41 completed, 8 unknown, 7 not yet recruiting, 6 recruiting. 43 Not applicable, 9 Phase 4, 8 Phase 3, 7 Phase 2, 1 Early Phase 1.
Follow Local Anesthesia: new trials by email Literature Review of Local Anesthesia trials Research Report on Local Anesthesia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| E-MOHS Trial of TENS and Vibration During Local Anesthesia Active Vibration:TENS, Sham TENS - Pain, Procedural Pain | Not applicable | Not yet recruiting | University of Minnesota | 90 | 2027-01-01 | 2026-10-06 |
| Comparison of Anesthetic Efficacy and Safety Between Inferior Alveolar Nerve Block and the Infiltrative Technique for the Treatment of Peri-implant Diseases in Posterior Mandibular Implants Comparison of anesthetic efficacy and safety between nerve block and infiltrative technique for periimplantitis surgical treatment in poosterior mandibular implants - Local Anesthesia, Dental Implants | Not applicable | Not yet recruiting | University of Barcelona | 30 | 2026-09-01 | 2026-05-22 |
| AI Avatar Video vs. Tell-Show-Do for Reducing Anxiety and Improving Cooperation in Children During Local Anesthesia AI Avatar-Based video, Tell-Show-Do Technique - Anxiety, Fear | Not applicable | Recruiting | Saint-Joseph University | 70 | 2026-02-16 | 2026-03-30 |
| Lavender vs Bitter Orange Aromatherapy to Reduce Anxiety and Pain in Pediatric Local Anesthesia Lavender essential oil in the inhaler, Bitter Orange essential oil in the inhaler, Epmty inhaler (Placebo) - Dental Anxiety, Local Anesthesia | Not applicable | Not yet recruiting | October University for Modern Sciences and Arts | 26 | 2026-02-01 | 2026-01-28 |
| Effect of AI-Supported Child-Friendly Communication on Dental Anxiety in Pediatric Patients AI-Assisted Child-Friendly Communication, Traditional Behavior Management Techniques - Caries, Dental, Local Anesthesia | Not applicable | Recruiting | Çanakkale Onsekiz Mart University | 60 | 2025-10-15 | 2025-12-24 |
| Hysteroscopy Anesthesia for Relief of Pain Local paracervical Anesthesia, Placebo - Pain Management, Outpatient Hysteroscopy | Not applicable | Not yet recruiting | Maimónides Biomedical Research Institute of Córdoba | 70 | 2025-09-06 | 2025-09-17 |
| Intraligamentary vs Inferior Alveolar Nerve Block for Pulpitis: A Randomized Clinical Trial Intraligamentary Injection, Inferior Alveolar Nerve Block - Symptomatic Irreversible Pulpitis (SIP), Dental Pain | Not applicable | Recruiting | Aula Dental Avanzada | 52 | 2025-06-20 | 2025-08-19 |
| Influence of Peri-operative Anesthetic and Analgesic Care on the Outcome of Patients Undergoing Hip Fracture Surgeries. A Prospective Study Ropivacaine - Fractures, Hip, Local Anesthesia | Withdrawn | Milton S. Hershey Medical Center | 2025-06-01 | 2026-10-02 | ||
| RCT of Minimalist vs Standard Procedure for LAAC in NVAF Patients Minimalism Transcatheter LAAC Group, Standard Transcatheter LAAC Group - Atrial Fibrillation, Left Atrial Appendage Occlusion | Not applicable | Not yet recruiting | Shanghai Zhongshan Hospital | 200 | 2025-06-01 | 2025-05-13 |
| Exploration of the Utility of Dental-dedicated MRI for Dentistry dental-dedicated MRI (ddMRI) - Dental Crowding, Dental Occlusion, Traumatic | Recruiting | University of Minnesota | 500 | 2025-03-17 | 2026-08-25 | |
| Comparison of Computer-Assisted and Conventional Local Anesthesia Methods in Mandibular Impacted Third Molar Surgery Computer-Assisted Local Anesthesia, Conventional Local Anesthesia - Molar, Third, Surgery, Oral | Not applicable | Completed | Afyonkarahisar Health Sciences University | 40 | 2025-03-01 | 2025-12-10 |
| Effect of AV Distraction and Acuapoint Stimulation in Pediatric Extraction on Pain and Anxiety Acualief, Audiovisual, TELL SHOW DO - Tooth Extraction, Local Anesthesia | Not applicable | Enrolling by invitation | Mansoura University | 69 | 2025-02-02 | 2026-01-28 |
| Result Of Use Of Wide Awake Local Anaesthesia In Fixation Of Ankle Fractures Wide Awake Local Anaesthesia In Fixation Of Ankle Fractures. - Local Anesthesia | Not yet recruiting | Assiut University | 60 | 2025-01-16 | 2024-12-05 | |
