529 completed, 83 recruiting, 76 terminated, 55 unknown. 820 Phase 2, 93 Phase 3, 92 Phase 1.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Psilocybin Assisted Psychotherapy for Treatment Resistant Depression and Co-occurring Substance Use Disorder Psilocybin - Treatment Resistant Depression, Substance Use Disorders | Phase 1 / Phase 2 | Not yet recruiting | Indiana University | 50 | 2027-02-01 | 2026-10-23 |
| A Phase I/II Study of PDC-1421 for Treating Depression in Cancer Patients PDC-1421 Capsule - Major Depressive Disorder | Phase 1 / Phase 2 | Not yet recruiting | BioLite, Inc. | 12 | 2027-01-15 | 2026-04-20 |
| Psilocybin for Depression in Veterans Psilocybin, modafinil, zolpidem - Major Depression | Phase 2 | Not yet recruiting | VA Office of Research and Development | 150 | 2027-01-01 | 2026-10-26 |
| N-Acetylcysteine for Bipolar and Alcohol Use Disorders N-acetyl cysteine, Placebo - Bipolar Disorder, Alcohol Use Disorder | Phase 2 | Not yet recruiting | Medical University of South Carolina | 70 | 2027-01-01 | 2026-11-03 |
| Assessing of Behavioral Risk and Response to Electromagnetic and Psychedelic Therapies Transcranial Magnetic Stimulation, Psilocybin (drug), Neurofeedback - PTSD, PTSD - Post Traumatic Stress Disorder | Phase 2 | Not yet recruiting | University of New Mexico | 150 | 2026-12-31 | 2026-10-30 |
| Ketamine-Assisted Psychotherapy for Treatment-Resistant Depression Ketamine hydrochloride injection - Treatment Resistant Depression (TRD), Chronic Pain | Phase 2 | Not yet recruiting | University of Rochester | 25 | 2026-12-01 | 2026-09-24 |
| Mild-Intensity Whole Body Hyperthermia (WBH) for Major Depressive Disorder Tocilizumab, Placebo, Whole-Body Hyperthermia - Major Depressive Disorder | Phase 2 | Suspended | Massachusetts General Hospital | 35 | 2026-12-01 | 2025-11-13 |
| A Randomized, Double-Blind Controlled Comparison of NRX-101 vs. Placebo for Adults Being Treated With Robotic Transcranial Magnetic Stimulation for Treatment Resistant Depression: The SPARC-TMS Trial Neuronavigated robotic-enabled TMS, NRX-101, Sham TMS - Treatment Resistant Depression, Treatment Resistant Depression (TRD) | Phase 2 / Phase 3 | Recruiting | NeuroRx, Inc. | 240 | 2026-12-01 | 2026-10-21 |
| A Mechanistic Study to Assess a Single Dose of CYB003 in Participants With Depression and Anxiety CYB003, Placebo - Depression, Anxiety | Phase 2 | Recruiting | Ohio State University | 40 | 2026-11-01 | 2026-10-20 |
| A Study of Brenipatide in Participants With Major Depressive Disorder Brenipatide, Placebo - Major Depressive Disorder | Phase 2 | Not yet recruiting | Eli Lilly and Company | 330 | 2026-11-01 | 2026-11-10 |
| Precision Depression Adalimumab Trial Adalimumab Biosimilars Injection, Placebo - Major Depressive Disorder (MDD) | Phase 2 | Recruiting | Daniel Moriarity | 60 | 2026-11-01 | 2026-11-12 |
| The BAARD Study : Evaluating a Computerized Approach to Treatment Selection in Older Adults With Treatment Resistant Depression. Aripiprazole Augmentation, Bupropion Augmentation - Late Life Treatment Resistant Depression, Depression - Major Depressive Disorder | Phase 2 | Not yet recruiting | Washington University School of Medicine | 300 | 2026-11-01 | 2026-11-13 |
| A Study to Evaluate BMS-986511 in Adults With Major Depressive Disorder BMS-986511, Placebo - Major Depressive Disorder | Phase 2 | Not yet recruiting | Bristol-Myers Squibb | 200 | 2026-10-30 | 2026-09-04 |
| Behavioural Activation Therapy and Ketamine for Treatment-Resistant Depression Ketamine (0.5 mg/kg), Behavioural Activation Therapy - Treatment Resistant Depression, Major Depressive Disorder (MDD) | Phase 2 / Phase 3 | Recruiting | The Royal's Institute of Mental Health Research | 60 | 2026-10-30 | 2026-11-09 |
| Oral Thiamine (Vitamin B1) for Depression in Children and Adolescents thiamine hydrochloride 100 mg - Major Depressive Disorder (MDD), Thiamine | Phase 2 | Not yet recruiting | Massachusetts General Hospital | 40 | 2026-10-01 | 2026-08-28 |
| Pregnenolone Treatment for Alcohol Use Disorder and Major Depressive Disorder Pregnenolone, Placebo - Alcohol Use Disorder (AUD), Major Depressive Disorder (MDD) | Phase 2 | Not yet recruiting | Sherwood Brown, MD, PhD | 100 | 2026-10-01 | 2026-08-24 |
