81 completed, 75 unknown, 27 recruiting, 25 not yet recruiting. 78 Not applicable, 40 Phase 2, 21 Phase 1, 12 Phase 3, 9 Phase 4.
Follow Liver Failure, Acute: new trials by email Literature Review of Liver Failure, Acute trials Research Report on Liver Failure, Acute
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| National Collaborative Centre for Hepatic Regenerative Medicine (NC-CHRM): Evaluating Mesenchymal Stem-Cell (MSC) Therapy in Non-viral Acute on Chronic Liver Failure (ACLF) Patients - Phase-III Trial Umbilical cord Mesenchymal stem cell, Steroid, Standard Medical Treatment - Acute-On-Chronic Liver Failure | Phase 3 | Not yet recruiting | Institute of Liver and Biliary Sciences, India | 100 | 2028-01-01 | 2025-08-17 |
| National Collaborative Centre for Hepatic Regenerative Medicine (NC-CHRM): Evaluating Mesenchymal Stem Cell Therapy in Non-viral Acute on Chronic Liver Failure (ACLF) Patient- Phase-II Trial ucMSC and Standard medical treatment, Standard medical treatment - Acute-On-Chronic Liver Failure | Phase 2 | Not yet recruiting | Institute of Liver and Biliary Sciences, India | 100 | 2027-01-01 | 2025-08-20 |
| A Novel Extracorporeal Liver Support Therapy In ALCF and to Evaluate the Efficacy of DIALIVE 2.0, a Liver Dialysis Device. Standard of Care (Investigator Choice), DIALIVE 2.0 liver dialysis Device plus available Standard of Care - Acute-on-Chronic Liver Failure (ACLF), Liver Cirrhosis | Not applicable | Recruiting | Yaqrit Ltd | 72 | 2026-10-01 | 2026-09-22 |
| Prevalence and Prognosis of Drug-Induced Liver Injury Drug-Induced Liver Injury | Not yet recruiting | Assiut University | 80 | 2026-10-01 | 2026-09-21 | |
| RENEW: Study of Porcine Liver Support in Participants With Acute-on-Chronic Liver Failure metra® Extracorporeal Liver Cross-Circulation (ELC) system (OrganOx), EGEN-5784 (genetically engineered porcine liver) - Acute on Chronic Liver Failure (ACLF), Hepatic Encephalopathy (HE) | Phase 1 / Phase 2 | Not yet recruiting | eGenesis, INC | 20 | 2026-10-01 | 2026-09-21 |
| Phase 2 Study of 500 mg BID NTZ on Top of Standard of Care in Patients With Acute Decompensation of Liver Cirrhosis at High Risk of Progression to Acute-on-Chronic Liver Failure or Established Acute-on-Chronic Liver Failure NTZ 500mg BID on top of SOC - Acute Decompensation of Liver Cirrhosis, Established Acute-on-Chronic Liver Failure | Phase 2 | Not yet recruiting | Genfit | 16 | 2026-10-01 | 2026-07-09 |
| Very Low-volume Plasma Exchange in ACLF Double Plasma Molecular Adsorption System (DPMAS), Low-volume plasma exchange, Prothrombin Complex Concentrate (PCC) - Acute on Chronic Liver Failure (ACLF) | Not applicable | Not yet recruiting | Third Affiliated Hospital, Sun Yat-Sen University | 840 | 2026-10-01 | 2026-10-05 |
| Risk Factors and Outcomes of Hepatitis A in Children Hepatitis A, Acute Hepatitis | Not yet recruiting | Assiut University | 190 | 2026-09-26 | 2026-09-30 | |
| Evaluating Novel Scoring Systems to Predict Outcomes in Acute-on-Chronic Liver Failure Acute-on-Chronic Liver Failure (ACLF), Liver Cirrhosis | Not yet recruiting | Assiut University | 100 | 2026-08-01 | 2026-07-29 | |
| Role of N-Acetylcysteine in Non-Acetaminophen-Induced Liver Failure N Acetyl Cysteine, Standard supportive care - Acute Liver Failure | Not applicable | Recruiting | King Edward Medical University | 62 | 2026-07-16 | 2026-08-19 |
| Plasma Exchange Half-dose and Extracorporeal Detoxification for ACLF DPMAS plus plasma exchange - Acute on Chronic Liver Failure (ACLF) | Not applicable | Not yet recruiting | Unidade Local de Saude do Nordeste | 240 | 2026-07-01 | 2026-05-18 |
| A-TANGO Phase 2 Study Placebo, TAK-242, G-CSF (Filgrastim) - Acute-On-Chronic Liver Failure, Alcoholic Hepatitis | Phase 2 | Recruiting | Yaqrit Ltd | 78 | 2026-06-29 | 2026-09-21 |
| Chinese Phase II Trail of AS1501 in Acute-on-chronic Liver Failure (ACLF) Patients AS1501 for injection - Acute-On-Chronic Liver Failure | Phase 2 | Recruiting | Shenzhen Third People's Hospital | 96 | 2026-06-15 | 2026-07-17 |
| Double Plasma Separation and Adsorption in Acute-on-Chronic Liver Failure (DPMAS-ACLF Trial) Standard medical therapy (SMT), Double Plasma Molecular Adsorption System (DPMAS) - Acute-on-Chronic Liver Failure (ACLF) | Not applicable | Not yet recruiting | Institute of Liver and Biliary Sciences, India | 56 | 2026-05-10 | 2026-03-25 |
