53 completed, 25 unknown, 14 recruiting, 11 active not recruiting. 78 Not applicable, 13 Phase 4, 6 Phase 2, 4 Phase 3, 2 Phase 1.
Follow Knee Pain Chronic: new trials by email Literature Review of Knee Pain Chronic trials Research Report on Knee Pain Chronic
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| IMAGES: Identifying Metabolic Imaging Association With Genicular Artery Embolization Success Embolization - Knee Osteoarthritis, Knee Discomfort | Not applicable | Not yet recruiting | Lucas R. Cusumano, MD | 25 | 2026-12-30 | 2026-09-21 |
| Stimulation of Peripheral Afferents to Reduce Muscle Inhibition at the Knee Peripheral Electrical Stimulation (PES), Paired Pulse Electrical Stimulation (ppES) - Knee Osteoarthristis, Knee Pain Arthritis | Not applicable | Not yet recruiting | Northeastern University | 50 | 2026-09-01 | 2026-09-22 |
| A+HA Premium Oral Hyaluronic Acid Drink Functional Evaluation Trial for Delaying Joint Pain Placebo, A+HA premium oral hyaluronic acid drink - Knee Pain Chronic | Not applicable | Not yet recruiting | Taipei Medical University | 60 | 2026-09-01 | 2026-09-02 |
| Advanced Brain Imaging-TKA (fMRI-TKA) fMRI Brain Scan - Knee Osteoarthritis (Knee OA), Knee Pain Chronic | Not applicable | Recruiting | Ottawa Hospital Research Institute | 50 | 2026-04-01 | 2026-03-11 |
| Knee Pain Relief After Endovenous Treatment for Lower Limb Varicose Veins: A Prospective Observational Study Endovenous Ablation for Varicose Veins - Varicose Veins of Lower Limb, Chronic Venous Insufficiency, CVI | Not yet recruiting | Chengdu University of Traditional Chinese Medicine | 50 | 2025-10-01 | 2025-09-09 | |
| Investigation of the Effectiveness of Myofascial Release Techniques Applied to the Popliteus Muscle in Individuals With Knee Pain. Myofascial Release - Knee Pain Chronic | Not applicable | Completed | Istanbul Rumeli University | 45 | 2025-10-01 | 2026-03-17 |
| Impact of Dexamethasone Route on Pain and Inflammation in iPACK With ACB for Knee Arthroplasty NaCl 0.9%, Dexamethasone 4mg - Osteoarthritis, Knee, Knee Pain Chronic | Phase 4 | Completed | Poznan University of Medical Sciences | 90 | 2025-09-13 | 2026-05-22 |
| Pain Reprocessing Therapy in Post-Operative Knee Pain Pain reprocessing therapy (PRT), Usual care - Pain, Chronic, Knee Pain Chronic | Phase 2 | Recruiting | Weill Medical College of Cornell University | 110 | 2025-08-13 | 2026-08-05 |
| Light Therapy on Pain and Synovitis 810 nm Light Therapy, Sham Light Therapy - Knee Pain Chronic, Synovitis of Knee | Not applicable | Recruiting | The Hong Kong Polytechnic University | 80 | 2025-07-13 | 2025-11-26 |
| BioPoly® Partial Resurfacing Knee Implant IDE BioPoly, surgical standard of care (SSOC) - Knee Pain Chronic, Knee Osteoarthritis | Not applicable | Recruiting | BioPoly LLC | 152 | 2025-03-17 | 2026-07-08 |
| Efficacy of Microparticle Geniculate Artery Embolization in Total Knee Prosthesis Patients With Pain Resistant to Medical Treatment. A Prospective Randomized Controlled Trial microparticles, embolization, sham embolization - Knee Pain Chronic, Knee Pain Swelling | Not applicable | Recruiting | Societe Francaise de Rhumatologie | 112 | 2025-03-10 | 2025-05-30 |
| Association Of Knee Pain With High-Impact Workouts Among Gym Participants: A Cross-Sectional Study Knee Pain With High-Impact Workouts - Knee Pain Chronic | Active not recruiting | Superior University | 119 | 2025-03-03 | 2025-07-09 | |
| Genicular Artery Embolization (GAE) for Osteoarthritic Knee Pain Genicular artery embolization (GAE) - Knee Osteoarthritis, Knee Pain Chronic | Not applicable | Withdrawn | Andrew Picel | 2025-01-15 | 2025-02-24 | |
| The Acute Effects of Ankle Exercises on Knee Proprioception Ankle Exercise, Knee Exercise - Knee Pain Chronic | Not applicable | Completed | Gaziantep Islam Science and Technology University | 114 | 2025-01-06 | 2025-09-26 |
| Biomechanical and Clinical Evaluation of a Gait Modifying Device for Treating Knee Pain Gait-Modifying Shoe Intervention - Knee Osteoarthritis, Knee Pain Chronic | Completed | Scientific Motion Technologies, Inc. | 42 | 2025-01-03 | 2026-11-02 | |
