26 completed, 15 unknown, 11 recruiting, 6 withdrawn. 68 Phase 1, 39 Phase 2.
Follow Liver Failure: new trials by email Literature Review of Liver Failure trials Research Report on Liver Failure
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| RENEW: Study of Porcine Liver Support in Participants With Acute-on-Chronic Liver Failure metra® Extracorporeal Liver Cross-Circulation (ELC) system (OrganOx), EGEN-5784 (genetically engineered porcine liver) - Acute on Chronic Liver Failure (ACLF), Hepatic Encephalopathy (HE) | Phase 1 / Phase 2 | Not yet recruiting | eGenesis, INC | 20 | 2026-10-01 | 2026-09-21 |
| TLI- and ATG-Enabled Minimization Protocol in Liver Transplantation Anti-Thymocyte Globulin, ATG (Rabbit), Total lymphoid irradiation - Liver Failure | Phase 1 / Phase 2 | Recruiting | Stanford University | 12 | 2026-09-01 | 2026-10-07 |
| Evaluation of the Outcome of Fecal Microbiota Transplantation Fecal Microbiota Transplantation, FMT Matched Placebo, Rifaximin、Lactulose - Hepatic Encephalopathy, Fecal Microbiota Transplantation | Phase 1 / Phase 2 | Not yet recruiting | Air Force Military Medical University, China | 40 | 2026-03-07 | 2026-03-06 |
| Immune Tolerance Induction After Liver Transplantation Donor Hematopoietic Stem and Progenitor Cell Infusion - Liver Transplantation, Immune Tolerance | Phase 1 / Phase 2 | Recruiting | University of California, Los Angeles | 12 | 2026-02-20 | 2026-03-12 |
| National Collaborative Centre for Hepatic Regenerative Medicine (NC-CHRM): Phase I Study on Safety and Efficacy of Mesenchymal Stem-Cell (MSC) Therapy in Non-Viral Acute-on-Chronic Liver Failure (ACLF) umbilical cord Mesenchymal Stem Cell - Acute-On-Chronic Liver Failure | Phase 1 | Not yet recruiting | Institute of Liver and Biliary Sciences, India | 10 | 2026-01-01 | 2025-08-28 |
| Safety and Tolerability Study of a Novel Bioartificial Liver in Liver Failure and Small-for-Size Syndrome Chemically induced pluripotent stem cells biological Artificial Liver - Liver Failure, Small-for-Size Syndrome | Phase 1 / Phase 2 | Recruiting | Beijing Friendship Hospital | 12 | 2025-12-01 | 2026-04-20 |
| Pharmacokinetic Study on G1090N (Nitazoxanide) Capsules in Healthy Volunteers Single Dose G1090N, Multiple dosing of G1090N - Acute-on-Chronic Liver Failure | Phase 1 | Completed | Genfit | 52 | 2025-08-26 | 2026-01-16 |
| The Microbiota Augmentation to Reestablish Commensal Organisms (MARCO) Trial Commensal Bacteria Strains - Liver Diseases, Liver Failure | Phase 1 | Recruiting | University of Chicago | 24 | 2025-08-04 | 2025-11-04 |
| CRISPR-Edited HLA Donor Liver Transplant to Reduce Rejection Ex Vivo CRISPR-Cas9 Gene Editing of Donor Liver - Liver Diseases, Liver Cancer | Phase 1 / Phase 2 | Recruiting | AMERICAN ORGAN TRANSPLANT AND CANCER RESEARCH INSTITUTE LLC | 90 | 2025-06-01 | 2025-07-08 |
| Phase I Trial of QH-1A Hybrid Bio-Artificial Liver With Ex Vivo Blood-Purifying MSCs in Acute-on-Chronic Liver Failure Combining the QH-1A bioartificial liver device with mesenchymal stem cells for blood purification（4 hours）, Combining the QH-1A bioartificial liver device with mesenchymal stem cells for blood purification（6 hours）, Combining the QH-1A bioartificial liver device with mesenchymal stem cells for blood purification（8 hours） - Acute-On-Chronic Liver Failure | Phase 1 | Active not recruiting | Third Affiliated Hospital, Sun Yat-Sen University | 15 | 2025-05-07 | 2025-05-30 |
| MSC-EVs in Acute/ Acute-on-Chronic Liver Failure After Liver Transplantation MSC-EVs - Liver Failure, Mesenchymal Stem Cell | Phase 1 | Not yet recruiting | Third Affiliated Hospital, Sun Yat-Sen University | 30 | 2025-04-01 | 2025-02-13 |
| RTX001 Autologous Engineered Macrophages for Liver Cirrhosis RTX001 - End-stage Liver Disease (ESLD), Cirrhosis, Liver | Phase 1 / Phase 2 | Active not recruiting | Resolution Therapeutics Limited | 30 | 2024-10-15 | 2026-10-05 |
| miroliverELAP® for the Treatment of Acute Liver Failure: A Phase 1 Trial miroliverELAP treatment - Acute Liver Failure, Acute Liver Injury, Drug Induced | Phase 1 | Completed | Miromatrix Medical Inc. | 10 | 2024-10-05 | 2026-03-06 |
| A Study of SIPLIZUMAB in AILD and LT Patients Siplizumab - Autoimmune Liver Disease, Liver Transplant Disorder | Phase 1 | Recruiting | Elizabeth C. Verna | 8 | 2024-09-11 | 2025-11-24 |
