227 completed, 58 unknown, 44 recruiting, 29 terminated. 423 Phase 1, 166 Phase 2.
Follow Mouth Diseases: new trials by email Literature Review of Mouth Diseases trials Research Report on Mouth Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Autogenous Mesenchymal Stem Cell Culture-Derived Signalling Molecules as Enhancers of Bone Formation in Bone Grafting Maxillary sinus floor elevation grafting with synthetic bone substitute. - Bone Loss, Osteoclastic, Bone Loss, Alveolar | Phase 1 | Not yet recruiting | Pontificia Universidade Católica do Rio Grande do Sul | 20 | 2027-12-15 | 2026-09-21 |
| Testing the Addition of an Anti-Cancer Drug, Camonsertib, to Radiation Therapy for Recurrent Head and Neck Squamous Cell Carcinoma Biospecimen Collection, Camonsertib, Computed Tomography - Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Recurrent Head and Neck Squamous Cell Carcinoma | Phase 1 | Recruiting | National Cancer Institute (NCI) | 39 | 2027-02-13 | 2026-09-03 |
| Taste Acceptance and Effectiveness of Hyaluronic Acid and Chlorhexidine Mouthwashes in Children With Gingivitis Hyaluronic Acid mouthwash, Chlorohexidine 0.12% mouthwash - Plaque Induced Gingival Disease | Phase 1 | Not yet recruiting | Cairo University | 24 | 2027-01-01 | 2026-10-13 |
| Docetaxel and SX-682 in Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma, Salivary Gland Carcinoma, and Advanced Prostate Cancer SX-682, DTX - Head and Neck Cancer, Head and Neck Squamous Cell Carcinoma | Phase 1 / Phase 2 | Recruiting | National Cancer Institute (NCI) | 120 | 2026-11-02 | 2026-10-28 |
| Safety and Efficacy of Universal CAR-T Cells (UWD-CD19) Combined With Immunosuppressants in the Treatment of Refractory Autoimmune Diseases anti-CD19 CAR-T cells - Systemic Lupus Erthematosus, Systemic Sclerosis (SSc) | Phase 1 / Phase 2 | Not yet recruiting | Peking University Third Hospital | 9 | 2026-11-01 | 2026-09-23 |
| R-2487 in Patients With Sjogren's Syndrome (SS) R-2487 - Sjogren's Syndrome, Sjögren | Phase 1 | Not yet recruiting | Rise Therapeutics LLC | 36 | 2026-11-01 | 2026-09-28 |
| A Novel Proline-rich Peptide Hydrogel for Periodontal Regeneration in Adult Periodontitis Patients Hydrogel - Periodontal Disease, Intrabony Periodontal Defects | Phase 1 / Phase 2 | Not yet recruiting | Siddharth Shanbhag | 40 | 2026-11-01 | 2026-05-14 |
| A Study of BMS-986553 in Participants With Refractory Autoimmune Diseases BMS-986553 - Systemic Lupus Erythematosus, Sjögren's Disease | Phase 1 | Not yet recruiting | Bristol-Myers Squibb | 60 | 2026-10-30 | 2026-10-14 |
| A Study of Phenytoin Mucoadhesive Film for Oral Ulcers in Healthy Volunteers 1% Phenytoin Mucoadhesive Film, Blank Mucoadhesive Film - Oral Ulcer, Oral Mucositis | Phase 1 | Not yet recruiting | Misr University for Science and Technology | 10 | 2026-10-20 | 2026-10-28 |
| The Effect of Dexamethasone on Short Term Patient Response: IV vs Oral Administration Dexamethasone IV injection, Dexamethasone Capsule, Placebo IV administration - Post Operative Pain, Acute, Periodontitis | Phase 1 / Phase 2 | Not yet recruiting | The University of Texas Health Science Center at San Antonio | 40 | 2026-10-01 | 2026-09-21 |
