15 completed, 8 terminated, 6 unknown, 5 recruiting. 8 Not applicable, 8 Phase 2, 5 Phase 3, 4 Phase 1, 4 Phase 4.
Follow Persistent Fetal Circulation Syndrome: new trials by email Literature Review of Persistent Fetal Circulation Syndrome trials Research Report on Persistent Fetal Circulation Syndrome
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Post Market Clinical Follow-up to Assess the Portable Nitric Oxide Generation and Delivery System (INOwill N200) for the Treatment of Neonatal Hypoxic Respiratory Failure Complicated by Pulmonary Hypertension Nitric Oxide Generator and Delivery System - Persistent Pulmonary Hypertension of the Newborn, Hypoxic Respiratory Failure | Not yet recruiting | Novlead Inc. | 50 | 2026-10-01 | 2026-09-24 | |
| Close Loop Smart Weaning for INO With PPHN Nitric Oxide Generation and Delivery System - Persistent Pulmonary Hypertension of the Newborn, Inhaled Nitric Oxide | Not applicable | Recruiting | Children's Hospital of Fudan University | 30 | 2025-10-01 | 2026-05-13 |
| Effect of Melatonin on Pulmonary Hypertension in Full Term Neonates Melatonin, nitric oxide generator - Congenital Peumonia, Persistent Pulmonary Hypertension of Newborn | Not applicable | Recruiting | Ain Shams University | 52 | 2025-07-01 | 2026-10-22 |
| The Relationship Between Umbilical Cord Coiling Index and Fetal Cardiac Functions. Determining the relationship between the coiling number and fetal echocardiography findings. - Umbilical Cord Coiling Index and Fetal Cardiac Functions | Completed | Sanliurfa Education and Research Hospital | 202 | 2025-03-01 | 2025-11-18 | |
| Treprostinil in Newborns With Pulmonary Hypertension; a Non-Interventional Study to Collect Data on Drug Utilization, Safety, and Effectiveness Persistent Pulmonary Hypertension of Newborn | Recruiting | Ferrer Internacional S.A. | 60 | 2025-02-25 | 2025-09-03 | |
| The Effect Of Nebulizied Nitroglycerin As An Adjuvant Therapy For Persistent Pulmonary Hypertension Of Newborns Nebulized nitroglycerine as adjunctive therapy, conventional therapy for PPHN - Persistent Pulmonary Hypertension of the Newborn, Echocardiography | Not applicable | Completed | Alexandria University | 80 | 2024-01-01 | 2025-06-29 |
| Efficacy of Milrinone With Sildenafil in Persistent Pulmonary Hypertension in Children Sildenafil, Milrinone - Persistent Pulmonary Hypertension of the Newborn | Not applicable | Completed | Muhammad Aamir Latif | 42 | 2023-12-01 | 2024-08-26 |
| Preductal Oxygen Saturation Target in Term and Late Preterm Neonates With Hypoxemic Respiratory Failure or Pulmonary Hypertension 95% - 99% SpO2 target - Persistent Pulmonary Hypertension of the Newborn, Hypoxemic Respiratory Failure | Not applicable | Active not recruiting | University of California, Davis | 54 | 2021-08-01 | 2026-04-08 |
| NEURodevelopmental Outcome After Persistent Pulmonary Hypertension Of the Newborn Ages & Stages Questionnaires®, Third Edition (ASQ3) - Persistent Pulmonary Hypertension of the Newborn | Not applicable | Completed | University Hospital, Toulouse | 55 | 2021-07-25 | 2021-11-23 |
| Nebulized Magnesium Sulfate and Sildenafil for Persistent Pulmonary Hypertension of Newborn Magnesium sulfate, Sildenafil Citrate, Isotonic saline - Persistent Pulmonary Hypertension of Newborn | Phase 1 / Phase 2 | Recruiting | Sohag University | 40 | 2021-06-02 | 2024-11-27 |
| Doppler Ultrasonographic Assessment of Fetal Internal Thoracic Artery Indexes Pregnancy Related, Fetal; Circulation | Unknown | Ankara City Hospital Bilkent | 150 | 2021-01-01 | 2020-12-28 | |
| Effects of Maternal Smoking on Fetal Liver Circulation smoking - Smoking, Cigarette, Maternal Exposure | Unknown | Bezmialem Vakif University | 160 | 2020-07-07 | 2021-01-25 | |
| Population Pharmacokinetics and Dosage Individualization of Oral Pulmonary Vasodilators in PPHN Bosentan Tablets, Sildenafil Tablet, Tadalafil Tablets - Persistent Pulmonary Hypertension of the Newborn | Unknown | Shandong University | 500 | 2020-04-26 | 2020-05-07 | |
| Nebulized MgSO4 in Persistent Pulmonary Hypertension of Newborn Nebulized Magnesium Sulfate, Intravenous Magnesium Sulfate - Persistent Fetal Circulation, Persistent Pulmonary Hypertension of the Newborn | Phase 1 / Phase 2 | Completed | Sohag University | 28 | 2017-11-01 | 2020-08-18 |
