27 completed, 20 unknown, 7 terminated, 4 recruiting. 61 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 61 | Completed 27, Unknown 20, Terminated 7, Recruiting 4, Active not recruiting 2, Not yet recruiting 1 |
Follow Liver Failure: new trials by email Literature Review of Liver Failure trials Research Report on Liver Failure
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Daridorexant for Sleep Disturbance in Adults With Liver Cirrhosis Daridorexant, Placebo - Liver Cirrhosis, Sleep Disturbance | Phase 4 | Not yet recruiting | Wang Fengmei | 180 | 2026-09-01 | 2026-10-16 |
| Apixaban-PK Trial: Preventing Portal Hypertension Complications in Cirrhosis Apixaban, Carvedilol, Placebo - Cirrhosis, Esophageal and Gastric Varices | Phase 4 | Recruiting | Asian Institute Of Medical Sciences | 220 | 2026-04-01 | 2026-04-09 |
| A Study to Evaluate Role of Inhaled Amikacin to Prevent Ventilator Associated Pneumonia in Patients With Cirrhosis Inhaled amikacin, Placebo - Hepatic Encephalopathy, Cirrhosis | Phase 4 | Recruiting | Asian Institute of Gastroenterology, India | 162 | 2025-02-12 | 2025-04-04 |
| BCAA vs. Rifaximin in Patients With Cirrhosis for Secondary Prophylaxis of HE Oral Branched chain Amino acid, Rifaximin 550 MG, Lactulose - Hepatic Encephalopathy, Decompensated Cirrhosis | Phase 4 | Recruiting | Post Graduate Institute of Medical Education and Research, Chandigarh | 336 | 2025-02-01 | 2025-06-10 |
| Efficacy of L-Ornithine L-Aspartate and Polyethylene Glycol in Cirrhotic Patients With Overt Hepatic Encephalopathy Polyethylene Glycols, Lactulose oral solution, L-ornithine L-aspartate - Hepatic Encephalopathy Stage 2, Hepatic Encephalopathy Stage 3 | Phase 4 | Unknown | Jinnah Postgraduate Medical Centre | 360 | 2023-10-01 | 2023-07-13 |
| Effectiveness of Oral Lactulose Versus Lactulose Enema in Hepatic Encephalopathy Tap water, Lactulose - Hepatic Encephalopathy, Chronic Liver Disease | Phase 4 | Unknown | Khyber Medical College, Peshawar | 100 | 2023-04-01 | 2023-04-05 |
| Efficacy of L-Ornithine L-Aspartate (LOLA) as an Adjunct to Branched Chain Amino Acids (BCAA) Enriched Solutions on Clinical Outcomes in ICU Patients With Hepatic Encephalopathy Branched-chain amino acids (BCAA), enriched solution (Aminoleban) and L-ornithine L-aspartate (LOLA), Branched-chain amino acids (BCAA), enriched solution (Aminoleban) - Hepatic Encephalopathy | Phase 4 | Completed | Ain Shams University | 140 | 2022-09-20 | 2024-11-26 |
| Intravenous Ketamine Infusion on Postoperative Analgesia of Living Liver Donors Low dose ketamine infusion, 0.9% NaCl infusion - Liver Failure, Liver Transplant; Complications | Phase 4 | Unknown | Inonu University | 2 | 2022-06-01 | 2022-07-05 |
| Efficacy and Safety of Avatrombopag for Treating TCP in HBV-ACLF Patients Receiving ALSS Treatment Avatrombopag, Artificial Liver Support System, Comprehensive internal medical treatment. - Thrombocytopenia, Hepatitis B, Chronic | Phase 4 | Unknown | Third Affiliated Hospital, Sun Yat-Sen University | 60 | 2022-04-27 | 2022-11-10 |
| Angiotensin 2 for AKI After OLT Angiotensin II, Norepinephrine - Cirrhosis, Liver, End Stage Liver DIsease | Phase 4 | Active not recruiting | University of California, Los Angeles | 30 | 2022-04-08 | 2026-06-12 |
| Pharmacokinetic Study of Continuous Infusion of Remazolam in Mechanically Ventilated Patients in ICU Remimazolam 0.1mg/kg/h, Remimazolam 0.3mg/kg/h, Remimazolam 0.5mg/kg/h - Intensive Care Unit, Mechanical Ventilation | Phase 4 | Unknown | The First Affiliated Hospital with Nanjing Medical University | 30 | 2022-02-01 | 2022-07-29 |
| Effects of the SGLT2 Inhibitor Empagliflozin in Patients With Euvolemic and Hypervolemic Hyponatremia Empagliflozin 25 MG, Placebo - Hyponatremia, SIADH | Phase 4 | Completed | University Hospital, Basel, Switzerland | 113 | 2021-02-04 | 2026-09-22 |
| Avatrombopag in Patients With End-stage Liver Disease and Thrombocytopenia Avatrombopag, Standard medical treatment - Liver Failure, Thrombocytopenia | Phase 4 | Unknown | Tongji Hospital | 150 | 2021-02-01 | 2021-06-07 |
| 20% Albumin vs. Balanced Salt Solution as Resuscitation Fluid in Cirrhosis With Sepsis Induced Hypotension 20% albumin, Balanced salt solution - Cirrhosis, Liver, Acute-On-Chronic Liver Failure | Phase 4 | Unknown | Post Graduate Institute of Medical Education and Research, Chandigarh | 150 | 2020-08-15 | 2022-07-01 |
| Polyethylene Glycol Versus Lactulose on Hepatic Encephalopathy in Patients With Cirrhosis;(PEGHE Trial) Polyethylene Glycols, Lactulose - Hepatic Encephalopathy | Phase 4 | Unknown | Aga Khan University | 102 | 2020-03-09 | 2023-04-19 |
