23 terminated. 23 Phase 3, 5 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 23 | Terminated 23 |
| Phase 2 | 5 | Terminated 5 |
Follow Lung Injury: new trials by email Literature Review of Lung Injury trials Research Report on Lung Injury
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Individualized Positive End-expiratory Pressure Guided by End-expiratory Lung Volume in the Acute Respiratory Distress Syndrome Invasive Mechanical ventilation, Neuromuscular Blocking Agents, Prone positioning - Respiratory Distress Syndrome, Adult | Phase 3 | Terminated | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 18 | 2022-11-01 | 2025-09-30 |
| Inhaled ZYESAMI™ (Aviptadil Acetate) for the Treatment of Severe COVID-19 ZYESAMI™ (aviptadil acetate), Placebo, Nebulized administration of ZYESAMI™ or Placebo - SARS-CoV 2, COVID | Phase 2 / Phase 3 | Terminated | APR Applied Pharma Research s.a. | 144 | 2021-02-15 | 2023-02-03 |
| Dociparstat for the Treatment of Severe COVID-19 in Adults at High Risk of Respiratory Failure Dociparstat sodium, Placebo - Coronavirus Disease 2019 (COVID-19), Acute Lung Injury | Phase 2 / Phase 3 | Terminated | Jazz Pharmaceuticals | 27 | 2020-07-08 | 2022-08-30 |
| Efficacy and Safety Study of IV Ravulizumab in Patients With COVID-19 Severe Pneumonia Ravulizumab, BSC - COVID-19 Severe Pneumonia, Acute Lung Injury | Phase 3 | Terminated | Alexion Pharmaceuticals, Inc. | 202 | 2020-05-10 | 2022-05-24 |
| Maternal Omega-3 Supplementation to Reduce Bronchopulmonary Dysplasia DHA-rich algal oil, Placebo - Bronchopulmonary Dysplasia, Child Development | Phase 3 | Terminated | CHU de Quebec-Universite Laval | 461 | 2015-06-23 | 2026-08-13 |
| Study of Inhaled Nitric Oxide (iNO) and Respiratory Outcomes in Late Preterm Infants inhaled nitric oxide, Placebo Comparator - nitrogen gas - Bronchopulmonary Dysplasia | Phase 2 / Phase 3 | Terminated | Tufts Medical Center | 3 | 2013-03-01 | 2017-07-19 |
| Flow-flow ECCO2-R and 4 ml/kg Tidal Volume vs. 6 ml/kg Tidal Volume to Enhance Protection From VILI in Acute Lung Injury ARDS-Net Strategy, ECCO2-R - Acute Respiratory Distress Syndrome | Phase 3 | Terminated | University of Turin, Italy | 230 | 2012-04-01 | 2014-06-17 |
| INR-Triggered Transfusion In GI Bleeders From ER Transfuse plasma to High INR target, Transfuse plasma to Low INR target - Respiratory Distress Syndrome, Adult, Gastrointestinal Hemorrhage | Phase 3 | Terminated | University of Colorado, Denver | 50 | 2011-07-01 | 2017-03-27 |
| Effect of Enteral Nutrition Support for Critically Ill Patients Enteral nutrition with fatty acids, Standard Enteral Nutrition - Respiratory Distress Syndrome,Adult, Acute Lung Injury | Phase 3 | Terminated | Abbott Nutrition | 84 | 2010-04-01 | 2011-11-04 |
| Low Doses Corticosteroids as Adjuvant Therapy for the Treatment of Severe H1N1 Flu hydrocortisone, isotonic saline - Pneumonia, Viral, Influenza in Humans | Phase 3 | Terminated | University of Versailles | 40 | 2010-03-01 | 2014-12-18 |
| Statins for Acutely Injured Lungs From Sepsis Rosuvastatin, Placebo - Sepsis, Acute Lung Injury | Phase 3 | Terminated | National Heart, Lung, and Blood Institute (NHLBI) | 745 | 2010-01-01 | 2016-05-16 |
| The Oscillation for Acute Respiratory Distress Syndrome (ARDS) Treated Early (OSCILLATE) Trial SensorMedics 3100B High Frequency Oscillatory Ventilator, Lung Protective Ventilation - Acute Respiratory Distress Syndrome (ARDS) | Phase 3 | Terminated | Canadian Critical Care Trials Group | 548 | 2009-06-01 | 2015-08-06 |
| Comparative Evaluation of Albumin and Starch Effects in Acute Lung Injury (ALI) 5% human albumin, 6% hetastarch - Lung Injury, Acute (ALI), Respiratory Distress Syndrome, Acute (ARDS) | Phase 3 | Terminated | Emory University | 31 | 2009-01-01 | 2017-04-28 |
| Inhaled Nitric Oxide and Neuroprotection in Premature Infants inhaled nitric oxide, oxygen - Prematurity, Bronchopulmonary Dysplasia | Phase 2 / Phase 3 | Terminated | University of Chicago | 273 | 2008-05-01 | 2024-10-17 |
| Early Versus Delayed Enteral Feeding and Omega-3 Fatty Acid/Antioxidant Supplementation for Treating People With Acute Lung Injury or Acute Respiratory Distress Syndrome (The EDEN-Omega Study) Minimal (Trophic) Feeding, Full Feeding, Omega-3 Fatty Acids and Antioxidant Supplements - Respiratory Distress Syndrome, Adult | Phase 3 | Terminated | National Heart, Lung, and Blood Institute (NHLBI) | 272 | 2007-12-01 | 2016-04-13 |
