288 completed, 86 unknown, 69 recruiting, 37 not yet recruiting. 197 Not applicable, 105 Phase 2, 60 Phase 1, 39 Phase 3, 28 Phase 4.
Follow Xerostomia: new trials by email Literature Review of Xerostomia trials Research Report on Xerostomia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Penn SICCA Follow-up Study Dry Eye, Sjogren's Syndrome | Not yet recruiting | University of Pennsylvania | 220 | 2027-01-01 | 2026-03-02 | |
| Continued Access to Deucravacitinib for Adult SLE/SjD and Pediatric PsO/PsA Study Completers Deucravacitinib - Systemic Lupus Erythematosus, Sjögren's Disease | Phase 3 | Not yet recruiting | Bristol-Myers Squibb | 2300 | 2026-12-31 | 2026-09-03 |
| Safety and Efficacy of Topical Infliximab in Autoimmune Dry Eye Disease Infliximab 0.1%, Loteprednol - Sjogren Syndrome, Sjogren Syndrome With Keratoconjunctivitis | Phase 2 | Not yet recruiting | Instituto de Oftalmología Fundación Conde de Valenciana | 38 | 2026-12-01 | 2026-06-26 |
| Exosome and Mesenchymal Stem Cell Treatment for Salivary Gland Dysfunction in Primary Sjögren Syndrome exosomes derived from human umbilical cord mesenchymal stem cells, Mesenchymal Stem Cells (MSC), Placebo - Sjogren Syndrome, Xerostomia | Phase 2 | Not yet recruiting | Banu Erkal | 30 | 2026-12-01 | 2026-09-24 |
| Safety and Efficacy of Universal CAR-T Cells (UWD-CD19) Combined With Immunosuppressants in the Treatment of Refractory Autoimmune Diseases anti-CD19 CAR-T cells - Systemic Lupus Erthematosus, Systemic Sclerosis (SSc) | Phase 1 / Phase 2 | Not yet recruiting | Peking University Third Hospital | 9 | 2026-11-01 | 2026-09-23 |
| R-2487 in Patients With Sjogren's Syndrome (SS) R-2487 - Sjogren's Syndrome, Sjögren | Phase 1 | Not yet recruiting | Rise Therapeutics LLC | 36 | 2026-11-01 | 2026-09-28 |
| A Study of BMS-986553 in Participants With Refractory Autoimmune Diseases BMS-986553 - Systemic Lupus Erythematosus, Sjögren's Disease | Phase 1 | Not yet recruiting | Bristol-Myers Squibb | 60 | 2026-10-30 | 2026-10-14 |
| Pain Phenotyping of Rheumatic Diseases - An Observational Study Bedside quantitative sensory testing - Rheumatic Diseases, Lupus Erythematosus, Systemic | Not yet recruiting | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) | 225 | 2026-10-27 | 2026-10-22 | |
| Effectiveness of an Oral Exercise Program for Xerostomia in Patients With Sjögren Disease Oral exercise - Sjogren Syndrome | Not applicable | Not yet recruiting | Nazli Elif Nacar | 56 | 2026-10-26 | 2026-10-08 |
| Effects of GLP-1 Receptor Agonists on Saliva and Oral Health GLP-1 Receptor Agonists - Type 2 Diabetes, Obesity & Overweight | Not yet recruiting | Kırıkkale University | 50 | 2026-10-16 | 2026-09-14 | |
| A Study of IBI355 in Participants With Moderate-to-Severe Sjögren's Disease Part A - Placebo for IBI355, Part B -Telitacicept, PartB -Placebo for Telitacicept - Sjögren's Disease | Phase 2 | Not yet recruiting | Innovent Biologics (Suzhou) Co. Ltd. | 198 | 2026-10-15 | 2026-09-23 |
| Exploratory Study of the Efficacy of HuMoSCs (Human Monocyte-derived Suppressor Cells) on Glandular Involvement in Sjögren's Syndrome Blood sample, Salivary gland biopsy - Sjogren's Syndrome, Autoimmune Diseases | Not applicable | Not yet recruiting | Centre Hospitalier Universitaire Dijon | 20 | 2026-10-10 | 2026-10-06 |
| Effect of the Dietary Supplement to Alleviate Dry Mouth. Dietary Supplement - Xerostomia | Not applicable | Not yet recruiting | Lacer S.A. | 35 | 2026-10-01 | 2026-09-29 |
| Ocular Surface Changes and Meibomian Gland Dysfunction in Rheumatologic Patients Meibomian Gland Dysfunction, Dry Eye Syndromes | Not yet recruiting | Assiut University | 150 | 2026-10-01 | 2026-09-09 | |
| ONO-4915 in Patients With Primary Sjogren's Disease ONO-4915, Placebo - Sjogren's Disease | Phase 2 | Not yet recruiting | Ono Pharmaceutical Co., Ltd. | 60 | 2026-10-01 | 2026-09-16 |
| Effects of a 50+ Toothpaste on Halitosis and Oral Comfort in Healthy Adults 50+ Toothpaste, Standard Fluoride Toothpaste - Oral Malodor (Halitosis), Oral Dryness | Not applicable | Not yet recruiting | University of Pavia | 30 | 2026-10-01 | 2026-08-21 |