| Milrinone in Congenital Diaphragmatic Hernia Milrinone, Placebo (5% Dextrose) - Congenital Diaphragmatic Hernia, Persistent Pulmonary Hypertension of the Newborn | Phase 2 | Completed | NICHD Neonatal Research Network | 66 | 2017-10-24 | 2025-11-06 |
| Early iNO for Oxidative Stress, Vascular Tone and Inflammation in Babies With Hypoxic Respiratory Failure Inhaled nitric oxide, Nitrogen Gas, Crossover iNO - Persistent Fetal Circulation Syndrome, Hypertension, Pulmonary, of Newborn, Persistent | Phase 4 | Withdrawn | University of Florida | 2016-05-01 | 2020-01-07 | |
| Markers of Inflammation and Lung Recovery in ECMO Patients for PPHN Persistent Pulmonary Hypertension of the Newborn | Completed | University of Leicester | 24 | 2016-02-19 | 2020-03-19 | |
| Remodulin as Add-on Therapy for the Treatment of Persistent Pulmonary Hypertension of the Newborn IV Remodulin, Placebo - Persistent Pulmonary Hypertension of the Newborn | Phase 2 | Terminated | United Therapeutics | 42 | 2015-07-29 | 2024-03-05 |
| Plethismographic Perfusion Index in Neonates PPG - Patent Ductus Arteriosus, Persistent Pulmonary Hypertension of the Newborn | Unknown | Shaare Zedek Medical Center | 100 | 2015-03-01 | 2016-09-07 | |
| A Study To Evaluate Safety And Efficacy Of IV Sildenafil In The Treatment Of Neonates With Persistent Pulmonary Hypertension Of The Newborn placebo, iv sildenafil - Pulmonary Hypertension, Familial Persistent, of the Newborn | Phase 3 | Completed | Pfizer's Upjohn has merged with Mylan to form Viatris Inc. | 59 | 2013-08-05 | 2021-08-16 |
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Hypertension, Pulmonary (7) · Respiratory Insufficiency (6) · Meconium Aspiration Syndrome (5) · Hypoxia (3) · Respiratory Distress Syndrome (3) · Respiratory Distress Syndrome, Newborn (3) · Heart Defects, Congenital (2) · Hernias, Diaphragmatic, Congenital (2) · Lung Diseases (2) · Methemoglobinemia (2) · Pneumonia, Aspiration (2) · Cardiovascular Diseases (1) · Cigarette Smoking (1) · Ductus Arteriosus, Patent (1)
Congenital, Hereditary, and Neonatal Diseases and Abnormalities (40) · Infant, Newborn, Diseases (40) · Respiratory Tract Diseases (40) · Lung Diseases (38) · Hypertension, Pulmonary (33) · Respiration Disorders (9) · Cardiovascular Diseases (8) · Hypertension (7) · Vascular Diseases (7) · Female Urogenital Diseases and Pregnancy Complications (6) · Pathological Conditions, Signs and Symptoms (6) · Pregnancy Complications (6) · Urogenital Diseases (6) · Congenital Abnormalities (5) · Fetal Diseases (5)
Sildenafil Citrate (9) · Milrinone (3) · Bosentan (2) · Iloprost (2) · Saline Solution (2) · Alprostadil (1) · Endothelium-Dependent Relaxing Factors (1) · Glucose (1) · Glycation End Products, Advanced (1) · Magnesium Sulfate (1) · Melatonin (1) · Nitric Oxide (1) · Nitrogen (1) · Oxygen (1) · Smoking Devices (1)
NICHD Neonatal Research Network (5) · Pfizer's Upjohn has merged with Mylan to form Viatris Inc. (3) · National Heart, Lung, and Blood Institute (NHLBI) (2) · Sohag University (2) · Actelion (1) · Ain Shams University (1) · Alexandria University (1) · Ankara City Hospital Bilkent (1) · Bezmialem Vakif University (1) · Children's Hospital of Fudan University (1) · Children's Hospital of Philadelphia (1) · Christiana Care Health Services (1) · Ferrer Internacional S.A. (1) · Hamad Medical Corporation (1) · Medical College of Wisconsin (1)
United States (16) · Egypt (4) · China (3) · France (3) · United Kingdom (3) · Canada (2) · Israel (2) · Turkey (Türkiye) (2) · Belgium (1) · Denmark (1) · Germany (1) · India (1) · Italy (1) · Netherlands (1) · Norway (1)
Seetha Shankaran, MD (4) · Edward F. Donovan, MD (3) · Lu-Ann Papile, MD (3) · Richard A. Ehrenkranz, MD (3) · Sheldon B. Korones, MD (3) · Avroy A. Fanaroff, MD (2) · Barbara J. Stoll, MD (2) · Charles R. Bauer, MD (2) · David K. Stevenson, MD (2) · Elsayed Abdelkreem, MD, PhD (2) · G. Ganesh Konduri, MD (2) · James A. Lemons, MD (2) · Krisa P. Van Meurs, MD (2) · Mary Wearden, MD (2)
PMID 10617698, PMID 10802492, PMID 11416871, PMID 14510322, PMID 14993550, PMID 17307536, PMID 25496504, PMID 27502103, PMID 29209510, PMID 29943734, PMID 31725531, PMID 33415555, PMID 34052232, PMID 34741102, PMID 35327768, PMID 40888971, PMID 9036320, PMID 9190553
U10HD021364 (4), U10HD021385 (4), U10HD027880 (4), M01RR000070 (3), M01RR000750 (3), M01RR000997 (3), M01RR006022 (3), M01RR008084 (3), U01HD019897 (3), U10HD021373 (3), U10HD021397 (3), U10HD021415 (3), U10HD027853 (3), U10HD027856 (3), U10HD027871 (3)