33 completed, 15 unknown, 11 recruiting, 8 active not recruiting. 78 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 78 | Completed 33, Unknown 15, Recruiting 11, Active not recruiting 8, Withdrawn 6, Not yet recruiting 4, Terminated 1 |
Follow Knee Pain Chronic: new trials by email Literature Review of Knee Pain Chronic trials Research Report on Knee Pain Chronic
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| IMAGES: Identifying Metabolic Imaging Association With Genicular Artery Embolization Success Embolization - Knee Osteoarthritis, Knee Discomfort | Not applicable | Not yet recruiting | Lucas R. Cusumano, MD | 25 | 2026-12-30 | 2026-09-21 |
| Stimulation of Peripheral Afferents to Reduce Muscle Inhibition at the Knee Peripheral Electrical Stimulation (PES), Paired Pulse Electrical Stimulation (ppES) - Knee Osteoarthristis, Knee Pain Arthritis | Not applicable | Not yet recruiting | Northeastern University | 50 | 2026-09-01 | 2026-09-22 |
| A+HA Premium Oral Hyaluronic Acid Drink Functional Evaluation Trial for Delaying Joint Pain Placebo, A+HA premium oral hyaluronic acid drink - Knee Pain Chronic | Not applicable | Not yet recruiting | Taipei Medical University | 60 | 2026-09-01 | 2026-09-02 |
| Advanced Brain Imaging-TKA (fMRI-TKA) fMRI Brain Scan - Knee Osteoarthritis (Knee OA), Knee Pain Chronic | Not applicable | Recruiting | Ottawa Hospital Research Institute | 50 | 2026-04-01 | 2026-03-11 |
| Investigation of the Effectiveness of Myofascial Release Techniques Applied to the Popliteus Muscle in Individuals With Knee Pain. Myofascial Release - Knee Pain Chronic | Not applicable | Completed | Istanbul Rumeli University | 45 | 2025-10-01 | 2026-03-17 |
| Light Therapy on Pain and Synovitis 810 nm Light Therapy, Sham Light Therapy - Knee Pain Chronic, Synovitis of Knee | Not applicable | Recruiting | The Hong Kong Polytechnic University | 80 | 2025-07-13 | 2025-11-26 |
| BioPoly® Partial Resurfacing Knee Implant IDE BioPoly, surgical standard of care (SSOC) - Knee Pain Chronic, Knee Osteoarthritis | Not applicable | Recruiting | BioPoly LLC | 152 | 2025-03-17 | 2026-11-05 |
| Efficacy of Microparticle Geniculate Artery Embolization in Total Knee Prosthesis Patients With Pain Resistant to Medical Treatment. A Prospective Randomized Controlled Trial microparticles, embolization, sham embolization - Knee Pain Chronic, Knee Pain Swelling | Not applicable | Recruiting | Societe Francaise de Rhumatologie | 112 | 2025-03-10 | 2025-05-30 |
| Genicular Artery Embolization (GAE) for Osteoarthritic Knee Pain Genicular artery embolization (GAE) - Knee Osteoarthritis, Knee Pain Chronic | Not applicable | Withdrawn | Andrew Picel | 2025-01-15 | 2025-02-24 | |
| The Acute Effects of Ankle Exercises on Knee Proprioception Ankle Exercise, Knee Exercise - Knee Pain Chronic | Not applicable | Completed | Gaziantep Islam Science and Technology University | 114 | 2025-01-06 | 2025-09-26 |
| Effects of UC-II, Glucosamine and Curcumin Supplementation on Knee Pain and Inflammation. UCII, glucosamine and curcumin, Placebo - Inflammation, Knee Pain Chronic | Not applicable | Completed | Taipei Medical University | 32 | 2024-08-20 | 2026-01-07 |
| Evaluation Study for the "Jockey Club E-Generation: Impact Extension Project for Chronic Knee Pain Management" 12-week intervention, 12-week attention control - Knee Discomfort, Knee Pain Chronic | Not applicable | Recruiting | The University of Hong Kong | 858 | 2024-08-19 | 2024-12-05 |
| Computer-guided Action Planning to Support Physical Activity (CAPPA) for Employees With Chronic Knee Symptoms CAPPA, Health education - Osteoarthritis of Knee, Knee Pain Chronic | Not applicable | Completed | Marquette University | 39 | 2024-08-12 | 2026-04-01 |
| Transcranial Direct Current Stimulation in Conjunction With Individualized Physical Therapy for Individuals With Chronic Knee Pain transcranial direct current stimulation, physical therapy - Knee Pain Chronic | Not applicable | Active not recruiting | University of Illinois at Chicago | 30 | 2024-06-06 | 2026-05-11 |
