3 completed, 2 active not recruiting, 2 unknown, 1 recruiting. 9 Early Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Early Phase 1 | 9 | Completed 3, Active not recruiting 2, Unknown 2, Recruiting 1, Withdrawn 1 |
Follow Liver Failure: new trials by email Literature Review of Liver Failure trials Research Report on Liver Failure
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Fecal Microbiota Transplantation for the Treatment of Refractory Hepatic Encephalopathy After TIPS Surgery Fecal Microbiota Transplantation, Rifaximin、Lactulose, Dietary Fiber Prebiotic - Hepatic Encephalopathy, Fecal Microbiota Transplantation | Early Phase 1 | Recruiting | Air Force Military Medical University, China | 26 | 2026-06-01 | 2026-07-06 |
| Ex Vivo Perfusion of Gene-Edited Porcine Livers in Patients With Severe Hepatic Failure Ex vivo perfusion of six-gene-edited porcine liver, Multi-drug immunosuppressive therapy - Hepatic Failure | Early Phase 1 | Active not recruiting | Xijing Hospital | 1 | 2026-01-31 | 2026-04-09 |
| PT-MSCs Exosome Injection in the Treatment of Chronic-to-acute Liver Failure exosome injection, standard comprehensive internal medical treatment, - Acute-on-Chronic Liver Failure (ACLF) | Early Phase 1 | Active not recruiting | Third Affiliated Hospital, Sun Yat-Sen University | 20 | 2026-01-01 | 2026-02-13 |
| The Efficacy and Safety of Rifaximin Treatment Rifaximin 200 mg, Standard Treatment without Rifaximin - Liver Failure, Acute on Chronic, Hepatic Encephalopathy | Early Phase 1 | Unknown | Sun Yat-sen University | 124 | 2023-03-09 | 2023-03-28 |
| Secondary Prophylaxis of Hepatic Encephalopathy in Cirrhotic Patients lactulose, colistin - Hepatic Encephalopathy | Early Phase 1 | Unknown | Madonna Magdy Fahmy | 316 | 2022-03-01 | 2022-03-15 |
| Pilot Trial of Eculizumab Therapy to Reduce Preservation Injury in Human Macrosteatotic Liver Transplantation Eculizumab, No intervention - End Stage Liver Disease | Early Phase 1 | Withdrawn | Yale University | 2021-10-01 | 2021-04-08 | |
| Safety and Efficacy of ProQuad® in Children 6-24 Month Being Evaluated for Solid Organ Transplant ProQuad - RENAL INSUFFICIENCY, CHRONIC, LIVER FAILURE, ACUTE | Early Phase 1 | Completed | Medical University of South Carolina | 5 | 2015-12-01 | 2019-02-12 |
| Spray Diathermy Versus Harmonic Scalpel Technique for Hepatic Parenchymal Transection harmonic scalpel, spray mode diathermy - End Stage Liver Disease | Early Phase 1 | Completed | Mansoura University | 80 | 2013-04-01 | 2016-03-22 |
| Human Tissue Distribution of Orally Supplemented Natural Vitamin E Tocotrienol To surgery patients, Tocopherol capsules., Tocotrienol to healthy subjects., To surgery patients, Tocotrienol capsules. - End Stage Cardiac Failure, Pulmonary Failure | Early Phase 1 | Completed | Chandan K Sen | 80 | 2006-03-01 | 2014-09-16 |
End Stage Liver Disease (3) · Hepatic Encephalopathy (3) · Acute-On-Chronic Liver Failure (2) · Heart Diseases (1) · Hepatitis B (1) · Liver Failure, Acute (1) · Obesity, Morbid (1) · Renal Insufficiency, Chronic (1)
Digestive System Diseases (9) · Hepatic Insufficiency (9) · Liver Diseases (9) · Nutritional and Metabolic Diseases (4) · Brain Diseases (3) · Brain Diseases, Metabolic (3) · Central Nervous System Diseases (3) · Metabolic Diseases (3) · Nervous System Diseases (3) · Liver Failure, Acute (2) · Pathological Conditions, Signs and Symptoms (2) · Blood-Borne Infections (1) · Body Weight (1) · Cardiovascular Diseases (1)
Colistin (1) · Fecal Microbiota Transplantation (1) · Lactulose (1) · Rifaximin (1) · Tocopherols (1) · Tocotrienols (1) · eculizumab (1) · measles, mumps, rubella, varicella vaccine (1)
Air Force Military Medical University, China (1) · Chandan K Sen (1) · Madonna Magdy Fahmy (1) · Mansoura University (1) · Medical University of South Carolina (1) · Sun Yat-sen University (1) · Third Affiliated Hospital, Sun Yat-Sen University (1) · Xijing Hospital (1) · Yale University (1)
China (4) · United States (3)
Ayman El Nakeeb, MD (1) · Chandan Sen, PhD (1) · Jing LI (1) · Kaishan Tao, Professor (1) · Katherine Twombley, MD (1) · Kefeng Dou, Professor (1) · Lin Wang, Professor (1) · Sanjay Kulkarni, M.D. (1)
PMID 10898704, PMID 18639230, PMID 19109835, PMID 20335583, PMID 21157444, PMID 22298568, PMID 22370735, PMID 23993913, PMID 25060964, PMID 25309092, PMID 25819304, PMID 26084406, PMID 27512927, PMID 28902040, PMID 28994123, PMID 31172417, PMID 31988585, PMID 32004593, PMID 32781201, PMID 33385299, PMID 33421158, PMID 34006193, PMID 35220659, PMID 35313729