159 completed, 44 recruiting, 43 unknown, 24 terminated. 107 Not applicable, 49 Phase 2, 33 Phase 3, 28 Phase 1, 3 Early Phase 1.
Follow this condition Literature Review of Cachexia trials Research Report on Cachexia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Routine Validation and Reproducibility Testing of Laboratory Assays and Research Techniques Used for Endocrine, Cardiometabolic, and Musculoskeletal Disorder Research (VALD) Endothelial cell collection - Obesity and Obesity-related Medical Conditions, Diabetes | Recruiting | Bettina Mittendorfer | 100 | 2027-01-01 | 2026-05-07 | |
| Building Opportunities for Nurturing Care to Enhance Child Development in Eastern and Southern Africa Friendship Bench, Infant and Young Child Feeding (IYCF) Curriculum, Play-Based Curriculum - Neurodevelopment, Child Growth | Not applicable | Not yet recruiting | University of Washington | 1260 | 2026-11-01 | 2026-03-03 |
| A Study to Learn About the Study Medicine Called Ponsegromab in Adults With Lung Cancer-Associated Significant Body Weight Loss ponsegromab, placebo - Non-small Cell Lung Cancer (NSCLC), Cachexia | Phase 1 | Not yet recruiting | Pfizer | 80 | 2026-10-23 | 2026-09-25 |
| A Multimodal Integrated Intervention for Kidney Cachexia Multi-Modal Integrated Intervention Combining Exercise, Anti-inflammatory & Dietary Advice (MMIEAD) - Cachexia, CKD | Not applicable | Recruiting | Queen's University, Belfast | 40 | 2026-09-01 | 2026-08-26 |
| Hospital-Based Prospective Cohort of Malnutrition Under 6-Month Study (HOSPIC-6-Study) Not applicable- observational study - Malnutrition, Infant, Malnutrition | Recruiting | Universitas Indonesia | 1780 | 2026-08-28 | 2026-10-20 | |
| Using Strength Tests to Better Understand How Pancreatic Cancer Affects Muscle Mass and Quality of Life Hand grip strength assessments using a dynamometer - Pancreatic Ductal Adenocarcinoma (PDAC), Hand Grip Strength | Not applicable | Recruiting | British Columbia Cancer Agency | 50 | 2026-08-13 | 2026-09-15 |
| Effectiveness of Positive Deviance/Hearth in Treating Uncomplicated Moderate Acute Malnutrition in Children 6-59 Months in Mymensingh Division, Bangladesh PD/Hearth is a behavioral change program that teaches caregivers how to cook and feed their children. A nutrient-dense meal using local ingredients will be fed to children during Hearth sessions., Standard of Care (Investigator Selected) - Moderate Acute Malnutrition (MAM), Undernutrition | Not applicable | Enrolling by invitation | World Vision US | 400 | 2026-07-08 | 2026-10-21 |
| Nanocrystalline Megestrol Acetate Versus Placebo for Anorexia in Patients With Unresectable Hepatocellular Carcinoma Receiving TACE Combined With Targeted and Immunotherapy Nanocrystalline megestrol acetate, Placebo - Hepatocellular Carcinoma (HCC), Cachexia | Phase 2 | Not yet recruiting | Nanfang Hospital, Southern Medical University | 88 | 2026-06-22 | 2026-05-04 |
| A Phase I Clinical Study to Evaluate the Efficacy and Safety of GB18 Injection in Patients With Tumor Cachexia GB18 - Cachexia; Cancer | Phase 1 | Recruiting | Kexing Biopharm Co., Ltd. | 18 | 2026-06-10 | 2026-06-12 |
| Phase 2 Cachexia Clinical Trial to Evaluate the Efficacy and Safety of ASCA101 Active Comparator, ASCA101 24.32mg/kg, ASCA101 32.43mg/kg - Cachexia; Cancer | Phase 2 | Recruiting | MetaFines | 135 | 2026-05-08 | 2026-06-17 |
| Regular Growth Monitoring (RGM) of Young Children in Guinea-Bissau Regular Growth Monitoring (RGM) by Community Health Agents - Severe Acute Malnutrition, Moderate Acute Malnutrition (MAM) | Not applicable | Active not recruiting | Trustees of Dartmouth College | 400 | 2026-05-05 | 2026-07-15 |
| Telemedicine Nutritional Counseling for Cancer Cachexia in Pakistan Telemedicine-Delivered Nutritional Counseling, Standard In-Person Nutritional Counseling - Cachexia; Cancer; Sarcopenia | Not applicable | Active not recruiting | King Edward Medical University | 80 | 2026-05-01 | 2026-06-08 |
| Intestinal Microbiota Transplantation for Treating Advanced Tumor Cachexia FMT capsule - Cachexia; Cancer, Fecal Microbiota Transplantation (FMT) | Phase 2 | Not yet recruiting | Hua Jiang | 66 | 2026-05-01 | 2026-04-16 |
| A Clinical Study of Nanocrystalline Megestrol Acetate in Concurrent Chemoradiotherapy for Locally Advanced Cervical Cancer Nanocrystalline Megestrol Acetate Oral Suspension - Locally Advanced Cervical Cancer, Cachexia | Phase 1 | Recruiting | Second Xiangya Hospital of Central South University | 88 | 2026-04-30 | 2026-04-24 |
| Study of the Safety and Efficacy of DS010 in Patients With Cancer Cachexia DS010 injection - Cancer, Cachexia | Phase 1 / Phase 2 | Not yet recruiting | Dartsbio Pharmaceuticals Ltd. | 58 | 2026-04-30 | 2026-04-15 |
| Spatial Multi-omics and Intelligent Early Warning of Pancreatic Cancer Cachexia Pancreatic Cancer, Cachexia; Cancer; Sarcopenia | Recruiting | Peking Union Medical College Hospital | 500 | 2026-04-24 | 2026-06-26 | |
| Visugromab in Cachexia International Trial Visugromab (CTL-002), Placebo - Cancer-associated Cachexia | Phase 2 / Phase 3 | Recruiting | CatalYm GmbH | 518 | 2026-04-16 | 2026-09-22 |
| Study on the Pathogenesis and Reversal Strategies of Cancer Cachexia Based on Multi-Omics Validation of intervention efficacy through enhanced intervention in nutritionally high-risk patients, Standard nutritional intervention was administered as a positive control to validate experimental efficacy., Administration of placebo as a negative control to validate experimental efficacy - Cachexia; Cancer; Sarcopenia | Not applicable | Recruiting | China Medical University, China | 1000 | 2026-03-18 | 2026-04-09 |
| Reduced Dosage and/or Visitation Protocol for the Treatment of Acute Malnutrition in Kenya WHO-reduced, WHO-full, Kenya-IMAM - Acute Malnutrition in Childhood, Acute Malnutrition, Severe | Not applicable | Not yet recruiting | International Food Policy Research Institute | 2274 | 2026-03-01 | 2026-02-19 |
| Effectiveness of Small-Quantity vs Medium-Quantity Lipid-Based Nutrient Supplements for Prevention of Undernutrition in Young Children Medium-quantity lipid-based nutrient supplement (MQ-LNS), Small-quantity lipid-based nutrient supplement (SQ-LNS) - Undernutrition | Not applicable | Recruiting | Aga Khan University | 1568 | 2026-02-26 | 2026-09-03 |
Showing 20 of 300. Sign in to see all of them.
