10 completed, 4 unknown, 2 recruiting. 9 Phase 4, 3 Not applicable, 3 Phase 2, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 9 | Completed 7, Unknown 2 |
| Not applicable | 3 | Completed 1, Recruiting 1, Unknown 1 |
| Phase 2 | 3 | Completed 1, Recruiting 1, Unknown 1 |
| Phase 3 | 2 | Completed 2 |
Follow ornithylaspartate: new trials by email Literature Review of ornithylaspartate trials Research Report on ornithylaspartate
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| An Open-Label, Bayesian Adaptive Phase II Clinical Study in HR+/HER2- Advanced Breast Cancer After Progression on Standard Therapy L-Ornithine L-Aspartate, CDK4/6 inhibitor, Fulvestrant - Breast Cancer | Phase 2 | Recruiting | Fudan University | 60 | 2025-09-25 | 2026-07-13 |
| Human Albumin Infusion in Liver Cirrhosis and Overt Hepatic Encephalopathy (HACHE) Human albumin infusion at a modified dosage, Human albumin infusion at a routine dosage, Lactulose - Overt Hepatic Encephalopathy | Not applicable | Recruiting | General Hospital of Shenyang Military Region | 174 | 2025-06-24 | 2025-08-26 |
| A Trial for Comparing Rifaximin, Probiotic and L-ornithine- L Aspartate With Lactulose in Overt Hepatic Encephalopathy. Probiotic plus lactulose, Rifaximin plus lactulose, L-ornithine-L-aspartate plus latulose - Overt Hepatic Encephalopathy | Phase 4 | Completed | Qurratul Ain Jamil | 252 | 2024-12-02 | 2025-06-25 |
| Efficacy of L-Ornithine L-Aspartate and Polyethylene Glycol in Cirrhotic Patients With Overt Hepatic Encephalopathy Polyethylene Glycols, Lactulose oral solution, L-ornithine L-aspartate - Hepatic Encephalopathy Stage 2, Hepatic Encephalopathy Stage 3 | Phase 4 | Unknown | Jinnah Postgraduate Medical Centre | 360 | 2023-10-01 | 2023-07-13 |
| Efficacy of L-ornithine L-aspartate and Therapeutic Plasma Exchange Versus Plasma Exchange Alone in Lowering Ammonia and Improving Outcomes in Pediatric Acute Liver Failure. L-ornithine L-Aspartate, Placebo - Liver Failure, Acute | Not applicable | Unknown | Institute of Liver and Biliary Sciences, India | 32 | 2023-03-15 | 2023-03-21 |
| Effect of L-ornithine-L-aspertate (LOLA) on the Gut Microbiome L-ornithine L-aspartate - Cirrhosis | Phase 4 | Completed | Medical University of Graz | 52 | 2023-02-06 | 2026-10-09 |
| Efficacy of L-Ornithine L-Aspartate (LOLA) as an Adjunct to Branched Chain Amino Acids (BCAA) Enriched Solutions on Clinical Outcomes in ICU Patients With Hepatic Encephalopathy Branched-chain amino acids (BCAA), enriched solution (Aminoleban) and L-ornithine L-aspartate (LOLA), Branched-chain amino acids (BCAA), enriched solution (Aminoleban) - Hepatic Encephalopathy | Phase 4 | Completed | Ain Shams University | 140 | 2022-09-20 | 2024-11-26 |
| Lactulose, L-ornithine L-aspartate, or Rifaximin Versus Placebo for Preventing Hepatic Encephalopathy in Variceal Bleeding Lactulose, L-ornithine L-aspartate, Rifaximin - Hepatic Encephalopathy | Phase 4 | Completed | Hospital General de Mexico | 88 | 2014-07-01 | 2018-05-22 |
| L-ornithine L-aspartate in Overt Hepatic Encephalopathy L-ornithine L-aspartate, Placebo - Cirrhosis of Liver, Hepatic Encephalopathy | Phase 4 | Completed | Dayanand Medical College and Hospital | 200 | 2013-12-01 | 2017-02-08 |
