105 completed, 30 unknown, 16 recruiting, 16 terminated. 65 Not applicable, 40 Phase 4, 34 Phase 3, 32 Phase 2, 19 Phase 1.
Follow Sodium Bicarbonate: new trials by email Literature Review of Sodium Bicarbonate trials Research Report on Sodium Bicarbonate
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Oral Sodium Bicarbonate for the Prevention of Labour Dystocia oral sodium bicarbonate - Labour Dystocia | Not applicable | Not yet recruiting | Liz Darling | 200 | 2027-10-01 | 2026-10-23 |
| Evaluation of the Effect of Adding Sodium Bicarbonate to Lidocaine in the Treatment of Myofascial Pain Syndrome Lidocaine 2 %, Lidocaine + Sodium Bicarbonate - Myofacial Pain, Myofacial Pain Syndrome | Not applicable | Recruiting | Cairo University | 30 | 2026-11-01 | 2026-10-21 |
| A Study of Tris-Hydroxymethyl Aminomethane (THAM) Versus Sodium Bicarbonate in Cardiac Surgical Patients Sodium bicarbonate, Tris-hydroxymethyl Aminomethane - Metabolic Acidosis | Phase 4 | Recruiting | Mayo Clinic | 250 | 2026-09-14 | 2026-09-21 |
| Perioperative Haemostasis, Procedure-Related Pain After Physiological or Pharmacological Modifications of Local Anaesthesia Around the Eyes Sodium Bicarbonate (NaHCO3), Warmed lignocaine, Hyaluronidase Injection - Dermatochalasis of Upper Eyelid, Blepharoplasty | Phase 3 | Not yet recruiting | Prince of Wales Hospital, Shatin, Hong Kong | 80 | 2026-08-01 | 2026-08-03 |
| Comparing Alkalinizing Agents Efficacy on Stone Risk in Patients on a Metabolically Controlled Diet Potassium citrate, Sodium bicarbonate, Litholyte - Kidney Stone | Early Phase 1 | Not yet recruiting | University of Texas Southwestern Medical Center | 15 | 2026-07-01 | 2026-02-13 |
| Pilot Trial of Oral Sodium Bicarbonate Versus Higher Dialysate Bicarbonate in Hemodialysis Patients With Metabolic Acidosis Oral sodium bicarbonate, Increased Dialysate Bicarbonate - End-stage Renal Disease (ESRD), Chronic Hemodialysis | Not applicable | Not yet recruiting | University of Sfax | 37 | 2026-07-01 | 2026-07-21 |
| Acute Kidney Injury and Ultra-endurance Running Sodium Bicarbonate (NaHCO3), Placebo - AKI (Acute Kidney Injury) Due to Trauma | Not applicable | Not yet recruiting | Arizona State University | 30 | 2026-06-27 | 2026-04-09 |
| Evaluation of Perfusion and Ventilation Distribution in Children: a Pilot Study. Evaluation of perfusion with Electrical impedance tomography using sodium chloride or sodium bicarbonate - Acute Respiratory Failure | Not applicable | Recruiting | Hospices Civils de Lyon | 20 | 2026-05-13 | 2026-05-19 |
| Sodium Bicarbonate for Critically Ill Patients With Metabolic Acidosis and Acute Kidney Injury Sodium Bicarbonate 8.4% Solution for Injection, Balanced crystalloid solution - Acute Kidney Injury, Metabolic Acidosis | Phase 4 | Recruiting | Universität Münster | 660 | 2026-05-07 | 2026-09-04 |
| Acute Sodium Bicarbonate Supplementation in Female Basketball Players Sodium Bicarbonate (NaHCO3), Placebo - Supplementation, Sports | Phase 3 | Recruiting | Krzysztof Durkalec-Michalski | 100 | 2026-03-01 | 2026-07-28 |
| Sodium Bicarbonate as an Alternative to Potassium Citrate for Kidney Stones Potassium Citrate, Sodium Bicarbonate - Kidney Stones, Urolithiasis, Hypocitraturia, Nephrolithiasis | Phase 1 / Phase 2 | Not yet recruiting | University of California, Los Angeles | 30 | 2026-02-01 | 2026-02-12 |