| Drug Study of Albuterol to Treat Acute Lung Injury Albuterol Sulfate, Mini-Bronchoalveolar Lavage (BAL), Placebo - Respiratory Distress Syndrome, Adult | Phase 2 / Phase 3 | Terminated | National Heart, Lung, and Blood Institute (NHLBI) | 282 | 2007-08-01 | 2017-02-10 |
| Probiotics for the Prevention of Premature Birth and Neonatal Related Morbidity Lactobacillus rhamnosus GR1 and Lactobacillus reuteri RC-14 - Bacterial Vaginosis, Premature Birth | Phase 3 | Terminated | Oswaldo Cruz Foundation | 645 | 2006-01-01 | 2011-06-15 |
| Management of Hyponatremia in Preterm Infants on Diuretics Sodium supplementation, Fluid restriction - Bronchopulmonary Dysplasia, Hyponatremia on Diuretics | Phase 3 | Terminated | The University of Texas Health Science Center, Houston | 58 | 2005-04-01 | 2007-12-27 |
| Efficacy and Safety of 3 Doses of HL10 Given at Fixed Time Intervals Compared to Standard Therapy HL 10 - Acute Lung Injury, Acute Respiratory Distress Syndrome | Phase 3 | Terminated | LEO Pharma | 418 | 2003-01-01 | 2025-02-24 |
| Phase III Randomized Study of Lucinactant in Full Term Newborn Infants With Meconium Aspiration Syndrome Lucinactant, Standard Care - Meconium Aspiration | Phase 3 | Terminated | Windtree Therapeutics | 69 | 2000-03-01 | 2012-05-03 |
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Respiratory Distress Syndrome (15) · Acute Lung Injury (11) · Bronchopulmonary Dysplasia (6) · Respiratory Insufficiency (4) · Meconium Aspiration Syndrome (3) · Premature Birth (3) · COVID-19 (2) · Hypertension, Pulmonary (2) · Leukomalacia, Periventricular (2) · Methemoglobinemia (2) · Persistent Fetal Circulation Syndrome (2) · Pneumonia, Aspiration (2) · Pneumonia, Viral (2) · Respiratory Distress Syndrome, Newborn (2) · Sepsis (2)
Lung Diseases (23) · Respiratory Tract Diseases (22) · Respiration Disorders (16) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (9) · Infant, Newborn, Diseases (9) · Infant, Premature, Diseases (8) · Infections (7) · Pathological Conditions, Signs and Symptoms (7) · Female Urogenital Diseases and Pregnancy Complications (6) · Pathologic Processes (6) · Pregnancy Complications (6) · Urogenital Diseases (6) · Ventilator-Induced Lung Injury (6) · Respiratory Tract Infections (5)
Sodium Chloride (4) · Saline Solution (2) · Airway Extubation (1) · Albuterol (1) · Dexamethasone (1) · Endothelium-Dependent Relaxing Factors (1) · Enteral Nutrition (1) · Fatty Acids (1) · Fatty Acids, Omega-3 (1) · Hydrocortisone (1) · Hydroxyethyl Starch Derivatives (1) · Inosine (1) · Neuromuscular Blocking Agents (1) · Oxygen (1) · Prone Position (1)
NICHD Neonatal Research Network (3) · National Heart, Lung, and Blood Institute (NHLBI) (3) · APR Applied Pharma Research s.a. (1) · Abbott Nutrition (1) · Alexion Pharmaceuticals, Inc. (1) · CHU de Quebec-Universite Laval (1) · Canadian Critical Care Trials Group (1) · Emory University (1) · Fondazione Policlinico Universitario Agostino Gemelli IRCCS (1) · Jazz Pharmaceuticals (1) · LEO Pharma (1) · Oswaldo Cruz Foundation (1) · The University of Texas Health Science Center, Houston (1) · Tufts Medical Center (1) · University of Chicago (1)
United States (16) · Canada (4) · France (3) · Italy (2) · Spain (2) · United Kingdom (2) · Austria (1) · Belgium (1) · Brazil (1) · Chile (1) · Denmark (1) · Finland (1) · Germany (1) · India (1) · Japan (1)
Avroy A. Fanaroff, MD (3) · Edward F. Donovan, MD (3) · Lu-Ann Papile, MD (3) · Richard A. Ehrenkranz, MD (3) · Seetha Shankaran, MD (3) · Sheldon B. Korones, MD (3) · Barbara J. Stoll, MD (2) · Charles R. Bauer, MD (2) · David K. Stevenson, MD (2) · Mary Wearden, MD (2) · Waldemar A. Carlo, MD (2) · William Oh, MD (2) · A. Johnston, MD (1) · A. Solimano, MD (1) · Abbot R. Laptook, MD (1)
PMID 27440140, PMID 10802492, PMID 11150359, PMID 11416871, PMID 12219057, PMID 14510322, PMID 14993550, PMID 17307536, PMID 19713451, PMID 20591191, PMID 20633284, PMID 21562125, PMID 21976613, PMID 22059409, PMID 22120766, PMID 22307571, PMID 23339639, PMID 24835849, PMID 26138630, PMID 26192398, PMID 26832963, PMID 26936876, PMID 32554923, PMID 32660611, PMID 32662862, PMID 33231656, PMID 33784416, PMID 33826106, PMID 34473343, PMID 34728723, PMID 35057852, PMID 35244208, PMID 35403244, PMID 35413719, PMID 35508343, PMID 35652296, PMID 36119770, PMID 36958364, PMID 37268036, PMID 37452341, PMID 39396702, PMID 9036320, PMID 9190553
M01RR000070 (3), M01RR000750 (3), M01RR000997 (3), M01RR001032 (3), M01RR006022 (3), M01RR008084 (3), N01HR056179 (3), U10HD021373 (3), U10HD021385 (3), U10HD021397 (3), U10HD021415 (3), U10HD027853 (3), U10HD027871 (3), U10HD027880 (3), U10HD027881 (3)