67 completed, 31 unknown, 21 recruiting, 13 terminated. 58 Not applicable, 16 Phase 1, 16 Phase 2, 8 Phase 3, 8 Phase 4.
Follow End Stage Liver Disease: new trials by email Literature Review of End Stage Liver Disease trials Research Report on End Stage Liver Disease
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| VitaSmart HOPE System: Bridge to HOPE Registry hypothermic oxygenated perfusion therapy of a donor liver under standard of care conditions - End Stage Liver DIsease, Liver Failure | Enrolling by invitation | Bridge to Life Ltd. | 5000 | 2026-09-01 | 2026-05-22 | |
| Evaluating Novel Scoring Systems to Predict Outcomes in Acute-on-Chronic Liver Failure Acute-on-Chronic Liver Failure (ACLF), Liver Cirrhosis | Not yet recruiting | Assiut University | 100 | 2026-08-01 | 2026-07-29 | |
| Effect of Preoperative Oral Carbohydrate Loading on Postoperative Outcomes in Liver Transplant Patients Preoperative Oral Carbohydrate Loading, Placebo - Liver Transplantation, Liver Transplant | Not applicable | Recruiting | Medical University of Warsaw | 434 | 2026-05-27 | 2026-06-03 |
| Establishing a Reference Framework for Outcomes After Machine-Preserved Liver Transplantation in Europe Endischemic hypothermic oxygenated machine perfusion (any device), Endischemic (back-to-base) normothermic machine perfusion (any device), Continuous (device-to-donor) normothermic machine perfusion (any device) - End-stage Liver Disease (ESLD), Acute Liver Failure | Recruiting | University Medical Center Groningen | 10000 | 2026-04-21 | 2026-10-22 | |
| Immune Tolerance Induction After Liver Transplantation Donor Hematopoietic Stem and Progenitor Cell Infusion - Liver Transplantation, Immune Tolerance | Phase 1 / Phase 2 | Recruiting | University of California, Los Angeles | 12 | 2026-02-20 | 2026-03-12 |
| Restrictive Fluid Management In Liver Transplantation (REFIL) Low splanchnic blood volume restrictive fluid management strategy, Phlebotomy, Optimized cardiac output liberal fluid management strategy - Liver Transplantation (LT), End-stage Liver Disease (ESLD) | Not applicable | Recruiting | Centre hospitalier de l'Université de Montréal (CHUM) | 866 | 2026-02-15 | 2026-07-10 |
| Nutrition and Exercise Prehabilitation in Patients Awaiting Liver Transplantation Diet with even protein distribution plus exercise program, Diet with skewed protein distribution plus exercise program, Standard dietary and physical activity advice - End-stage Liver Disease, Liver Cirrhosis | Not applicable | Recruiting | Kalliopi Anna Poulia | 90 | 2026-01-08 | 2026-05-01 |
| Multidimensional Frailty Assessment and Post-Transplant Outcomes in Liver Transplant Candidates Comprehensive Observational Assessment in Liver Transplant Candidates - End-Stage Liver Disease, Liver Transplantation | Recruiting | Izmir Bakircay University | 60 | 2025-12-15 | 2026-02-17 | |
| Efficacy and Safety of Tranexamic Acid in Adult Liver Transplantation---ESTA Trial tranexamic acid, 0.9 % saline - Liver Transplantation, Tranexamic Acid | Not applicable | Recruiting | RenJi Hospital | 1546 | 2025-11-01 | 2025-12-08 |
| HepHospital: A Pilot Trial of a Hepatology Home Hospital Intervention for Patients With Advanced Liver Disease Hepatology Home Hospital - Cirrhosis, End Stage Liver DIsease | Not applicable | Recruiting | Massachusetts General Hospital | 30 | 2025-07-21 | 2026-10-07 |
| Assessment of a Quantra-guided Transfusion Algorithm in Liver Transplantation Transfusion algorithm based on Quantra®, Conventional transfusion algorithm - Liver Transplantation | Not applicable | Recruiting | University Hospital, Toulouse | 56 | 2025-03-08 | 2025-09-22 |
| View of Cerebral Perfusion in Liver Transplantation Carotid Doppler Ultrasonography and Near-Infrared Spectroscopy (NIRS) - End-stage Liver Disease (ESLD), Liver Transplantation | Active not recruiting | Inonu University | 43 | 2025-02-01 | 2026-03-02 | |
| Physical and Cognitive Outcomes After Post-Transplant Physiotherapy in Liver Transplant Recipients Routine Post-Transplant Physiotherapy - Liver Transplantation (LT), End-Stage Liver Disease | Completed | Hasan Kalyoncu University | 106 | 2024-10-27 | 2026-07-10 | |
| RTX001 Autologous Engineered Macrophages for Liver Cirrhosis RTX001 - End-stage Liver Disease (ESLD), Cirrhosis, Liver | Phase 1 / Phase 2 | Active not recruiting | Resolution Therapeutics Limited | 30 | 2024-10-15 | 2026-10-05 |
