124 completed, 61 unknown, 24 recruiting, 13 terminated. 119 Not applicable, 10 Phase 2, 9 Phase 3, 9 Phase 4, 5 Phase 1.
Follow Mechanical Ventilation Complication: new trials by email Literature Review of Mechanical Ventilation Complication trials Research Report on Mechanical Ventilation Complication
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Enteral Feeding in Mechanically Ventilated Children Critical Illness, Mechanical Ventilation Complication | Not yet recruiting | Assiut University | 60 | 2026-10-26 | 2026-10-21 | |
| BURN-ASV Trial: Adaptive Support Ventilation in Severe Burn Injury Adaptive Support Ventilation (ASV), Conventional Lung-Protective Mechanical Ventilation - Burn, Mechanical Ventilation | Not applicable | Not yet recruiting | Ukrainian Society of Regional Anesthesia and Pain Therapy | 100 | 2026-09-23 | 2026-06-29 |
| Mechanical Power and Mortality in Mechanically Ventilated Adults Mechanical Ventilation Complication, Ventilator Induced Lung Injury | Not yet recruiting | Zagazig University | 116 | 2026-09-10 | 2026-09-23 | |
| Silent Aspiration Following Extubation in the ICU Fiberoptic Endoscopic Evaluation of Swallowing (FEES) - Silent Aspiration, Post-Extubation Dysphagia | Not yet recruiting | Cleveland Clinic Abu Dhabi | 274 | 2026-06-01 | 2026-06-09 | |
| Effects of Mechanical Insufflation-Exsufflation With Optimized Settings on Wet Mucus Volume During Invasive Ventilation MI-E Intervention protocol, Standard MI-E setting - Mucus Retention, Mechanical Ventilation Complication | Not applicable | Recruiting | Hospital Clinic of Barcelona | 26 | 2026-05-08 | 2026-05-08 |
| ClusterVAP: Multicentre Proteomic Endotyping of Ventilator-associated Pneumonia Ventilator Acquired Pneumonia, Mechanical Ventilation Complication | Recruiting | Region Skane | 400 | 2026-05-01 | 2026-06-30 | |
| Ventilator-based Inspiratory Muscle Training for Patients With Respiratory Failure adjustment of parameters on mechanical ventilation device, routine plan of weaning and Conventional Chest Physiotherapy - Respiratory Failure, Mechanical Ventilation Complication | Not applicable | Not yet recruiting | Cairo University | 60 | 2026-01-01 | 2026-01-20 |
| Mechanical Insufflation-exsufflation and Hypertonic Saline in Nosocomial Bacterial Respiratory Tract Infection Mechanical insufflation-exsufflation, Standard of Care, Hypertonic saline with hyaluronic acid - Nosocomial Infection, Nosocomial Pneumonia | Not applicable | Not yet recruiting | Hospital San Carlos, Madrid | 100 | 2026-01-01 | 2025-03-26 |
| Nebulized Furosemide, Heparin, Hypertonic Saline in Mechanically Ventilated Acute Respiratory Distress Syndrome Adult Patients nebulization - Respiratory Distress Syndrome, Mechanical Ventilation Complication | Not applicable | Not yet recruiting | Tanta University | 344 | 2026-01-01 | 2025-12-16 |
| Controlled Versus Standard Oxygen Therapy in ICU Patients With Acute Exacerbation of COPD Controlled oxygen therapy, Standard oxygen therapy - Chronic Obstructive Pulmonary Disease (COPD), Acute Exacerbation of COPD | Not applicable | Recruiting | Hôpital Universitaire Taher Sfar | 240 | 2026-01-01 | 2026-09-25 |
| Targeting prEssure-Muscle-index to Avoid Ventilatory Over-Assistance During Pressure Support Ventilation Variation of Pressure Support Levels - Acute Hypoxemic Respiratory Failure, Mechanical Ventilation Complication | Not applicable | Recruiting | Centre for Medical Sciences | 36 | 2025-10-08 | 2026-06-05 |
| EIT-guided PEEP Titration Versus Standard Ventilation in Bariatric Surgery Group P-eit, Group P-8 - Electrical Impedance Tomography (EIT), Postoperative Pulmonary Complications (PPCs) | Not applicable | Recruiting | Jianbo Wu | 118 | 2025-07-28 | 2025-10-06 |
| Prevalence of Pain in Mechanically Ventilated Patients in Intensive Care Units Sedation and Analgesia, Pain Intensity Assessment | Recruiting | Centro Universitário Augusto Motta | 370 | 2025-06-01 | 2025-09-19 | |
| VentilO Prospective Study Clinicians, VenitlO - Mechanical Ventilation Complication, Respiratory Acidosis | Not applicable | Recruiting | Laval University | 76 | 2025-04-24 | 2025-09-04 |