| Effects of IASTM With and Without CT on Pain, ROM, and Functional Disability in Post-Operative Knee Stiffness Patients Instrumental Soft Tissue Mobilization Technique with Conservative Treatment, Conservative Treatment - Pain, Pain, Postoperative | Not applicable | Completed | University of Lahore | 84 | 2024-01-28 | 2025-01-31 |
| Ultrasound-Guided Adductor Canal Block for Total Knee Arthroplasty Surgery 20 ml volume adductor canal block, 30 ml volume adductor canal block, 40 ml volume adductor canal block - Knee Disease, Knee Deformity | Not applicable | Completed | Bursa City Hospital | 90 | 2023-12-20 | 2025-12-19 |
| Optimizing Pain Self-Management in Total Knee Arthroplasty Savoring Meditation, Pain Self-Management and Education - Osteo Arthritis Knee, Knee Pain Chronic | Not applicable | Recruiting | University of Virginia | 150 | 2023-11-27 | 2026-08-17 |
| RFA or Chemical Neurolysis of the Genicular Nerves Compared to Conservative Treatment for Knee Pain Caused by OA Diagnostic genicular nerve block, Genicular nerve block with Radiofrequency Ablation (RFA), Genicular nerve block with Phenol 6% - Osteo Arthritis Knee, Knee Pain Chronic | Not applicable | Recruiting | Dijklander Ziekenhuis | 192 | 2023-11-27 | 2023-12-05 |
| Upper and Lower Extremity Exercise and Exercise-Induced Hypoalgesia in Knee Osteoarthritis Exercise - Knee Osteoarthritis, Knee Pain Chronic | Not applicable | Recruiting | University of Texas, El Paso | 60 | 2023-11-15 | 2024-12-16 |
| Finding the Optimal Aim of Correction in Opening Wedge High Tibial Osteotomy Procedure: HTO using PSI aiming at 55% correction, Procedure: HTO using PSI aiming at 62% correction - Osteoarthritis, Knee, Knee Pain Chronic | Not applicable | Not yet recruiting | Vestre Viken Hospital Trust | 70 | 2023-11-01 | 2023-11-18 |
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Osteoarthritis, Knee (33) · Osteoarthritis (15) · Pain (9) · Arthritis (7) · Arthritis, Rheumatoid (6) · Patellofemoral Pain Syndrome (6) · Arthralgia (3) · Back Pain (3) · Chronic Pain (3) · Knee Injuries (3) · Motor Activity (3) · Arterial Occlusive Diseases (2) · Low Back Pain (2) · Osteonecrosis (2) · Pain, Postoperative (2)
Joint Diseases (49) · Musculoskeletal Diseases (49) · Rheumatic Diseases (40) · Arthritis (34) · Osteoarthritis (25) · Pathological Conditions, Signs and Symptoms (22) · Neurologic Manifestations (18) · Signs and Symptoms (18) · Pain (8) · Pathologic Processes (8) · Connective Tissue Diseases (7) · Immune System Diseases (7) · Skin and Connective Tissue Diseases (7) · Behavior (6) · Autoimmune Diseases (5)
Arthroplasty, Replacement, Knee (2) · Cholecalciferol (2) · Embolization, Therapeutic (2) · Exercise (2) · Physical Therapy Modalities (2) · ATF7IP protein, human (1) · Anesthesia, General (1) · Anesthesia, Spinal (1) · Anesthetics, Local (1) · Arthroscopy (1) · Ascorbic Acid (1) · Blood Flow Restriction Therapy (1) · Cognitive Training (1) · Conservative Treatment (1) · Curcumin (1)
Zimmer Biomet (5) · Riphah International University (3) · Aalborg University (2) · Brigham and Women's Hospital (2) · Hawler Medical University (2) · Northeastern University (2) · Ottawa Hospital Research Institute (2) · Taipei Medical University (2) · 4Life Research, LLC (1) · Abant Izzet Baysal University (1) · Andrew Picel (1) · Aspetar (1) · BioPoly LLC (1) · Bursa City Hospital (1) · Centre Hospitalier Departemental Vendee (1)
United States (34) · Turkey (Türkiye) (6) · Canada (4) · Pakistan (4) · Hong Kong (3) · Denmark (2) · France (2) · Italy (2) · Poland (2) · Taiwan (2) · Belgium (1) · Brazil (1) · China (1) · Finland (1) · Iraq (1)
Hillary Overholser (2) · Alishba Mustansar, M.Phil./tDPT (1) · Andrew C Picel, MD (1) · Annick Timmermans, PhD, PT (1) · Antonia Patruno, PhD (1) · Asim Arif, M.Phil MSK (1) · Boonchana Pongcharoen, MD (1) · Christian Roux, Pr, MD (1) · Daniel Pinto, PhD (1) · Daniel Rhon, DSc (1) · David R Veroff, MPP (1) · Einar Ottestad (1)
PMID 21540705, PMID 29324820, PMID 30580277, PMID 31662373, PMID 31699704, PMID 32583982, PMID 33620447, PMID 34431329, PMID 35082139, PMID 35317254, PMID 35689683, PMID 36474880, PMID 36869680, PMID 37706686, PMID 38272846, PMID 38518540, PMID 40255927, PMID 40623740, PMID 41116173, PMID 42552011, PMID 42689852, PMID 7386476
R01AR059086 (1), R21AR081007 (1)