| Two-level ESPB in Total Knee Arthroplasty 2 x 20 ml of Ropivacaine 0.2% Injectable Solution, 2 x 20ml of Ropivacaine 0.2% Injectable Solution - Knee Osteoarthritis, Knee Pain Chronic | Phase 4 | Completed | Poznan University of Medical Sciences | 60 | 2024-11-07 | 2025-11-25 |
| Effects of UC-II, Glucosamine and Curcumin Supplementation on Knee Pain and Inflammation. UCII, glucosamine and curcumin, Placebo - Inflammation, Knee Pain Chronic | Not applicable | Completed | Taipei Medical University | 32 | 2024-08-20 | 2026-01-07 |
| Evaluation Study for the "Jockey Club E-Generation: Impact Extension Project for Chronic Knee Pain Management" 12-week intervention, 12-week attention control - Knee Discomfort, Knee Pain Chronic | Not applicable | Recruiting | The University of Hong Kong | 858 | 2024-08-19 | 2024-12-05 |
| Dexamethasone vs. Dexmedetomidine for ESPB in Pain Management After Knee Arthroplasty 0.9% Sodium Chloride Injection, Dexamethasone, Dexmedetomidine - Knee Osteoarthritis, Knee Arthritis | Phase 4 | Completed | Poznan University of Medical Sciences | 90 | 2024-08-13 | 2026-03-30 |
| Dexamethasone for iPACK Block With ACB in Total Knee Arthroplasty Ropivacaine, Ropivacaine+Dexamethasone - Knee Osteoarthritis, Knee Pain Chronic | Phase 4 | Completed | Poznan University of Medical Sciences | 60 | 2024-08-13 | 2025-07-23 |
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Osteoarthritis, Knee (63) · Osteoarthritis (24) · Pain (11) · Arthritis (10) · Arthritis, Rheumatoid (8) · Chronic Pain (7) · Knee Injuries (6) · Patellofemoral Pain Syndrome (6) · Arthralgia (4) · Motor Activity (4) · Pain, Postoperative (4) · Back Pain (3) · Joint Diseases (3) · Low Back Pain (3) · Osteonecrosis (3)
Musculoskeletal Diseases (83) · Joint Diseases (81) · Rheumatic Diseases (74) · Arthritis (65) · Osteoarthritis (49) · Pathological Conditions, Signs and Symptoms (35) · Neurologic Manifestations (30) · Signs and Symptoms (30) · Pain (14) · Pathologic Processes (11) · Nervous System Diseases (10) · Connective Tissue Diseases (9) · Immune System Diseases (9) · Skin and Connective Tissue Diseases (9) · Autoimmune Diseases (7)
Ropivacaine (8) · Sodium Chloride (7) · Arthroplasty, Replacement, Knee (3) · resiniferatoxin (3) · Anesthesia, Spinal (2) · Ascorbic Acid (2) · Cholecalciferol (2) · Dexamethasone (2) · Embolization, Therapeutic (2) · Exercise (2) · Physical Therapy Modalities (2) · Radiofrequency Ablation (2) · Saline Solution (2) · ATF7IP protein, human (1) · Acetaminophen (1)
Poznan University of Medical Sciences (9) · Zimmer Biomet (6) · Brigham and Women's Hospital (4) · Diskapi Teaching and Research Hospital (3) · Riphah International University (3) · Sorrento Therapeutics, Inc. (3) · University of Nottingham (3) · Aalborg University (2) · Hawler Medical University (2) · Kessler Foundation (2) · Medacta USA (2) · Medical University of Warsaw (2) · Northeastern University (2) · Ottawa Hospital Research Institute (2) · Taipei Medical University (2)
United States (49) · Poland (13) · Turkey (Türkiye) (11) · Canada (6) · Pakistan (5) · Denmark (3) · Hong Kong (3) · United Kingdom (3) · Belgium (2) · France (2) · Israel (2) · Italy (2) · Netherlands (2) · Spain (2) · Taiwan (2)
Hillary Overholser (3) · Ana M Valdes, PhD (2) · Malgorzata Domagalska, Ph.D. (2) · Malgorzata Reysner, M.D. Ph.D. (2) · Monica Luchi, MD (2) · Alishba Mustansar, M.Phil./tDPT (1) · Amal Fawzy, Ph.d (1) · Andrew C Picel, MD (1) · Anne Thackeray, PhD, MPH, PT (1) · Annick Timmermans, PhD, PT (1) · Antonia Patruno, PhD (1) · Asim Arif, M.Phil MSK (1)
PMID 21540705, PMID 29324820, PMID 29910837, PMID 30580277, PMID 31315794, PMID 31662373, PMID 31699704, PMID 32318673, PMID 32434498, PMID 32583982, PMID 33620447, PMID 34038916, PMID 34239634, PMID 34431329, PMID 35082139, PMID 35317254, PMID 35689683, PMID 36474880, PMID 36869680, PMID 37706686, PMID 38272846, PMID 38518540, PMID 40255927, PMID 40623740, PMID 41116173, PMID 41902932, PMID 42552011, PMID 42689852, PMID 7386476
P30AG022845 (1), R01AR059086 (1), R21AR081007 (1)