| Effects of Aerobic and Resistance Exercises on Inpatients Liver Transplantation Recipients Aerobic and resistance exercise, Respiratory physiotherapy - Liver Transplant Disorder, Liver Transplant; Complications | Not applicable | Unknown | Tehran University of Medical Sciences | 40 | 2024-10-01 | 2024-09-27 |
| A Study of SIPLIZUMAB in AILD and LT Patients Siplizumab - Autoimmune Liver Disease, Liver Transplant Disorder | Phase 1 | Recruiting | Elizabeth C. Verna | 8 | 2024-09-11 | 2025-11-24 |
| Surprise Question in End of Life (SeQuEL) Care and the Effect of Prompting Palliative Care Consultation: End-Stage Liver Disease Prompted Palliative Care Consult - End-Stage Liver Disease | Not applicable | Completed | Vanderbilt University Medical Center | 97 | 2024-08-05 | 2025-08-19 |
| Testing LiverWatch, a Home-Based Remote-Monitoring Intervention for Advanced Liver Disease LiverWatch Intervention - Cirrhosis, Liver, End Stage Liver DIsease | Not applicable | Active not recruiting | University of Pennsylvania | 110 | 2024-05-01 | 2026-08-10 |
| Effect of Different Frequencies of Umbilical Cord-mesenchymal Stem Cells Through Peripheral Vein in Patients With ESLD umbilical cord-mesenchymal stem cells - End-Stage Liver DIsease | Not applicable | Completed | General Hospital of Shenyang Military Region | 92 | 2024-03-05 | 2026-03-31 |
| Micro-encapsulated Hepatocyte Intraperitoneal Transplantation in Liver Failure Adults a single course of micro-encapsulated hepatocytes intraperitoneal transplantation therapy - Acute-On-Chronic Liver Failure, Chronic Liver Failure | Phase 1 | Recruiting | RenJi Hospital | 10 | 2024-03-01 | 2025-06-27 |
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Liver Cirrhosis (26) · Fibrosis (24) · Liver Diseases (15) · Sarcopenia (11) · Kidney Failure, Chronic (9) · Frailty (8) · Liver Failure (8) · Hepatic Encephalopathy (7) · Hepatitis C (7) · Hypertension, Portal (7) · Liver Failure, Acute (7) · Heart Failure (6) · Acute Kidney Injury (5) · Acute-On-Chronic Liver Failure (5)
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Mycophenolic Acid (4) · Liver Transplantation (3) · Anti-Bacterial Agents (2) · Glutathione (2) · Mass Screening (2) · Observation (2) · Phlebotomy (2) · Resistance Training (2) · Thrombelastography (2) · Tocotrienols (2) · Analgesia, Patient-Controlled (1) · Angiotensin II (1) · Basiliximab (1) · Blood Specimen Collection (1) · Bretschneider cardioplegic solution (1)
Mayo Clinic (5) · Centre hospitalier de l'Université de Montréal (CHUM) (4) · Massachusetts General Hospital (4) · Post Graduate Institute of Medical Education and Research, Chandigarh (4) · RenJi Hospital (4) · Air Force Military Medical University, China (3) · Baylor Research Institute (3) · Tongji Hospital (3) · University of California, Los Angeles (3) · University of California, San Francisco (3) · University of Pennsylvania (3) · University of Washington (3) · Albert Einstein Healthcare Network (2) · Arbor Research Collaborative for Health (2) · Asan Medical Center (2)
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Daiming Fan (3) · J. Randall Curtis, MD, MPH (2) · James Trotter, MD (2) · Jennifer C Lai, MD, MBA (2) · Kymberly Watt, MD (2) · Victor Navarro, MD (2) · Won Ho Kim, MD, PhD (2) · Achal Dhir, MD (1) · Achuthan Sourianarayanane (1) · Adrian H Cotterell, MD, FACS (1) · Alfonso W Avolio (1) · Amrish Sahney, MD (1) · Amy E Taylor, MD (1) · Anders Boyd, MPH, PhD (1)
PMID 10189326, PMID 10218526, PMID 10371175, PMID 10546860, PMID 10563713, PMID 10634199, PMID 10670636, PMID 10789605, PMID 10971863, PMID 10988097, PMID 11071184, PMID 11188837, PMID 11216928, PMID 11262215, PMID 11303131, PMID 11366976, PMID 11399982, PMID 11544428, PMID 11719381, PMID 11722270, PMID 11737323, PMID 11740189, PMID 11807691, PMID 11895160, PMID 12008784, PMID 12126821, PMID 12134254, PMID 12172088, PMID 12186514, PMID 12534953, PMID 12553482, PMID 12558340, PMID 12640206, PMID 12741625, PMID 12819520, PMID 12853195, PMID 12859325, PMID 12891060, PMID 12957089, PMID 14518432, PMID 14581998, PMID 14627784, PMID 14991809, PMID 14999610, PMID 1506645, PMID 15195254, PMID 15197808, PMID 15232720, PMID 15234856, PMID 15272393
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