23 completed, 10 unknown, 5 withdrawn, 4 recruiting. 50 Phase 3, 14 Phase 2.
Follow Liver Failure: new trials by email Literature Review of Liver Failure trials Research Report on Liver Failure
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| National Collaborative Centre for Hepatic Regenerative Medicine (NC-CHRM): Evaluating Mesenchymal Stem-Cell (MSC) Therapy in Non-viral Acute on Chronic Liver Failure (ACLF) Patients - Phase-III Trial Umbilical cord Mesenchymal stem cell, Steroid, Standard Medical Treatment - Acute-On-Chronic Liver Failure | Phase 3 | Not yet recruiting | Institute of Liver and Biliary Sciences, India | 100 | 2028-01-01 | 2025-08-17 |
| Umbilical Cord-derived Mesenchymal Stem Cell Infusion for Treating ACLF Low-dose experimental group, High-dose experimental group, Low-dose placebo control group - Acute-On-Chronic Liver Failure | Phase 2 / Phase 3 | Not yet recruiting | National Engineering Center of Cell Products | 96 | 2025-04-15 | 2025-03-19 |
| Efficacy and Safety of Continuous Infusion of Terlipressin vs Bolus Terlipressin in ACLF Patients With Acute Esophageal Variceal Bleed Terlipressin Injectable Product - Acute on Chronic Liver Failure | Phase 2 / Phase 3 | Not yet recruiting | Institute of Liver and Biliary Sciences, India | 60 | 2025-02-10 | 2025-02-07 |
| Implications of Fecal Microbiota Transplantation in Modulating the Effects of Liver Cirrhosis Fecal microbiota transplantation - Liver Cirrhosis | Phase 3 | Completed | Cristian Ichim | 19 | 2024-08-05 | 2026-03-27 |
| A PROspective Faecal MIcrobiota tranSplantation Trial to Improve outcomEs in Patients With Cirrhosis Encapsulated FMT, Placebo - Liver Cirrhosis | Phase 3 | Recruiting | King's College London | 300 | 2023-06-21 | 2026-02-24 |
| Efficacy and Safety of Nifuroxazide in the Treatment of Hepatic Encephalopathy in Egyptian Patients With Liver Cirrhosis Nifuroxazide, Lactulose, Rifaximin 550Mg Tab - Hepatic Encephalopathy | Phase 3 | Completed | Cairo University | 80 | 2023-03-12 | 2025-09-02 |
| Allopurinol Versus Atorvastatin to Prevent Complications of Liver Cirrhosis Allopurinol 300 MG, Atorvastatin 20mg, Placebo - Cirrhosis, Hepatic Encephalopathy | Phase 2 / Phase 3 | Completed | Tanta University | 150 | 2022-11-15 | 2026-08-11 |
| Evaluation of Rifaximin SSD for Delaying Encephalopathy Decompensation in Patients With Cirrhosis Rifaximin SSD, Placebo - Hepatic Encephalopathy | Phase 3 | Completed | Bausch Health Americas, Inc. | 517 | 2022-08-03 | 2026-10-28 |
| Study to Assess Rifaximin Soluble Solid Dispersion (SSD) for the Delay of Encephalopathy Decompensation in Cirrhosis Rifaximin SSD, Placebo - Hepatic Encephalopathy | Phase 3 | Active not recruiting | Bausch Health Americas, Inc. | 524 | 2022-04-07 | 2025-07-24 |
| Growth Hormone in Decompensated Liver Cirrhosis Growth Hormone - Liver Cirrhosis, Fibrosis | Phase 2 / Phase 3 | Completed | Post Graduate Institute of Medical Education and Research, Chandigarh | 96 | 2022-02-01 | 2025-12-16 |
| Integrated Traditional Chinese and Clinical Medicine for Chronic Hepatitis B and Its Complication traditional Chinese medicine1 and traditional Chinese medicine 2 - Hepatic Encephalopathy, Cirrhosis, Liver | Phase 3 | Unknown | Qianfoshan Hospital | 276 | 2021-12-01 | 2021-11-19 |
| A Trial to Improve Quality of Life in People With Cirrhosis Lactulose - Cirrhosis | Phase 2 / Phase 3 | Completed | University of Michigan | 56 | 2021-11-10 | 2023-11-21 |
| MNK-6105 for Patients With Cirrhosis and High Ammonia Levels Affecting Brain Function MNK-6105, Placebo, Standard of Care - Hepatic Encephalopathy | Phase 3 | Withdrawn | Mallinckrodt | 2021-11-01 | 2021-09-22 | |
| Faecal Microbiota Transplantation for Liver Cirrhosis Faecal microbiota transplantation, Placebo - Liver Cirrhosis | Phase 2 / Phase 3 | Recruiting | University of Aarhus | 220 | 2021-07-01 | 2025-01-24 |
| The Effect of Terlipressin on Recovery of Liver Function After Hepatectomy Terlipressin plus standard care, Standard care - Terlipressin Adverse Reaction, Ascites Hepatic | Phase 3 | Unknown | Shanghai Zhongshan Hospital | 86 | 2019-11-07 | 2020-01-09 |
| Plasma Exchange in Acute on Chronic Liver Failure Plasma exchange, Standard medical treatment - Cirrhosis, Liver, Acute-On-Chronic Liver Failure | Phase 3 | Unknown | Asian Institute of Gastroenterology, India | 130 | 2019-08-15 | 2019-08-09 |
| Short-term Survival of Subjects With Acute-on-chronic Liver Failure After Plasma Exchange With Human Serum Albumin 5% SMT + PE-A 5%, Standard Medical Treatment - Acute-On-Chronic Liver Failure | Phase 3 | Terminated | Instituto Grifols, S.A. | 274 | 2019-06-17 | 2026-06-04 |
| Custodiol-N Solution Compared With Custodiol Solution in Organ Transplantation (Kidney, Liver and Pancreas) Custodiol-N Solution, Custodiol HTK Solution - Kidney Failure, Liver Failure, Chronic | Phase 3 | Recruiting | Dr. F. Köhler Chemie GmbH | 362 | 2019-05-23 | 2025-09-10 |
| Efficacy and Safety of Nitazoxanide in Preventing Recurrence of Hepatic Encephalopathy Rifaximin, Nitazoxanide - Hepatic Encephalopathy | Phase 3 | Recruiting | Tanta University | 60 | 2018-11-01 | 2019-11-13 |
| Autologous Endothelial Progenitor Cell Therapy for Reversal of Liver Cirrhosis GCSF, CD133 Cells Transplantation - End Stage Liver Disease | Phase 3 | Unknown | National University Hospital, Singapore | 66 | 2017-08-24 | 2021-01-19 |
Showing 20 of 50. Sign in to see all of them.