| Prevention of Post-TIPS Hepatic Encephalopathy by Administration of Rifaximin and Lactulose Rifaximin 550 milligram Oral Tablet [XIFAXAN], Placebo oral tablet, Lactulose 667 milligram/milliliter Oral Solution - Hepatic Encephalopathy, Cirrhosis, Liver | Phase 4 | Recruiting | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 238 | 2020-01-21 | 2025-01-28 |
| Use of HA 330-II for Hemofiltration in Patients With ALF as a Bridge to Liver Transplantation . HA 330-II, Standard medical treatment (SMT) - Acute-On-Chronic Liver Failure | Phase 4 | Unknown | Asian Institute of Gastroenterology, India | 10 | 2019-12-30 | 2020-01-28 |
| Somatostatin in Living Donor Liver Transplantation Somatostatin, Placebo - End Stage Liver DIsease, Portal Hypertension | Phase 4 | Unknown | King Faisal Specialist Hospital & Research Center | 56 | 2019-12-01 | 2019-09-27 |
| PEG3350 in ACLF With Hepatic Encephalopathy PEG-3350 with Electolytes, Lactulose - Hepatic Encephalopathy, Acute-On-Chronic Liver Failure | Phase 4 | Unknown | Post Graduate Institute of Medical Education and Research, Chandigarh | 60 | 2018-05-20 | 2019-06-17 |
| DAA Treatment in Donor HCV-positive to Recipient HCV-negative Liver Transplant Treatment with Direct Acting Antiviral tablet - End Stage Liver Disease, Hepatitis C | Phase 4 | Terminated | Massachusetts General Hospital | 33 | 2017-11-21 | 2022-07-28 |
Showing 20 of 61. Sign in to see all of them.
Hepatic Encephalopathy (35) · Fibrosis (15) · Liver Cirrhosis (10) · End Stage Liver Disease (8) · Liver Diseases (7) · Acute-On-Chronic Liver Failure (6) · Brain Diseases (4) · Hypertension, Portal (4) · Renal Insufficiency (4) · Hepatic Insufficiency (3) · Hepatitis B (3) · Hepatitis C (3) · Hyponatremia (3) · Liver Failure, Acute (3)
Digestive System Diseases (61) · Hepatic Insufficiency (58) · Liver Diseases (54) · Nutritional and Metabolic Diseases (37) · Central Nervous System Diseases (36) · Metabolic Diseases (36) · Nervous System Diseases (36) · Brain Diseases, Metabolic (35) · Brain Diseases (32) · Pathological Conditions, Signs and Symptoms (29) · Pathologic Processes (28) · Fibrosis (9) · Infections (9) · Blood-Borne Infections (6)
Lactulose (13) · Rifaximin (7) · ornithylaspartate (7) · Albumins (4) · Amino Acids, Branched-Chain (3) · Polyethylene Glycols (3) · Carvedilol (2) · Fat Emulsions, Intravenous (2) · Mycophenolic Acid (2) · Serum Albumin, Human (2) · Sodium Chloride (2) · Tacrolimus (2) · avatrombopag (2) · Acetylcysteine (1) · Angiotensin II (1)
Govind Ballabh Pant Hospital (4) · Post Graduate Institute of Medical Education and Research, Chandigarh (4) · Hospital Universitari Vall d'Hebron Research Institute (3) · Asian Institute of Gastroenterology, India (2) · Bausch Health Americas, Inc. (2) · Stanley Dudrick's Memorial Hospital (2) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (1) · Advanced Circulatory Systems (1) · Aga Khan University (1) · Ain Shams University (1) · All India Institute of Medical Sciences (1) · Asian Institute Of Medical Sciences (1) · Baylor College of Medicine (1) · Baylor Research Institute (1) · Beijing 302 Hospital (1)
India (12) · United States (10) · Spain (6) · China (5) · Belgium (3) · Egypt (3) · Mexico (3) · Pakistan (3) · Netherlands (2) · Poland (2) · United Kingdom (2) · Brazil (1) · Canada (1) · Germany (1) · South Korea (1)
Barjesh C Sharma, MD,DM (3) · Alexander P Wilmer, MD Ph D (1) · Aliena Badshah (1) · Amany Abd El-Rahim Abdin, MD (1) · B C Sharma, D.M. (1) · Bart Takkenberg, MD, PhD (1) · Claudia Isabel Blanco Vela, MD (1) · Debbie Shawcross, MBBS PhD (1) · Dieter Broering, MD, PhD (1) · Dr. Fatima Nadeem, Pharm-D, Mphil (1) · Eric J. Lawitz, MD (1) · Francisco J Bosques, MD, PhD (1) · German Soriano (1)
PMID 37467180, PMID 29960156, PMID 17326150, PMID 21261975, PMID 21294143, PMID 21714640, PMID 22632574, PMID 22861074, PMID 23204255, PMID 23348400, PMID 23506003, PMID 23872605, PMID 24461665, PMID 24825371, PMID 25603822, PMID 26266842, PMID 28130688, PMID 28475354, PMID 30079329, PMID 30138685, PMID 30420883, PMID 30910320, PMID 31083000, PMID 31361307, PMID 31481633, PMID 31970446, PMID 32928255, PMID 33060437, PMID 33372103, PMID 33712505, PMID 33905794, PMID 34487412, PMID 34571050, PMID 34816288, PMID 34915907, PMID 35274472, PMID 35651610, PMID 37183883, PMID 39017697, PMID 40493222, PMID 40517312, PMID 42437371
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