14 completed, 3 unknown, 2 recruiting, 2 terminated. 6 Not applicable, 4 Early Phase 1, 4 Phase 4, 3 Phase 2, 2 Phase 1.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Positron Emission Tomography (PET) Imaging of Cholesterol Trafficking: Clinical Evaluation of [18F]FNP-59 in Normal Human Subjects (Groups 2, 3 & 4) Dexamethasone (Group 2), Cosyntropin (Group 3), PET/CT Scan with FNP-59 - Radiotracer, Hypertension | Early Phase 1 | Recruiting | Benjamin Viglianti | 24 | 2021-11-01 | 2025-12-05 |
| Defining the Mechanisms Underlying Adrenal Insufficiency in Cirrhosis Cosyntropin - Cirrhosis, Adrenal Insufficiency | Completed | University of Virginia | 76 | 2021-08-02 | 2024-12-10 | |
| Relative Contributions of Predictors of Hyperandrogenism in Older vs. Young Women With PCOS ACTH, rhCG - Polycystic Ovary Syndrome | Early Phase 1 | Unknown | University of Virginia | 144 | 2019-10-08 | 2023-11-03 |
| Comparison of Intramuscular and Intravenous ACTH Stimulation Test in Normal Volunteers Cosyntropin - Adrenal Insufficiency | Phase 4 | Withdrawn | Johns Hopkins University | 2019-07-01 | 2019-05-10 | |
| A Study to Assess the Efficacy and Safety of MNK-1411 in Duchenne Muscular Dystrophy MNK-1411, Placebo - Muscular Dystrophy, Duchenne | Phase 2 | Terminated | Mallinckrodt ARD LLC | 44 | 2018-07-27 | 2021-03-16 |
| Effect of Longer-term Adrenal Suppression Using Low Dose Hydrocortisone on Androgen Overproduction Hydrocortisone, dexamethasone, Cosyntropin - Hyperandrogenemia, Obesity | Early Phase 1 | Withdrawn | University of Virginia | 2018-06-01 | 2018-07-19 | |
| Is Adrenal Insufficiency Under-diagnosed in Hospitalized Cirrhosis Patients? Cosyntropin - Adrenal Insufficiency, Cirrhosis | Phase 3 | Completed | University of Virginia | 100 | 2018-01-29 | 2021-12-09 |
| Effect of Adrenocorticotropic Hormone on Vascular Endothelial Growth Factor Release in Children Study Low Dose Cosyntropin (ACTH) stimulation test, High Dose Cosyntropin (ACTH) stimulation test - Adrenal Insufficiency, Osteopenia, Osteoporosis | Early Phase 1 | Completed | Nationwide Children's Hospital | 10 | 2017-10-01 | 2019-02-21 |
| Evaluation of the Effectiveness and Tolerance of Tetracosactide Synacthen® in the Treatment of Post Dural Puncture Headaches (ESYBRECHE) Tetracosactide (Synacthène®), placebo saline (0.9% NaCl) - Post-dural Puncture Headache | Phase 2 | Terminated | Hospices Civils de Lyon | 46 | 2016-10-01 | 2025-08-08 |
| Mass Spectrometry Based Cutoffs for Cortisol After Stimulation Tests Synachten - Adrenal Insufficiency | Not applicable | Completed | Haukeland University Hospital | 232 | 2016-05-21 | 2024-03-01 |
| Stress and the Nervous System Cosyntropin, Placebo - Autonomic Nervous System, Baroreflex | Not applicable | Completed | Brigham and Women's Hospital | 23 | 2015-04-01 | 2025-12-03 |
| Adrenocorticotropic Hormone Stimulation in Postural Orthostatic Tachycardia Syndrome (POTS) Cosyntropin administration - Postural Tachycardia Syndrome | Not applicable | Completed | Vanderbilt University | 13 | 2013-01-01 | 2022-03-31 |
| NeSST2: The Development of a Noninvasive Short Synacthen Test nasal Tetracosactide, IV tetracosactide - Adrenal Suppression | Phase 2 | Recruiting | Sheffield Children's NHS Foundation Trust | 12 | 2012-10-12 | 2024-12-03 |
