10 completed, 2 terminated. 3 Phase 1, 2 Phase 3, 1 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 3 | Completed 3 |
| Phase 3 | 2 | Terminated 2 |
| Not applicable | 1 | Completed 1 |
Follow Methemoglobinemia: new trials by email Literature Review of Methemoglobinemia trials Research Report on Methemoglobinemia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Ferric Carboxymaltose Methemoglobinemia Study Ferric Carboxymaltose (FCM) - Methemoglobinemia, Anemia, Iron-Deficiency | Completed | Ordu University | 977 | 2025-04-14 | 2025-11-19 | |
| Methemoglobinemia Following Intravenous Iron Treatment Blood sample after treatment, Case reports - Methemoglobinemia, Anemia | Completed | Claudia Seiler | 50 | 2024-09-02 | 2025-12-09 | |
| Accuracy of Detection of Methemoglobin With Pulse Oximetry Sensor to spot check blood levels - Collect Blood Values With Induced Hypoxia, Induced Methemoglobinemia, and Induced Hypoxia and Methemoglobinemia | Completed | Nonin Medical, Inc | 13 | 2019-03-26 | 2019-04-08 | |
| Acquired Methemoglobinemia Observational Registry Methylene Blue - Methemoglobinemia, Acquired, Methemoglobinemia | Completed | Hospital Quality Foundation | 24 | 2018-05-31 | 2023-04-12 | |
| Safety, Tolerability, and Pharmacokinetic Study of Methylene Blue Following a 1 mg/kg Intravenous Dose in Healthy Adults Methylene Blue - Methemoglobinemia, Congenital Methemoglobinemia | Phase 1 | Completed | American Regent, Inc. | 12 | 2012-10-01 | 2025-06-05 |
| Pharmacokinetics and Distribution of Dapsone in Leucocytes After Single-dose and Multiple-dose Administration Dapsone single dose, Dapsone multiple dose, leucocytes - Methemoglobinemia, Linear IgA Bullous Dermatosis | Phase 1 | Completed | University Medicine Greifswald | 23 | 2011-09-01 | 2015-07-09 |
| Methemoglobin Levels in Generally Anesthetized Pediatric Dental Patients Receiving Local Anesthetics 4% prilocaine plain, 2% Lidocaine with 1:100,000 epinephrine - Methemoglobinemia | Not applicable | Completed | Loma Linda University | 91 | 2011-08-01 | 2014-04-25 |
| Methemoglobinemia in Young Patients With Hematologic Cancer or Aplastic Anemia Treated With Dapsone chemotherapy, dapsone, medical chart review - Chronic Myeloproliferative Disorders, Leukemia | Completed | Vanderbilt University | 41 | 2009-01-01 | 2017-04-17 | |
| Methemoglobinemia After Liposuction - Diagnostic by Pulse Oximetry and Blood Gas Analysis. Methemoglobinemia | Completed | University Hospital Schleswig-Holstein | 133 | 2008-08-01 | 2020-11-03 | |
| Nitrite Infusion in Healthy Volunteers Sodium Nitrite, Sodium Nitrite Injection - Healthy | Phase 1 | Completed | National Institute of Neurological Disorders and Stroke (NINDS) | 12 | 2005-02-04 | 2017-07-02 |
| Early Inhaled Nitric Oxide for Respiratory Failure in Newborns Inhaled Nitric Oxide, Standard iNO therapy - Infant, Newborn, Hypertension, Pulmonary | Phase 3 | Terminated | NICHD Neonatal Research Network | 302 | 1998-08-01 | 2017-09-26 |
| Inhaled Nitric Oxide Study for Respiratory Failure in Newborns Inhaled nitric oxide, Placebo - Infant, Newborn, Hypertension, Pulmonary | Phase 3 | Terminated | NICHD Neonatal Research Network | 235 | 1995-10-01 | 2017-09-26 |
Hypertension, Pulmonary (2) · Meconium Aspiration Syndrome (2) · Persistent Fetal Circulation Syndrome (2) · Pneumonia, Aspiration (2) · Respiratory Distress Syndrome (2) · Respiratory Distress Syndrome, Newborn (2) · Respiratory Insufficiency (2) · Anemia (1) · Anemia, Aplastic (1) · Anemia, Iron-Deficiency (1) · Aneurysm (1) · Blast Crisis (1) · Burkitt Lymphoma (1) · Congenital Methemoglobinemia (1)
Hematologic Diseases (12) · Hemic and Lymphatic Diseases (12) · Cardiovascular Diseases (4) · Vascular Diseases (4) · Infections (3) · Metabolic Diseases (3) · Nutritional and Metabolic Diseases (3) · Anemia (2) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (2) · Female Urogenital Diseases and Pregnancy Complications (2) · Fetal Diseases (2) · Hypertension (2) · Immune System Diseases (2) · Infant, Newborn, Diseases (2) · Infant, Premature, Diseases (2)
Dapsone (2) · Methylene Blue (2) · Drug Therapy (1) · Epinephrine (1) · Leukocyte Count (1) · Lidocaine (1) · Prilocaine (1) · Sodium Nitrite (1) · ferric carboxymaltose (1)
NICHD Neonatal Research Network (2) · American Regent, Inc. (1) · Claudia Seiler (1) · Hospital Quality Foundation (1) · Loma Linda University (1) · National Institute of Neurological Disorders and Stroke (NINDS) (1) · Nonin Medical, Inc (1) · Ordu University (1) · University Hospital Schleswig-Holstein (1) · University Medicine Greifswald (1) · Vanderbilt University (1)
United States (7) · Canada (1) · Germany (1) · Sweden (1) · Turkey (Türkiye) (1)
Avroy A. Fanaroff, MD (2) · Edward F. Donovan, MD (2) · Lu-Ann Papile, MD (2) · Mary Wearden, MD (2) · Richard A. Ehrenkranz, MD (2) · Seetha Shankaran, MD (2) · Sheldon B. Korones, MD (2) · A. Johnston, MD (1) · A. Solimano, MD (1) · Abbot R. Laptook, MD (1) · Adam J. Esbenshade, MD (1) · Ali Erol, MD (1) · Ant Uzay, MD (1)
PMID 10802492, PMID 11416871, PMID 14510322, PMID 14993550, PMID 17307536, PMID 21249218, PMID 9036320, PMID 9190553
M01RR000070 (2), M01RR000750 (2), M01RR000997 (2), M01RR001032 (2), M01RR006022 (2), M01RR008084 (2), U01HD019897 (2), U10HD021364 (2), U10HD021373 (2), U10HD021385 (2), U10HD021397 (2), U10HD021415 (2), U10HD027853 (2), U10HD027856 (2), U10HD027871 (2)