| Sertraline Combined With Multi-Strain Probiotics for Adolescent Depression Sertraline - Major Depressive Disorder (MDD), Probiotic Intervention | Phase 2 | Recruiting | First Affiliated Hospital of Chongqing Medical University | 120 | 2026-10-01 | 2026-06-12 |
| A Study to Evaluate the Safety and Efficacy of ALKS 7290 as an Adjunctive Therapy to Antidepressants in Adult Participants With Major Depressive Disorder ALKS 7290 Dose, Placebo - Major Depressive Disorder (MDD) | Phase 2 | Recruiting | Alkermes, Inc. | 180 | 2026-10-01 | 2026-10-28 |
| Synaptic Mechanisms of Intermittent Theta Burst Stimulation for Major Depressive Disorder Sham iTBS, TMS, D-cycloserine - Major Depression, Healthy Participants | Phase 1 / Phase 2 | Recruiting | Mclean Hospital | 100 | 2026-10-01 | 2026-10-30 |
| Pregnenolone for Cannabis Use Disorder and Depression Pregnenolone - Cannabis Use Disorder, Major Depressive Disorder (MDD) | Phase 1 / Phase 2 | Not yet recruiting | University of Texas Southwestern Medical Center | 20 | 2026-09-01 | 2026-07-06 |
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Depressive Disorder, Major (508) · Depression (296) · Bipolar Disorder (177) · Depressive Disorder (108) · Depressive Disorder, Treatment-Resistant (93) · Anxiety Disorders (40) · Depression, Postpartum (33) · Mental Disorders (28) · Psychotic Disorders (24) · Alcoholism (19) · Mania (19) · Schizophrenia (18) · Suicidal Ideation (18) · Dysthymic Disorder (14)
Mental Disorders (792) · Depressive Disorder (545) · Behavior (323) · Behavioral Symptoms (306) · Bipolar and Related Disorders (176) · Pathological Conditions, Signs and Symptoms (82) · Nervous System Diseases (61) · Signs and Symptoms (57) · Neurologic Manifestations (46) · Urogenital Diseases (39) · Female Urogenital Diseases and Pregnancy Complications (36) · Neurobehavioral Manifestations (34) · Chemically-Induced Disorders (33) · Pathologic Processes (32)
Ketamine (54) · Psilocybin (44) · Escitalopram (25) · Sertraline (20) · Transcranial Direct Current Stimulation (16) · Therapeutics (15) · Cognitive Behavioral Therapy (14) · Transcranial Magnetic Stimulation (14) · Fluoxetine (13) · Venlafaxine Hydrochloride (12) · Bupropion (11) · Citalopram (11) · Midazolam (11) · Quetiapine Fumarate (10) · Vortioxetine (10)
National Institute of Mental Health (NIMH) (35) · Massachusetts General Hospital (21) · GlaxoSmithKline (17) · Janssen Research & Development, LLC (16) · Mclean Hospital (11) · H. Lundbeck A/S (10) · Medical University of South Carolina (10) · New York State Psychiatric Institute (10) · The University of New South Wales (10) · University of Pittsburgh (10) · Washington University School of Medicine (10) · Icahn School of Medicine at Mount Sinai (9) · University of Sao Paulo (9) · Alto Neuroscience (8) · University of Texas Southwestern Medical Center (8)
United States (510) · Canada (79) · Germany (41) · China (30) · United Kingdom (30) · Australia (29) · Poland (29) · Russia (25) · Brazil (21) · Bulgaria (21) · Japan (21) · France (17) · Spain (17) · Czechia (16) · Sweden (16)
Carlos A Zarate, M.D. (9) · Maurizio Fava, MD (7) · Andre R Brunoni, MD (3) · Andrew A Nierenberg, MD (3) · Beth L Murphy, MD, PhD (3)
PMID 34510411, PMID 23146246, PMID 34817851, PMID 35092868, PMID 42171126, PMID 22215866, PMID 25150403, PMID 27685842, PMID 28086004, PMID 29111077, PMID 30508090, PMID 31270774, PMID 31969269, PMID 32785636, PMID 32792252, PMID 33128208, PMID 33146667, PMID 34131914, PMID 34623633, PMID 36322843, PMID 37585253, PMID 37651119, PMID 39240566, PMID 39955416, PMID 40398609, PMID 42304135, PMID 42521762, PMID 42560883, PMID 10197825, PMID 10990547, PMID 11063978, PMID 11723286, PMID 12113998, PMID 12217271, PMID 12244081, PMID 12949224, PMID 14557145, PMID 14677403, PMID 15147306, PMID 15351385, PMID 15365580, PMID 15580167, PMID 15583115, PMID 15630071, PMID 15982444, PMID 15987799, PMID 16002441, PMID 16319710, PMID 16390366, PMID 16491981
2015 (5), 2017 (4), 2019 (4), 2023 (4), 2008 (3), 2016 (3), 2018 (3), 2025 (3), 271201100006I-0-27100007-1 (2), R33MH122464 (2), U54DA036114 (2), 1UG3DA066242-01 (1), 1UG3MH137353-01 (1), 2009 (1), 2014 (1)