| Stress Biomarkers:Attaching Biological Meaning to Field Friendly Salivary Measures Metyrapone, Dexamethasone, Cortrosyn - Stress | Phase 1 | Completed | University of Michigan | 256 | 2012-10-01 | 2018-04-23 |
| Cosyntropin Versus Epidural Blood Patch (EBP) for Treatment of Treatment of Post Dural Puncture Headache Cosyntropin, Epidural Blood Patch - Postdural Puncture Headache | Phase 4 | Completed | United States Naval Medical Center, San Diego | 29 | 2010-08-01 | 2016-11-01 |
| The Adrenal Contribution to Androgen Production in Girls During Puberty Adrenocorticotropin, Dexamethasone - Development | Phase 3 | Completed | University of California, San Diego | 50 | 2010-02-01 | 2019-08-26 |
| Mechanisms of Increased Androgen Production Among Women With Polycystic Ovary Syndrome 3-D Ultrasound, recombinant human chorionic gonadotropin, Recombinant human follicle stimulating hormone - Polycystic Ovary Syndrome | Not applicable | Completed | University of California, San Diego | 41 | 2009-09-01 | 2018-06-04 |
| Adrenal Responsiveness During the Perioperative Period in Children Undergoing Congenital Cardiac Surgery Cosyntropin - Adrenal Cortex Diseases, Infant Morbidity | Phase 1 | Completed | Mayo Clinic | 35 | 2009-03-01 | 2014-06-16 |
| Determination of Method-specific Normal Cortisol and Adrenal Hormone Responses to the Short Synacthen Test Synacthen (Tetracosactrin) - Healthy, Adrenal Insufficiency | Phase 4 | Completed | Cardiff University | 165 | 2008-09-01 | 2020-08-12 |
| Effect of Etomidate on Hemodynamics and Adrenocortical Function After Cardiac Surgery Etomidate, Propofol, Hydrocortisone - Coronary Artery Disease, Mitral Valve Regurgitation | Phase 4 | Completed | Insel Gruppe AG, University Hospital Bern | 130 | 2006-11-01 | 2010-03-04 |
Showing 20 of 23. Sign in to see all of them.
Adrenal Insufficiency (6) · Polycystic Ovary Syndrome (4) · Fibrosis (2) · Obesity (2) · Post-Dural Puncture Headache (2) · Abetalipoproteinemia (1) · Addison Disease (1) · Adrenal Cortex Diseases (1) · Bone Diseases, Metabolic (1) · Brain Injuries (1) · Coronary Artery Disease (1) · Craniocerebral Trauma (1) · Hypertension (1) · Hypopituitarism (1) · Lecithin Cholesterol Acyltransferase Deficiency (1)
University of Virginia (5) · University of California, San Diego (2) · Benjamin Viglianti (1) · Brigham and Women's Hospital (1) · Cardiff University (1) · Haukeland University Hospital (1) · Hospices Civils de Lyon (1) · Insel Gruppe AG, University Hospital Bern (1) · Istanbul University (1) · Johns Hopkins University (1) · Mallinckrodt ARD LLC (1) · Mayo Clinic (1) · National Center for Research Resources (NCRR) (1) · Nationwide Children's Hospital (1) · Sheffield Children's NHS Foundation Trust (1)
United States (15) · Turkey (Türkiye) (2) · United Kingdom (2) · Bulgaria (1) · France (1) · Israel (1) · Italy (1) · Mexico (1) · Norway (1) · Serbia (1) · Spain (1) · Switzerland (1)
Christine Burt Solorzano, MD (2) · Aled Rees, MB BCh, PhD (1) · Alfredo J Gamboa, MD (1) · Benjamin L Viglianti, M.D, Ph.D. (1) · Bora Uslu, Fellow (1) · Charlotte Elder (1) · Chris McCartney, MD (1) · Fatih Tufan, Fellow (1) · Gail Adler, MD, PhD (1) · James L Abelson, MD (1)
PMID 23761380, PMID 26914224, PMID 29452421, PMID 31915040, PMID 32353115, PMID 32761088, PMID 34788228, PMID 35725670, PMID 40393818
2015 (1), 2017 (1), R01HL102387 (1), U54HD028934 (1)