| Subconjunctival Humira for Boston Keratoprosthesis Adalimumab Injection - Penetrating Keratoplasty, Multiple Graft Failure | Phase 1 | Not yet recruiting | Massachusetts Eye and Ear Infirmary | 8 | 2026-10-01 | 2026-08-31 |
| TMV Vaccine Alone or With Toripalimab-tpzi for Recurrent Head and Neck Squamous Cell Carcinoma TMV Vaccine, Toripalimab-tpzi - Squamous Cell Carcinoma of Head and Neck, Squamous Cell Carcinoma of Head and Neck (SCCHN) | Phase 1 | Recruiting | Metaclipse Therapeutics Corporation | 30 | 2026-10-01 | 2026-10-27 |
| Ficerafusp Alfa, Pembrolizumab, and Stereotactic Body Radiotherapy (SBRT) for Head and Neck Squamous Cell Carcinoma (HNSCC) Hypofractionated Stereotactic Body Radiotherapy (SBRT), Pembrolizumab, Ficerafusp alfa - Head and Neck Squamous Cell Carcinoma, HPV-Negative Squamous Cell Carcinoma | Phase 1 / Phase 2 | Not yet recruiting | Washington University School of Medicine | 45 | 2026-09-30 | 2026-08-13 |
| Minimally Invasive Non-Surgical Periodontal Therapy Alone vs. Minimally Invasive Non-Surgical Periodontal Therapy With I-PRF With or Without Chlorhexidine on Stage III Periodontitis Patients Minimally Invasive Nonsurgical Therapy, Injectable Platelet-Rich Fibrin, Chlorhexidine 2% - Bony Defects, Periodontal Disease | Phase 1 / Phase 2 | Not yet recruiting | Cairo University | 63 | 2026-09-30 | 2026-08-27 |
| A Study of ATG-201 in Adult Participants With Autoimmune Diseases ATG-201 - Systemic Lupus Erythematosus, Systemic Sclerosis (SSc) | Phase 1 | Recruiting | Antengene Biologics Limited | 149 | 2026-09-26 | 2026-10-28 |
| A Trial in Healthy Adult Participants and Adults With Autoimmune Disease to Test How HBM7020 is Tolerated and Absorbed in the Body HBM7020 - Rheumatoid Arthritis, Systemic Lupus Erythematosus | Phase 1 | Recruiting | Otsuka Pharmaceutical Development & Commercialization, Inc. | 63 | 2026-09-24 | 2026-10-13 |
| RP-008 in Combination With Daily Oral Varenicline for the Treatment of Trigeminal Neuralgia RP-008, Varenicline tartrate - Trigeminal Neuralgia | Phase 1 / Phase 2 | Recruiting | Kriya Therapeutics, Inc. | 24 | 2026-09-10 | 2026-10-23 |
| Thermotherapy for Head and Neck Cancer Patients Thermotherapy, Radiotherapy, Concurrent chemoradiation - Head and Neck Cancer, Oropharyngeal Carcinoma | Phase 1 | Recruiting | Erasmus Medical Center | 30 | 2026-09-01 | 2026-09-02 |
| Photobiomodulation Alone Versus Photobiomodulation Combined With Topical Oral Oxygen Therapy for Radiotherapy-Induced Oral Mucositis in Head and Neck Cancer Patients: A Randomized Clinical Trial sirolase xtent laser, blue m gel - Mucositis Oral, Head & Neck Cancer | Phase 1 / Phase 2 | Enrolling by invitation | Assiut University | 46 | 2026-08-15 | 2026-10-08 |
| Evaluation of NIPSA Using Alloplastic Bone Graft and Cross-Linked Hyaluronic Acid in theTreatment of Intrabony Defects allopastic bone graft, cross-linked hyaluronic acid, Non-Incised Papillae Surgical Approach - Intrabony Periodontal Defect, Periodontal Disease | Phase 1 / Phase 2 | Not yet recruiting | Mansoura University | 60 | 2026-08-01 | 2026-08-04 |
Showing 20 of 423. Sign in to see all of them.
