36 completed, 20 unknown, 11 terminated, 9 recruiting. 40 Not applicable, 18 Phase 2, 18 Phase 3, 4 Early Phase 1, 3 Phase 1.
Follow Plasma Exchange: new trials by email Literature Review of Plasma Exchange trials Research Report on Plasma Exchange
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Autoantibody Reduction Therapy for Progressive Idiopathic Pulmonary Fibrosis Therapeutic Plasma Exchange, Rituximab, Intravenous immunoglobulin - Idiopathic Pulmonary Fibrosis | Phase 2 | Not yet recruiting | University of Alabama at Birmingham | 52 | 2026-12-01 | 2026-10-20 |
| Human Albumin Combined With Plasma Exchange for Frailty Intervention Plasma Exchange, 5% human albumin, Intravenous immunoglobulin (IVIG) - Frailty, Plasma Exchange | Not applicable | Not yet recruiting | Institute of Hematology & Blood Diseases Hospital, China | 34 | 2026-09-24 | 2026-09-23 |
| Plasma Exchange in Children With Severe Sepsis and Septic Shock Plasma exchange (PE) - Severe Sepsis | Not applicable | Recruiting | Menoufia University | 22 | 2026-08-01 | 2026-10-07 |
| Plasma Exchange in Pediatric Autoimmune Encephalitis Plasma exchange (PE) - Autoimmune Encephalitis (AE) | Not applicable | Recruiting | Menoufia University | 22 | 2026-08-01 | 2026-10-07 |
| Plasma Exchange Half-dose and Extracorporeal Detoxification for ACLF DPMAS plus plasma exchange - Acute on Chronic Liver Failure (ACLF) | Not applicable | Not yet recruiting | Unidade Local de Saude do Nordeste | 240 | 2026-07-01 | 2026-05-18 |
| Modified Zipper Therapy for AQP4-IgG Positive Neuromyelitis Optica Spectrum Disorder Eculizumab administration, High-dose corticosteroid pulse therapy, Plasma exchange (PE) - Neuromyelitis Optica Spectrum Disorders (NMOSD) | Phase 3 | Recruiting | Tianjin Medical University General Hospital | 198 | 2026-01-01 | 2026-05-14 |
| Therapeutic Plasma Exchange With Enfortumab Vedotin and Pembrolizumab for Treatment of Bladder Cancers Best Practice, Biospecimen Collection, Central Venous Cannula Insertion - Metastatic Bladder Urothelial Carcinoma, Metastatic Renal Pelvis and Ureter Urothelial Carcinoma | Phase 2 | Recruiting | Mayo Clinic | 70 | 2025-08-01 | 2026-05-08 |
| Efficacy and Safety of Therapeutic Plasma Exchange vs Standard Medical Therapy in Severe Autoimmune Hepatitis. Plasma Exchange, Steroid, Diet - Autoimmune Hepatitis | Not applicable | Not yet recruiting | Institute of Liver and Biliary Sciences, India | 50 | 2025-03-03 | 2025-03-04 |
| Efficacy of Add-on Plasma Exchange As an Adjunctive Strategy Against Septic Shock Therapeutic Plasma Exchange (TPE) - Septic Shock | Not applicable | Recruiting | Hannover Medical School | 274 | 2025-02-19 | 2025-03-13 |
| Daily Versus Alternate Day Plasma Exchange in Wilson Disease With Acute Liver Failure in Children Plasma Exchange, Standard Medical Treatment - Acute Liver Failure, Wilson Disease | Not applicable | Not yet recruiting | Institute of Liver and Biliary Sciences, India | 20 | 2024-11-10 | 2024-11-21 |
| A Clinical Trial With KJ103 in Anti-GBM Disease KJ103 for Injection, Cyclophosphamide, Glucocorticoids - Anti-Glomerular Basement Membrane Disease | Phase 2 | Active not recruiting | Shanghai Bao Pharmaceuticals Co., Ltd. | 12 | 2024-10-21 | 2025-06-13 |
| Efficacy and Safety of Cytokine Adsorption and Plasma Exchange in Patients With ACLF and Sepsis double plasma cytokine adsorption system with sequential low-dose plasma exchange, plasma exchange - Acute-On-Chronic Liver Failure, Sepsis | Not applicable | Recruiting | Third Affiliated Hospital, Sun Yat-Sen University | 192 | 2024-09-27 | 2026-09-11 |
| Clinical Performance of the New Plasma Filter PX2 in TPE Treatments Therapeutic Plasma Exchange (TPE) with the Plasma Filter PX2 - Autoimmune Diseases | Not applicable | Recruiting | Fresenius Medical Care Deutschland GmbH | 46 | 2024-07-18 | 2026-06-24 |