| A Trial in Healthy Adult Participants and Adults With Autoimmune Disease to Test How HBM7020 is Tolerated and Absorbed in the Body HBM7020 - Rheumatoid Arthritis, Systemic Lupus Erythematosus | Phase 1 | Recruiting | Otsuka Pharmaceutical Development & Commercialization, Inc. | 63 | 2026-09-24 | 2026-10-13 |
| A Study of ATG-201 in Adult Participants With Autoimmune Diseases ATG-201 - Systemic Lupus Erythematosus, Systemic Sclerosis (SSc) | Phase 1 | Not yet recruiting | Antengene Biologics Limited | 149 | 2026-09-01 | 2026-09-21 |
| CD19/BCMA-Targeted Universal CAR-T Cell Injection for the Treatment of Autoimmune Diseases RD06-05 CAR-T Cell Injection - SLE - Systemic Lupus Erythematosus, Systemic Sclerosis | Early Phase 1 | Not yet recruiting | Nanjing Bioheng Biotech Co., Ltd. | 30 | 2026-09-01 | 2026-07-16 |
| New Functional Ingredient for Oral Care Botanical A, Botanical B, Vehicle (Placebo solution) - Oral Health Related Quality of Life (OHRQoL) | Not applicable | Not yet recruiting | Access Business Group | 100 | 2026-09-01 | 2026-08-19 |
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Sjogren's Syndrome (318) · Lupus Erythematosus, Systemic (67) · Head and Neck Neoplasms (63) · Dry Eye Syndromes (58) · Arthritis, Rheumatoid (44) · Scleroderma, Systemic (44) · Autoimmune Diseases (39) · Myositis (32) · Scleroderma, Diffuse (20) · Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (19) · Antiphospholipid Syndrome (15) · Mucositis (15) · Arthritis, Psoriatic (14) · Dermatomyositis (13)
Stomatognathic Diseases (548) · Mouth Diseases (545) · Salivary Gland Diseases (540) · Eye Diseases (321) · Musculoskeletal Diseases (319) · Skin and Connective Tissue Diseases (319) · Lacrimal Apparatus Diseases (318) · Immune System Diseases (317) · Joint Diseases (316) · Connective Tissue Diseases (313) · Rheumatic Diseases (311) · Arthritis (309) · Autoimmune Diseases (280) · Arthritis, Rheumatoid (274)
Pilocarpine (11) · Low-Level Light Therapy (10) · Blood Specimen Collection (9) · Radiotherapy (8) · Acupuncture Therapy (7) · Hydroxychloroquine (7) · ianalumab (7) · Rituximab (6) · Sodium Chloride (5) · Cisplatin (4) · Radiation (4) · Saliva, Artificial (4) · Surveys and Questionnaires (4) · Tacrolimus (4) · Xylitol (4)
National Institute of Dental and Craniofacial Research (NIDCR) (19) · Novartis Pharmaceuticals (14) · Ain Shams University (9) · University of Sao Paulo General Hospital (9) · Peking Union Medical College Hospital (8) · Taipei Veterans General Hospital, Taiwan (8) · Amgen (7) · Assistance Publique - Hôpitaux de Paris (6) · GlaxoSmithKline (6) · Roxane Laboratories (6) · University Hospital, Brest (6) · M.D. Anderson Cancer Center (5) · University of Nove de Julho (5) · University of Pennsylvania (5) · University of Rochester (5)
United States (173) · France (69) · China (60) · Brazil (36) · Spain (36) · Taiwan (35) · Italy (34) · Turkey (Türkiye) (32) · Germany (31) · Canada (27) · United Kingdom (27) · Poland (23) · Egypt (20) · Australia (18) · Netherlands (18)
Ching-Mao Chang, M.D., Ph.D. (6) · Daniel V Freeland, DO (4) · Aroonwan Lam-ubol, DDS, PhD (3) · Blake M Warner, D.D.S. (3) · Ilias G Alevizos, D.M.D. (3) · Adeline Vanderver, MD (2) · Andreas Charalambous, PhD (2) · Anurag Singh (2) · Charlotte Lynggaard, MD (2) · Darin Brimhall, DO (2) · Emilio C Campos, MD (2)
PMID 28279391, PMID 29784145, PMID 20882668, PMID 21280008, PMID 26631691, PMID 30309472, PMID 31095438, PMID 32939030, PMID 37612654, PMID 39839752, PMID 10435146, PMID 10530742, PMID 10775736, PMID 10929962, PMID 11180122, PMID 11208206, PMID 11355268, PMID 11395238, PMID 11491236, PMID 11508435, PMID 12108756, PMID 12673463, PMID 12765470, PMID 14697016, PMID 15361396, PMID 15368347, PMID 15529389, PMID 15590764, PMID 15712851, PMID 15716838, PMID 15990024, PMID 16142864, PMID 16424527, PMID 16648432, PMID 16700739, PMID 16759558, PMID 16980725, PMID 16987829, PMID 16996579, PMID 17000452, PMID 17141973, PMID 17471524, PMID 17665393, PMID 17824884, PMID 17854932, PMID 17986340, PMID 17992096, PMID 18195175, PMID 18808626, PMID 19294365
2018 (5), 2025 (5), 2015 (4), 2023 (4), 2016 (2), 2019 (2), R01CA148707 (2), 2008 (1), 2014 (1), 4UH3DE030431-02 (1), 4UH3DE030856-03 (1), P01CA257907 (1), P30CA006516 (1), P30CA015083 (1), P30CA023074 (1)