| The Effectiveness of L-ornithine-L-aspartate (LOLA) on Plasma Ammonia in Cirrhotic Patients After TIPS L-ornithine-L-aspartate - Decompensated Cirrhosis, Portal Hypertension | Phase 2 / Phase 3 | Completed | Air Force Military Medical University, China | 40 | 2011-12-01 | 2012-12-19 |
| Efficacy of L-Ornithine L-Aspartate in Acute Hepatic Encephalopathy. L-ornithine-L-aspartate, Lactose - Hepatic Encephalopathy | Phase 4 | Completed | Centro Regional para el Estudio de las Enfermedades Digestivas | 30 | 2009-11-01 | 2021-05-10 |
| Therapeutic Efficacy of Oral L-Ornithine-L-Aspartate on Minimal Encephalopathy L-ornithine-L-aspartate, placebo - Hepatic Encephalopathy | Phase 4 | Unknown | Hospital de Clinicas de Porto Alegre | 96 | 2008-11-01 | 2009-06-10 |
| Efficacy of Combined Oral L-ornithine-L-aspartate and Lactulose in Patients With Hepatic Encephalopathy L-ornithine-L-aspartate and lactulose, placebo and lactulose - Hepatic Encephalopathy | Phase 4 | Completed | Mahidol University | 35 | 2008-09-01 | 2020-09-04 |
| Brain Imaging in Patients With Chronic Liver Disease and Functional Impairment. l-ornithine l-aspartate - Cirrhosis, Hepatic Encephalopathy | Not applicable | Completed | Imperial College London | 50 | 2006-03-01 | 2015-05-29 |
| Therapeutic Efficacy of L-Ornithine L-Aspartate Infusion in Patients With Acute Liver Failure L-Ornithine L-Aspartate - Acute Liver Failure | Phase 2 | Unknown | All India Institute of Medical Sciences | 150 | 2005-01-01 | 2008-01-07 |
| Efficacy of L-Ornithine-L-Aspartate in Cirrhotics With Hepatic Encephalopathy L-Ornithine L-Aspartate - Hepatic Encephalopathy | Phase 3 | Completed | Aga Khan University | 108 | 2003-10-01 | 2007-02-09 |
Hepatic Encephalopathy (10) · Fibrosis (5) · Liver Cirrhosis (5) · Brain Diseases (3) · Liver Failure, Acute (2) · Ascites (1) · Breast Neoplasms (1) · Hepatic Insufficiency (1) · Hypertension, Portal (1) · Inflammation (1) · Liver Diseases (1)
Aga Khan University (1) · Ain Shams University (1) · Air Force Military Medical University, China (1) · All India Institute of Medical Sciences (1) · Centro Regional para el Estudio de las Enfermedades Digestivas (1) · Dayanand Medical College and Hospital (1) · Fudan University (1) · General Hospital of Shenyang Military Region (1) · Hospital General de Mexico (1) · Hospital de Clinicas de Porto Alegre (1) · Imperial College London (1) · Institute of Liver and Biliary Sciences, India (1) · Jinnah Postgraduate Medical Centre (1) · Mahidol University (1) · Medical University of Graz (1)
China (3) · India (3) · Pakistan (3) · Mexico (2) · Austria (1) · Brazil (1) · Egypt (1) · Thailand (1) · United Kingdom (1)
Amit Singhal, M.D. (1) · B C Sharma, D.M. (1) · Claudia Isabel Blanco Vela, MD (1) · Dr Tamoghna Biswas, MD (1) · Francisco J Bosques, MD, PhD (1) · Guohong Han, PhD & MD (1) · Omesh Goyal, MD, DM (1) · QurratulAin Jamil, PhD (1) · Sandeep S Sidhu, MD,DM (1) · Shahab Abid, MD (1) · Simon D Taylor-Robinson, MBBS, FRCP (1) · Siwaporn Chainuvati, MD (1) · Subrat Kr Acharya, M.D., D.M. (1) · Vikram Bhatia, M.D., D.M. (1)
PMID 19505424, PMID 23872605, PMID 27885712, PMID 30079329, PMID 31596729, PMID 33657293, PMID 41198206, PMID 41272855, PMID 41406626