| Establishing a Reference Framework for Outcomes After Machine-Preserved Liver Transplantation in Europe Endischemic hypothermic oxygenated machine perfusion (any device), Endischemic (back-to-base) normothermic machine perfusion (any device), Continuous (device-to-donor) normothermic machine perfusion (any device) - End-stage Liver Disease (ESLD), Acute Liver Failure | Recruiting | University Medical Center Groningen | 10000 | 2026-04-21 | 2026-10-22 | |
| Vitamin C for Acute Kidney Injury in ACLF With Septic Shock: A Randomized Controlled Trial Vitamin C, Standard of Care (SOC) - Acute-on-Chronic Liver Failure (ACLF) | Not applicable | Not yet recruiting | Institute of Liver and Biliary Sciences, India | 110 | 2026-04-01 | 2026-03-25 |
| Etiology and Prognostic Factors in Patients With Acute Liver Failure Acute Liver Failure | Not yet recruiting | Li-Ying Sun | 400 | 2026-03-30 | 2026-04-29 | |
| Efficacy and Safety of Early Initiation of Midodrine for Control and Prevention of Ascites and Its Related Complications in Acute-on-chronic Liver Failure. Midodrine, Standard Medical Treatment - Acute on Chronic Liver Failure | Not applicable | Not yet recruiting | Institute of Liver and Biliary Sciences, India | 113 | 2026-02-05 | 2026-02-20 |
| PT-MSCs Exosome Injection in the Treatment of Chronic-to-acute Liver Failure exosome injection, standard comprehensive internal medical treatment, - Acute-on-Chronic Liver Failure (ACLF) | Early Phase 1 | Active not recruiting | Third Affiliated Hospital, Sun Yat-Sen University | 20 | 2026-01-01 | 2026-02-13 |
| National Collaborative Centre for Hepatic Regenerative Medicine (NC-CHRM): Phase I Study on Safety and Efficacy of Mesenchymal Stem-Cell (MSC) Therapy in Non-Viral Acute-on-Chronic Liver Failure (ACLF) umbilical cord Mesenchymal Stem Cell - Acute-On-Chronic Liver Failure | Phase 1 | Not yet recruiting | Institute of Liver and Biliary Sciences, India | 10 | 2026-01-01 | 2025-08-28 |
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Acute-On-Chronic Liver Failure (163) · Liver Cirrhosis (26) · Liver Failure (24) · Fibrosis (23) · Liver Diseases (19) · Hepatic Encephalopathy (17) · Hepatitis B (17) · End Stage Liver Disease (10) · Sepsis (9) · Acute Kidney Injury (6) · Chemical and Drug Induced Liver Injury (6) · Hepatitis, Alcoholic (6) · Hepatitis (5) · Carcinoma, Hepatocellular (4)
Digestive System Diseases (246) · Hepatic Insufficiency (244) · Liver Diseases (227) · Liver Failure (222) · Pathological Conditions, Signs and Symptoms (70) · Pathologic Processes (66) · Infections (33) · Nervous System Diseases (28) · Hepatitis (27) · Central Nervous System Diseases (25) · Fibrosis (23) · Nutritional and Metabolic Diseases (23) · Brain Diseases (22) · Metabolic Diseases (21)
Plasma Exchange (11) · Acetylcysteine (9) · Albumins (8) · Standard of Care (6) · Granulocyte Colony-Stimulating Factor (5) · Lactulose (5) · Tenofovir (5) · Rifaximin (4) · Terlipressin (4) · Acetaminophen (3) · Blood Specimen Collection (3) · Continuous Renal Replacement Therapy (3) · Sodium Chloride (3) · entecavir (3) · Carvedilol (2)
Institute of Liver and Biliary Sciences, India (48) · Third Affiliated Hospital, Sun Yat-Sen University (13) · Post Graduate Institute of Medical Education and Research, Chandigarh (12) · Nanfang Hospital, Southern Medical University (9) · Assistance Publique - Hôpitaux de Paris (5) · Assiut University (5) · Copenhagen University Hospital, Rigshospitalet (4) · Genfit (4) · RenJi Hospital (4) · Vital Therapies, Inc. (4) · Cellaion SA (3) · European Foundation for Study of Chronic Liver Failure (3) · Hai Li (3) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (3) · Qin Ning (3)
India (64) · China (47) · United States (31) · France (20) · Germany (20) · United Kingdom (17) · Italy (13) · Spain (13) · Belgium (12) · Austria (9) · Denmark (6) · Portugal (6) · Canada (5) · Taiwan (5) · Pakistan (4)
Liang Peng, Doctor (6) · Dr. Shiv Kumar Sarin, DM (3) · Hai Li (3) · William M Lee, MD (3) · Dana Tomescu, Prof (2) · Ed Doo, MD (2) · Michael Praktiknjo, MD (2) · Parvez Mantry, MD (2) · Qin Ning, MD., PhD. (2) · Robert A Ashley (2) · Ahlam B Ali, prof (1) · Alexander Supady, MD, MPH (1) · Amit Singhal, M.D. (1) · Amrish Sahney, MD (1)
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