| Efficacy of Bicarbonate on the Risk of Assisted Delivery in Nulliparous Women With Prolonged Labour Sodium bicarbonate, Placebo - Prolonged Labor, Labor Dystocia | Not applicable | Not yet recruiting | Copenhagen University Hospital, Hvidovre | 1520 | 2026-02-01 | 2026-01-12 |
| The Effect of Sodium Bicarbonate (Nephrotrans®) on Calcification Propensity of Serum in Kidney Transplant Recipients Low dose sodium bicarbonate, High dose sodium bicarbonate - Kidney Transplant; Complications | Phase 2 | Withdrawn | Prim. Priv. Doz. Dr. Daniel Cejka | 2025-12-31 | 2026-04-27 | |
| Sodium Bicarbonate in Intra-dialytic Hypertension in Chronic Hemodialysis Patients Sodium Bicarbonate (NaHCO3), Placebo - Hypertension in Dialysis Patients | Phase 2 / Phase 3 | Not yet recruiting | Assaf-Harofeh Medical Center | 40 | 2025-11-10 | 2025-11-17 |
| Prophylactic Analgesia for Bladder Botox Injections Phenazopyridine, 1% lidocaine with sodium bicarbonate - Urinary Incontinence, Urinary Incontinence, Urge | Phase 4 | Withdrawn | Montefiore Medical Center | 2025-07-01 | 2025-07-18 | |
| Effects of Single Sodium Bicarbonate Supplementation on National-Level Finswimming Performance Sodium Bicarbonate (NaHCO3), Placebo - Sport Performance, Acid Base Imbalance | Not applicable | Recruiting | Palacky University | 20 | 2025-07-01 | 2025-08-22 |
| Efficacy and Safety of Sodium Hyaluronate Gel Combined With Sodium Bicarbonate Versus Sodium Bicarbonate Alone in Prevention of Failed Back Surgery Syndrome Sodium hyaluronate jell, Sodium Bicarbonate, Saline - Postdiscectomy Epidural Fibrosis, Pain | Phase 2 / Phase 3 | Active not recruiting | Misr University for Science and Technology | 60 | 2025-06-20 | 2025-07-29 |
| Pain Related to Local Anesthetic Administration for Nexplanon Placement we will prepare 3cc of buffered lidocaine consisting of 2.7cc of 1% lidocaine and 0.3cc of 8.4% sodium bicarbonate, Unbuffered lidocaine - Pain Related to Local Anesthetic Administration for Nexplanon Placement | Not applicable | Not yet recruiting | University of California, San Diego | 68 | 2025-06-01 | 2025-06-06 |
| Oral Care With Maternal Milk in Mechanically Ventilated Preterm Infants oral care with maternal milk, oral care with sodium bicarbonate - Role of Oral Care in Mechanically Ventilated Preterm Infants | Not applicable | Completed | Ain Shams University | 70 | 2025-06-01 | 2026-03-06 |
| Impact of Sodium Bicarbonate on 24-hour Urine Parameters in Hypocitriuric and Uric Acid Stone Formers Potassium citrate, Sodium bicarbonate - Uric Acid Stones | Phase 1 | Recruiting | University of California, Irvine | 100 | 2025-05-01 | 2025-06-24 |
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Renal Insufficiency, Chronic (24) · Acidosis (20) · Acute Kidney Injury (19) · Pain (10) · Stomatitis (8) · Kidney Diseases (6) · Kidney Failure, Chronic (5) · COVID-19 (4) · Heart Arrest (4) · Hypertension (4) · Motor Activity (4) · Mucositis (4) · Neoplasms (4) · Cardiovascular Diseases (3) · Diabetes Mellitus (3)
University of Colorado, Denver (6) · GlaxoSmithKline (5) · Austin Health (4) · Bayer (3) · Duke University (3) · H. Lee Moffitt Cancer Center and Research Institute (3) · Mansoura University (3) · Mayo Clinic (3) · University of Zurich (3) · Ain Shams University (2) · Albert Einstein College of Medicine (2) · Catholic University of the Sacred Heart (2) · Donald Wesson (2) · Emory University (2) · M.D. Anderson Cancer Center (2)
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