune Biomarker Study for Salivary Gland Carcinoma Sampling - Salivary Gland Tumor, Benign Salivary Gland Tumor		Recruiting	University of Erlangen-Nürnberg Medical School	300	2024-01-08	2026-03-16
Drug Screening Using Novel IMD in Salivary and Head and Neck Cancers Implantable Microdevice (IMD) - Salivary Gland Cancer, Adenoid Cystic Carcinoma of the Salivary Gland	Early Phase 1	Recruiting	Brigham and Women's Hospital	30	2023-11-01	2026-01-26
A Study to Evaluate TROP2 ADC LCB84 Single Agent and in Combination With an Anti-PD-1 Ab in Advanced Solid Tumors LCB84, Anti-PD-1 monoclonal antibody - Advanced Solid Tumors	Phase 1 / Phase 2	Recruiting	LigaChem Biosciences, Inc.	300	2023-10-05	2025-09-24

Showing 20 of 264. Sign in to see all of them.

Narrower conditions

Squamous Cell Carcinoma of Head and Neck (125)  ·  Head and Neck Neoplasms (111)  ·  Breast Neoplasms (51)  ·  Carcinoma, Non-Small-Cell Lung (50)  ·  Esthesioneuroblastoma, Olfactory (47)  ·  Tongue Neoplasms (40)  ·  Pancreatic Neoplasms (37)  ·  Stomach Neoplasms (35)  ·  Prostatic Neoplasms (34)  ·  Colonic Neoplasms (33)  ·  Esophageal Neoplasms (32)  ·  Lung Neoplasms (27)  ·  Parotid Neoplasms (27)  ·  Hypopharyngeal Neoplasms (26)

Broader conditions

Mouth Diseases (264)  ·  Salivary Gland Diseases (264)  ·  Stomatognathic Diseases (264)  ·  Neoplasms by Site (262)  ·  Neoplasms (243)  ·  Mouth Neoplasms (238)  ·  Neoplasms by Histologic Type (171)  ·  Neoplasms, Glandular and Epithelial (168)  ·  Carcinoma (164)  ·  Head and Neck Neoplasms (153)  ·  Carcinoma, Squamous Cell (124)  ·  Respiratory Tract Diseases (77)  ·  Respiratory Tract Neoplasms (77)  ·  Neoplasms, Germ Cell and Embryonal (68)  ·  Neoplasms, Nerve Tissue (67)

Interventions

Cisplatin (20)  ·  Docetaxel (18)  ·  Carboplatin (12)  ·  Cetuximab (12)  ·  Radiotherapy (12)  ·  Magnetic Resonance Spectroscopy (11)  ·  Biopsy (10)  ·  pembrolizumab (10)  ·  Erlotinib Hydrochloride (9)  ·  Paclitaxel (9)  ·  Immunohistochemistry (8)  ·  Radiotherapy, Intensity-Modulated (8)  ·  Chemotherapy, Adjuvant (7)  ·  Gemcitabine (7)  ·  Trastuzumab (7)

Sponsors

National Cancer Institute (NCI) (42)  ·  Vanderbilt-Ingram Cancer Center (9)  ·  Dana-Farber Cancer Institute (7)  ·  Eastern Cooperative Oncology Group (6)  ·  Mayo Clinic (6)  ·  Memorial Sloan Kettering Cancer Center (6)  ·  Alliance for Clinical Trials in Oncology (5)  ·  Fox Chase Cancer Center (5)  ·  M.D. Anderson Cancer Center (5)  ·  University of Washington (5)  ·  European Organisation for Research and Treatment of Cancer - EORTC (4)  ·  Radboud University Medical Center (4)  ·  University Health Network, Toronto (4)  ·  Abramson Cancer Center at Penn Medicine (3)  ·  Fondazione IRCCS Istituto Nazionale dei Tumori, Milano (3)

Countries

United States (172)  ·  Canada (21)  ·  France (14)  ·  United Kingdom (12)  ·  China (10)  ·  Italy (10)  ·  Germany (9)  ·  Netherlands (9)  ·  Egypt (6)  ·  Belgium (5)  ·  South Korea (5)  ·  Australia (4)  ·  Japan (4)  ·  Singapore (4)  ·  Spain (4)

Top investigators

Barbara Murphy, MD (6)  ·  Athanassios Argiris, MD (4)  ·  Corey J. Langer, MD (3)  ·  Alan Ho, MD, PhD (2)  ·  Alan L Ho (2)  ·  Barbara A. Murphy, MD (2)  ·  Barbara Burtness (2)  ·  Barry L. Gause, MD (2)  ·  Carla ML van Herpen, MD, PhD (2)  ·  Chris Nutting (2)  ·  Cristina Rodriguez (2)  ·  Eric Lartigau, MD, PhD (2)  ·  Glenn J Hanna, MD (2)  ·  Herbert K. Lyerly, MD (2)

Results publications

PMID 34503735, PMID 31838007, PMID 40086048, PMID 40341199, PMID 12533152, PMID 15659505, PMID 16470745, PMID 16760642, PMID 17545536, PMID 17985341, PMID 18470481, PMID 18484593, PMID 18819792, PMID 19372041, PMID 19602035, PMID 19634157, PMID 19671873, PMID 19735988, PMID 19924794, PMID 20145168, PMID 20179219, PMID 20406930, PMID 20407240, PMID 21367608, PMID 21791630, PMID 21917515, PMID 22252927, PMID 22480131, PMID 23188068, PMID 23868427, PMID 24585506, PMID 24733799, PMID 24799460, PMID 25057165, PMID 25965900, PMID 26062933, PMID 26611425, PMID 26841273, PMID 26928328, PMID 26951097, PMID 27020837, PMID 27974047, PMID 29118225, PMID 29149611, PMID 29466156, PMID 29472484, PMID 30539471, PMID 30850872, PMID 30943124, PMID 31175091

NIH funding

P30CA068485 (10), P30CA006516 (6), U10CA031946 (4), U10CA032102 (4), 2015 (3), N01CM62201 (3), P30CA006927 (3), U01CA076576 (3), U10CA021115 (3), 2016 (2), 2025 (2), N01CM00071 (2), N01CM62202 (2), N01CM62203 (2), P30CA006973 (2)