| Comparison of Anesthetic Efficacy and Safety Between Nerve Block and Infiltrative Technique for Mandibular Posterior Implant Placement. Comparison of anesthetic efficacy and safety between nerve block and infiltrative technique for mandibular posterior implant placement. - Dental Implants, Local Anesthesia | Not applicable | Active not recruiting | University of Barcelona | 42 | 2024-11-05 | 2026-10-06 |
| Can Caudal Dexmedetomidine Provide Effective Analgesia? Caudal Bupivacaine injection, Caudal Dexmedetomidine Injection - Anesthesia, Local Anesthesia | Not applicable | Not yet recruiting | Benha University | 50 | 2024-09-01 | 2024-02-13 |
| Effect of Virtual Reality on Patient's Comfort During Cardiac Electronic Device Implantation. Virtual reality application - Virtual Reality, Medical Device | Not applicable | Recruiting | Schlotterbeck Hervé | 150 | 2024-03-29 | 2026-03-20 |
| Analgesic Efficacy of Peritonsillar Ropivacaine Infiltration After Tonsillectomy in Children Peritonsillar infiltration with ropivacaine, Peritonsillar infiltration with normal saline, Normal Saline - Tonsillectomy, Ropivacaine | Not applicable | Completed | University Hospital, Mahdia | 60 | 2024-03-01 | 2026-09-17 |
| Efficacy of EMLA Cream Assisted Loco-sedation for Office-based Andrology Procedures Eutectic mixture of local anesthetics (EMLA; Astra Pharmaceutical Products Inc., Westborough, MA), Control cream - Scrotum Disease, Hydrocele Male | Phase 3 | Unknown | University of Manitoba | 72 | 2024-01-25 | 2024-02-05 |
| Effect of Pre-Warming of Local Anesthesia in Reducing Pain Perception During Injection in Children Local anesthesia solution at room temperature, Local anesthesia solution pre-warmed to 37°C, Local anesthesia solution pre-warmed to 40°C - Local Anesthesia, Dental Anesthesia | Not applicable | Completed | Andrew Emad | 72 | 2024-01-01 | 2024-07-25 |
| Pain Perception Comparison of Computerized vs Conventional Injection Methods Conventional Syringe, STA Single Tooth Anesthesia® System., Star Pen anesthesia device. - Pain Perception, Local Anesthesia | Not applicable | Unknown | Mansoura University | 120 | 2023-10-30 | 2023-11-13 |
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Pain (14) · Agnosia (6) · Anxiety Disorders (5) · Pain, Postoperative (5) · Dental Pulp Diseases (2) · Disease (2) · Periodontal Diseases (2) · Pulpitis (2) · Toothache (2) · Atrial Fibrillation (1) · Behavior (1) · Breast Neoplasms (1) · Child Behavior (1) · Colonic Diseases (1) · Crowding (1)
Pathological Conditions, Signs and Symptoms (30) · Signs and Symptoms (27) · Neurologic Manifestations (26) · Pathologic Processes (10) · Stomatognathic Diseases (9) · Nervous System Diseases (7) · Pain (7) · Neurobehavioral Manifestations (6) · Perceptual Disorders (6) · Mental Disorders (5) · Postoperative Complications (5) · Tooth Diseases (5) · Neoplasms (4) · Neoplasms by Site (4) · Mouth Diseases (3)
Lidocaine (12) · Epinephrine (5) · Anesthesia, Local (3) · Bupivacaine (3) · Dexmedetomidine (3) · Mepivacaine (3) · Saline Solution (3) · Sodium Bicarbonate (3) · Anesthetics, Local (2) · Congresses as Topic (2) · Dexamethasone (2) · Lidocaine, Prilocaine Drug Combination (2) · Ropivacaine (2) · Acetaminophen (1) · Alkalies (1)
Isfahan University of Medical Sciences (3) · University of Alberta (3) · University of Belgrade (3) · Cairo University (2) · Mansoura University (2) · Masoud Saatchi (2) · University Hospital, Mahdia (2) · University of Barcelona (2) · University of Minnesota (2) · Afshan Amjad Ali (1) · Afyonkarahisar Health Sciences University (1) · Ain Shams University (1) · Al-Azhar University (1) · Alexandria University (1) · Andrew Emad (1)
Turkey (Türkiye) (10) · Egypt (8) · United States (6) · Spain (5) · Brazil (4) · Canada (4) · China (3) · Iran (3) · Serbia (3) · Syria (2) · Tunisia (2) · Bulgaria (1) · Denmark (1) · France (1) · Hong Kong (1)
Bozidar M Brkovic, DDS, PhD (2) · Marija S Milic, DDS (2) · Masoud Saatchi (2) · Andrej Cretnik, MD, PhD (1) · Antonia Dalmau, PhD (1) · Antonio Campo Voegeli, MD (1) · Arif Bolaca, Dr. (1) · Asma Khan, DDS (1) · Ban Tsui, MD, MSc (1) · Chaza Kouchaji, Professor (1) · Dejan Cetkovic, DDS (1)
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