40 completed, 29 unknown, 15 terminated, 14 recruiting. 118 Phase 2, 39 Phase 1, 14 Phase 3.
Follow Liver Failure: new trials by email Literature Review of Liver Failure trials Research Report on Liver Failure
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| National Collaborative Centre for Hepatic Regenerative Medicine (NC-CHRM): Evaluating Mesenchymal Stem Cell Therapy in Non-viral Acute on Chronic Liver Failure (ACLF) Patient- Phase-II Trial ucMSC and Standard medical treatment, Standard medical treatment - Acute-On-Chronic Liver Failure | Phase 2 | Not yet recruiting | Institute of Liver and Biliary Sciences, India | 100 | 2027-01-01 | 2025-08-20 |
| Study to Evaluate ALN-CIDEB in Adults With Fibrotic Alcohol-Associated Liver Disease (ALD) ALN-CIDEB, Placebo - Alcohol-Associated Liver Disease, ALD | Phase 2 | Not yet recruiting | Regeneron Pharmaceuticals | 120 | 2026-12-09 | 2026-11-12 |
| Microbiota trAnSplant ThERaPy In hEpatiC Encephalopathy (MASTERPIECE) Microbiota transplant therapy (MTT) capsules, Placebo capsule - Hepatic Encephalopathy, Cirrhosis | Phase 2 | Not yet recruiting | VA Office of Research and Development | 162 | 2026-10-30 | 2026-04-14 |
| RENEW: Study of Porcine Liver Support in Participants With Acute-on-Chronic Liver Failure metra® Extracorporeal Liver Cross-Circulation (ELC) system (OrganOx), EGEN-5784 (genetically engineered porcine liver) - Acute on Chronic Liver Failure (ACLF), Hepatic Encephalopathy (HE) | Phase 1 / Phase 2 | Not yet recruiting | eGenesis, INC | 20 | 2026-10-01 | 2026-09-21 |
| Phase 2 Study of 500 mg BID NTZ on Top of Standard of Care in Patients With Acute Decompensation of Liver Cirrhosis at High Risk of Progression to Acute-on-Chronic Liver Failure or Established Acute-on-Chronic Liver Failure NTZ 500mg BID on top of SOC - Acute Decompensation of Liver Cirrhosis, Established Acute-on-Chronic Liver Failure | Phase 2 | Not yet recruiting | Genfit | 16 | 2026-10-01 | 2026-07-09 |
| TLI- and ATG-Enabled Minimization Protocol in Liver Transplantation Anti-Thymocyte Globulin, ATG (Rabbit), Total lymphoid irradiation - Liver Failure | Phase 1 / Phase 2 | Recruiting | Stanford University | 12 | 2026-09-01 | 2026-10-07 |
| A-TANGO Phase 2 Study Placebo, TAK-242, G-CSF (Filgrastim) - Acute-On-Chronic Liver Failure, Alcoholic Hepatitis | Phase 2 | Recruiting | Yaqrit Ltd | 78 | 2026-06-29 | 2026-09-21 |
| Chinese Phase II Trail of AS1501 in Acute-on-chronic Liver Failure (ACLF) Patients AS1501 for injection - Acute-On-Chronic Liver Failure | Phase 2 | Recruiting | Shenzhen Third People's Hospital | 96 | 2026-06-15 | 2026-07-17 |
| Evaluation of the Outcome of Fecal Microbiota Transplantation Fecal Microbiota Transplantation, FMT Matched Placebo, Rifaximin、Lactulose - Hepatic Encephalopathy, Fecal Microbiota Transplantation | Phase 1 / Phase 2 | Not yet recruiting | Air Force Military Medical University, China | 40 | 2026-03-07 | 2026-03-06 |
| Immune Tolerance Induction After Liver Transplantation Donor Hematopoietic Stem and Progenitor Cell Infusion - Liver Transplantation, Immune Tolerance | Phase 1 / Phase 2 | Recruiting | University of California, Los Angeles | 12 | 2026-02-20 | 2026-03-12 |
| Safety and Tolerability Study of a Novel Bioartificial Liver in Liver Failure and Small-for-Size Syndrome Chemically induced pluripotent stem cells biological Artificial Liver - Liver Failure, Small-for-Size Syndrome | Phase 1 / Phase 2 | Recruiting | Beijing Friendship Hospital | 12 | 2025-12-01 | 2026-04-20 |
| A Study to See if an Investigational Medicine Called VS-01 Can Help and How Safe it is in the Treatment of Patients With Overt Hepatic Encephalopathy VS-01 on top of SOC (Active Treatment Group), SOC - Hepatic Encephalopathy, Acute on Chronic Liver Failure (ACLF) | Phase 2 | Terminated | Genfit | 3 | 2025-08-25 | 2026-01-12 |
| CRISPR-Edited HLA Donor Liver Transplant to Reduce Rejection Ex Vivo CRISPR-Cas9 Gene Editing of Donor Liver - Liver Diseases, Liver Cancer | Phase 1 / Phase 2 | Recruiting | AMERICAN ORGAN TRANSPLANT AND CANCER RESEARCH INSTITUTE LLC | 90 | 2025-06-01 | 2025-07-08 |
| Umbilical Cord-derived Mesenchymal Stem Cell Infusion for Treating ACLF Low-dose experimental group, High-dose experimental group, Low-dose placebo control group - Acute-On-Chronic Liver Failure | Phase 2 / Phase 3 | Not yet recruiting | National Engineering Center of Cell Products | 96 | 2025-04-15 | 2025-03-19 |