| Novel Treatments in Improving Renal Outcomes in Light Chain Cast Nephropathy Plasma exchange, Daratumumab - Multiple Myeloma, Light Chain Nephropathy | Completed | Brigham and Women's Hospital | 549 | 2024-06-01 | 2026-07-09 | |
| Analysis of TPE Treatments With multiFiltratePRO Therapeutic Plasma Exchange (TPE) option of multiFiltratePRO - Autoimmune Diseases | Active not recruiting | Fresenius Medical Care Deutschland GmbH | 60 | 2024-05-22 | 2026-09-11 | |
| Efficacy of Plasma Exchange Therapy vs Standard Medical Therapy in Severe Alcoholic Hepatitis With High Discriminant Function Plasma Exchange, Standard Medical Treatment - Alcoholic Hepatitis | Not applicable | Unknown | Institute of Liver and Biliary Sciences, India | 60 | 2024-04-09 | 2024-06-24 |
| An Open-label Randomized Controlled Trial Comparing the Role of Therapeutic Plasma-exchange in Ameliorating Secondary Organ Dysfunctions in Patients With ACLF and Develop Biomarkers of Treatment Response Plasma Exchange, Standard Medical Treatment - Acute on Chronic Liver Failure | Not applicable | Not yet recruiting | Institute of Liver and Biliary Sciences, India | 190 | 2024-03-01 | 2024-02-26 |
| Plasma Exchange for Amanita Toxin-induced Acute Liver Failure Therapeutic Plasma Exchange (PEX) - Acute Liver Failure | Completed | Hannover Medical School | 111 | 2024-01-01 | 2025-03-12 | |
| Therapeutic Plasma Exchange in Septic Shock: A Pilot Study Therapeutic Plasma Exchange - Septic Shock | Phase 2 | Recruiting | University of Manitoba | 80 | 2023-06-01 | 2025-08-17 |
| Comparison Between Centrifugation Based and Membrane Based Plasma Exchange plasma exchange - Therapeutic Plasma Exchange | Not applicable | Completed | Alexandria University | 20 | 2023-01-05 | 2024-10-22 |
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COVID-19 (9) · Acute-On-Chronic Liver Failure (8) · Sepsis (7) · Purpura, Thrombotic Thrombocytopenic (5) · Shock, Septic (5) · Acute Kidney Injury (4) · Autoimmune Diseases (4) · Cytokine Release Syndrome (4) · Multiple Sclerosis (4) · Granulomatosis with Polyangiitis (3) · Liver Failure, Acute (3) · Microscopic Polyangiitis (3) · Neuromyelitis Optica (3) · Vasculitis (3) · Anemia, Sickle Cell (2)
Institute of Liver and Biliary Sciences, India (8) · Hansa Biopharma AB (3) · Alexandria University (2) · Emory University (2) · Fresenius Medical Care Deutschland GmbH (2) · Hannover Medical School (2) · London Health Sciences Centre (2) · Mayo Clinic (2) · Menoufia University (2) · Third Affiliated Hospital, Sun Yat-Sen University (2) · UNICEF (2) · Alberta Health Services, Calgary (1) · Asian Institute of Gastroenterology, India (1) · Assistance Publique - Hôpitaux de Paris (1) · Assiut University (1)
United States (23) · China (10) · Germany (9) · India (8) · France (7) · United Kingdom (7) · Canada (5) · Egypt (5) · Spain (5) · Austria (3) · Czechia (3) · Denmark (3) · Italy (3) · Australia (2) · Belgium (2)
Liang Peng, Doctor (2) · Akram M Fayed, MD (1) · Alasdair Coles, 01223 762016 (1) · Anders Perner, Prof (1) · Ayman I Baess, MD (1) · Barbara Konkle, MD (1) · Brian G. Weinshenker (1) · Cheryl Maier, MD, PhD (1) · Christian Bode, PD Dr. (1) · Christophe Legendre, MD, PhD (1) · Christopher Hillyer, MD (1)
PMID 16271648, PMID 16330788, PMID 21670440, PMID 21745374, PMID 23235588, PMID 23615499, PMID 23956564, PMID 26083430, PMID 27358333, PMID 28916122, PMID 30373638, PMID 31348553, PMID 32053298, PMID 32369661, PMID 32583446, PMID 33190086, PMID 33524593, PMID 34786746, PMID 34934447, PMID 35492338, PMID 36155131, PMID 36427162, PMID 36809199, PMID 37061693, PMID 37178148, PMID 38299639, PMID 38346237, PMID 38509495, PMID 38544553, PMID 39023092, PMID 39043682, PMID 39095866, PMID 39376877, PMID 40424097, PMID 40458542, PMID 41422826, PMID 42846119
2018 (2), 1RC2HL101496 (1), 2009 (1), U01HL072268 (1)