Squamous Cell Carcinoma of Head and Neck (75) · Head and Neck Neoplasms (72) · Salivary Gland Neoplasms (70) · Mouth Neoplasms (56) · Sjogren's Syndrome (43) · Breast Neoplasms (37) · Periodontitis (34) · Carcinoma, Non-Small-Cell Lung (31) · Stomach Neoplasms (30) · Oropharyngeal Neoplasms (29) · Tongue Neoplasms (29) · Laryngeal Neoplasms (26) · Pancreatic Neoplasms (26) · Hypopharyngeal Neoplasms (25) · Colonic Neoplasms (24)
Stomatognathic Diseases (422) · Neoplasms by Site (157) · Neoplasms (151) · Salivary Gland Diseases (139) · Skin and Connective Tissue Diseases (117) · Neoplasms by Histologic Type (113) · Neoplasms, Glandular and Epithelial (102) · Carcinoma (95) · Periodontal Diseases (94) · Skin Diseases (90) · Head and Neck Neoplasms (84) · Mouth Neoplasms (80) · Pathological Conditions, Signs and Symptoms (80) · Immune System Diseases (72)
Cisplatin (20) · Radiotherapy (16) · Docetaxel (11) · Tooth Exfoliation (11) · pembrolizumab (11) · Cetuximab (10) · Erlotinib Hydrochloride (9) · Fibroblast Growth Factor 7 (7) · Magnetic Resonance Spectroscopy (7) · Paclitaxel (7) · Radiation (7) · Biopsy (6) · Fluorouracil (6) · Root Planing (6) · Specimen Handling (6)
National Cancer Institute (NCI) (30) · Cairo University (14) · M.D. Anderson Cancer Center (6) · Krishnadevaraya College of Dental Sciences & Hospital (5) · Roswell Park Cancer Institute (5) · Swedish Orphan Biovitrum (5) · University of Michigan (5) · Assiut University (4) · GlaxoSmithKline (4) · National Institute of Allergy and Infectious Diseases (NIAID) (4) · University of Washington (4) · University of Wisconsin, Madison (4) · Ain Shams University (3) · Biogen (3) · Copenhagen University Hospital, Rigshospitalet (3)
United States (190) · Egypt (32) · China (31) · Canada (18) · Brazil (14) · India (12) · Iran (11) · Spain (11) · Germany (10) · United Kingdom (10) · France (9) · Australia (7) · Netherlands (7) · Japan (6) · Norway (6)
Anurag Singh (2) · Arash Khojasteh, DMD, OMFS (2) · Blake M Warner, D.D.S. (2) · Charlotte Lynggaard, MD (2) · Cristina Rodriguez (2) · Dilip Khambete, MDS (2) · Erling A Tronvik, PhD, MD (2) · Greg Krempl, MD (2) · Hassan Arshad, MD (2) · Herbert K. Lyerly, MD (2) · Jacques Galipeau, MD (2) · James Chodosh, MD, MPH (2)
PMID 34483038, PMID 10916328, PMID 11240232, PMID 15108222, PMID 15159012, PMID 15287078, PMID 15793381, PMID 16004814, PMID 16415901, PMID 16884839, PMID 16950583, PMID 17604143, PMID 17896890, PMID 17985341, PMID 18407446, PMID 18470481, PMID 18485252, PMID 18973181, PMID 19372041, PMID 19602035, PMID 19671873, PMID 19735988, PMID 19892587, PMID 20006669, PMID 20131246, PMID 20145168, PMID 20179219, PMID 20407240, PMID 20668585, PMID 20950166, PMID 21367608, PMID 21555774, PMID 21845241, PMID 21864666, PMID 22114446, PMID 22527350, PMID 22691124, PMID 22776413, PMID 22848877, PMID 22923859, PMID 22927248, PMID 23046006, PMID 23052923, PMID 23292233, PMID 23334994, PMID 23469127, PMID 23671833, PMID 23685937, PMID 23763951, PMID 23773637
U01CA076576 (3), 2014 (2), 2015 (2), 2018 (2), 2023 (2), P30CA015704 (2), P30CA043703 (2), U01CA062502 (2), UM1CA186688 (2), UM1CA186690 (2), 2016 (1), 2025 (1), 4UH3DE030431-02 (1), 5UH3CA189901-04 (1), D43TW012274 (1)