| Efficacy and Safety of Remimazolam Besylate for Sedation in Post-Non-Cardiac Surgery Patients Requiring Mechanical Ventilation Remimazolam Besylate, Dexmedetomidine Hydrochloride - Effect of Drug, Adverse Drug Event | Phase 4 | Recruiting | Beijing Shijitan Hospital, Capital Medical University | 306 | 2025-01-20 | 2026-06-16 |
| Lung Recruitment and PEEP Effects on Intracranial Pressure in Cranial Surgery Subdural pressure measurement - Intracranial Pressure Increase, Mechanical Ventilation Complication | Not yet recruiting | University of Chile | 20 | 2025-01-01 | 2025-01-13 | |
| Flow Controlled Ventilation in Robot-assisted Laparoscopic Surgery Flow-controlled ventilation, Pressure-controlled ventilation - Mechanical Ventilation Complication, Postoperative Pulmonary Atelectasis | Not applicable | Withdrawn | Cantonal Hospital of St. Gallen | 2024-10-29 | 2025-04-24 | |
| Maximum Inspiratory Pressure, Grip Strength and Physical Functional Status Relationship in MV Patients HG and NIF - Mechanical Ventilation Complication, Intensive Care Medicine | Completed | Saglik Bilimleri Universitesi | 47 | 2024-09-19 | 2025-05-13 | |
| Ventilator Settings for Bronchoscopy During Mechanical Ventilation: a Randomized Controlled Study specific ventilator settings - Mechanical Ventilation Complication, Fiberoptic Bronchoscopy | Not applicable | Completed | Centre Hospitalier Arras | 46 | 2024-09-10 | 2025-07-08 |
| TESTO-TRIAL: Use of Testosterone in Critically Ill Patients Testosterone cypionate (200mg/3ml), Sesame oil (3ml) - Weaning Failure, Muscle Weakness | Phase 4 | Active not recruiting | Leticia Maria Defendi Barboza Marson | 94 | 2024-09-09 | 2024-12-18 |
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Critical Illness (25) · Respiratory Insufficiency (23) · Respiratory Distress Syndrome (16) · Ventilator-Induced Lung Injury (15) · Delirium (12) · Pneumonia, Ventilator-Associated (11) · COVID-19 (10) · Respiratory Aspiration (10) · Postoperative Complications (8) · Muscle Weakness (7) · Pain (6) · Agnosia (5) · Pneumonia (5) · Lung Injury (4) · Pulmonary Atelectasis (4)
Respiratory Tract Diseases (100) · Pathological Conditions, Signs and Symptoms (86) · Lung Diseases (68) · Pathologic Processes (63) · Respiration Disorders (52) · Signs and Symptoms (39) · Disease Attributes (38) · Nervous System Diseases (31) · Infections (29) · Neurologic Manifestations (26) · Respiratory Tract Infections (25) · Pneumonia (21) · Lung Injury (20) · Mental Disorders (18) · Neurobehavioral Manifestations (17)
Dexmedetomidine (7) · Propofol (6) · Fentanyl (4) · Saline Solution (4) · Standard of Care (3) · Ultrasonography (3) · Control Groups (2) · Early Ambulation (2) · Hyaluronic Acid (2) · Midazolam (2) · Observation (2) · Positive-Pressure Respiration (2) · Prone Position (2) · Respiration, Artificial (2) · 3,6-di-O-acetyl-2-deoxy-D-glucopyranose (1)
University Health Network, Toronto (6) · Università degli Studi di Ferrara (6) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (4) · Assiut University (4) · Centre hospitalier de l'Université de Montréal (CHUM) (4) · Corporacion Parc Tauli (4) · Laval University (4) · Ohio State University (4) · Australian and New Zealand Intensive Care Research Centre (3) · Cairo University (3) · Duke University (3) · Hospital de Clinicas de Porto Alegre (3) · Johns Hopkins University (3) · Royal Brompton & Harefield NHS Foundation Trust (3) · Tanta University (3)
United States (35) · Italy (23) · Canada (18) · Egypt (17) · France (16) · Spain (15) · China (14) · Turkey (Türkiye) (14) · Brazil (13) · Netherlands (10) · United Kingdom (9) · Germany (7) · Australia (4) · Chile (4) · Switzerland (4)
Ewan Goligher, MD, PhD (4) · Martin Girard, MD, FRCPC (3) · Aidan Burrell, MBBS (2) · Barbara Smith, PhD, PT (2) · David MP van Meenen, PhD (2) · Dong-Xin Wang, MD, PhD (2) · Ewan C Goligher, MD, PhD (2) · Frederique Paulus, PhD (2) · Jian-Xin Zhou, MD (2) · Mariangela Pellegrini, MD, PhD (2) · Stefan J Schaller, MD (2) · Aarti Sarwal, MD (1) · Abraham Schoe, MD, PhD (1) · Adel Mohamed, MD (1) · Ahmed A Ibrahim, Lecturer of anesthesia, Icu (1)
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1UG3HL165740-01A1 (1), 2016 (1), 2023 (1), 2025 (1), 4UH3HL165740-02 (1), K23DC013569 (1), R01AR072328 (1), R01HL121228 (1), R01HL146781 (1), R01NR007652 (1), R01NR017433 (1), R34HL125859 (1), U24TR001608 (1)