53 completed, 22 unknown, 7 recruiting, 5 not yet recruiting. 34 Not applicable, 24 Phase 4, 17 Phase 2, 17 Phase 3, 8 Phase 1.
Follow Lactulose: new trials by email Literature Review of Lactulose trials Research Report on Lactulose
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Lactulose to Improve Gut Health in Cancer Patients Receiving Immunotherapy Lactulose - Cancer | Phase 1 / Phase 2 | Recruiting | University of Chicago | 55 | 2026-12-15 | 2026-06-16 |
| Dietary Supplements in Patients With Coronary Artery Bypass Grafting for Improving the Quality of Healthcare Delivery. Vitamin C, Omega 3 PUFA (EPO/DHA), Lignin, Lactulose - Cardio-pulmonary Bypass, Cardiovascular Diseases | Not applicable | Not yet recruiting | Nicosia General Hospital | 108 | 2026-09-01 | 2026-05-13 |
| Oral Lactulose for Gastrointestinal Recovery After Complex Appendectomy Lactulose oral solution, Placebo - Ileus Postoperative, Gastrointestinal Function | Not applicable | Recruiting | Nanchong Central Hospital | 150 | 2026-06-21 | 2026-06-25 |
| A Prospective, Multicenter, Randomized, Parallel-controlled, Superiority Trial the Shouhui Tongbian Capsule, Lactulose - OIC | Phase 3 | Not yet recruiting | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine | 270 | 2026-05-30 | 2026-04-27 |
| New Microbiota-endocrine Axis in Fructose Malabsorption-caused Visceral Hypersensitivity in Irritable Bowel Syndrome. urine intestinal permeability test or lactulose/mannitol test, Blood test, food diary - Irritable Bowel Syndrome (IBS) | Not applicable | Not yet recruiting | University Hospital, Rouen | 60 | 2026-02-01 | 2026-01-13 |
| UDCA to Prevent Post-TIPS Hepatic Encephalopathy Ursodeoxycholic Acid (UDCA), Lactulose - Hepatic Encephalopathy (HE), TIPS | Not applicable | Not yet recruiting | West China Hospital | 270 | 2026-01-01 | 2025-12-09 |
| Combination of Lactulose and Polyethylene Glycol Electrolytes Powder (PEG-ELS) for Bowel Preparation in Type II Diabetes Mellitus Patients lactulose, PEG (solution given 4 L) - Type II Diabetes Mellitus | Not applicable | Completed | General Hospital of Shenyang Military Region | 300 | 2025-09-04 | 2026-09-25 |
| Human Albumin Infusion in Liver Cirrhosis and Overt Hepatic Encephalopathy (HACHE) Human albumin infusion at a modified dosage, Human albumin infusion at a routine dosage, Lactulose - Overt Hepatic Encephalopathy | Not applicable | Recruiting | General Hospital of Shenyang Military Region | 174 | 2025-06-24 | 2025-08-26 |
| Effect of Single vs Repeated Cycles of a Combination of Granulocyte Colony Stimulating Factor and Darbepoetin vs Standard Medical Treatment on Immunometabolic Profile in Patient With Early Decompensated Cirrhosis. Darbepoetin, G-CSF, Lactulose - Decompensated Liver Cirrhosis | Not applicable | Recruiting | Institute of Liver and Biliary Sciences, India | 60 | 2025-06-04 | 2026-05-22 |
| Goal Directed Ammonia Lowering Therapy in Hyperammonemic ACLF Patients With no Overt HE to Reduce Major Adverse Liver Related Outcomes (GOAL Trial) Lactulose, Rifaximin, Standard Medical treatment - Acute on Chronic Liver Failure | Not applicable | Not yet recruiting | Institute of Liver and Biliary Sciences, India | 90 | 2025-02-05 | 2025-02-04 |
| BCAA vs. Rifaximin in Patients With Cirrhosis for Secondary Prophylaxis of HE Oral Branched chain Amino acid, Rifaximin 550 MG, Lactulose - Hepatic Encephalopathy, Decompensated Cirrhosis | Phase 4 | Recruiting | Post Graduate Institute of Medical Education and Research, Chandigarh | 336 | 2025-02-01 | 2025-06-10 |
| A Trial for Comparing Rifaximin, Probiotic and L-ornithine- L Aspartate With Lactulose in Overt Hepatic Encephalopathy. Probiotic plus lactulose, Rifaximin plus lactulose, L-ornithine-L-aspartate plus latulose - Overt Hepatic Encephalopathy | Phase 4 | Completed | Qurratul Ain Jamil | 252 | 2024-12-02 | 2025-06-25 |