| Safety and Effectiveness of Mesenchymal Stem Cells in Blood Purification for the Treatment of Liver Failure It is loaded with a mesenchymal stem cells reaction device for blood purification - Liver Failure | Phase 1 | Recruiting | Kebo Zhong | 10 | 2024-04-23 | 2026-04-15 |
| Micro-encapsulated Hepatocyte Intraperitoneal Transplantation in Liver Failure Adults a single course of micro-encapsulated hepatocytes intraperitoneal transplantation therapy - Acute-On-Chronic Liver Failure, Chronic Liver Failure | Phase 1 | Recruiting | RenJi Hospital | 10 | 2024-03-01 | 2025-06-27 |
| MSC-EV in Acute-on-Chronic Liver Failure After Liver Transplantation MSC-EV - Liver Failure, Acute on Chronic | Phase 1 | Withdrawn | Third Affiliated Hospital, Sun Yat-Sen University | 2023-09-30 | 2023-10-12 | |
| Human Umbilical Cord Mesenchymal Stem Cell Transplantation for The Treatment of Acute-on-Chronic Liver Failure standard medical treatment, Placebo, hUC-MSC - Acute-On-Chronic Liver Failure | Phase 1 / Phase 2 | Recruiting | Beijing 302 Hospital | 150 | 2023-09-30 | 2024-05-07 |
| The Safety ,Tolerability and Efficacy Study of HepaCure in Chinese Subjects with Acute-On-Chronic Liver Failure HepaCure, DPMAS and LPE - Acute on Chronic Hepatic Failure, Liver Failure | Phase 1 / Phase 2 | Recruiting | Hexaell Biotech Co., Ltd. | 92 | 2023-09-22 | 2025-02-25 |
| The Safety and Efficacy of MSC-EVs in Acute/Acute-on-Chronic Liver Failure MSC-EVs - Acute-On-Chronic Liver Failure, Acute Liver Failure | Phase 1 / Phase 2 | Withdrawn | Third Affiliated Hospital, Sun Yat-Sen University | 2023-09-01 | 2023-10-12 |
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Acute-On-Chronic Liver Failure (17) · End Stage Liver Disease (16) · Hepatic Encephalopathy (16) · Fibrosis (9) · Liver Cirrhosis (9) · Liver Diseases (7) · Liver Failure, Acute (7) · Renal Insufficiency (3) · Hepatic Insufficiency (2) · Hepatitis B (2) · Neoplasm Metastasis (2) · Acute Kidney Injury (1) · Brain Diseases (1) · Brain Edema (1)
Digestive System Diseases (68) · Hepatic Insufficiency (66) · Liver Diseases (61) · Pathological Conditions, Signs and Symptoms (21) · Pathologic Processes (20) · Central Nervous System Diseases (17) · Nervous System Diseases (17) · Nutritional and Metabolic Diseases (17) · Brain Diseases (16) · Brain Diseases, Metabolic (16) · Metabolic Diseases (16) · Liver Failure, Acute (14) · Fibrosis (7) · Urogenital Diseases (6)
Congresses as Topic (3) · Fecal Microbiota Transplantation (3) · Lactulose (2) · Amino Acids (1) · Amino Acids, Branched-Chain (1) · Antilymphocyte Serum (1) · Antiviral Agents (1) · Carboplatin (1) · Drug Delivery Systems (1) · Filgrastim (1) · Flumazenil (1) · Granulocyte Colony-Stimulating Factor (1) · NOS2 protein, human (1) · Paclitaxel (1) · Peripheral Blood Stem Cell Transplantation (1)
Third Affiliated Hospital, Sun Yat-Sen University (6) · Air Force Military Medical University, China (4) · University of Alberta (4) · Post Graduate Institute of Medical Education and Research, Chandigarh (3) · Virginia Commonwealth University (3) · Assistance Publique - Hôpitaux de Paris (2) · Beijing 302 Hospital (2) · AMERICAN ORGAN TRANSPLANT AND CANCER RESEARCH INSTITUTE LLC (1) · ANRS, Emerging Infectious Diseases (1) · Amgen (1) · Beijing Friendship Hospital (1) · Bristol-Myers Squibb (1) · Duke University (1) · Elizabeth C. Verna (1) · Fondazione Policlinico Universitario Agostino Gemelli IRCCS (1)
United States (23) · China (19) · Canada (5) · France (5) · Spain (4) · Belgium (3) · India (3) · United Kingdom (3) · Germany (2) · Italy (2) · Austria (1) · Hungary (1) · Iran (1) · Japan (1) · Poland (1)
Daiming Fan (3) · Yang Yang, PHD, MD (2) · Anil Dhawan, Professor (1) · Baburao Koneru, MD (1) · Charles Gorodetzky, MD, PhD (1) · Cray V. Noah, MD (1) · David R Grant, MD (1) · Deborah Haller (1) · Dina Kao, MD (1) · Dr. Shiv Kumar Sarin, DM (1)
PMID 17903050, PMID 19455046, PMID 20512995, PMID 25715177, PMID 28284916, PMID 30568347, PMID 30863450, PMID 31038755, PMID 31751317, PMID 33011075, PMID 35313729, PMID 35728046, PMID 37975059, PMID 38109364, PMID 38153225, PMID 38925694, PMID 40233953, PMID 41503571, PMID 6749458, PMID 818729
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