Neoplasms (77) · Anorexia (43) · Malnutrition (43) · Weight Loss (30) · Pancreatic Neoplasms (29) · Carcinoma, Non-Small-Cell Lung (27) · Growth Disorders (25) · Sarcopenia (24) · Lung Neoplasms (16) · Severe Acute Malnutrition (15) · Motor Activity (14) · Muscular Atrophy (14) · Pulmonary Disease, Chronic Obstructive (13) · Thinness (13)
Pathological Conditions, Signs and Symptoms (300) · Signs and Symptoms (300) · Body Weight Changes (294) · Body Weight (293) · Thinness (287) · Weight Loss (270) · Neoplasms by Site (89) · Nutritional and Metabolic Diseases (79) · Nutrition Disorders (72) · Neoplasms (71) · Pathologic Processes (66) · Digestive System Diseases (54) · Respiratory Tract Diseases (54) · Lung Diseases (52) · Signs and Symptoms, Digestive (51)
Megestrol Acetate (14) · Exercise (7) · Standard of Care (6) · Blood Specimen Collection (4) · Olanzapine (4) · GSK2881078 (3) · Ibuprofen (3) · Infliximab (3) · Nutrition Assessment (3) · Amoxicillin (2) · Cholecalciferol (2) · Cyproheptadine (2) · Diet Therapy (2) · Dietary Supplements (2) · Enteral Nutrition (2)
International Food Policy Research Institute (7) · National Taiwan University Hospital (6) · Pfizer (6) · University of Erlangen-Nürnberg Medical School (6) · Aga Khan University (5) · GlaxoSmithKline (5) · M.D. Anderson Cancer Center (5) · Norwegian University of Science and Technology (5) · The University of Texas Medical Branch, Galveston (5) · Helsinn Therapeutics (U.S.), Inc (4) · Novartis Pharmaceuticals (4) · University of Edinburgh (4) · Wake Forest University Health Sciences (4) · Alliance for Clinical Trials in Oncology (3) · Andrew Hendifar, MD (3)
United States (90) · United Kingdom (23) · Germany (21) · China (20) · Canada (17) · France (14) · Italy (12) · Pakistan (12) · Poland (12) · Taiwan (12) · Belgium (10) · India (10) · Denmark (8) · Kenya (8) · Netherlands (8)
Aminah Jatoi, MD (4) · Andrew Hendifar, MD (2) · Annemie Schols, PhD (2) · Dejan Reljic, Dr. (2) · Elodie Becquey, PhD (2) · Ihab Tewfik, PhD (2) · Lieven Huybregts, PhD (2) · Lynn D Kramer, MD (2) · Mark J Manary, MD (2) · Melinda Sheffield-Moore, Ph.D. (2) · Melinda Sheffield-Moore, PhD (2)
PMID 28472437, PMID 26906526, PMID 39992021, PMID 42665333, PMID 11786587, PMID 12457271, PMID 12648025, PMID 14602249, PMID 15197210, PMID 15778874, PMID 15857739, PMID 16314085, PMID 16317825, PMID 16376734, PMID 16408219, PMID 1666930, PMID 16843954, PMID 16849753, PMID 17566383, PMID 17589370, PMID 17662149, PMID 17674351, PMID 18257397, PMID 18293016, PMID 18402303, PMID 18728826, PMID 18989154, PMID 19342610, PMID 19587829, PMID 19665818, PMID 19883531, PMID 19896326, PMID 20060626, PMID 20076976, PMID 20392703, PMID 20937647, PMID 21093718, PMID 21296615, PMID 21343383, PMID 21448087, PMID 21475692, PMID 22076835, PMID 22419719, PMID 22795905, PMID 22831162, PMID 23006802, PMID 23141881, PMID 23439759, PMID 23499390, PMID 24067666
2018 (2), R01CA127971 (2), U10CA081920 (2), 2017 (1), 2023 (1), 2025 (1), K01TW009987 (1), P30CA012197 (1), P30CA043703 (1), P30CA069533 (1), R01AR060209 (1), R01HD103642 (1), R33HD110150 (1), R43AR054993 (1), R44AR054993 (1)