| Clinical Study on the Application of Lactulose Combined with Linaclotide in Bowel Preparation for Colonoscopy Lactulose, Lactulose+ linaclotide, polyethylene glycol (PEG) - Lactulose, Bowel Preparation | Phase 4 | Unknown | Haifeng Lan | 444 | 2024-09-01 | 2024-12-27 |
| Ultra-low Split-dose Oral Lactulose vs High-volume Split-dose Polyethylene Glycol as Bowel Preparation for Outpatient Colonoscopies. lactulose, polyethylene glycol (PEG) - Colonoscopy | Not applicable | Completed | National Institute of Medical Sciences and Nutrition, Salvador Zubiran | 200 | 2024-07-29 | 2026-08-26 |
| Bowel Preparation in Colonoscopy: Lactulose vs Polyethyleneglycol, Randomized Double-blind Comparative Clinical Trial, Multicenter Study. Bowel preparation before colonoscopy - Colorectal Cancer Screening | Phase 4 | Completed | Hospital Civil de Guadalajara | 449 | 2024-07-20 | 2026-07-28 |
| Efficacy and Safety of Clotrimazole+Lactulose Vaginal Suppositories Vs. Clotrimazole Monotherapy in Adult Women with Candidal Vaginitis/Vulvovaginitis Clotrimazole+Lactulose., Canesten (Clotrimazole), Lactulose - Candidal Vulvovaginitis (ICD-10 Code: B37.3), Vulvovaginal Candidiasis (VVC) | Phase 2 / Phase 3 | Recruiting | AVVA Pharmaceuticals Ltd. | 264 | 2024-02-29 | 2025-02-19 |
| Assesment of Lactulose vs Lactobacillus Acidophilus Effect in CKD Patients Lactulose - CKD | Unknown | Assiut University | 150 | 2023-12-01 | 2023-07-07 | |
| Efficacy of L-Ornithine L-Aspartate and Polyethylene Glycol in Cirrhotic Patients With Overt Hepatic Encephalopathy Polyethylene Glycols, Lactulose oral solution, L-ornithine L-aspartate - Hepatic Encephalopathy Stage 2, Hepatic Encephalopathy Stage 3 | Phase 4 | Unknown | Jinnah Postgraduate Medical Centre | 360 | 2023-10-01 | 2023-07-13 |
| Effects of Lactulose on Gut Microbiota and Metabolism in Diabetic Constipated Patients Lactulose oral solution, Live Combined B. Subtilis and E. Faecium Enteric-coated Capsules - Diabetes Mellitus, Constipation - Functional | Not applicable | Recruiting | Peking Union Medical College Hospital | 60 | 2023-07-01 | 2025-07-15 |
| LiveSMART Trial to Prevent Falls in Patients With Cirrhosis Enhanced Usual Care, Lactulose, Investigator recommended exercise - Cirrhosis, Liver, Portal Hypertension | Phase 3 | Completed | University of Michigan | 233 | 2023-06-13 | 2026-07-31 |
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Hepatic Encephalopathy (36) · Constipation (13) · Liver Cirrhosis (10) · Fibrosis (8) · Acute-On-Chronic Liver Failure (5) · Brain Diseases (5) · Liver Diseases (5) · Hypertension, Portal (4) · Hepatic Insufficiency (3) · Irritable Bowel Syndrome (3) · Liver Failure (3) · Candidiasis, Vulvovaginal (2) · Fissure in Ano (2) · Pruritus (2) · Abdominal Pain (1)
Institute of Liver and Biliary Sciences, India (6) · Post Graduate Institute of Medical Education and Research, Chandigarh (5) · Govind Ballabh Pant Hospital (3) · Mayo Clinic (3) · Aga Khan University (2) · Avva Rus, JSC (2) · Bnai Zion Medical Center (2) · General Hospital of Shenyang Military Region (2) · Norgine (2) · Renmin Hospital of Wuhan University (2) · Sherief Abd-Elsalam (2) · Solvay Pharmaceuticals (2) · Tongji Hospital (2) · University of Michigan (2) · AVVA Pharmaceuticals Ltd. (1)
United States (22) · China (16) · India (16) · Egypt (6) · United Kingdom (5) · Mexico (4) · Pakistan (4) · Russia (3) · Canada (2) · Denmark (2) · France (2) · Israel (2) · Spain (2) · Belarus (1) · Cyprus (1)
Barjesh C Sharma, MD,DM (2) · David CA Candy, MD (2) · Madhusudan Grover, MBBS (2) · Aliena Badshah (1) · Amany Abd El-Rahim Abdin, MD (1) · Andres Blei (1) · Anthony Davis, MBCHB (1) · Arieh Riskin, MD (1) · Asem Elfert, Prof (1) · Asmaa A. Elrakaybi, Bachelor (1) · Athanasios D. Athanasiou, MD, MSc, MPA (1) · Chakradhar Reddy, MD (1) · Chien-Hsun Huang, MD, MSc (1)
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