Hepatic Encephalopathy (24) · Fibrosis (10) · End Stage Liver Disease (8) · Liver Cirrhosis (7) · Acute-On-Chronic Liver Failure (6) · Liver Failure, Acute (6) · Hepatitis, Alcoholic (3) · Renal Insufficiency (3) · Ascites (2) · Heart Failure (2) · Liver Diseases (2) · Acute Kidney Injury (1) · Biliary Tract Diseases (1) · Digestive System Diseases (1)
Digestive System Diseases (49) · Hepatic Insufficiency (49) · Liver Diseases (48) · Nervous System Diseases (25) · Brain Diseases (24) · Brain Diseases, Metabolic (24) · Central Nervous System Diseases (24) · Metabolic Diseases (24) · Nutritional and Metabolic Diseases (24) · Pathologic Processes (17) · Pathological Conditions, Signs and Symptoms (17) · Liver Failure, Acute (6) · Female Urogenital Diseases (5) · Female Urogenital Diseases and Pregnancy Complications (5)
Lactulose (7) · Rifaximin (6) · Acetylcysteine (2) · Fecal Microbiota Transplantation (2) · Standard of Care (2) · nitazoxanide (2) · Allopurinol (1) · Atorvastatin (1) · Basiliximab (1) · Bretschneider cardioplegic solution (1) · Colonoscopy (1) · Custodiol-N solution (1) · Glucose (1) · Glutathione (1) · Granulocyte Colony-Stimulating Factor (1)
Bausch Health Americas, Inc. (4) · Institute of Liver and Biliary Sciences, India (3) · Aga Khan University (2) · Assistance Publique - Hôpitaux de Paris (2) · CD Pharma India Pvt. Ltd. (2) · Tanta University (2) · Vital Therapies, Inc. (2) · A.O. Ospedale Papa Giovanni XXIII (1) · Asian Institute of Gastroenterology, India (1) · Birmingham Women's and Children's NHS Foundation Trust (1) · Cairo University (1) · Cardiox Corporation (1) · Cristian Ichim (1) · Dr. F. Köhler Chemie GmbH (1) · Helsinki University Central Hospital (1)
United States (14) · India (7) · United Kingdom (7) · Germany (5) · Belgium (4) · Canada (4) · Egypt (4) · France (4) · Italy (3) · South Korea (3) · Spain (3) · Australia (2) · Austria (2) · China (2) · Pakistan (2)
Lindsey Mathew (2) · Adrian Boicean, Prof. Dr. (1) · Alexander Kuo, MD (1) · Alexander Wilmer, MD, PhD (1) · Andreas A Schnitzbauer, MD (1) · Andres Duarte-Rojo, MD (1) · Anne M Larson, MD (1) · Anupama Duddempudi, MD (1) · Asem Elfert, Prof (1) · Bjorn Meijers, MD (1) · Chakradhar Reddy, MD (1) · Dan Yock Young (1)
PMID 37467180, PMID 37183883, PMID 19524577, PMID 20102716, PMID 20335583, PMID 20840760, PMID 21837746, PMID 21848797, PMID 24126646, PMID 24302090, PMID 24365449, PMID 24649963, PMID 25009371, PMID 25450083, PMID 26018348, PMID 30263981, PMID 30283499, PMID 30866837, PMID 31325468, PMID 31352795, PMID 31420387, PMID 31421008, PMID 33626248, PMID 34712928, PMID 39853733, PMID 39938959, PMID 40943741, PMID 41082480, PMID 41464526
U01DK058369 (2), 2016 (1), 2017 (1), 2019 (1), R01DK058369 (1), R01NR009987 (1), R03DK052827 (1), U01DK072146 (1)