| Efficacy and Safety of Continuous Infusion of Terlipressin vs Bolus Terlipressin in ACLF Patients With Acute Esophageal Variceal Bleed Terlipressin Injectable Product - Acute on Chronic Liver Failure | Phase 2 / Phase 3 | Not yet recruiting | Institute of Liver and Biliary Sciences, India | 60 | 2025-02-10 | 2025-02-07 |
| RTX001 Autologous Engineered Macrophages for Liver Cirrhosis RTX001 - End-stage Liver Disease (ESLD), Cirrhosis, Liver | Phase 1 / Phase 2 | Active not recruiting | Resolution Therapeutics Limited | 30 | 2024-10-15 | 2026-10-05 |
| Efficacy and Safety of Lemborexant for Patients With Cirrhosis and Sleep Problems Lemborexant, Placebo - Cirrhosis, Liver Cirrhosis | Phase 2 | Completed | Universitas Indonesia | 82 | 2024-10-01 | 2026-03-18 |
| A Novel COMBinATorial Therapy With Albumin and Enoxaparin in Patients With Decompensated Cirrhosis at High-risk of Poor Outcome (COMBAT Trial). Human albumin, Enoxaparin, Standard medical treatment - Liver Cirrhosis, Decompensated Cirrhosis of Liver | Phase 2 | Recruiting | European Foundation for Study of Chronic Liver Failure | 90 | 2024-07-01 | 2026-09-11 |
| Hepatic Encephalopathy and Albumin Lasting Cognitive Improvement Albumin Infusion - Cirrhosis, Hepatic Encephalopathy | Phase 2 | Active not recruiting | Hunter Holmes Mcguire Veteran Affairs Medical Center | 25 | 2023-11-02 | 2026-08-25 |
| Efficacy of Lactoferrin as an Adjunct Therapy in Patients With Hepatic Encephalopathy Lactoferrin Bovine - Hepatic Encephalopathy | Phase 2 | Unknown | Al-Azhar University | 45 | 2023-10-01 | 2023-10-17 |
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Hepatic Encephalopathy (39) · Fibrosis (28) · Acute-On-Chronic Liver Failure (25) · Liver Failure, Acute (19) · Liver Cirrhosis (18) · End Stage Liver Disease (17) · Liver Diseases (15) · Hepatitis, Alcoholic (6) · Hypertension, Portal (5) · Brain Diseases (4) · Hepatitis B (4) · Ascites (3) · Carcinoma, Hepatocellular (3) · Liver Neoplasms (3)
Digestive System Diseases (117) · Hepatic Insufficiency (116) · Liver Diseases (103) · Pathologic Processes (46) · Pathological Conditions, Signs and Symptoms (46) · Nervous System Diseases (42) · Central Nervous System Diseases (41) · Nutritional and Metabolic Diseases (40) · Brain Diseases, Metabolic (39) · Metabolic Diseases (39) · Brain Diseases (37) · Liver Failure, Acute (22) · Fibrosis (14) · Hepatitis (11)
Lactulose (6) · Fecal Microbiota Transplantation (4) · Rifaximin (4) · Antilymphocyte Serum (3) · Congresses as Topic (3) · nitazoxanide (3) · AST 120 (2) · Albumins (2) · Injections (2) · Probiotics (2) · Standard of Care (2) · Tacrolimus (2) · ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate (2) · ornithine phenylacetate (2) · 3-(2-(2-tert-butylphenylaminooxalyl)aminopropionylamino)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid (1)
Air Force Military Medical University, China (4) · Sun Yat-sen University (4) · University of Alberta (4) · Vital Therapies, Inc. (4) · Genfit (3) · Hunter Holmes Mcguire Veteran Affairs Medical Center (3) · Third Affiliated Hospital, Sun Yat-Sen University (3) · All India Institute of Medical Sciences (2) · Amgen (2) · Assistance Publique - Hôpitaux de Paris (2) · Azienda Ospedaliera di Padova (2) · Beijing 302 Hospital (2) · CD Pharma India Pvt. Ltd. (2) · Cellaion SA (2) · Institute of Liver and Biliary Sciences, India (2)
United States (43) · China (19) · France (10) · India (8) · Italy (8) · Spain (8) · United Kingdom (8) · Belgium (7) · Canada (6) · Germany (6) · Egypt (4) · Austria (3) · Denmark (3) · Hungary (3) · Bulgaria (2)
Daiming Fan (3) · Jasmohan S. Bajaj, MD MS (2) · Robert A Ashley (2) · Umberto Cillo, MD (2) · Alexander Wilmer, MD, PhD (1) · Amin M. Abdel Baki, Doctoral (1) · Amit Singhal, M.D. (1) · Andres Blei (1) · Andres Duarte-Rojo, M.D. (1) · Angel Alsina, M.D. (1) · Angel Alsina, MD (1) · Anil Dhawan, Professor (1)
PMID 37183883, PMID 17903050, PMID 19455046, PMID 19505424, PMID 22859317, PMID 23607614, PMID 23847109, PMID 24144944, PMID 24493215, PMID 25450083, PMID 26155840, PMID 26690886, PMID 26838529, PMID 26983031, PMID 27908546, PMID 28284916, PMID 28951631, PMID 29389088, PMID 30251931, PMID 30667591, PMID 30863450, PMID 31325468, PMID 31352795, PMID 31680011, PMID 33011075, PMID 33069881, PMID 34319926, PMID 34712928, PMID 34786649, PMID 35238476, PMID 35313729, PMID 35384391, PMID 36152764, PMID 37681263, PMID 38109364, PMID 38153225, PMID 38409886, PMID 38925694, PMID 39938959, PMID 39969428, PMID 41503571, PMID 42414855
2009 (2), U01DK058369 (2), 2019 (1), 2025 (1), P30DK034989 (1), U01DK062436 (1)